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ONTOLOGY REPORT - ANNOTATIONS


Term:heterochromatin assembly
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Accession:GO:0031507 term browser browse the term
Definition:The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.
Synonyms:exact_synonym: establishment of heterochromatin architecture;   heterochromatin formation
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing
 alt_id: GO:0006343;   GO:0070869;   GO:1904497


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heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bahd1 bromo adjacent homology domain containing 1 JBrowse link NW_004955416 7,376,794 7,388,577 RGD:9068941
G Baz2a bromodomain adjacent to zinc finger domain 2A JBrowse link NW_004955458 4,149,610 4,186,647 RGD:9068941
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit JBrowse link NW_004955451 16,548,898 16,563,449 RGD:9068941
G Hmga2 high mobility group AT-hook 2 JBrowse link NW_004955458 12,493,790 12,624,805 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link NW_004955469 7,264,431 7,367,059 RGD:9068941
G Dnmt3b DNA methyltransferase 3 beta JBrowse link NW_004955422 28,380,595 28,427,012 RGD:9068941
G Hdac1 histone deacetylase 1 JBrowse link NW_004955452 10,636,366 10,668,873 RGD:9068941
G Hells helicase, lymphoid specific JBrowse link NW_004955507 995,389 1,034,852 RGD:9068941
G Mbd2 methyl-CpG binding domain protein 2 JBrowse link NW_004955402 38,761,668 38,829,830 RGD:9068941
G Mbd3 methyl-CpG binding domain protein 3 JBrowse link NW_004955495 6,385,449 6,388,911 RGD:9068941
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link NW_004955495 2,021,671 2,105,155 RGD:9068941
inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link NW_004955402 7,544,265 7,661,191 RGD:9068941
negative regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 JBrowse link NW_004955413 6,471,933 6,480,475 RGD:9068941
G Tet1 tet methylcytosine dioxygenase 1 JBrowse link NW_004955425 20,767,406 20,857,165 RGD:9068941
negative regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Phf2 PHD finger protein 2 JBrowse link NW_004955515 4,428,068 4,471,642 RGD:9068941
G Phf8 PHD finger protein 8 JBrowse link NW_004955475 1,105,619 1,230,758 RGD:9068941
pericentric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cenpv centromere protein V JBrowse link NW_004955467 1,657,765 1,669,758 RGD:9068941
G Dicer1 dicer 1, ribonuclease III JBrowse link NW_004955438 17,374,899 17,431,599 RGD:9068941
G H3f3a H3 histone, family 3A JBrowse link NW_004955489 269,900 278,398 RGD:9068941
G H3f3b H3 histone, family 3B JBrowse link NW_004955506 6,475,336 6,478,781 RGD:9068941
G Hells helicase, lymphoid specific JBrowse link NW_004955507 995,389 1,034,852 RGD:9068941
positive regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf7ip activating transcription factor 7 interacting protein JBrowse link NW_004955413 11,117,369 11,261,787 RGD:9068941
G Dnmt1 DNA methyltransferase 1 JBrowse link NW_004955495 1,465,529 1,505,379 RGD:9068941
G Morc2 MORC family CW-type zinc finger 2 JBrowse link NW_004955455 5,124,737 5,164,495 RGD:9068941
G Mphosph8 M-phase phosphoprotein 8 JBrowse link NW_004955497 518,462 546,748 RGD:9068941
G Pphln1 periphilin 1 JBrowse link NW_004955500 1,744,968 1,892,056 RGD:9068941
G Resf1 retroelement silencing factor 1 JBrowse link NW_004955505 3,684,848 3,709,624 RGD:9068941
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 JBrowse link NW_004955588 290,497 338,438 RGD:9068941
G Tasor transcription activation suppressor JBrowse link NW_004955430 6,440,655 6,480,956 RGD:9068941
G Trim28 tripartite motif containing 28 JBrowse link NW_004955584 1,148,903 1,156,001 RGD:9068941
positive regulation of heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tpr translocated promoter region, nuclear basket protein JBrowse link NW_004955406 24,742,525 24,805,989 RGD:9068941
positive regulation of subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sirt6 sirtuin 6 JBrowse link NW_004955495 4,641,883 4,650,518 RGD:9068941
rDNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baz2a bromodomain adjacent to zinc finger domain 2A JBrowse link NW_004955458 4,149,610 4,186,647 RGD:9068941
