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ONTOLOGY REPORT - ANNOTATIONS


Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


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endocrine pancreas development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 TAS Reactome Reactome:R-HSA-210745 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ANXA1 annexin A1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G BAK1 BCL2 antagonist/killer 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G CLU clusterin ISO RGD PMID:16411126 RGD:1582421 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 IMP (PMID:12086964) UniProtKB PMID:12086964 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,627,464
JBrowse link
G FOXA2 forkhead box A2 IDA (PMID:12124776) BHF-UCL PMID:12124776 NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,581,005...22,585,455
JBrowse link
G FOXO1 forkhead box O1 TAS Reactome Reactome:R-HSA-210745 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G GIP gastric inhibitory polypeptide IEA Ensembl GO_REF:0000107 NCBI chr17:48,958,554...48,968,596
Ensembl chr17:48,958,554...48,968,596
JBrowse link
G GIPR gastric inhibitory polypeptide receptor IEA Ensembl GO_REF:0000107 NCBI chr19:45,668,187...45,683,722
Ensembl chr19:45,668,221...45,683,722
JBrowse link
G HNF1A HNF1 homeobox A IEA Ensembl GO_REF:0000107 NCBI chr12:120,977,683...121,002,512
Ensembl chr12:120,978,543...121,002,512
JBrowse link
G HNF1B HNF1 homeobox B IMP (PMID:16801329) UniProtKB PMID:16801329 NCBI chr17:37,686,431...37,745,059
Ensembl chr17:37,686,431...37,745,105
JBrowse link
G IL6 interleukin 6 ISS BHF-UCL GO_REF:0000024 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6R interleukin 6 receptor IC
IMP
(PMID:18719127) BHF-UCL PMID:18719127 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G INSM1 INSM transcriptional repressor 1 TAS Reactome Reactome:R-HSA-210746 NCBI chr20:20,368,104...20,370,949
Ensembl chr20:20,368,104...20,370,949
JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:157,004,854...157,010,663
Ensembl chr 7:156,994,051...157,010,663
JBrowse link
G MYT1 myelin transcription factor 1 ISO (MGI:MGI:3763794|PMID:17928203) MGI PMID:17928203 MGI:MGI:3763794 NCBI chr20:64,164,452...64,242,253
Ensembl chr20:64,102,394...64,242,253
JBrowse link
G NEUROD1 neuronal differentiation 1 TAS
ISS
(PMID:9308961) Reactome
BHF-UCL
PMID:9308961 GO_REF:0000024, Reactome:R-HSA-210746 NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,673,088...181,680,547
Ensembl chr 2:181,673,088...181,680,547
JBrowse link
G NEUROG3 neurogenin 3 IEA InterPro GO_REF:0000002 NCBI chr10:69,571,440...69,573,425
Ensembl chr10:69,571,698...69,573,422
JBrowse link
G NKX2-2 NK2 homeobox 2 TAS Reactome Reactome:R-HSA-210746 NCBI chr20:21,511,010...21,514,064
Ensembl chr20:21,511,017...21,514,064
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 NCBI chr 4:84,491,985...84,499,292
Ensembl chr 4:84,491,987...84,498,450
JBrowse link
G NKX6-2 NK6 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr10:132,782,229...132,786,147
Ensembl chr10:132,783,179...132,786,147
JBrowse link
G ONECUT1 one cut homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr15:52,755,053...52,790,336
Ensembl chr15:52,755,053...52,791,078
JBrowse link
G ONECUT2 one cut homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr18:57,435,374...57,491,298
Ensembl chr18:57,435,374...57,491,298
JBrowse link
G PAX4 paired box 4 TAS Reactome Reactome:R-HSA-210746 NCBI chr 7:127,610,292...127,618,142
Ensembl chr 7:127,610,292...127,618,142
JBrowse link
G PDE3B phosphodiesterase 3B ISO (MGI:MGI:3040550|PMID:14736883) MGI PMID:14736883 MGI:MGI:3040550 NCBI chr11:14,643,691...14,874,139
Ensembl chr11:14,643,804...14,872,044
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:27,919,982...27,926,313
Ensembl chr13:27,920,000...27,926,313
JBrowse link
G RFX3 regulatory factor X3 ISS UniProtKB GO_REF:0000024 NCBI chr 9:3,218,297...3,526,529
Ensembl chr 9:3,218,297...3,526,004
JBrowse link
G RFX6 regulatory factor X6 IMP (PMID:20148032) UniProtKB PMID:20148032 NCBI chr 6:116,877,218...116,932,163
Ensembl chr 6:116,877,212...116,932,161
JBrowse link
G SOX4 SRY-box transcription factor 4 IEA Ensembl GO_REF:0000107 NCBI chr 6:21,593,751...21,598,619
Ensembl chr 6:21,593,751...21,598,619
JBrowse link
