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ONTOLOGY REPORT - ANNOTATIONS


Term:endocrine pancreas development
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Accession:GO:0031018 term browser browse the term
Definition:The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


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endocrine pancreas development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO RGD PMID:7527053 RGD:2306957 NCBI chrNW_004936503:9,124,314...9,142,372 JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO RGD PMID:11000281 RGD:2315710 NCBI chrNW_004936476:25,347,608...25,354,772 JBrowse link
G Clu clusterin ISO RGD PMID:16411126 RGD:1582421 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (PMID:12086964) UniProtKB PMID:12086964 NCBI chrNW_004936712:413,602...454,443 JBrowse link
G Foxa2 forkhead box A2 ISO (PMID:12124776)
(MGI:MGI:3530180|PMID:15680365)
BHF-UCL
MGI
PMID:12124776, PMID:15680365 MGI:MGI:3530180 NCBI chrNW_004936620:2,966,341...2,969,349 JBrowse link
G Gip gastric inhibitory polypeptide ISO (MGI:MGI:4940930|PMID:21270265) MGI PMID:21270265 MGI:MGI:4940930 NCBI chrNW_004936490:12,487,025...12,492,214 JBrowse link
G Gipr gastric inhibitory polypeptide receptor ISO (MGI:MGI:4940930|PMID:21270265) MGI PMID:21270265 MGI:MGI:4940930 NCBI chrNW_004936706:2,052,069...2,062,722 JBrowse link
G Hnf1a HNF1 homeobox A ISO (MGI:MGI:1266996|PMID:9593777) MGI PMID:9593777 MGI:MGI:1266996 NCBI chrNW_004936668:62,103...81,549 JBrowse link
G Hnf1b HNF1 homeobox B ISO (PMID:16801329) UniProtKB PMID:16801329 NCBI chrNW_004936490:649,551...702,448 JBrowse link
G Il6r interleukin 6 receptor ISO (PMID:18719127) BHF-UCL PMID:18719127 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) MGI PMID:16511571 MGI:MGI:3619850 NCBI chrNW_004936485:66,889...69,792 JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 ISO (MGI:MGI:1344214|PMID:10471501) MGI PMID:10471501 MGI:MGI:1344214 NCBI chrNW_004936797:618,696...623,219 JBrowse link
G Myt1 myelin transcription factor 1 ISO (MGI:MGI:3763794|PMID:17928203) MGI PMID:17928203 MGI:MGI:3763794 NCBI chrNW_004936514:11,305,929...11,367,935 JBrowse link
G Neurod1 neuronal differentiation 1 ISO (MGI:MGI:1096974|PMID:9308961), (MGI:MGI:1352314|PMID:10639171) BHF-UCL PMID:9308961, PMID:10639171 MGI:MGI:1096974, MGI:MGI:1352314 NCBI chrNW_004936509:10,421,821...10,425,927 JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO (MGI:MGI:1270972|PMID:9584121) MGI PMID:9584121 MGI:MGI:1270972 NCBI chrNW_004936620:3,961,106...3,962,910 JBrowse link
G Nkx6-1 NK6 homeobox 1 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 NCBI chrNW_004936738:318,020...322,869 JBrowse link
G Nkx6-2 NK6 homeobox 2 ISO (MGI:MGI:3579924|PMID:15944193) MGI PMID:15944193 MGI:MGI:3579924 NCBI chrNW_004936486:19,024,106...19,025,387 JBrowse link
G Onecut1 one cut homeobox 1 ISO (MGI:MGI:3710726|PMID:17400205) MGI PMID:17400205 MGI:MGI:3710726 NCBI chrNW_004936471:14,532,888...14,581,258 JBrowse link
G Onecut2 one cut homeobox 2 ISO (MGI:MGI:3710726|PMID:17400205) MGI PMID:17400205 MGI:MGI:3710726 NCBI chrNW_004936497:6,853,739...6,896,408 JBrowse link
G Pde3b phosphodiesterase 3B ISO (MGI:MGI:3040550|PMID:14736883) MGI PMID:14736883 MGI:MGI:3040550 NCBI chrNW_004936528:3,922,436...4,087,991 JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 ISO (MGI:MGI:3771560|PMID:18155690) MGI PMID:18155690 MGI:MGI:3771560 NCBI chrNW_004936472:23,102,534...23,107,127 JBrowse link
G Rfx3 regulatory factor X3 ISO (MGI:MGI:3713191|PMID:17229940) UniProtKB PMID:17229940 MGI:MGI:3713191 NCBI chrNW_004936503:1,506,944...1,802,256 JBrowse link
G Rfx6 regulatory factor X6 ISO (PMID:20148032) UniProtKB PMID:20148032 NCBI chrNW_004936658:94,589...145,135 JBrowse link
