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ONTOLOGY REPORT - ANNOTATIONS


Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


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endocrine pancreas development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,307...226,432,287
JBrowse link
G BAK1 BCL2 antagonist/killer 1 ISO RGD PMID:11000281 RGD:2315710 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G CLU clusterin ISO RGD PMID:16411126 RGD:1582421 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,590...11,352,475
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G FOXA2 forkhead box A2 IEA Ensembl GO_REF:0000107 NCBI chr17:29,997,397...30,001,704
Ensembl chr17:29,997,400...30,001,707
JBrowse link
G GIP gastric inhibitory polypeptide IEA Ensembl GO_REF:0000107 NCBI chr12:25,160,783...25,167,952
Ensembl chr12:25,160,789...25,167,940
JBrowse link
G GIPR gastric inhibitory polypeptide receptor IEA Ensembl GO_REF:0000107 NCBI chr 6:52,022,667...52,033,959
Ensembl chr 6:52,022,681...52,033,954
JBrowse link
G HNF1A HNF1 homeobox A IEA Ensembl GO_REF:0000107 NCBI chr14:40,868,819...40,888,322
Ensembl chr14:40,868,676...40,888,328
JBrowse link
G HNF1B HNF1 homeobox B ISS UniProt GO_REF:0000024 NCBI chr12:39,143,119...39,201,631
Ensembl chr12:39,143,121...39,313,511
JBrowse link
G IL6 interleukin 6 ISO (MGI:MGI:3807360|PMID:18719127) BHF-UCL PMID:18719127 MGI:MGI:3807360 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IL6R interleukin 6 receptor IEA Ensembl GO_REF:0000107 NCBI chr 4:95,322,426...95,381,393
Ensembl chr 4:95,322,426...95,381,282
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) MGI PMID:16511571 MGI:MGI:3619850 NCBI chr17:28,379,529...28,382,554 JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:1,724,930...1,730,724
Ensembl chr18:1,725,244...1,730,170
JBrowse link
G MYT1 myelin transcription factor 1 ISO (MGI:MGI:3763794|PMID:17928203) MGI PMID:17928203 MGI:MGI:3763794 NCBI chr17:62,955,052...63,020,652
Ensembl chr17:62,979,350...63,014,697
JBrowse link
G NEUROD1 neuronal differentiation 1 ISO (MGI:MGI:1096974|PMID:9308961), (MGI:MGI:1352314|PMID:10639171) BHF-UCL PMID:9308961, PMID:10639171 MGI:MGI:1096974, MGI:MGI:1352314 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,764...87,179,961
JBrowse link
G NEUROG3 neurogenin 3 IEA InterPro GO_REF:0000002 NCBI chr14:72,604,203...72,606,362
Ensembl chr14:72,604,467...72,606,360
JBrowse link
G NKX2-2 NK2 homeobox 2 ISO (MGI:MGI:1270972|PMID:9584121) MGI PMID:9584121 MGI:MGI:1270972 NCBI chr17:29,275,656...29,279,572
Ensembl chr17:29,275,682...29,278,606
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 NCBI chr 8:134,137,064...134,143,524
Ensembl chr 8:134,138,296...134,145,219
JBrowse link
G NKX6-2 NK6 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr14:140,895,622...140,899,114
Ensembl chr14:140,897,642...140,899,115
JBrowse link
G ONECUT1 one cut homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:118,913,400...118,958,140
Ensembl chr 1:118,913,785...118,954,614
JBrowse link
G ONECUT2 one cut homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:106,751,346...106,812,484
Ensembl chr 1:106,751,173...106,799,607
JBrowse link
G PDE3B phosphodiesterase 3B ISO (MGI:MGI:3040550|PMID:14736883) MGI PMID:14736883 MGI:MGI:3040550 NCBI chr 2:44,416,934...44,614,075
Ensembl chr 2:44,416,175...44,614,028
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,639...5,310,843
JBrowse link
G RFX3 regulatory factor X3 ISO (MGI:MGI:3713191|PMID:17229940) UniProtKB PMID:17229940 MGI:MGI:3713191 NCBI chr 1:218,340,427...218,647,389
Ensembl chr 1:218,340,446...218,647,389
JBrowse link
G RFX6 regulatory factor X6 ISO (PMID:20148032) UniProtKB PMID:20148032 NCBI chr 1:44,765,451...44,826,884
Ensembl chr 1:44,765,450...44,823,516
JBrowse link
