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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic component of endoplasmic reticulum membrane
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Accession:GO:0031227 term browser browse the term
Definition:The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
Synonyms:narrow_synonym: intrinsic to endoplasmic reticulum membrane


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intrinsic component of endoplasmic reticulum membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:1626310
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 9 82,436,453 82,444,669 RGD:1624291
RGD:13792537
G Esyt1 extended synaptotagmin 1 JBrowse link 7 2,924,216 2,941,213 RGD:13792537
G Esyt2 extended synaptotagmin 2 JBrowse link 6 144,156,021 144,248,374 RGD:1624291
RGD:13792537
G Esyt3 extended synaptotagmin 3 JBrowse link 8 107,555,417 107,602,414 RGD:1624291
RGD:13792537
G Gramd1a GRAM domain containing 1A JBrowse link 1 89,563,982 89,590,406 RGD:1600115
RGD:1624291
G Gramd2a GRAM domain containing 2A JBrowse link 8 64,503,058 64,539,149 RGD:1624291
RGD:13792537
G Pgap3 post-GPI attachment to proteins phospholipase 3 JBrowse link 10 86,343,058 86,356,146 RGD:1624291
RGD:13792537
G Rnf180 ring finger protein 180 JBrowse link 2 35,718,100 35,892,578 RGD:1624291
RGD:1600115
ER membrane protein complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Emc1 ER membrane protein complex subunit 1 JBrowse link 5 157,820,908 157,846,226 RGD:1624291
RGD:13792537
G Emc10 ER membrane protein complex subunit 10 JBrowse link 1 100,495,112 100,501,468 RGD:1624291
RGD:13792537
RGD:1600115
G Emc2 ER membrane protein complex subunit 2 JBrowse link 7 82,338,639 82,377,389 RGD:1624291
RGD:1600115
RGD:13792537
G Emc3 ER membrane protein complex subunit 3 JBrowse link 4 145,471,466 145,487,375 RGD:1624291
RGD:13792537
RGD:1600115
G Emc4 ER membrane protein complex subunit 4 JBrowse link 3 103,852,139 103,857,172 RGD:1624291
RGD:13792537
G Emc6 ER membrane protein complex subunit 6 JBrowse link 10 59,741,772 59,743,338 RGD:1624291
RGD:13792537
G Emc7 ER membrane protein complex subunit 7 JBrowse link 3 103,945,276 103,955,970 RGD:1624291
RGD:13792537
G Emc8 ER membrane protein complex subunit 8 JBrowse link 19 54,235,949 54,245,810 RGD:1624291
RGD:13792537
RGD:1600115
G Emc9 ER membrane protein complex subunit 9 JBrowse link 15 34,258,940 34,263,156 RGD:1624291
RGD:13792537
RGD:1600115
G Mmgt1 membrane magnesium transporter 1 JBrowse link X 158,966,694 158,978,995 RGD:1624291
RGD:1600115
RGD:13792537
G Mmgt2 membrane magnesium transporter 2 JBrowse link 10 48,986,163 48,989,596 RGD:13792537
GPI-anchor transamidase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 JBrowse link 7 117,394,367 117,397,950 RGD:1331364
RGD:1624291
RGD:1600115
RGD:13792537
G Pigk phosphatidylinositol glycan anchor biosynthesis, class K JBrowse link 2 257,911,099 257,997,735 RGD:1600115
RGD:1624291
RGD:13792537
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S JBrowse link 10 65,591,638 65,606,175 RGD:1624291
G Pigt phosphatidylinositol glycan anchor biosynthesis, class T JBrowse link 3 160,945,556 160,954,738 RGD:1624291
RGD:13792537
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U JBrowse link 3 150,803,096 150,885,597 RGD:1600115
RGD:13792537
RGD:1624291
integral component of cytoplasmic side of endoplasmic reticulum membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hm13 histocompatibility minor 13 JBrowse link 3 148,150,695 148,189,623 RGD:1624291
RGD:13792537
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link 14 6,602,004 6,645,257 RGD:1624291
G Sppl2a signal peptide peptidase-like 2A JBrowse link 3 119,361,651 119,405,453 RGD:1624291
RGD:13792537
G Sppl2b signal peptide peptidase-like 2B JBrowse link 7 11,712,187 11,724,915 RGD:1624291
RGD:13792537
RGD:1600115
G Sppl2c signal peptide peptidase like 2C JBrowse link 10 92,245,434 92,248,758 RGD:1624291
RGD:13792537
G Sppl3 signal peptide peptidase like 3 JBrowse link 12 47,276,485 47,360,552 RGD:1624291
RGD:13792537
integral component of endoplasmic reticulum membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb9 ATP binding cassette subfamily B member 9 JBrowse link 12 37,923,974 37,956,678 RGD:1600115
RGD:1624291
