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ONTOLOGY REPORT - ANNOTATIONS


Term:endoplasmic reticulum unfolded protein response
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Accession:GO:0030968 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
Comment:Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
Synonyms:exact_synonym: ER unfolded protein response;   erUPR
 related_synonym: SREBP-mediated signalling pathway


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Path 1
Term Annotations click to browse term
  biological_process 0
    cellular process 0
      signal transduction 0
        endoplasmic reticulum unfolded protein response 0
          ATF6-mediated unfolded protein response + 0
          IRE1-mediated unfolded protein response + 0
          PERK-mediated unfolded protein response + 0
          negative regulation of endoplasmic reticulum unfolded protein response + 0
          positive regulation of endoplasmic reticulum unfolded protein response + 0
          positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 0
          regulation of endoplasmic reticulum unfolded protein response + 0
Path 2
Term Annotations click to browse term
  biological_process 0
    response to stimulus 0
      cellular response to stimulus 0
        cellular response to chemical stimulus 0
          cellular response to organic substance 0
            cellular response to topologically incorrect protein 0
              cellular response to unfolded protein 0
                endoplasmic reticulum unfolded protein response 0
                  ATF6-mediated unfolded protein response + 0
                  IRE1-mediated unfolded protein response + 0
                  PERK-mediated unfolded protein response + 0
                  negative regulation of endoplasmic reticulum unfolded protein response + 0
                  positive regulation of endoplasmic reticulum unfolded protein response + 0
                  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 0
                  regulation of endoplasmic reticulum unfolded protein response + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.