G SOX4 SRY-box transcription factor 4 ISO (MGI:MGI:3611650|PMID:16306355) MGI PMID:16306355 MGI:MGI:3611650 NCBI chr 7:16,886,834...16,895,488 JBrowse link
G SOX9 SRY-box transcription factor 9 IEA Ensembl GO_REF:0000107 NCBI chr12:8,642,154...8,647,315
Ensembl chr12:8,642,158...8,647,315
JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HES1 hes family bHLH transcription factor 1 IEA Ensembl GO_REF:0000107 NCBI chr13:131,135,970...131,137,865
Ensembl chr13:131,135,724...131,138,236
JBrowse link
G MIR7-2 microRNA mir-7-2 ISO (MGI:MGI:5437569|PMID:22764048) MGI PMID:22764048 MGI:MGI:5437569 NCBI chr10:30,986,180...30,986,288
Ensembl chr10:30,986,180...30,986,288
JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator ISO RGD PMID:23178930 RGD:11567224 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
pancreatic A cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAX6 paired box 6 IEA Ensembl GO_REF:0000107 NCBI chr 2:28,971,565...29,001,149
Ensembl chr 2:28,971,567...29,001,200
JBrowse link
pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chr17:28,379,529...28,382,554 JBrowse link
G PAX6 paired box 6 ISO RGD PMID:20592023 RGD:8552352 NCBI chr 2:28,971,565...29,001,149
Ensembl chr 2:28,971,567...29,001,200
JBrowse link
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:44,765,451...44,826,884
Ensembl chr 1:44,765,450...44,823,516
JBrowse link
G VHL von Hippel-Lindau tumor suppressor IEA Ensembl GO_REF:0000107 NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654
JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 IEA Ensembl GO_REF:0000107 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,764...87,179,961
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr17:29,275,656...29,279,572
Ensembl chr17:29,275,682...29,278,606
JBrowse link
pancreatic D cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:44,765,451...44,826,884
Ensembl chr 1:44,765,450...44,823,516
JBrowse link
pancreatic epsilon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:44,765,451...44,826,884
Ensembl chr 1:44,765,450...44,823,516
JBrowse link
pancreatic PP cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEUROD1 neuronal differentiation 1 IEA Ensembl GO_REF:0000107 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,764...87,179,961
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr17:29,275,656...29,279,572
Ensembl chr17:29,275,682...29,278,606
JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death IEA Ensembl GO_REF:0000107 NCBI chr 2:7,831,192...7,842,864
Ensembl chr 2:7,830,920...7,842,863
JBrowse link
G RFX3 regulatory factor X3 IEA Ensembl GO_REF:0000107 NCBI chr 1:218,340,427...218,647,389
Ensembl chr 1:218,340,446...218,647,389
JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARNTL aryl hydrocarbon receptor nuclear translocator like IEA Ensembl GO_REF:0000107 NCBI chr 2:45,895,637...46,025,174
Ensembl chr 2:45,895,289...46,025,165
JBrowse link
G CLOCK clock circadian regulator IEA Ensembl GO_REF:0000107 NCBI chr 8:54,793,323...54,910,192
Ensembl chr 8:54,788,864...54,910,146
JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO (PMID:19258434) CACAO PMID:19258434 NCBI chr18:5,779,439...5,821,839
Ensembl chr18:5,779,212...5,822,257
JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G BMP5 bone morphogenetic protein 5 IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G BMP6 bone morphogenetic protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 7:5,058,817...5,208,868
Ensembl chr 7:5,058,817...5,211,316
JBrowse link
G CDH2 cadherin 2 ISO (PMID:26750727) UniProt PMID:26750727 NCBI chr 6:112,396,713...112,629,073
Ensembl chr 6:112,396,721...112,628,432
JBrowse link
G CDK6 cyclin dependent kinase 6 IEA Ensembl GO_REF:0000107 NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129
JBrowse link