G Bend3 BEN domain containing 3 JBrowse link NW_004955411 32,346,573 32,384,796 RGD:9068941
G Rrp8 ribosomal RNA processing 8 JBrowse link NW_004955414 22,311,038 22,316,144 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 JBrowse link NW_004955471 12,206,462 12,240,219 RGD:9068941
G Suv39h1 suppressor of variegation 3-9 homolog 1 JBrowse link NW_004955543 258,479 271,128 RGD:9068941
G Ubtf upstream binding transcription factor JBrowse link NW_004955451 17,294,163 17,302,807 RGD:9068941
regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pou5f1 POU class 5 homeobox 1 JBrowse link NW_004955583 995,707 1,003,202 RGD:9068941
regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC102008188 core histone macro-H2A.1 JBrowse link NW_004955408 30,497,531 30,550,095 RGD:9068941
senescence-associated heterochromatin focus assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmga1 high mobility group AT-hook 1 JBrowse link NW_004955437 2,478,414 2,486,809 RGD:9068941
G Hmga2 high mobility group AT-hook 2 JBrowse link NW_004955458 12,493,790 12,624,805 RGD:9068941
subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G H3f3a H3 histone, family 3A JBrowse link NW_004955489 269,900 278,398 RGD:9068941
G H3f3b H3 histone, family 3B JBrowse link NW_004955506 6,475,336 6,478,781 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11825
    cellular process 11033
      cellular component organization or biogenesis 4817
        cellular component organization 4737
          chromatin organization 528
            chromatin remodeling 117
              heterochromatin assembly 40
                DNA methylation-dependent heterochromatin assembly + 19
                heterochromatin assembly by small RNA + 0
                heterochromatin domain assembly + 0
                heterochromatin island assembly + 0
                inactivation of X chromosome by heterochromatin assembly 1
                negative regulation of heterochromatin assembly + 4
                pericentric heterochromatin assembly + 5
                positive regulation of heterochromatin assembly + 11
                rDNA heterochromatin assembly + 10
                regulation of heterochromatin assembly + 17
                senescence-associated heterochromatin focus assembly 2
                silent mating-type cassette heterochromatin assembly + 0
                subtelomeric heterochromatin assembly + 3
Path 2
Term Annotations click to browse term
  biological_process 11825
    metabolic process 7568
      cellular metabolic process 6988
        cellular aromatic compound metabolic process 3713
          nucleobase-containing compound metabolic process 3544
            nucleic acid metabolic process 3258
              RNA metabolic process 2891
                regulation of RNA metabolic process 2475
                  negative regulation of RNA metabolic process 1140
                    negative regulation of RNA biosynthetic process 1050
                      negative regulation of nucleic acid-templated transcription 1048
                        negative regulation of transcription, DNA-templated 1044
                          chromatin organization involved in negative regulation of transcription 58
                            heterochromatin assembly 40
                              DNA methylation-dependent heterochromatin assembly + 19
                              heterochromatin assembly by small RNA + 0
                              heterochromatin domain assembly + 0
                              heterochromatin island assembly + 0
                              inactivation of X chromosome by heterochromatin assembly 1
                              negative regulation of heterochromatin assembly + 4
                              pericentric heterochromatin assembly + 5
                              positive regulation of heterochromatin assembly + 11
                              rDNA heterochromatin assembly + 10
                              regulation of heterochromatin assembly + 17
                              senescence-associated heterochromatin focus assembly 2
                              silent mating-type cassette heterochromatin assembly + 0
                              subtelomeric heterochromatin assembly + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.