ONTOLOGY REPORT - ANNOTATIONS


Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


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endocrine pancreas development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:2306957
RGD:13792537
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2315710
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:1582421
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
RGD:1600115
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
RGD:1600115
G Gip gastric inhibitory polypeptide JBrowse link 10 83,835,080 83,848,399 RGD:1624291
RGD:1600115
G Gipr gastric inhibitory polypeptide receptor JBrowse link 1 80,063,047 80,073,223 RGD:1624291
RGD:1600115
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1600115
RGD:1624291
G Hnf1b HNF1 homeobox B JBrowse link 10 71,159,863 71,218,902 RGD:1624291
RGD:8554679
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
RGD:1600115
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:1624291
G Insm1 INSM transcriptional repressor 1 JBrowse link 3 140,427,961 140,430,467 RGD:1624291
G Mnx1 motor neuron and pancreas homeobox 1 JBrowse link 4 2,376,350 2,381,308 RGD:1624291
RGD:13792537
G Myt1 myelin transcription factor 1 JBrowse link 3 177,281,365 177,341,550 RGD:1624291
G Neurod1 neuronal differentiation 1 JBrowse link 3 66,414,314 66,417,617 RGD:1600115
RGD:1624291
G Neurog3 neurogenin 3 JBrowse link 20 31,761,419 31,762,893 RGD:1600115
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:1624291
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
RGD:1600115
G Onecut1 one cut homeobox 1 JBrowse link 8 81,765,779 81,799,894 RGD:1624291
RGD:1600115
G Onecut2 one cut homeobox 2 JBrowse link 18 59,830,375 59,882,490 RGD:1624291
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:1624291
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:1624291
RGD:13792537
G Rfx3 regulatory factor X3 JBrowse link 1 245,853,332 246,110,648 RGD:1624291
G Rfx6 regulatory factor X, 6 JBrowse link 20 32,709,282 32,764,040 RGD:1624291
RGD:13792537
G Sox4 SRY box 4 JBrowse link 17 37,615,022 37,619,728 RGD:1624291
G Sox9 SRY box 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:1624291
RGD:1600115
G Mir7a1 microRNA 7a-1 JBrowse link 17 6,675,016 6,675,112 RGD:1624291
negative regulation of type B pancreatic cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr cystic fibrosis transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11567224
pancreatic A cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
RGD:8552352
pancreatic A cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:1624291
RGD:1600115
G Insm1 INSM transcriptional repressor 1 JBrowse link 3 140,427,961 140,430,467 RGD:1624291
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:8552352
G Rfx6 regulatory factor X, 6 JBrowse link 20 32,709,282 32,764,040 RGD:1624291
RGD:13792537
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1624291
RGD:1600115
pancreatic A cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Neurod1 neuronal differentiation 1 JBrowse link 3 66,414,314 66,417,617 RGD:1624291
RGD:1600115
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
pancreatic D cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rfx6 regulatory factor X, 6 JBrowse link 20 32,709,282 32,764,040 RGD:1624291
RGD:13792537
pancreatic epsilon cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rfx6 regulatory factor X, 6 JBrowse link 20 32,709,282 32,764,040 RGD:1624291
RGD:13792537
pancreatic PP cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Neurod1 neuronal differentiation 1 JBrowse link 3 66,414,314 66,417,617 RGD:1624291
RGD:1600115
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
positive regulation of type B pancreatic cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
RGD:1600115
G Rfx3 regulatory factor X3 JBrowse link 1 245,853,332 246,110,648 RGD:1624291
RGD:1600115
regulation of type B pancreatic cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:1600115
RGD:1624291
G Clock clock circadian regulator JBrowse link 14 34,418,226 34,502,218 RGD:1600115
RGD:1624291
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:1624291
RGD:1600115
type B pancreatic cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
RGD:1600115
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:1624291
RGD:1600115
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:1600115
G Hnf4g hepatocyte nuclear factor 4, gamma JBrowse link 2 100,225,880 100,372,710 RGD:1600115
G Insm1 INSM transcriptional repressor 1 JBrowse link 3 140,427,961 140,430,467 RGD:1624291
G Mir375 microRNA 375 JBrowse link 9 82,161,716 82,161,790 RGD:1624291
G Mir503 microRNA 503 JBrowse link X 158,148,476 158,148,546 RGD:1624291
G Mir541 microRNA 541 JBrowse link 6 133,892,655 133,892,744 RGD:1624291
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:2326025
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
RGD:1600115
G Sidt2 SID1 transmembrane family, member 2 JBrowse link 8 50,230,335 50,246,979 RGD:1624291
RGD:1600115
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:1624291
RGD:1600115
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
type B pancreatic cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:1624291
RGD:1600115
G Insm1 INSM transcriptional repressor 1 JBrowse link 3 140,427,961 140,430,467 RGD:1624291
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:9589069
G Mir7a1 microRNA 7a-1 JBrowse link 17 6,675,016 6,675,112 RGD:1624291
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:8552355
RGD:1600115
RGD:1624291
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:8553608
RGD:13792537
RGD:1624291
G Rfx6 regulatory factor X, 6 JBrowse link 20 32,709,282 32,764,040 RGD:1624291
RGD:13792537
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1624291
RGD:1600115
type B pancreatic cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
type B pancreatic cell maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rfx3 regulatory factor X3 JBrowse link 1 245,853,332 246,110,648 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17895
    developmental process 6321
      anatomical structure development 5927
        endocrine pancreas development 52
          pancreatic A cell differentiation + 9
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 2
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 30
Path 2
Term Annotations click to browse term
  biological_process 17895
    developmental process 6321
      anatomical structure development 5927
        multicellular organism development 5423
          system development 5002
            animal organ development 3817
              pancreas development 96
                endocrine pancreas development 52
                  pancreatic A cell differentiation + 9
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.