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ONTOLOGY REPORT - ANNOTATIONS


Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


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endocrine pancreas development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
JBrowse link
G BAK1 BCL2 antagonist/killer 1 ISO RGD PMID:11000281 RGD:2315710 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018
JBrowse link
G CLU clusterin ISO RGD PMID:16411126 RGD:1582421 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812
JBrowse link
G FOXA2 forkhead box A2 IEA Ensembl GO_REF:0000107 NCBI chr24:1,010,370...1,013,791
Ensembl chr24:1,010,651...1,013,072
JBrowse link
G GIP gastric inhibitory polypeptide IEA Ensembl GO_REF:0000107 NCBI chr 9:25,167,938...25,174,402
Ensembl chr 9:25,167,926...25,174,575
JBrowse link
G GIPR gastric inhibitory polypeptide receptor IEA Ensembl GO_REF:0000107 NCBI chr 1:109,898,617...109,909,331
Ensembl chr 1:109,899,874...109,909,410
JBrowse link
G HNF1A HNF1 homeobox A IEA Ensembl GO_REF:0000107 NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790
JBrowse link
G HNF1B HNF1 homeobox B ISO (PMID:16801329) UniProtKB PMID:16801329 NCBI chr 9:37,437,992...37,493,200
Ensembl chr 9:37,438,583...37,492,993
JBrowse link
G IL6 interleukin 6 ISO (MGI:MGI:3807360|PMID:18719127) BHF-UCL PMID:18719127 MGI:MGI:3807360 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G IL6R interleukin 6 receptor IEA Ensembl GO_REF:0000107 NCBI chr 7:42,877,731...42,920,149
Ensembl chr 7:42,880,885...42,920,090
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) MGI PMID:16511571 MGI:MGI:3619850 NCBI chr24:3,008,387...3,011,186 JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:19,509,038...19,514,378
Ensembl chr16:19,499,582...19,512,836
JBrowse link
G MYT1 myelin transcription factor 1 ISO (MGI:MGI:3763794|PMID:17928203) MGI PMID:17928203 MGI:MGI:3763794 NCBI chr24:47,574,201...47,639,962
Ensembl chr24:47,574,255...47,638,315
JBrowse link
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:1096974|PMID:9308961), (MGI:MGI:1352314|PMID:10639171) BHF-UCL PMID:9308961, PMID:10639171 MGI:MGI:1096974, MGI:MGI:1352314 NCBI chr36:24,853,591...24,857,886 JBrowse link
G NEUROG3 neurogenin 3 IEA InterPro GO_REF:0000002 NCBI chr 4:20,654,824...20,657,816
Ensembl chr 4:20,656,791...20,657,438
JBrowse link
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:1270972|PMID:9584121) MGI PMID:9584121 MGI:MGI:1270972 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 NCBI chr32:8,256,513...8,263,238
Ensembl chr32:8,256,254...8,262,004
JBrowse link
G NKX6-2 NK6 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr28:40,568,948...40,570,240
Ensembl chr28:40,569,093...40,570,793
JBrowse link
G ONECUT1 one cut homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr30:18,384,533...18,425,940
Ensembl chr30:18,387,130...18,425,497
JBrowse link
G ONECUT2 one cut homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:18,428,112...18,486,047
Ensembl chr 1:18,440,172...18,486,048
JBrowse link
G PDE3B phosphodiesterase 3B ISO (MGI:MGI:3040550|PMID:14736883) MGI PMID:14736883 MGI:MGI:3040550 NCBI chr21:37,364,940...37,532,152
Ensembl chr21:37,364,623...37,530,597
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:11,741,863...11,746,885
Ensembl chr25:11,741,863...11,746,885
JBrowse link
G RFX3 regulatory factor X3 ISO (MGI:MGI:3713191|PMID:17229940) UniProtKB PMID:17229940 MGI:MGI:3713191 NCBI chr 1:91,773,492...92,060,895
Ensembl chr 1:91,778,481...92,059,792
JBrowse link
G RFX6 regulatory factor X6 ISO (PMID:20148032) UniProtKB PMID:20148032 NCBI chr 1:57,242,563...57,297,300
Ensembl chr 1:57,241,927...57,296,546
JBrowse link
G SOX4 SRY-box transcription factor 4 IEA Ensembl GO_REF:0000107 NCBI chr35:20,098,783...20,101,357
Ensembl chr35:20,099,773...20,101,154
JBrowse link
G SOX9 SRY-box transcription factor 9 ISO (MGI:MGI:3815251|PMID:18723011) MGI PMID:18723011 MGI:MGI:3815251 NCBI chr 9:8,275,049...8,278,172
Ensembl chr 9:8,275,049...8,278,172
JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR7-1 microRNA mir-7-1 ISO (MGI:MGI:5437569|PMID:22764048) MGI PMID:22764048 MGI:MGI:5437569 NCBI chr 1:75,509,765...75,509,828
Ensembl chr 1:75,509,743...75,509,851
JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator ISO RGD PMID:23178930 RGD:11567224 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 ISO (MGI:MGI:3701716|PMID:16887115) MGI PMID:16887115 MGI:MGI:3701716 NCBI chr 7:65,932,114...65,962,574 JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chr24:3,008,387...3,011,186 JBrowse link
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:57,242,563...57,297,300
Ensembl chr 1:57,241,927...57,296,546
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323
JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chr36:24,853,591...24,857,886 JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874
JBrowse link
pancreatic D cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:57,242,563...57,297,300
Ensembl chr 1:57,241,927...57,296,546
JBrowse link
pancreatic epsilon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:57,242,563...57,297,300
Ensembl chr 1:57,241,927...57,296,546
JBrowse link
