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Term:nuclear pore outer ring
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Accession:GO:0031080 term browser browse the term
Definition:A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
Synonyms:exact_synonym: Nup107-120 complex;   Nup107-160 complex;   Nup84 complex

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nuclear pore outer ring term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07041481.1 RGD:13792537
G Ahctf1 AT hook containing transcription factor 1 JBrowse link 13 98,023,528 98,079,138 RGD:1624291
G Nup107 nucleoporin 107 JBrowse link 7 60,781,724 60,825,225 RGD:1624291
G Nup133 nucleoporin 133 JBrowse link 19 56,681,965 56,731,404 RGD:1624291
G Nup160 nucleoporin 160 JBrowse link 3 79,496,239 79,562,163 RGD:1624291
G Nup37 nucleoporin 37 JBrowse link 7 28,715,299 28,750,978 RGD:1624291
G Nup43 nucleoporin 43 JBrowse link 1 1,771,468 1,781,554 RGD:1624291
G Nup85 nucleoporin 85 JBrowse link 10 104,118,999 104,137,258 RGD:1600115
G Nup98 nucleoporin 98 and 96 precursor JBrowse link 1 167,213,866 167,308,851 RGD:1624291
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:1624291
G Seh1l SEH1-like nucleoporin JBrowse link 18 63,545,150 63,568,101 RGD:1624291

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  cellular_component 19843
    protein-containing complex 5779
      nuclear pore outer ring 11
Path 2
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  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          intracellular membrane-bounded organelle 9976
            nucleus 6783
              nuclear envelope 465
                nuclear pore 71
                  nuclear pore outer ring 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.