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Term:chromosome breakage
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Accession:GO:0031052 term browser browse the term
Definition:Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
Comment:Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences.
Synonyms:exact_synonym: establishment or maintenance of heterochromatin architecture

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chromosome breakage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
G Rfwd3 ring finger and WD repeat domain 3 JBrowse link 19 42,960,597 42,971,894 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19676
    cellular process 18449
      cellular component organization or biogenesis 6664
        cellular component organization 6424
          organelle organization 4011
            chromosome organization 1231
              chromosome breakage 2
Path 2
Term Annotations click to browse term
  biological_process 19676
    metabolic process 11952
      cellular metabolic process 10780
        cellular nitrogen compound metabolic process 6417
          nucleobase-containing compound metabolic process 5310
            nucleic acid metabolic process 4821
              DNA metabolic process 906
                programmed DNA elimination 2
                  chromosome breakage 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.