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ONTOLOGY REPORT - ANNOTATIONS


Term:endoplasmic reticulum unfolded protein response
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Accession:GO:0030968 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
Comment:Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
Synonyms:exact_synonym: ER unfolded protein response;   erUPR
 related_synonym: SREBP-mediated signalling pathway


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endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
RGD:13792537
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:1624291
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:1600115
RGD:1624291
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:1600115
G Atf6b activating transcription factor 6 beta JBrowse link 20 4,414,283 4,422,283 RGD:1600115
G Bhlha15 basic helix-loop-helix family, member a15 JBrowse link 12 12,403,385 12,409,103 RGD:1624291
RGD:1600115
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:13792537
G Calr3 calreticulin 3 JBrowse link 16 19,097,391 19,124,062 RGD:13792537
G Calr4 calreticulin 4 JBrowse link 5 128,865,339 128,900,135 RGD:13792537
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:1624291
RGD:1600115
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:1624291
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Clgn calmegin JBrowse link 19 24,545,257 24,578,527 RGD:13792537
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:1624291
RGD:1600115
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:1600115
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:1600115
G Creb3l4 cAMP responsive element binding protein 3-like 4 JBrowse link 2 189,596,657 189,602,243 RGD:1600115
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:1600115
RGD:1624291
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
RGD:13792537
G Derl2 derlin 2 JBrowse link 10 57,641,682 57,653,554 RGD:1624291
RGD:13792537
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:1624291
RGD:13792537
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1600115
RGD:1624291
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:1624291
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
RGD:13792537
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:13792537
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha JBrowse link 15 19,619,947 19,655,381 RGD:1624291
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:10401883
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:1304324
RGD:13792537
RGD:1624291
G Herpud2 HERPUD family member 2 JBrowse link 8 26,266,571 26,311,528 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
RGD:13792537
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G LOC103694875 derlin-3 RGD:13792537
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
G Parp16 poly (ADP-ribose) polymerase family, member 16 JBrowse link 8 70,712,393 70,731,212 RGD:1624291
RGD:13792537
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:1624291
RGD:9999413
RGD:9999171
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
RGD:1600115
G Rnf121 ring finger protein 121 JBrowse link 1 167,095,916 167,165,257 RGD:13792537
G Selenos selenoprotein S JBrowse link 1 126,979,579 126,989,344 RGD:1600115
RGD:13792537
RGD:1624291
G Serp1 stress-associated endoplasmic reticulum protein 1 JBrowse link 2 148,718,279 148,722,263 RGD:1624291
RGD:13792537
G Serp2 stress-associated endoplasmic reticulum protein family member 2 JBrowse link 15 58,687,784 58,712,023 RGD:13792537
G Stc2 stanniocalcin 2 JBrowse link 10 16,542,909 16,552,675 RGD:1624291
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
G Tbl2 transducin (beta)-like 2 JBrowse link 12 24,565,843 24,578,855 RGD:1624291
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 JBrowse link 15 109,338,762 109,394,905 RGD:1624291
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1624291
RGD:1600115
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:13792537
RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1304536
RGD:1624291
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1624291
RGD:13792537
RGD:1600115
IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:13792537
RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Parp16 poly (ADP-ribose) polymerase family, member 16 JBrowse link 8 70,712,393 70,731,212 RGD:1600115
RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1600115
RGD:1624291
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6b activating transcription factor 6 beta JBrowse link 20 4,414,283 4,422,283 RGD:1624291
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:1624291
RGD:10047363
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crebrf CREB3 regulatory factor JBrowse link 10 16,693,846 16,753,162 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bfar bifunctional apoptosis regulator JBrowse link 10
10
1,464,658
1,464,783
1,471,152
1,497,653
RGD:1624291
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1624291
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 6 64,165,913 64,170,122 RGD:1600115
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1600115
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:1624291
G Ufl1 Ufm1-specific ligase 1 JBrowse link 5 39,616,479 39,650,894 RGD:1624291
RGD:1600115
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:1624291
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:1600115
RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:1624291
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:1600115
RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
RGD:13792537
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Creb3 cAMP responsive element binding protein 3 JBrowse link 5 59,063,532 59,068,196 RGD:1624291
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
RGD:13792537
RGD:1600115
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pigbos1 PIGB opposite strand 1 JBrowse link 8 79,715,337 79,719,706 RGD:1624291
RGD:1600115
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
G Ficd FIC domain protein adenylyltransferase JBrowse link 12 48,658,283 48,663,175 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      signal transduction 6968
        endoplasmic reticulum unfolded protein response 72
          ATF6-mediated unfolded protein response + 3
          IRE1-mediated unfolded protein response + 15
          PERK-mediated unfolded protein response + 11
          negative regulation of endoplasmic reticulum unfolded protein response + 13
          positive regulation of endoplasmic reticulum unfolded protein response + 10
          positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 4
          regulation of endoplasmic reticulum unfolded protein response + 25
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      cellular response to stimulus 8858
        cellular response to chemical stimulus 3497
          cellular response to organic substance 2825
            cellular response to topologically incorrect protein 122
              cellular response to unfolded protein 99
                endoplasmic reticulum unfolded protein response 72
                  ATF6-mediated unfolded protein response + 3
                  IRE1-mediated unfolded protein response + 15
                  PERK-mediated unfolded protein response + 11
                  negative regulation of endoplasmic reticulum unfolded protein response + 13
                  positive regulation of endoplasmic reticulum unfolded protein response + 10
                  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 4
                  regulation of endoplasmic reticulum unfolded protein response + 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.