G SOX9 SRY-box transcription factor 9 IEA Ensembl GO_REF:0000107 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HES1 hes family bHLH transcription factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
JBrowse link
G MIR7-1 microRNA 7-1 ISO (MGI:MGI:5437569|PMID:22764048) MGI PMID:22764048 MGI:MGI:5437569 NCBI chr 9:83,969,748...83,969,857
Ensembl chr 9:83,969,748...83,969,857
JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator ISO RGD PMID:23178930 RGD:11567224 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha TAS (PMID:19366350) UniProtKB PMID:19366350 NCBI chr19:42,230,186...42,243,330
Ensembl chr19:42,230,190...42,242,625
JBrowse link
G GSK3B glycogen synthase kinase 3 beta TAS (PMID:19366350) UniProtKB PMID:19366350 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
pancreatic A cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAX6 paired box 6 IMP (PMID:20592023) BHF-UCL PMID:20592023 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISS UniProtKB GO_REF:0000024 NCBI chr20:20,368,104...20,370,949
Ensembl chr20:20,368,104...20,370,949
JBrowse link
G PAX6 paired box 6 ISO RGD PMID:20592023 RGD:8552352 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G RFX6 regulatory factor X6 ISS UniProtKB GO_REF:0000024 NCBI chr 6:116,877,218...116,932,163
Ensembl chr 6:116,877,212...116,932,161
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chr 3:10,141,778...10,153,667
Ensembl chr 3:10,141,008...10,152,220
Ensembl chr 3:10,141,008...10,152,220
JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,673,088...181,680,547
Ensembl chr 2:181,673,088...181,680,547
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr20:21,511,010...21,514,064
Ensembl chr20:21,511,017...21,514,064
JBrowse link
pancreatic D cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 ISS UniProtKB GO_REF:0000024 NCBI chr 6:116,877,218...116,932,163
Ensembl chr 6:116,877,212...116,932,161
JBrowse link
pancreatic epsilon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 ISS UniProtKB GO_REF:0000024 NCBI chr 6:116,877,218...116,932,163
Ensembl chr 6:116,877,212...116,932,161
JBrowse link
pancreatic PP cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,673,088...181,680,547
Ensembl chr 2:181,673,088...181,680,547
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr20:21,511,010...21,514,064
Ensembl chr20:21,511,017...21,514,064
JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death ISS UniProtKB GO_REF:0000024 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G NKX6-1 NK6 homeobox 1 ISS BHF-UCL GO_REF:0000024 NCBI chr 4:84,491,985...84,499,292
Ensembl chr 4:84,491,987...84,498,450
JBrowse link
G RFX3 regulatory factor X3 ISS (PMID:20413507) BHF-UCL PMID:20413507 NCBI chr 9:3,218,297...3,526,529
Ensembl chr 9:3,218,297...3,526,004
JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARNTL aryl hydrocarbon receptor nuclear translocator like ISS UniProtKB GO_REF:0000024 NCBI chr11:13,276,552...13,387,268
Ensembl chr11:13,276,652...13,387,266
JBrowse link
G CLOCK clock circadian regulator ISS UniProtKB GO_REF:0000024 NCBI chr 4:55,427,903...55,547,138
Ensembl chr 4:55,427,903...55,546,909
JBrowse link
G RHEB Ras homolog, mTORC1 binding IMP (PMID:19258434) CACAO PMID:19258434 NCBI chr 7:151,466,012...151,519,895
Ensembl chr 7:151,466,012...151,520,120
JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 IDA (PMID:11865031) BHF-UCL PMID:11865031 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G BMP5 bone morphogenetic protein 5 IDA (PMID:11865031) BHF-UCL PMID:11865031 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G BMP6 bone morphogenetic protein 6 IDA (PMID:11865031) BHF-UCL PMID:11865031 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G CDH2 cadherin 2 ISS UniProt GO_REF:0000024 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK6 cyclin dependent kinase 6 IDA (PMID:20668294) UniProtKB PMID:20668294 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G DLL1 delta like canonical Notch ligand 1 ISS UniProtKB GO_REF:0000024 NCBI chr 6:170,282,200...170,291,078
Ensembl chr 6:170,282,206...170,306,565
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha IEA InterPro GO_REF:0000002 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G INSM1 INSM transcriptional repressor 1 IEA Ensembl GO_REF:0000107 NCBI chr20:20,368,104...20,370,949
