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ONTOLOGY REPORT - ANNOTATIONS


Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


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endocrine pancreas development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:7527053 RGD:2306957 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
JBrowse link
G BAK1 BCL2 antagonist/killer 1 ISO RGD PMID:11000281 RGD:2315710 NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211
JBrowse link
G CLU clusterin ISO RGD PMID:16411126 RGD:1582421 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (PMID:12086964) UniProtKB PMID:12086964 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468
JBrowse link
G FOXA2 forkhead box A2 ISO (PMID:12124776)
(MGI:MGI:3530180|PMID:15680365)
BHF-UCL
MGI
PMID:12124776, PMID:15680365 MGI:MGI:3530180 NCBI chr20:22,519,942...22,524,262 JBrowse link
G GIP gastric inhibitory polypeptide ISO (MGI:MGI:4940930|PMID:21270265) MGI PMID:21270265 MGI:MGI:4940930 NCBI chr17:8,573,104...8,580,424 JBrowse link
G GIPR gastric inhibitory polypeptide receptor ISO (MGI:MGI:4940930|PMID:21270265) MGI PMID:21270265 MGI:MGI:4940930 NCBI chr19:42,673,553...42,688,059
Ensembl chr19:51,213,090...51,225,293
JBrowse link
G HNF1A HNF1 homeobox A ISO (MGI:MGI:1266996|PMID:9593777) MGI PMID:9593777 MGI:MGI:1266996 NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911
JBrowse link
G HNF1B HNF1 homeobox B ISO (PMID:16801329) UniProtKB PMID:16801329 NCBI chr17:19,333,485...19,392,147
Ensembl chr17:19,633,424...19,691,863
JBrowse link
G IL6 interleukin 6 ISO (MGI:MGI:3807360|PMID:18719127) BHF-UCL PMID:18719127 MGI:MGI:3807360 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor ISO (PMID:18719127) BHF-UCL PMID:18719127 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) MGI PMID:16511571 MGI:MGI:3619850 NCBI chr20:20,317,060...20,320,051 JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 ISO (MGI:MGI:1344214|PMID:10471501) MGI PMID:10471501 MGI:MGI:1344214 NCBI chr 7:148,622,701...148,628,532 JBrowse link
G MYT1 myelin transcription factor 1 ISO (MGI:MGI:3763794|PMID:17928203) MGI PMID:17928203 MGI:MGI:3763794 Ensembl chr20:62,108,924...62,151,936 JBrowse link
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:1096974|PMID:9308961), (MGI:MGI:1352314|PMID:10639171) BHF-UCL PMID:9308961, PMID:10639171 MGI:MGI:1096974, MGI:MGI:1352314 NCBI chr2B:68,939,341...68,943,516 JBrowse link
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:1270972|PMID:9584121) MGI PMID:9584121 MGI:MGI:1270972 NCBI chr20:21,468,872...21,480,627
Ensembl chr20:21,429,401...21,432,492
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 NCBI chr 4:39,683,420...39,689,651 JBrowse link
G NKX6-2 NK6 homeobox 2 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 Ensembl chr10:133,682,456...133,683,445 JBrowse link
G ONECUT1 one cut homeobox 1 ISO (MGI:MGI:3710726|PMID:17400205) MGI PMID:17400205 MGI:MGI:3710726 NCBI chr15:31,694,830...31,727,644
Ensembl chr15:50,016,010...50,053,062
JBrowse link
G ONECUT2 one cut homeobox 2 ISO (MGI:MGI:3710726|PMID:17400205) MGI PMID:17400205 MGI:MGI:3710726 NCBI chr18:50,826,110...50,882,127 JBrowse link
G PDE3B phosphodiesterase 3B ISO (MGI:MGI:3040550|PMID:14736883) MGI PMID:14736883 MGI:MGI:3040550 NCBI chr11:14,746,301...14,961,316
Ensembl chr11:14,437,060...14,648,616
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 ISO (MGI:MGI:3771560|PMID:18155690) MGI PMID:18155690 MGI:MGI:3771560 NCBI chr13:9,199,572...9,206,202 JBrowse link
G RFX3 regulatory factor X3 ISO (MGI:MGI:3713191|PMID:17229940) UniProtKB PMID:17229940 MGI:MGI:3713191 NCBI chr 9:3,024,016...3,332,266
Ensembl chr 9:3,223,405...3,398,839
JBrowse link
G RFX6 regulatory factor X6 ISO (PMID:20148032) UniProtKB PMID:20148032 NCBI chr 6:114,686,132...114,741,072
Ensembl chr 6:118,828,973...118,883,884
JBrowse link
