ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cell killing
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Accession:GO:0031341 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.


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negative regulation of complement-dependent cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:13792592
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:10448271
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:1624291
RGD:1600115
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1624291
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 carcinoembryonic antigen related cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
RGD:1600115
G Clec12b C-type lectin domain family 12, member B JBrowse link 4 163,140,883 163,157,996 RGD:1624291
RGD:1600115
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:11568650
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:9685777
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:9685777
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313500
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
RGD:1600115
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 carcinoembryonic antigen related cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1299590
negative regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 carcinoembryonic antigen related cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Il7r interleukin 7 receptor RGD:1624291
RGD:1600115
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1624291
RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1600115
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Muc4 mucin 4, cell surface associated JBrowse link 11 71,242,973 71,285,217 RGD:2303754
positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:1624291
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
positive regulation of apoptotic process by virus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
RGD:1600115
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
RGD:1600115
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:4890424
positive regulation of cell killing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Oga O-GlcNAcase JBrowse link 1 265,506,752 265,542,452 RGD:2305938
positive regulation of complement-dependent cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd5l Cd5 molecule-like JBrowse link 2 186,685,104 186,696,117 RGD:1624291
RGD:1600115
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:1624291
positive regulation of cytolysis in other organism term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pglyrp1 peptidoglycan recognition protein 1 JBrowse link 1 79,790,879 79,796,064 RGD:1600115
RGD:13792537
RGD:1624291
G Pglyrp3 peptidoglycan recognition protein 3 JBrowse link 2 191,903,626 192,264,872 RGD:1624291
RGD:13792537
G Pglyrp3b peptidoglycan recognition protein 3b JBrowse link 2 191,900,147 191,916,863 RGD:13792537
G Pglyrp4 peptidoglycan recognition protein 4 JBrowse link 2 190,125,655 190,204,230 RGD:1624291
RGD:13792537
positive regulation of killing of cells of other organism term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcer2 Fc fragment of IgE receptor II JBrowse link 12 2,233,772 2,245,324 RGD:1624291
RGD:1600115
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:1624291
RGD:1600115
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:1600115
RGD:1624291
positive regulation of leukocyte mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549560
positive regulation of microglial cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
RGD:1600115
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:1624291
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
RGD:1600115
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
RGD:1600115
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1600115
RGD:1624291
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:2303778
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:1624291
RGD:1600115
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:1624291
RGD:1600115
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1600115
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:1600115
RGD:13792537
RGD:1624291
G Lag3 lymphocyte activating 3 JBrowse link 4 157,425,644 157,433,700 RGD:1624291
RGD:1600115
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:1624291
G Ly49s3 Ly-49 stimulatory receptor 3 RGD:633264
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link 20 5,170,169 5,175,773 RGD:1624291
RGD:13792537
RGD:1600115
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
G Raet1e retinoic acid early transcript 1E JBrowse link 1 1,101,666 1,120,340 RGD:1624291
G Raet1l retinoic acid early transcript 1L JBrowse link 7 114,233,896 114,234,243 RGD:9685184
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
RGD:1600115
G Rrlt similar to retinoic acid early transcript 1L JBrowse link 1 1,437,716 1,442,089 RGD:9685184
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 JBrowse link 20 1,814,661 1,833,033 RGD:1600115
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1a SH2 domain containing 1A JBrowse link X 128,897,053 128,925,408 RGD:1624291
RGD:1600115
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
RGD:1600115
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:1624291
RGD:1600115
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
RGD:13792537
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
RGD:1600115
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
RGD:1600115
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:9685180