Ensembl chr20:20,368,104...20,370,949
JBrowse link
G MIR214 microRNA 214 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr 1:172,138,798...172,138,907
Ensembl chr 1:172,138,798...172,138,907
JBrowse link
G MIR375 microRNA 375 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr 2:219,001,645...219,001,708
Ensembl chr 2:219,001,645...219,001,708
JBrowse link
G MIR503 microRNA 503 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr  X:134,546,328...134,546,398
Ensembl chr  X:134,546,328...134,546,398
JBrowse link
G MIR541 microRNA 541 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr14:101,064,495...101,064,578
Ensembl chr14:101,064,495...101,064,578
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr20:21,511,010...21,514,064
Ensembl chr20:21,511,017...21,514,064
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO RGD PMID:9603781 RGD:2326025 NCBI chr 4:84,491,985...84,499,292
Ensembl chr 4:84,491,987...84,498,450
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO (MGI:MGI:4365695|PMID:19635472) UniProtKB PMID:19635472 MGI:MGI:4365695 NCBI chr16:2,538,014...2,603,190
Ensembl chr16:2,537,979...2,603,188
JBrowse link
G SIDT2 SID1 transmembrane family member 2 IEA Ensembl GO_REF:0000107 NCBI chr11:117,178,743...117,197,442
Ensembl chr11:117,178,736...117,197,445
JBrowse link
G SMO smoothened, frizzled class receptor IEA Ensembl GO_REF:0000107 NCBI chr 7:129,188,633...129,213,548
Ensembl chr 7:129,188,633...129,213,545
JBrowse link
G WNT5A Wnt family member 5A IEA Ensembl GO_REF:0000107 NCBI chr 3:55,465,715...55,505,261
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
type B pancreatic cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISS UniProtKB GO_REF:0000024 NCBI chr20:20,368,104...20,370,949
Ensembl chr20:20,368,104...20,370,949
JBrowse link
G MEN1 menin 1 IEA Ensembl GO_REF:0000107 NCBI chr11:64,803,514...64,811,294
Ensembl chr11:64,803,510...64,811,294
JBrowse link
G MIR7-1 microRNA 7-1 ISO (MGI:MGI:5437569|PMID:22764048) MGI PMID:22764048 MGI:MGI:5437569 NCBI chr 9:83,969,748...83,969,857
Ensembl chr 9:83,969,748...83,969,857
JBrowse link
G NKX6-1 NK6 homeobox 1 IEA InterPro GO_REF:0000002 NCBI chr 4:84,491,985...84,499,292
Ensembl chr 4:84,491,987...84,498,450
JBrowse link
G PAX6 paired box 6 IEA Ensembl GO_REF:0000107 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 ISS
IBA
IDA
(PMID:21873635)
(PMID:12124776), (PMID:24567802)
BHF-UCL
GO_Central
PMID:12124776, PMID:21873635, PMID:24567802 GO_REF:0000024 NCBI chr13:27,919,982...27,926,313
Ensembl chr13:27,920,000...27,926,313
JBrowse link
G RFX6 regulatory factor X6 ISS UniProtKB GO_REF:0000024 NCBI chr 6:116,877,218...116,932,163
Ensembl chr 6:116,877,212...116,932,161
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chr 3:10,141,778...10,153,667
Ensembl chr 3:10,141,008...10,152,220
Ensembl chr 3:10,141,008...10,152,220
JBrowse link
G ZBED6 zinc finger BED-type containing 6 ISO (MGI:MGI:5511070|PMID:24043816) UniProt PMID:24043816 MGI:MGI:5511070 NCBI chr 1:203,797,523...203,801,074
Ensembl chr 1:203,795,714...203,854,999
JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr20:21,511,010...21,514,064
Ensembl chr20:21,511,017...21,514,064
JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX6-1 NK6 homeobox 1 ISS BHF-UCL GO_REF:0000024 NCBI chr 4:84,491,985...84,499,292
Ensembl chr 4:84,491,987...84,498,450
JBrowse link
G RFX3 regulatory factor X3 IEA Ensembl GO_REF:0000107 NCBI chr 9:3,218,297...3,526,529
Ensembl chr 9:3,218,297...3,526,004
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    developmental process 7464
      anatomical structure development 6871
        endocrine pancreas development 59
          pancreatic A cell differentiation + 9
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 2
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 34
Path 2
Term Annotations click to browse term
  biological_process 18670
    developmental process 7464
      anatomical structure development 6871
        multicellular organism development 6344
          system development 5748
            animal organ development 4412
              pancreas development 104
                endocrine pancreas development 59
                  pancreatic A cell differentiation + 9
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.