G Sox9 SRY-box transcription factor 9 ISO (MGI:MGI:3815251|PMID:18723011) MGI PMID:18723011 MGI:MGI:3815251 NCBI chrNW_004936655:1,849,044...1,852,648 JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 ISO (MGI:MGI:1351379|PMID:10615124) MGI PMID:10615124 MGI:MGI:1351379 NCBI chrNW_004936711:640,002...642,580 JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator ISO RGD PMID:23178930 RGD:11567224 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
pancreatic A cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax6 paired box 6 ISO PMID:20592023
(MGI:MGI:4943812|PMID:20592023)
(PMID:20592023)
BHF-UCL PMID:20592023 MGI:MGI:4943812, RGD:8552352 NCBI chrNW_004936533:5,952,529...5,980,889 JBrowse link
pancreatic A cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 ISO (MGI:MGI:3701716|PMID:16887115) MGI PMID:16887115 MGI:MGI:3701716 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chrNW_004936485:66,889...69,792 JBrowse link
G Pax6 paired box 6 ISO RGD PMID:20592023 RGD:8552352 NCBI chrNW_004936533:5,952,529...5,980,889 JBrowse link
G Rfx6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chrNW_004936658:94,589...145,135 JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chrNW_004936509:10,421,821...10,425,927 JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO (MGI:MGI:3703458|PMID:17202186)
(MGI:MGI:3768695|PMID:17988662)
MGI PMID:17202186, PMID:17988662 MGI:MGI:3703458, MGI:MGI:3768695 NCBI chrNW_004936620:3,961,106...3,962,910 JBrowse link
pancreatic D cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfx6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chrNW_004936658:94,589...145,135 JBrowse link
pancreatic epsilon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfx6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chrNW_004936658:94,589...145,135 JBrowse link
pancreatic PP cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chrNW_004936509:10,421,821...10,425,927 JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO (MGI:MGI:3768695|PMID:17988662) MGI PMID:17988662 MGI:MGI:3768695 NCBI chrNW_004936620:3,961,106...3,962,910 JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2 associated agonist of cell death ISO (MGI:MGI:3778846|PMID:18223655) UniProtKB PMID:18223655 MGI:MGI:3778846 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Rfx3 regulatory factor X3 ISO (MGI:MGI:4941444|PMID:20413507) BHF-UCL PMID:20413507 MGI:MGI:4941444 NCBI chrNW_004936503:1,506,944...1,802,256 JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator like ISO (MGI:MGI:4819446|PMID:20562852) UniProtKB PMID:20562852 MGI:MGI:4819446 NCBI chrNW_004936528:5,167,611...5,239,128 JBrowse link
G Clock clock circadian regulator ISO (MGI:MGI:4819446|PMID:20562852) UniProtKB PMID:20562852 MGI:MGI:4819446 NCBI chrNW_004936482:17,789,834...17,900,371 JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO (PMID:19258434) CACAO PMID:19258434 NCBI chrNW_004936527:6,832,286...6,877,938 JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO (PMID:11865031) BHF-UCL PMID:11865031 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:11865031) BHF-UCL PMID:11865031 NCBI chrNW_004936476:5,350,870...5,464,561 JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO (PMID:11865031) BHF-UCL PMID:11865031 NCBI chrNW_004936534:4,707,658...4,871,865 JBrowse link
G Cdh2 cadherin 2 ISO (PMID:26750727) UniProt PMID:26750727 NCBI chrNW_004936550:6,885,484...7,067,001 JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO (PMID:20668294) UniProtKB PMID:20668294 NCBI chrNW_004936803:1,025,047...1,229,396 JBrowse link
G Dll1 delta like canonical Notch ligand 1 ISO (MGI:MGI:5426345|PMID:22529374) UniProtKB PMID:22529374 MGI:MGI:5426345 NCBI chrNW_004937098:212,704...220,589 JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3655758|PMID:16951258) MGI PMID:16951258 MGI:MGI:3655758 NCBI chrNW_004936485:66,889...69,792 JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO (MGI:MGI:3761395|PMID:17456846)
