Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:response to methotrexate
go back to main search page
Accession:GO:0031427 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


show annotations for term's descendants       view all columns           Sort by:
 
response to methotrexate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:1598604
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:2316003
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:10054082
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:1598604
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:1598604

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    response to stimulus 10395
      response to chemical 6333
        response to antimetabolite 21
          response to methotrexate 5
            cellular response to methotrexate 0
Path 2
Term Annotations click to browse term
  biological_process 19336
    response to stimulus 10395
      response to chemical 6333
        response to organic substance 3792
          response to organic cyclic compound 1463
            response to methotrexate 5
              cellular response to methotrexate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.