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:1600115
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
G Rrlt similar to retinoic acid early transcript 1L JBrowse link 1 1,437,716 1,442,089 RGD:9685180
positive regulation of neutrophil mediated killing of fungus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:1624291
RGD:1600115
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:1600115
RGD:1624291
positive regulation of neutrophil mediated killing of gram-negative bacterium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:1600115
positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
RGD:1600115
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
RGD:13792537
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:1600115
G Fam49b family with sequence similarity 49, member B JBrowse link 7 104,514,566 104,641,875 RGD:1624291
RGD:1600115
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1298959
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10059395
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
RGD:1600115
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
RGD:1600115
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:1624291
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313503
RGD:13792537
G RT1-A2 RT1 class Ia, locus A2 JBrowse link 20 5,374,990 5,378,536 RGD:1624291
RGD:13792537
G RT1-CE10 RT1 class I, locus CE10 JBrowse link 20 129,192 157,689 RGD:13792537
G RT1-CE3 RT1 class I, locus CE3 JBrowse link 20 4,918,047 4,943,603 RGD:13792537
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:13792537
RGD:1624291
G RT1-EC2 RT1 class Ib, locus EC2 RGD:13792537
G RT1-M2 RT1 class Ib, locus M2 JBrowse link 20 1,337,242 1,339,488 RGD:13792537
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 JBrowse link 20 1,814,661 1,833,033 RGD:13792537
G RT1-M4 RT1 class Ib, locus M4 JBrowse link 20 2,043,710 2,048,575 RGD:13792537
G RT1-M5 RT1 class Ib, locus M5 JBrowse link 20 2,038,158 2,040,422 RGD:13792537
G RT1-M6-2 RT1 class I, locus M6, gene 2 JBrowse link 20 2,075,796 2,079,183 RGD:13792537
G RT1-N2 RT1 class Ib, locus N2 JBrowse link 20 3,146,579 3,150,852 RGD:13792537
G RT1-N3 RT1 class Ib, locus N3 JBrowse link 20 3,166,793 3,170,945 RGD:13792537
G RT1-S2 RT1 class Ib, locus S2 JBrowse link 20 3,152,073 3,165,871 RGD:13792537
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
RGD:13792537
G RT1-T24-1 RT1 class I, locus T24, gene 1 JBrowse link 20 3,269,315 3,282,523 RGD:13792537
G RT1-T24-3 RT1 class I, locus T24, gene 3 JBrowse link 20 3,226,010 3,257,254 RGD:13792537
G RT1-T24-4 RT1 class I, locus T24, gene 4 JBrowse link 20 3,189,457 3,197,457 RGD:13792537
G Stx7 syntaxin 7 JBrowse link 1 22,241,655 22,281,850 RGD:1624291
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:1299069
RGD:1624291
G Xcl1 X-C motif chemokine ligand 1 JBrowse link 13 83,199,402 83,202,845 RGD:1624291
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec2d C-type lectin domain family 2, member D JBrowse link 4 162,278,252 162,302,881 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A JBrowse link 13 27,153,500 27,159,319 RGD:1624291
G Serpinb9 serpin family B member 9 JBrowse link 17 32,648,846 32,673,047 RGD:1624291
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:2312378
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:2312378
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:2293335
regulation of complement-dependent cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:1624291
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 JBrowse link 10 55,085,269 55,135,069 RGD:1624291
RGD:1600115
regulation of neutrophil mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnase1 deoxyribonuclease 1 JBrowse link 10 11,757,681 11,760,672 RGD:1624291
RGD:13464261
G Dnase1l3 deoxyribonuclease 1-like 3 JBrowse link 15 18,710,492 18,736,476 RGD:1624291
RGD:13464261
regulation of neutrophil mediated killing of gram-negative bacterium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl6 C-X-C motif chemokine ligand 6 JBrowse link 14 18,860,201 18,920,839 RGD:1624291
regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
RGD:1600115
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
RGD:13792537
RGD:1600115
G LOC102547056 retinoic acid early-inducible protein 1-gamma-like JBrowse link 1 1,181,301 1,200,526 RGD:1624291
RGD:13792537
G Micb MHC class I polypeptide-related sequence B JBrowse link 1 79,754,587 79,772,092 RGD:13792537
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:13792537
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:1600115
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:1600115
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17895
    cell killing 184
      regulation of cell killing 117
        negative regulation of cell killing + 30
        positive regulation of cell killing + 84
        regulation of complement-dependent cytotoxicity + 12
        regulation of killing of cells of other organism + 16
        regulation of leukocyte mediated cytotoxicity + 92
Path 2
Term Annotations click to browse term
  biological_process 17895
    biological regulation 12603
      regulation of biological process 11946
        regulation of cell killing 117
          negative regulation of cell killing + 30
          positive regulation of cell killing + 84
          regulation of complement-dependent cytotoxicity + 12
          regulation of killing of cells of other organism + 16
          regulation of leukocyte mediated cytotoxicity + 92
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.