G Acer3 alkaline ceramidase 3 JBrowse link 1 163,160,987 163,263,621 RGD:1624291
RGD:13792537
G Alg3 ALG3, alpha-1,3- mannosyltransferase JBrowse link 11 83,985,484 83,991,706 RGD:1600115
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
G Ankle2 ankyrin repeat and LEM domain containing 2 JBrowse link 12 52,475,862 52,507,126 RGD:1600115
RGD:1624291
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 JBrowse link 1 187,770,160 187,779,675 RGD:1624291
G Asph aspartate-beta-hydroxylase JBrowse link 5 22,577,680 22,799,333 RGD:1624291
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:1624291
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor JBrowse link 4 113,887,030 113,890,103 RGD:13792537
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:1624291
RGD:1600115
RGD:13792537
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
RGD:1600115
G Cpt1c carnitine palmitoyltransferase 1c JBrowse link 1 100,955,094 100,970,579 RGD:1624291
G Creb3 cAMP responsive element binding protein 3 JBrowse link 5 59,063,532 59,068,196 RGD:1624291
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:70385
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:1624291
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
RGD:13792537
G Derl2 derlin 2 JBrowse link 10 57,641,682 57,653,554 RGD:1624291
RGD:13792537
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:1624291
RGD:13792537
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:1624291
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 1 217,018,916 217,034,890 RGD:13792537
G Dhrs9 dehydrogenase/reductase 9 JBrowse link 3 55,623,671 55,645,883 RGD:1624291
RGD:1600115
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 20 29,445,510 29,463,739 RGD:1624291
G Dolk dolichol kinase JBrowse link 3 8,850,154 8,852,192 RGD:1624291
RGD:13792537
G Dolpp1 dolichyldiphosphatase 1 JBrowse link 3 8,957,103 8,966,618 RGD:1624291
RGD:13792537
G Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory JBrowse link 3 11,587,941 11,590,528 RGD:1600115
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory JBrowse link 2 188,583,664 188,584,179 RGD:1624291
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 4 140,886,644 140,918,654 RGD:1624291
G Elovl1 ELOVL fatty acid elongase 1 JBrowse link 5 137,255,868 137,260,486 RGD:13792537
G Elovl2 ELOVL fatty acid elongase 2 JBrowse link 17 21,382,461 21,422,413 RGD:13792537
G Elovl3 ELOVL fatty acid elongase 3 JBrowse link 1 265,883,353 265,887,181 RGD:13792537
G Elovl4 ELOVL fatty acid elongase 4 JBrowse link 8 91,310,690 91,338,625 RGD:1624291
RGD:13792537
G Elovl5 ELOVL fatty acid elongase 5 JBrowse link 8 85,220,941 85,287,449 RGD:13792537
G Elovl6 ELOVL fatty acid elongase 6 JBrowse link 2 234,187,490 234,296,124 RGD:1624291
RGD:13792537
G Elovl7 ELOVL fatty acid elongase 7 JBrowse link 2 40,373,211 40,386,643 RGD:13792537
G Emc6 ER membrane protein complex subunit 6 JBrowse link 10 59,741,772 59,743,338 RGD:1624291
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 JBrowse link 10 16,821,393 16,912,050 RGD:13792537
G Ergic2 ERGIC and golgi 2 JBrowse link 4 182,569,086 182,600,258 RGD:13792537
G Ergic3 ERGIC and golgi 3 JBrowse link 3 151,553,567 151,563,318 RGD:13792537
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
G Esyt1 extended synaptotagmin 1 JBrowse link 7 2,924,216 2,941,213 RGD:1600115
RGD:1624291
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ficd FIC domain protein adenylyltransferase JBrowse link 12 48,658,283 48,663,175 RGD:1600115
RGD:1624291
G Fitm1 fat storage-inducing transmembrane protein 1 JBrowse link 15 34,251,805 34,253,074 RGD:1624291
RGD:13792537
G Fitm2 fat storage-inducing transmembrane protein 2 JBrowse link 3 159,856,994 159,863,506 RGD:1624291
RGD:13792537
RGD:1600115
G Fkbp8 FKBP prolyl isomerase 8 JBrowse link 16 20,645,956 20,652,890 RGD:1624291
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 17 81,173,238 81,196,012 RGD:13792537
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 JBrowse link 11 68,893,684 68,985,635 RGD:13792537
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 JBrowse link 8 70,471,572 70,509,874 RGD:13792537
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 JBrowse link 5 106,728,401 106,758,068 RGD:13792537
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:1624291