G DLL1 delta like canonical Notch ligand 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:198,815...211,346
Ensembl chr 1:199,231...211,344
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha IEA InterPro GO_REF:0000002 NCBI chr17:46,783,772...46,847,505
Ensembl chr17:46,783,777...46,847,503
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3655758|PMID:16951258) MGI PMID:16951258 MGI:MGI:3655758 NCBI chr17:28,379,529...28,382,554 JBrowse link
G MIR214 microRNA mir-214 ISO (MGI:MGI:3775688|PMID:17804764) MGI PMID:17804764 MGI:MGI:3775688 NCBI chr 9:114,527,992...114,528,101
Ensembl chr 9:114,527,990...114,528,101
JBrowse link
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr17:29,275,656...29,279,572
Ensembl chr17:29,275,682...29,278,606
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO RGD PMID:9603781 RGD:2326025 NCBI chr 8:134,137,064...134,143,524
Ensembl chr 8:134,138,296...134,145,219
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO (MGI:MGI:4365695|PMID:19635472) UniProtKB PMID:19635472 MGI:MGI:4365695 NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,429,931...39,532,583
JBrowse link
G SIDT2 SID1 transmembrane family member 2 IEA Ensembl GO_REF:0000107 NCBI chr 9:44,543,648...44,559,717
Ensembl chr 9:44,543,701...44,559,716
JBrowse link
G SMO smoothened, frizzled class receptor IEA Ensembl GO_REF:0000107 NCBI chr18:19,450,730...19,478,796
Ensembl chr18:19,450,734...19,479,374
JBrowse link
G WNT5A Wnt family member 5A IEA Ensembl GO_REF:0000107 NCBI chr13:37,344,684...37,367,215
Ensembl chr13:37,344,699...37,367,207
JBrowse link
type B pancreatic cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 IEA Ensembl GO_REF:0000107 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chr17:28,379,529...28,382,554 JBrowse link
G MEN1 menin 1 ISO RGD PMID:24157940 RGD:9589069 NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,357,951...7,365,128
JBrowse link
G MIR7-2 microRNA mir-7-2 ISO (MGI:MGI:5437569|PMID:22764048) MGI PMID:22764048 MGI:MGI:5437569 NCBI chr10:30,986,180...30,986,288
Ensembl chr10:30,986,180...30,986,288
JBrowse link
G NKX6-1 NK6 homeobox 1 IEA InterPro GO_REF:0000002 NCBI chr 8:134,137,064...134,143,524
Ensembl chr 8:134,138,296...134,145,219
JBrowse link
G PAX6 paired box 6 IEA Ensembl GO_REF:0000107 NCBI chr 2:28,971,565...29,001,149
Ensembl chr 2:28,971,567...29,001,200
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,639...5,310,843
JBrowse link
G RFX6 regulatory factor X6 IEA Ensembl GO_REF:0000107 NCBI chr 1:44,765,451...44,826,884
Ensembl chr 1:44,765,450...44,823,516
JBrowse link
G VHL von Hippel-Lindau tumor suppressor IEA Ensembl GO_REF:0000107 NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654
JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr17:29,275,656...29,279,572
Ensembl chr17:29,275,682...29,278,606
JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RFX3 regulatory factor X3 IEA Ensembl GO_REF:0000107 NCBI chr 1:218,340,427...218,647,389
Ensembl chr 1:218,340,446...218,647,389
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    developmental process 6302
      anatomical structure development 5842
        endocrine pancreas development 50
          pancreatic A cell differentiation + 9
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 2
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 28
Path 2
Term Annotations click to browse term
  biological_process 16545
    developmental process 6302
      anatomical structure development 5842
        multicellular organism development 5340
          system development 4963
            animal organ development 3802
              pancreas development 94
                endocrine pancreas development 50
                  pancreatic A cell differentiation + 9
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.