(MGI:MGI:3703458|PMID:17202186)
MGI PMID:17202186, PMID:17456846 MGI:MGI:3703458, MGI:MGI:3761395 NCBI chrNW_004936620:3,961,106...3,962,910 JBrowse link
G Nkx6-1 NK6 homeobox 1 ISO RGD PMID:9603781 RGD:2326025 NCBI chrNW_004936738:318,020...322,869 JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO (MGI:MGI:4365695|PMID:19635472) UniProtKB PMID:19635472 MGI:MGI:4365695 NCBI chrNW_004936694:1,444,819...1,487,628 JBrowse link
G Sidt2 SID1 transmembrane family member 2 ISO (MGI:MGI:5529865|PMID:23776622) MGI PMID:23776622 MGI:MGI:5529865 NCBI chrNW_004936542:2,426,937...2,443,721 JBrowse link
G Smo smoothened, frizzled class receptor ISO (MGI:MGI:4833770|PMID:20185815) MGI PMID:20185815 MGI:MGI:4833770 NCBI chrNW_004936579:5,893,064...5,917,021 JBrowse link
G Wnt5a Wnt family member 5A ISO (MGI:MGI:3663526|PMID:16246260) MGI PMID:16246260 MGI:MGI:3663526 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
type B pancreatic cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 ISO (MGI:MGI:3701716|PMID:16887115) MGI PMID:16887115 MGI:MGI:3701716 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3619850|PMID:16511571) UniProtKB PMID:16511571 MGI:MGI:3619850 NCBI chrNW_004936485:66,889...69,792 JBrowse link
G Men1 menin 1 ISO RGD PMID:24157940 RGD:9589069 NCBI chrNW_004936599:4,504,489...4,510,085 JBrowse link
G Pax6 paired box 6 ISO (MGI:MGI:5437569|PMID:22764048) RGD
MGI
PMID:22403172, PMID:22764048 MGI:MGI:5437569, RGD:8552355 NCBI chrNW_004936533:5,952,529...5,980,889 JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 ISO (PMID:12124776), (PMID:24567802)
PMID:21108535
BHF-UCL PMID:12124776, PMID:21108535, PMID:24567802 RGD:8553608 NCBI chrNW_004936472:23,102,534...23,107,127 JBrowse link
G Rfx6 regulatory factor X6 ISO (MGI:MGI:4422104|PMID:20148032) UniProtKB PMID:20148032 MGI:MGI:4422104 NCBI chrNW_004936658:94,589...145,135 JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO (MGI:MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:MGI:5618205 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
G Zbed6 zinc finger BED-type containing 6 ISO (MGI:MGI:5511070|PMID:24043816) UniProt PMID:24043816 MGI:MGI:5511070 NCBI chrNW_004936567:895,758...901,684 JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 ISO (MGI:MGI:3703458|PMID:17202186), (MGI:MGI:3768695|PMID:17988662) MGI PMID:17202186, PMID:17988662 MGI:MGI:3703458, MGI:MGI:3768695 NCBI chrNW_004936620:3,961,106...3,962,910 JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfx3 regulatory factor X3 ISO (MGI:MGI:4941444|PMID:20413507) BHF-UCL PMID:20413507 MGI:MGI:4941444 NCBI chrNW_004936503:1,506,944...1,802,256 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    developmental process 5648
      anatomical structure development 5286
        endocrine pancreas development 45
          pancreatic A cell differentiation + 8
          pancreatic D cell differentiation + 1
          pancreatic PP cell differentiation + 2
          pancreatic epsilon cell differentiation + 1
          type B pancreatic cell differentiation + 26
Path 2
Term Annotations click to browse term
  biological_process 11998
    developmental process 5648
      anatomical structure development 5286
        multicellular organism development 4845
          system development 4567
            animal organ development 3516
              pancreas development 86
                endocrine pancreas development 45
                  pancreatic A cell differentiation + 8
                  pancreatic D cell differentiation + 1
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  type B pancreatic cell differentiation + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.