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Irag2 inositol 1,4,5-triphosphate receptor associated 2 JBrowse link 4 179,402,929 179,440,792 RGD:1624291
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:13702190
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 JBrowse link 20 5,645,894 5,711,702 RGD:13702443
G Lnpk lunapark, ER junction formation factor JBrowse link 3 61,432,128 61,494,828 RGD:1624291
G LOC100910143 GPI ethanolamine phosphate transferase 2-like JBrowse link 14 1,567,713 1,596,004 RGD:13792537
G LOC102549542 elongation of very long chain fatty acids protein 6-like JBrowse link 2 234,375,172 234,486,639 RGD:13792537
G LOC103689968 protein FAM134B JBrowse link 2 78,103,358 78,257,109 RGD:1600115
RGD:13792537
G LOC103690028 zinc finger protein 622 JBrowse link 2 78,261,699 78,276,942 RGD:1600115
G LOC103694875 derlin-3 RGD:13792537
G LOC681458 similar to stearoyl-coenzyme A desaturase 3 JBrowse link 1 263,968,156 264,003,991 RGD:13792537
G Lrit1 leucine-rich repeat, Ig-like and transmembrane domains 1 JBrowse link 16 14,306,804 14,314,731 RGD:633658
RGD:13792537
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link 2 84,533,546 84,608,743 RGD:1624291
RGD:13792537
G Mboat4 membrane bound O-acyltransferase domain containing 4 JBrowse link 16 61,782,699 61,795,414 RGD:1624291
RGD:13792537
RGD:1600115
G Nfe2l1 nuclear factor, erythroid 2-like 1 JBrowse link 10 84,686,762 84,699,313 RGD:1624291
G Pigg phosphatidylinositol glycan anchor biosynthesis, class G JBrowse link 14 2,410,339 2,438,630 RGD:13792537
G Porcn porcupine O-acyltransferase JBrowse link X 15,035,569 15,048,440 RGD:1624291
G Preb prolactin regulatory element binding JBrowse link 6 26,784,088 26,787,875 RGD:11344947
RGD:13792537
G Rce1 Ras converting CAAX endopeptidase 1 JBrowse link 1 219,860,826 219,863,933 RGD:13792537
RGD:1600115
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:1624291
RGD:1600115
RGD:13792537
G Rhbdd1 rhomboid domain containing 1 JBrowse link 9 88,110,731 88,229,462 RGD:1624291
RGD:1600115
G Rnf183 ring finger protein 183 JBrowse link 5 78,283,722 78,292,729 RGD:1624291
G Rrbp1 ribosome binding protein 1 JBrowse link 3 138,054,938 138,116,858 RGD:1624291
RGD:13792537
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:633934
RGD:1624291
RGD:1600115
G Sacm1l SAC1 like phosphatidylinositide phosphatase JBrowse link 8 132,607,166 132,663,502 RGD:68842
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:1624291
RGD:13792537
G Saraf store-operated calcium entry-associated regulatory factor JBrowse link 16 61,735,189 61,753,438 RGD:1624291
RGD:1600115
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:1299253
RGD:13792537
RGD:1624291
G Scd2 stearoyl-Coenzyme A desaturase 2 JBrowse link 1 264,059,374 264,072,433 RGD:13792537
G Scd4 stearoyl-coenzyme A desaturase 4 JBrowse link 1 264,094,007 264,105,473 RGD:13792537
G Sec61a1 SEC61 translocon subunit alpha 1 JBrowse link 4 120,453,577 120,467,932 RGD:1624291
G Sec62 SEC62 homolog, preprotein translocation factor JBrowse link 2 116,188,736 116,225,510 RGD:1600115
G Selenos selenoprotein S JBrowse link 1 126,979,579 126,989,344 RGD:1600115
RGD:13792537
RGD:1624291
G Sgms1 sphingomyelin synthase 1 JBrowse link 1 250,692,448 250,951,685 RGD:13792537
G Sgms2 sphingomyelin synthase 2 JBrowse link 2 236,458,276 236,530,667 RGD:13792537
G Slc27a2 solute carrier family 27 member 2 JBrowse link 3 119,014,620 119,052,531 RGD:1600115
RGD:13792537
RGD:1624291
G Slc27a5 solute carrier family 27 member 5 JBrowse link 1 65,576,599 65,587,192 RGD:1624291
RGD:13792537
G Slc35b1 solute carrier family 35, member B1 JBrowse link 10 83,201,532 83,208,605 RGD:13792537
G Slc35b2 solute carrier family 35 member B2 JBrowse link 9 17,823,399 17,827,032 RGD:13792537
G Slc35b3 solute carrier family 35 member B3 JBrowse link 17 26,478,777 26,505,225 RGD:13792537
G Slc35b4 solute carrier family 35 member B4 JBrowse link 4 61,550,995 61,573,003 RGD:13792537
G Slc37a1 solute carrier family 37 member 1 JBrowse link 20 10,026,839 10,087,691 RGD:1624291
RGD:13792537
G Slc37a2 solute carrier family 37 member 2 JBrowse link 8 39,708,678 39,735,042 RGD:1624291
RGD:13792537
G Slc37a3 solute carrier family 37, member 3 JBrowse link 4 67,118,918 67,162,821 RGD:1624291