G SOX4 SRY-box transcription factor 4 ISO (MGI:MGI:3611650|PMID:16306355) MGI PMID:16306355 MGI:MGI:3611650 NCBI chr 6:21,422,846...21,427,779 JBrowse link
G SOX9 SRY-box transcription factor 9 ISO (MGI:MGI:3815251|PMID:18723011) MGI PMID:18723011 MGI:MGI:3815251 NCBI chr17:66,028,737...66,034,122 JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HES1 hes family bHLH transcription factor 1 ISO (MGI:MGI:1351379|PMID:10615124) MGI PMID:10615124 MGI:MGI:1351379 NCBI chr 3:191,432,513...191,435,387
Ensembl chr 3:201,749,044...201,754,257
JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator ISO RGD PMID:23178930 RGD:11567224 NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864
JBrowse link
pancreatic A cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAX6 paired box 6 ISO (MGI:MGI:4943812|PMID:20592023)
(PMID:20592023)
BHF-UCL PMID:20592023 MGI:MGI:4943812, RGD:8552352 NCBI chr11:31,753,190...31,782,225 JBrowse link
pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 ISO (MGI:MGI:3701716|PMID:16887115) MGI PMID:16887115 MGI:MGI:3701716 NCBI chr18:15,411,764...15,444,402 JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chr20:20,317,060...20,320,051 JBrowse link
G PAX6 paired box 6 ISO RGD PMID:20592023 RGD:8552352 NCBI chr11:31,753,190...31,782,225 JBrowse link
G RFX6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chr 6:114,686,132...114,741,072
Ensembl chr 6:118,828,973...118,883,884
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234
JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chr2B:68,939,341...68,943,516 JBrowse link
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:3768695|PMID:17988662)
(MGI:MGI:3703458|PMID:17202186)
MGI PMID:17202186, PMID:17988662 MGI:MGI:3703458, MGI:MGI:3768695 NCBI chr20:21,468,872...21,480,627
Ensembl chr20:21,429,401...21,432,492
JBrowse link
pancreatic D cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chr 6:114,686,132...114,741,072
Ensembl chr 6:118,828,973...118,883,884
JBrowse link
pancreatic epsilon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chr 6:114,686,132...114,741,072
Ensembl chr 6:118,828,973...118,883,884
JBrowse link
pancreatic PP cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chr2B:68,939,341...68,943,516 JBrowse link
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chr20:21,468,872...21,480,627
Ensembl chr20:21,429,401...21,432,492
JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death ISO (MGI:MGI:3778846|PMID:18223655) UniProtKB PMID:18223655 MGI:MGI:3778846 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257
JBrowse link
G RFX3 regulatory factor X3 ISO (MGI:MGI:4941444|PMID:20413507) BHF-UCL PMID:20413507 MGI:MGI:4941444 NCBI chr 9:3,024,016...3,332,266
Ensembl chr 9:3,223,405...3,398,839
JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARNTL aryl hydrocarbon receptor nuclear translocator like ISO (MGI:MGI:4819446|PMID:20562852) UniProtKB PMID:20562852 MGI:MGI:4819446 NCBI chr11:13,436,580...13,547,135
Ensembl chr11:13,163,028...13,240,376
JBrowse link
G CLOCK clock circadian regulator ISO (MGI:MGI:4819446|PMID:20562852) UniProtKB PMID:20562852 MGI:MGI:4819446 NCBI chr 4:68,391,310...68,509,813
Ensembl chr 4:75,018,898...75,066,726
JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO (PMID:19258434) CACAO PMID:19258434 NCBI chr 7:143,054,747...143,108,011 JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO (PMID:11865031) BHF-UCL PMID:11865031 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752
JBrowse link
G BMP5 bone morphogenetic protein 5 ISO (PMID:11865031) BHF-UCL PMID:11865031 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519
JBrowse link
G BMP6 bone morphogenetic protein 6 ISO (PMID:11865031) BHF-UCL PMID:11865031 NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649
JBrowse link
G CDH2 cadherin 2 ISO (PMID:26750727) UniProt PMID:26750727 NCBI chr18:21,210,001...21,435,919
Ensembl chr18:24,812,019...25,008,325
JBrowse link
G CDK6 cyclin dependent kinase 6 ISO (PMID:20668294) UniProtKB PMID:20668294 NCBI chr 7:84,603,419...84,835,082 JBrowse link