pancreatic PP cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chr36:24,853,591...24,857,886 JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874
JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death IEA Ensembl GO_REF:0000107 NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405
JBrowse link
G RFX3 regulatory factor X3 IEA Ensembl GO_REF:0000107 NCBI chr 1:91,773,492...92,060,895
Ensembl chr 1:91,778,481...92,059,792
JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARNTL aryl hydrocarbon receptor nuclear translocator like IEA Ensembl GO_REF:0000107 NCBI chr21:36,254,235...36,323,915
Ensembl chr21:36,290,070...36,323,622
JBrowse link
G CLOCK clock circadian regulator IEA Ensembl GO_REF:0000107 NCBI chr13:47,684,409...47,825,733
Ensembl chr13:47,691,709...47,758,784
JBrowse link
G RHEB Ras homolog, mTORC1 binding IEA Ensembl GO_REF:0000107 NCBI chr16:15,439,910...15,483,489
Ensembl chr16:15,434,111...15,483,419
JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 IEA Ensembl GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
G BMP5 bone morphogenetic protein 5 IEA Ensembl GO_REF:0000107 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348
JBrowse link
G BMP6 bone morphogenetic protein 6 IEA Ensembl GO_REF:0000107 NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845
JBrowse link
G CDH2 cadherin 2 ISO (PMID:26750727) UniProt PMID:26750727 NCBI chr 7:60,736,760...60,950,477
Ensembl chr 7:60,736,760...60,951,034
JBrowse link
G CDK6 cyclin dependent kinase 6 IEA Ensembl GO_REF:0000107 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869
JBrowse link
G DLL1 delta like canonical Notch ligand 1 IEA Ensembl GO_REF:0000107 NCBI chr12:72,265,078...72,272,347
Ensembl chr12:72,265,682...72,272,348
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha IEA InterPro GO_REF:0000002 NCBI chr24:31,847,864...31,908,337
Ensembl chr24:31,847,961...31,905,916
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3655758|PMID:16951258) MGI PMID:16951258 MGI:MGI:3655758 NCBI chr24:3,008,387...3,011,186 JBrowse link
G MIR214 microRNA mir-214 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr 7:26,818,559...26,818,668
Ensembl chr 7:26,818,559...26,818,670
JBrowse link
G MIR375 microRNA mir-375 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr37:25,568,052...25,568,121
Ensembl chr37:25,568,052...25,568,127
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO RGD PMID:9603781 RGD:2326025 NCBI chr32:8,256,513...8,263,238
Ensembl chr32:8,256,254...8,262,004
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO (MGI:MGI:4365695|PMID:19635472) UniProtKB PMID:19635472 MGI:MGI:4365695 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295
JBrowse link
G SIDT2 SID1 transmembrane family member 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:16,397,532...16,410,827
Ensembl chr 5:16,398,815...16,411,268
JBrowse link
G SMO smoothened, frizzled class receptor IEA Ensembl GO_REF:0000107 NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033
JBrowse link
G WNT5A Wnt family member 5A IEA Ensembl GO_REF:0000107 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673
JBrowse link
type B pancreatic cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 ISO (MGI:MGI:3701716|PMID:16887115) MGI PMID:16887115 MGI:MGI:3701716 NCBI chr 7:65,932,114...65,962,574 JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chr24:3,008,387...3,011,186 JBrowse link
G MEN1 menin 1 ISO RGD PMID:24157940 RGD:9589069 NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340
JBrowse link
G MIR7-1 microRNA mir-7-1 ISO (MGI:MGI:5437569|PMID:22764048) MGI PMID:22764048 MGI:MGI:5437569 NCBI chr 1:75,509,765...75,509,828
Ensembl chr 1:75,509,743...75,509,851
JBrowse link
G NKX6-1 NK6 homeobox 1 IEA InterPro GO_REF:0000002 NCBI chr32:8,256,513...8,263,238
Ensembl chr32:8,256,254...8,262,004
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:11,741,863...11,746,885
Ensembl chr25:11,741,863...11,746,885
JBrowse link
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:57,242,563...57,297,300
Ensembl chr 1:57,241,927...57,296,546
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323
JBrowse link
G ZBED6 zinc finger BED-type containing 6 ISO (MGI:MGI:5511070|PMID:24043816) UniProt PMID:24043816 MGI:MGI:5511070 NCBI chr38:461,394...467,894 JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874
JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX3 regulatory factor X3 IEA Ensembl GO_REF:0000107 NCBI chr 1:91,773,492...92,060,895
Ensembl chr 1:91,778,481...92,059,792
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    developmental process 6309
      anatomical structure development 5857
        endocrine pancreas development 50
          pancreatic A cell differentiation + 7
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 2
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 29
Path 2
Term Annotations click to browse term
  biological_process 16187
    developmental process 6309
      anatomical structure development 5857
        multicellular organism development 5350
          system development 4984
            animal organ development 3821
              pancreas development 94
                endocrine pancreas development 50
                  pancreatic A cell differentiation + 7
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.