RGD:13792537
G Slc37a4 solute carrier family 37 member 4 JBrowse link 8 48,716,914 48,723,024 RGD:1624291
G Spcs1 signal peptidase complex subunit 1 JBrowse link 16 7,080,389 7,081,957 RGD:1624291
RGD:13792537
G Stim1 stromal interaction molecule 1 JBrowse link 1 167,373,894 167,533,412 RGD:1600115
RGD:1624291
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 28,529,537 28,535,828 RGD:1624291
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:1624291
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:1624291
G Tapt1 transmembrane anterior posterior transformation 1 JBrowse link 14 71,416,153 71,462,646 RGD:13792537
G Tecr trans-2,3-enoyl-CoA reductase JBrowse link 19 24,705,478 24,732,024 RGD:1624291
RGD:1600115
G Tex261 testis expressed 261 JBrowse link 4 115,446,830 115,454,035 RGD:13792537
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 1 221,426,017 221,430,340 RGD:13792537
G Tmco1 transmembrane and coiled-coil domains 1 JBrowse link 13 85,465,015 85,559,113 RGD:1624291
RGD:1600115
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
G Tram1 translocation associated membrane protein 1 JBrowse link 5 5,215,196 5,297,337 RGD:1600115
RGD:1624291
G Ubxn8 UBX domain protein 8 JBrowse link 16 62,251,243 62,272,838 RGD:1624291
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:1624291
RGD:13792537
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
RGD:13792537
G Xxylt1 xyloside xylosyltransferase 1 JBrowse link 11 73,198,404 73,330,682 RGD:1624291
G Zfyve27 zinc finger FYVE-type containing 27 JBrowse link 1 261,415,172 261,438,539 RGD:1600115
RGD:1624291
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:13792537
integral component of lumenal side of endoplasmic reticulum membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hm13 histocompatibility minor 13 JBrowse link 3 148,150,695 148,189,623 RGD:1624291
RGD:13792537
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link 14 6,602,004 6,645,257 RGD:1624291
G Sppl2a signal peptide peptidase-like 2A JBrowse link 3 119,361,651 119,405,453 RGD:1624291
RGD:13792537
G Sppl2b signal peptide peptidase-like 2B JBrowse link 7 11,712,187 11,724,915 RGD:1624291
RGD:13792537
RGD:1600115
G Sppl2c signal peptide peptidase like 2C JBrowse link 10 92,245,434 92,248,758 RGD:1624291
RGD:13792537
G Sppl3 signal peptide peptidase like 3 JBrowse link 12 47,276,485 47,360,552 RGD:1624291
RGD:13792537
MHC class I peptide loading complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:1600115
RGD:1624291
RGD:13792542
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:13792542
RGD:13792537
RGD:1624291
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:1601415
RGD:13792537
RGD:1624291
RGD:13792542
G Tapbp TAP binding protein JBrowse link 20 5,468,056 5,476,007 RGD:634074
RGD:1624291
RGD:13792542
SREBP-SCAP-Insig complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:13792537
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
RGD:13792537
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:1624291
RGD:13792537
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1600115
RGD:1624291
TAP complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC103689996 antigen peptide transporter 2 JBrowse link 20 5,197,869 5,212,262 RGD:1600115
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:9999147
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:1300480
RGD:1600115
RGD:1624291
RGD:13792542
RGD:2312377
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:2312377
RGD:13792542
RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19951
    cellular anatomical entity 19598
      intrinsic component of membrane 6882
        intrinsic component of organelle membrane 395
          intrinsic component of endoplasmic reticulum membrane 152
            integral component of endoplasmic reticulum membrane + 144
Path 2
Term Annotations click to browse term
  cellular_component 19951
    cellular anatomical entity 19598
      organelle 12670
        membrane-bounded organelle 10978
          organelle membrane 2715
            endoplasmic reticulum membrane 874
              intrinsic component of endoplasmic reticulum membrane 152
                integral component of endoplasmic reticulum membrane + 144
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.