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ONTOLOGY REPORT - ANNOTATIONS


Term:anaphase-promoting complex-dependent catabolic process
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Accession:GO:0031145 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
Synonyms:exact_synonym: APC-dependent proteasomal ubiquitin-dependent protein catabolic process;   APC-dependent proteasomal ubiquitin-dependent protein catabolism;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation
 narrow_synonym: cyclin breakdown;   cyclin catabolic process;   cyclin catabolism;   cyclin degradation;   degradation of cyclin;   negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
 alt_id: GO:0008054


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anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anapc1 anaphase promoting complex subunit 1 JBrowse link 3 121,147,484 121,226,125 RGD:13792537
G Anapc10 anaphase promoting complex subunit 10 JBrowse link 19 31,814,686 31,867,928 RGD:1600115
G Anapc4 anaphase promoting complex subunit 4 JBrowse link 14 60,471,962 60,503,803 RGD:13792537
G Anapc5 anaphase-promoting complex subunit 5 JBrowse link 12 39,209,134 39,242,696 RGD:13792537
G Anapc7 anaphase promoting complex subunit 7 JBrowse link 12 39,613,898 39,641,999 RGD:13792537
G Cdc16 cell division cycle 16 JBrowse link 16 81,493,355 81,516,493 RGD:13792537
G Cdc20 cell division cycle 20 JBrowse link 5 137,260,728 137,264,931 RGD:1624291
RGD:13792537
G Cdc23 cell division cycle 23 JBrowse link 18 27,430,924 27,452,569 RGD:13792537
G Cdc26 cell division cycle 26 JBrowse link 5 78,252,168 78,267,137 RGD:1600115
G Cdc27 cell division cycle 27 JBrowse link 10 92,551,754 92,602,214 RGD:13792537
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:1600115
RGD:1624291
G Ecrg4 ECRG4 augurin precursor JBrowse link 9 50,526,811 50,548,056 RGD:1624291
RGD:13792537
G Fbxo31 F-box protein 31 JBrowse link 19 53,487,610 53,625,673 RGD:1624291
RGD:1600115
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:1624291
RGD:13792537
G Ube2c ubiquitin-conjugating enzyme E2C JBrowse link 3 161,236,971 161,239,371 RGD:1624291
RGD:13792537
G Ube2s ubiquitin-conjugating enzyme E2S JBrowse link 1 72,580,424 72,584,484 RGD:1600115
RGD:1624291
positive regulation of anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc20 cell division cycle 20 JBrowse link 5 137,260,728 137,264,931 RGD:13792537
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      primary metabolic process 10563
        protein metabolic process 6070
          protein catabolic process 970
            proteasomal protein catabolic process 478
              proteasome-mediated ubiquitin-dependent protein catabolic process 412
                anaphase-promoting complex-dependent catabolic process 16
                  negative regulation of anaphase-promoting complex-dependent catabolic process 0
                  positive regulation of anaphase-promoting complex-dependent catabolic process 2
                  regulation of anaphase-promoting complex-dependent catabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      nitrogen compound metabolic process 10025
        organonitrogen compound metabolic process 6969
          organonitrogen compound catabolic process 1282
            protein catabolic process 970
              cellular protein catabolic process 804
                proteolysis involved in cellular protein catabolic process 751
                  modification-dependent protein catabolic process 639
                    ubiquitin-dependent protein catabolic process 628
                      proteasome-mediated ubiquitin-dependent protein catabolic process 412
                        anaphase-promoting complex-dependent catabolic process 16
                          negative regulation of anaphase-promoting complex-dependent catabolic process 0
                          positive regulation of anaphase-promoting complex-dependent catabolic process 2
                          regulation of anaphase-promoting complex-dependent catabolic process + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.