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Term:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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Accession:GO:0031146 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
Synonyms:exact_synonym: SCF-dependent proteasomal ubiquitin-dependent protein breakdown;   SCF-dependent proteasomal ubiquitin-dependent protein catabolism;   SCF-dependent proteasomal ubiquitin-dependent protein degradation


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SCF-dependent proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07002848.1 RGD:13792537
G Amn1 antagonist of mitotic exit network 1 homolog JBrowse link 4 183,670,589 183,697,531 RGD:13792537
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:1624291
G Ccnf cyclin F JBrowse link 10 13,594,687 13,619,935 RGD:1624291
RGD:1600115
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:1624291
RGD:13792537
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:13792537
G Cul4a cullin 4A JBrowse link 16 81,718,784 81,756,653 RGD:13792537
G Cul4b cullin 4B JBrowse link X 124,831,391 124,870,329 RGD:13792537
G Cul5 cullin 5 JBrowse link 8 58,199,992 58,255,149 RGD:13792537
G Dmac2 distal membrane arm assembly complex 2 JBrowse link 1 82,413,171 82,419,157 RGD:13792537
G Fbxl12 F-box and leucine-rich repeat protein 12 JBrowse link 8 21,656,636 21,662,755 RGD:13792537
G Fbxl13 F-box and leucine-rich repeat protein 13 JBrowse link 4 10,020,349 10,170,012 RGD:13792537
G Fbxl15 F-box and leucine-rich repeat protein 15 JBrowse link 1 266,075,782 266,078,023 RGD:1624291
RGD:13792537
RGD:1600115
G Fbxl16 F-box and leucine-rich repeat protein 16 JBrowse link 10 15,176,489 15,188,729 RGD:13792537
G Fbxl17 F-box and leucine-rich repeat protein 17 JBrowse link 9 110,515,558 110,936,631 RGD:1624291
G Fbxl18 F-box and leucine-rich repeat protein 18 JBrowse link 12 13,728,155 13,751,781 RGD:13792537
G Fbxl2 F-box and leucine-rich repeat protein 2 JBrowse link 8 122,240,393 122,290,439 RGD:1624291
RGD:13792537
G Fbxl20 F-box and leucine-rich repeat protein 20 JBrowse link 10 86,036,745 86,099,699 RGD:13792537
G Fbxl21 F-box and leucine-rich repeat protein 21 JBrowse link 17 8,505,771 8,520,208 RGD:13792537
G Fbxl22 F-box and leucine-rich repeat protein 22 JBrowse link 8 72,198,043 72,204,730 RGD:13792537
G Fbxl3 F-box and leucine-rich repeat protein 3 JBrowse link 15 93,647,307 93,667,395 RGD:1624291
RGD:13792537
G Fbxl4 F-box and leucine-rich repeat protein 4 JBrowse link 5 36,555,061 36,628,920 RGD:13792537
G Fbxl5 F-box and leucine-rich repeat protein 5 JBrowse link 14 71,852,649 71,891,143 RGD:1624291
RGD:13792537
G Fbxl6 F-box and leucine-rich repeat protein 6 JBrowse link 7 117,602,056 117,604,954 RGD:13792537
G Fbxl7 F-box and leucine-rich repeat protein 7 JBrowse link 2 79,067,907 79,439,987 RGD:13792537
RGD:1624291
G Fbxl8 F-box and leucine-rich repeat protein 8 JBrowse link 19 37,216,696 37,225,701 RGD:13792537
G Fbxo17 F-box protein 17 JBrowse link 1 86,903,762 86,919,238 RGD:13792537
G Fbxo2 F-box protein 2 JBrowse link 5 164,972,483 164,977,912 RGD:1624291
RGD:13792537
G Fbxo31 F-box protein 31 JBrowse link 19 53,487,610 53,625,673 RGD:1600115
RGD:13792537
RGD:1624291
G Fbxo33 F-box protein 33 JBrowse link 6 80,302,291 80,334,536 RGD:1600115
G Fbxo38 F-box protein 38 JBrowse link 18 57,827,391 57,874,515 RGD:1624291
RGD:13792537
G Fbxo39 F-box protein 39 JBrowse link 10 58,874,028 58,878,445 RGD:13792537
G Fbxo4 F-box protein 4 JBrowse link 2 53,797,954 53,811,134 RGD:1624291
G Fbxo44 F-box protein 44 JBrowse link 5 164,962,921 164,972,273 RGD:13792537
G Fbxo48 F-box protein 48 JBrowse link 14 100,129,835 100,140,400 RGD:13792537
G Fbxo6 F-box protein 6 JBrowse link 5 164,956,285 164,962,075 RGD:1624291
RGD:13792537
RGD:1600115
G Fbxo9 f-box protein 9 JBrowse link 8 85,388,331 85,413,896 RGD:1624291
RGD:13792537
RGD:1600115
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:1624291
RGD:13792537
G Fbxw4 F-box and WD repeat domain containing 4 JBrowse link 1 265,318,526 265,420,503 RGD:13792537
G Fbxw5 F-box and WD repeat domain containing 5 JBrowse link 3 2,726,705 2,731,213 RGD:1624291
RGD:1600115
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:1624291
RGD:13464262
G Kif14 kinesin family member 14 JBrowse link 13 53,350,073 53,421,992 RGD:1624291
G Lrrc29 leucine rich repeat containing 29 JBrowse link 19 37,266,782 37,282,076 RGD:13792537
G Nccrp1 NCCRP1, F-box associated domain containing JBrowse link 1
1
85,558,420
85,213,578
85,559,652
85,218,030
RGD:13792537
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:1624291
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:1600115
RGD:13792537
RGD:1624291
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:13792537
G Wwtr1 WW domain containing transcription regulator 1 JBrowse link 2 147,577,149 147,693,033 RGD:1624291
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Styx serine/threonine/tyrosine interacting protein JBrowse link 15 19,690,079 19,720,683 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      primary metabolic process 10563
        protein metabolic process 6070
          protein catabolic process 970
            proteasomal protein catabolic process 478
              proteasome-mediated ubiquitin-dependent protein catabolic process 412
                SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 49
                  negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 1
                  positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                  regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      nitrogen compound metabolic process 10025
        organonitrogen compound metabolic process 6969
          organonitrogen compound catabolic process 1282
            protein catabolic process 970
              cellular protein catabolic process 804
                proteolysis involved in cellular protein catabolic process 751
                  modification-dependent protein catabolic process 639
                    ubiquitin-dependent protein catabolic process 628
                      proteasome-mediated ubiquitin-dependent protein catabolic process 412
                        SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 49
                          negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 1
                          positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                          regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.