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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet alpha granule
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Accession:GO:0031091 term browser browse the term
Definition:A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
Synonyms:xref: Wikipedia:Platelet_alpha-granule


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platelet alpha granule term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1624291
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:1624291
RGD:1600115
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:1624291
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:10402780
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:10402780
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:2316766
G Ppbp pro-platelet basic protein JBrowse link 14 18,852,433 18,853,237 RGD:1624291
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:1624291
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:1624291
RGD:1600115
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:1624291
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Thbs2 thrombospondin 2 JBrowse link 1 56,653,929 56,683,571 RGD:1624291
G Treml1 triggering receptor expressed on myeloid cells-like 1 JBrowse link 9 14,597,172 14,603,622 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
G Vps33b VPS33B, late endosome and lysosome associated JBrowse link 1 142,060,955 142,083,955 RGD:1624291
platelet alpha granule membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:1624291
RGD:1600115
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19737
    cellular anatomical entity 19353
      endomembrane system 3837
        secretory granule 392
          platelet alpha granule 20
            platelet alpha granule lumen 0
            platelet alpha granule membrane 3
Path 2
Term Annotations click to browse term
  cellular_component 19737
    cellular anatomical entity 19353
      organelle 12456
        membrane-bounded organelle 10810
          vesicle 1961
            intracellular vesicle 1816
              cytoplasmic vesicle 1811
                secretory vesicle 648
                  secretory granule 392
                    platelet alpha granule 20
                      platelet alpha granule lumen 0
                      platelet alpha granule membrane 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.