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ONTOLOGY REPORT - ANNOTATIONS


Term:heterochromatin assembly
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Accession:GO:0031507 term browser browse the term
Definition:The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.
Synonyms:exact_synonym: establishment of heterochromatin architecture;   heterochromatin formation
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing
 alt_id: GO:0006343;   GO:0070869;   GO:1904497


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heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAHD1 bromo adjacent homology domain containing 1 JBrowse link 15 19,376,233 19,404,699 RGD:9068941
G BAZ2A bromodomain adjacent to zinc finger domain 2A JBrowse link 12 32,274,240 32,313,839 RGD:9068941
G EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit JBrowse link 17 14,572,868 14,618,012 RGD:9068941
G HMGA2 high mobility group AT-hook 2 JBrowse link 12 22,954,946 23,096,623 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 64,368,878 64,401,684 RGD:9068941
DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DNMT3A DNA methyltransferase 3 alpha JBrowse link 2A 25,229,593 25,344,733 RGD:9068941
G DNMT3B DNA methyltransferase 3 beta JBrowse link 20 29,049,993 29,096,957 RGD:9068941
G HDAC1 histone deacetylase 1 JBrowse link 1 31,578,373 31,619,970 RGD:9068941
G HELLS helicase, lymphoid specific JBrowse link 10 91,282,330 91,344,156 RGD:9068941
G MBD2 methyl-CpG binding domain protein 2 JBrowse link 18 47,534,356 47,609,481 RGD:9068941
G MBD3 methyl-CpG binding domain protein 3 RGD:9068941
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 19 10,515,216 10,616,155 RGD:9068941
inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 18 11,479,742 11,627,035 RGD:9068941
negative regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AICDA activation induced cytidine deaminase JBrowse link 12 8,688,392 8,699,008 RGD:9068941
G APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 JBrowse link 12 7,777,734 7,793,960 RGD:9068941
G TET1 tet methylcytosine dioxygenase 1 JBrowse link 10 65,036,313 65,168,051 RGD:9068941
negative regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PHF2 PHD finger protein 2 JBrowse link 9 64,700,151 64,803,737 RGD:9068941
G PHF8 PHD finger protein 8 JBrowse link X 46,144,815 46,250,594 RGD:9068941
pericentric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CENPV centromere protein V JBrowse link 17 35,247,664 35,258,656 RGD:9068941
G DICER1 dicer 1, ribonuclease III JBrowse link 14 75,709,029 75,780,779 RGD:9068941
G HELLS helicase, lymphoid specific JBrowse link 10 91,282,330 91,344,156 RGD:9068941
G LOC100970414 histone H3.3A JBrowse link 1 201,523,670 201,533,005 RGD:9068941
G LOC100988671 histone H3.3A JBrowse link 17 69,728,165 69,730,519 RGD:9068941
positive regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATF7IP activating transcription factor 7 interacting protein JBrowse link 12 14,373,084 14,504,286 RGD:9068941
G DNMT1 DNA methyltransferase 1 JBrowse link 19 9,681,847 9,745,334 RGD:9068941
G MORC2 MORC family CW-type zinc finger 2 JBrowse link 22 11,912,043 11,995,497 RGD:9068941
G MPHOSPH8 M-phase phosphoprotein 8 JBrowse link 13 932,620 999,853 RGD:9068941
G PPHLN1 periphilin 1 JBrowse link 12 46,271,425 46,392,128 RGD:9068941
G RESF1 retroelement silencing factor 1 JBrowse link 12 54,238,276 54,272,288 RGD:9068941
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 JBrowse link 1 126,275,719 126,314,043 RGD:9068941
G TASOR transcription activation suppressor JBrowse link 3 56,555,945 56,619,151 RGD:9068941
G TRIM28 tripartite motif containing 28 JBrowse link 19 55,557,130 55,563,802 RGD:9068941
G ZNF304 zinc finger protein 304 JBrowse link 19 54,365,820 54,374,436 RGD:9068941
positive regulation of heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TPR translocated promoter region, nuclear basket protein JBrowse link 1 161,842,037 161,903,567 RGD:9068941
positive regulation of subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SIRT6 sirtuin 6 JBrowse link 19 3,196,092 3,204,602 RGD:9068941
rDNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAZ2A bromodomain adjacent to zinc finger domain 2A JBrowse link 12 32,274,240 32,313,839 RGD:9068941