G DLL1 delta like canonical Notch ligand 1 ISO (MGI:MGI:5426345|PMID:22529374) UniProtKB PMID:22529374 MGI:MGI:5426345 NCBI chr 6:168,440,192...168,449,071
Ensembl chr 6:173,534,292...173,544,759
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3655758|PMID:16951258) MGI PMID:16951258 MGI:MGI:3655758 NCBI chr20:20,317,060...20,320,051 JBrowse link
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:3761395|PMID:17456846)
(MGI:MGI:3703458|PMID:17202186)
MGI PMID:17202186, PMID:17456846 MGI:MGI:3703458, MGI:MGI:3761395 NCBI chr20:21,468,872...21,480,627
Ensembl chr20:21,429,401...21,432,492
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO RGD PMID:9603781 RGD:2326025 NCBI chr 4:39,683,420...39,689,651 JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO (MGI:MGI:4365695|PMID:19635472) UniProtKB PMID:19635472 MGI:MGI:4365695 NCBI chr16:1,394,447...1,463,735 JBrowse link
G SIDT2 SID1 transmembrane family member 2 ISO (MGI:MGI:5529865|PMID:23776622) MGI PMID:23776622 MGI:MGI:5529865 NCBI chr11:112,012,734...112,031,403
Ensembl chr11:115,946,725...115,963,408
JBrowse link
G SMO smoothened, frizzled class receptor ISO (MGI:MGI:4833770|PMID:20185815) MGI PMID:20185815 MGI:MGI:4833770 NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048
JBrowse link
G WNT5A Wnt family member 5A ISO (MGI:MGI:3663526|PMID:16246260) MGI PMID:16246260 MGI:MGI:3663526 NCBI chr 3:55,396,279...55,418,579
Ensembl chr 3:56,621,380...56,638,051
JBrowse link
type B pancreatic cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 ISO (MGI:MGI:3701716|PMID:16887115) MGI PMID:16887115 MGI:MGI:3701716 NCBI chr18:15,411,764...15,444,402 JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chr20:20,317,060...20,320,051 JBrowse link
G MEN1 menin 1 ISO RGD PMID:24157940 RGD:9589069 NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164
JBrowse link
G PAX6 paired box 6 ISO (MGI:MGI:5437569|PMID:22764048) RGD
MGI
PMID:22403172, PMID:22764048 MGI:MGI:5437569, RGD:8552355 NCBI chr11:31,753,190...31,782,225 JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 ISO (PMID:12124776), (PMID:24567802)
PMID:21108535
BHF-UCL PMID:12124776, PMID:21108535, PMID:24567802 RGD:8553608 NCBI chr13:9,199,572...9,206,202 JBrowse link
G RFX6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chr 6:114,686,132...114,741,072
Ensembl chr 6:118,828,973...118,883,884
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234
JBrowse link
G ZBED6 zinc finger BED-type containing 6 ISO (MGI:MGI:5511070|PMID:24043816) UniProt PMID:24043816 MGI:MGI:5511070 NCBI chr 1:179,400,520...179,405,501
Ensembl chr 1:183,691,160...183,694,099
JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:3703458|PMID:17202186), (MGI:MGI:3768695|PMID:17988662) MGI PMID:17202186, PMID:17988662 MGI:MGI:3703458, MGI:MGI:3768695 NCBI chr20:21,468,872...21,480,627
Ensembl chr20:21,429,401...21,432,492
JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX3 regulatory factor X3 ISO (MGI:MGI:4941444|PMID:20413507) BHF-UCL PMID:20413507 MGI:MGI:4941444 NCBI chr 9:3,024,016...3,332,266
Ensembl chr 9:3,223,405...3,398,839
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    developmental process 5839
      anatomical structure development 5452
        endocrine pancreas development 47
          pancreatic A cell differentiation + 8
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 2
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 26
Path 2
Term Annotations click to browse term
  biological_process 12561
    developmental process 5839
      anatomical structure development 5452
        multicellular organism development 4984
          system development 4688
            animal organ development 3620
              pancreas development 89
                endocrine pancreas development 47
                  pancreatic A cell differentiation + 8
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.