G BEND3 BEN domain containing 3 JBrowse link 6 104,875,201 104,926,926 RGD:9068941
G RRP8 ribosomal RNA processing 8 JBrowse link 11 6,630,695 6,735,711 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 64,368,878 64,401,684 RGD:9068941
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 JBrowse link 4 135,874,888 135,917,096 RGD:9068941
G SUV39H1 suppressor of variegation 3-9 homolog 1 JBrowse link X 40,993,911 41,007,362 RGD:9068941
G UBTF upstream binding transcription factor JBrowse link 17 13,176,228 13,191,283 RGD:9068941
regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G POU5F1 POU class 5 homeobox 1 JBrowse link 6 30,910,421 30,916,465 RGD:9068941
regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100974858 core histone macro-H2A.1 JBrowse link 5 130,727,065 130,791,932 RGD:9068941
senescence-associated heterochromatin focus assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,803,862 21,831,322 RGD:9068941
G HMGA1 high mobility group AT-hook 1 JBrowse link 6 33,807,171 33,816,603 RGD:9068941
G HMGA2 high mobility group AT-hook 2 JBrowse link 12 22,954,946 23,096,623 RGD:9068941
subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100970414 histone H3.3A JBrowse link 1 201,523,670 201,533,005 RGD:9068941
G LOC100988671 histone H3.3A JBrowse link 17 69,728,165 69,730,519 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12490
    cellular process 11599
      cellular component organization or biogenesis 4957
        cellular component organization 4877
          chromatin organization 555
            chromatin remodeling 121
              heterochromatin assembly 43
                DNA methylation-dependent heterochromatin assembly + 21
                heterochromatin assembly by small RNA + 0
                heterochromatin domain assembly + 0
                heterochromatin island assembly + 0
                inactivation of X chromosome by heterochromatin assembly 1
                negative regulation of heterochromatin assembly + 5
                pericentric heterochromatin assembly + 5
                positive regulation of heterochromatin assembly + 12
                rDNA heterochromatin assembly + 10
                regulation of heterochromatin assembly + 19
                senescence-associated heterochromatin focus assembly 3
                silent mating-type cassette heterochromatin assembly + 0
                subtelomeric heterochromatin assembly + 3
Path 2
Term Annotations click to browse term
  biological_process 12490
    metabolic process 7937
      cellular metabolic process 7295
        cellular aromatic compound metabolic process 3854
          nucleobase-containing compound metabolic process 3680
            nucleic acid metabolic process 3378
              RNA metabolic process 3000
                regulation of RNA metabolic process 2575
                  negative regulation of RNA metabolic process 1204
                    negative regulation of RNA biosynthetic process 1111
                      negative regulation of nucleic acid-templated transcription 1109
                        negative regulation of transcription, DNA-templated 1105
                          chromatin organization involved in negative regulation of transcription 61
                            heterochromatin assembly 43
                              DNA methylation-dependent heterochromatin assembly + 21
                              heterochromatin assembly by small RNA + 0
                              heterochromatin domain assembly + 0
                              heterochromatin island assembly + 0
                              inactivation of X chromosome by heterochromatin assembly 1
                              negative regulation of heterochromatin assembly + 5
                              pericentric heterochromatin assembly + 5
                              positive regulation of heterochromatin assembly + 12
                              rDNA heterochromatin assembly + 10
                              regulation of heterochromatin assembly + 19
                              senescence-associated heterochromatin focus assembly 3
                              silent mating-type cassette heterochromatin assembly + 0
                              subtelomeric heterochromatin assembly + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.