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ONTOLOGY REPORT - ANNOTATIONS


Term:heterochromatin assembly
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Accession:GO:0031507 term browser browse the term
Definition:The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.
Synonyms:exact_synonym: establishment of heterochromatin architecture;   heterochromatin formation
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing
 alt_id: GO:0006343;   GO:0070869;   GO:1904497


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heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bahd1 bromo adjacent homology domain containing 1 JBrowse link 2 118,900,336 118,924,528 RGD:2290270
G Baz2a bromodomain adjacent to zinc finger domain, 2A JBrowse link 10 128,091,370 128,129,303 RGD:2290270
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit JBrowse link 11 101,191,115 101,226,463 RGD:2290270
G Hmga2 high mobility group AT-hook 2 JBrowse link 10 120,361,268 120,476,469 RGD:9068941
G Pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) JBrowse link 4 62,523,798 62,525,014 RGD:2290270
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:2290270
DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt3a DNA methyltransferase 3A JBrowse link 12 3,801,559 3,914,443 RGD:2290270
G Dnmt3b DNA methyltransferase 3B JBrowse link 2 153,649,411 153,687,730 RGD:2290270
G Hdac1 histone deacetylase 1 JBrowse link 4 129,516,104 129,542,646 RGD:2290270
G Hells helicase, lymphoid specific JBrowse link 19 38,930,262 38,970,470 RGD:2290270
G Mbd2 methyl-CpG binding domain protein 2 JBrowse link 18 70,568,225 70,629,134 RGD:2290270
G Mbd3 methyl-CpG binding domain protein 3 JBrowse link 10 80,392,539 80,399,531 RGD:2290270
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 9 21,616,106 21,704,230 RGD:2290270
heterochromatin assembly by small RNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fam172a family with sequence similarity 172, member A JBrowse link 13 77,708,677 78,166,240 RGD:2290270
G Nrde2 nrde-2 necessary for RNA interference, domain containing JBrowse link 12 100,125,450 100,160,414 RGD:2290270
G Znfx1 zinc finger, NFX1-type containing 1 JBrowse link 2 167,035,790 167,063,015 RGD:2290270
inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smchd1 SMC hinge domain containing 1 JBrowse link 17 71,344,489 71,475,366 RGD:2290270
negative regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation-induced cytidine deaminase JBrowse link 6 122,553,809 122,564,180 RGD:2290270
G Apobec1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 JBrowse link 6 122,577,792 122,603,024 RGD:2290270
G Tet1 tet methylcytosine dioxygenase 1 JBrowse link 10 62,804,570 62,887,469 RGD:2290270
negative regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Phf2 PHD finger protein 2 JBrowse link 13 48,801,750 48,870,885 RGD:2290270
G Phf8 PHD finger protein 8 JBrowse link X 151,520,641 151,633,859 RGD:2290270
pericentric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cenpv centromere protein V JBrowse link 11 62,524,944 62,539,869 RGD:2290270
G Dicer1 dicer 1, ribonuclease type III JBrowse link 12 104,687,740 104,751,968 RGD:2290270
G H3f3a H3.3 histone A JBrowse link 1 180,802,560 180,813,605 RGD:2290270
G H3f3b H3.3 histone B JBrowse link 11 116,021,961 116,026,039 RGD:2290270
G Hells helicase, lymphoid specific JBrowse link 19 38,930,262 38,970,470 RGD:2290270
positive regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf7ip activating transcription factor 7 interacting protein JBrowse link 6 136,518,789 136,610,850 RGD:2290270
G Dnmt1 DNA methyltransferase (cytosine-5) 1 JBrowse link 9 20,907,206 20,959,888 RGD:2290270
G Morc2a microrchidia 2A JBrowse link 11 3,649,189 3,690,477 RGD:2290270
G Mphosph8 M-phase phosphoprotein 8 JBrowse link 14 56,668,235 56,697,430 RGD:2290270
G Pphln1 periphilin 1 JBrowse link 15 93,398,345 93,491,913 RGD:2290270
G Resf1 retroelement silencing factor 1 JBrowse link 6 149,309,409 149,335,663 RGD:2290270
G Setdb1 SET domain, bifurcated 1 JBrowse link 3 95,323,525 95,357,202 RGD:2290270
G Setdb2 SET domain, bifurcated 2 JBrowse link 14 59,402,009 59,440,880 RGD:2290270
G Tasor transcription activation suppressor JBrowse link 14 27,423,674 27,483,555 RGD:2290270
G Trim28 tripartite motif-containing 28 JBrowse link 7 13,024,152 13,031,032 RGD:2290270
positive regulation of heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tpr translocated promoter region, nuclear basket protein JBrowse link 1 150,392,802 150,449,935 RGD:2290270
positive regulation of subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sirt6 sirtuin 6 JBrowse link 10 81,621,787 81,627,792 RGD:2290270
rDNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baz2a bromodomain adjacent to zinc finger domain, 2A JBrowse link 10 128,091,370 128,129,303 RGD:2290270
G Bend3 BEN domain containing 3 JBrowse link 10 43,479,134 43,515,417 RGD:2290270
G Rrp8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) JBrowse link 7 105,731,730 105,737,385 RGD:2290270
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:2290270
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 JBrowse link 8 80,699,943 80,739,459 RGD:2290270
G Suv39h1 suppressor of variegation 3-9 1 JBrowse link X 8,061,171 8,074,760 RGD:2290270
G Ubtf upstream binding transcription factor, RNA polymerase I JBrowse link 11 102,304,560 102,323,649 RGD:2290270
regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pou5f1 POU domain, class 5, transcription factor 1 JBrowse link 17 35,506,032 35,510,777 RGD:2290270
regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Macroh2a1 macroH2A.1 histone JBrowse link 13 56,073,622 56,135,626 RGD:9068941
G Naa40 N(alpha)-acetyltransferase 40, NatD catalytic subunit JBrowse link 19 7,225,668 7,241,222 RGD:2290270
senescence-associated heterochromatin focus assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:2290270
G Hmga1 high mobility group AT-hook 1 JBrowse link 17 27,556,574 27,563,672 RGD:9068941
G Hmga2 high mobility group AT-hook 2 JBrowse link 10 120,361,268 120,476,469 RGD:9068941
subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G H3f3a H3.3 histone A JBrowse link 1 180,802,560 180,813,605 RGD:2290270
G H3f3b H3.3 histone B JBrowse link 11 116,021,961 116,026,039 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23163
    cellular process 17053
      cellular component organization or biogenesis 6347
        cellular component organization 6159
          chromatin organization 790
            chromatin remodeling 171
              heterochromatin assembly 48
                DNA methylation-dependent heterochromatin assembly + 21
                heterochromatin assembly by small RNA + 3
                heterochromatin domain assembly + 0
                heterochromatin island assembly + 0
                inactivation of X chromosome by heterochromatin assembly 1
                negative regulation of heterochromatin assembly + 5
                pericentric heterochromatin assembly + 5
                positive regulation of heterochromatin assembly + 12
                rDNA heterochromatin assembly + 11
                regulation of heterochromatin assembly + 20
                senescence-associated heterochromatin focus assembly 3
                silent mating-type cassette heterochromatin assembly + 0
                subtelomeric heterochromatin assembly + 3
Path 2
Term Annotations click to browse term
  biological_process 23163
    metabolic process 10979
      cellular metabolic process 9774
        cellular aromatic compound metabolic process 5140
          nucleobase-containing compound metabolic process 4911
            nucleic acid metabolic process 4474
              RNA metabolic process 3990
                regulation of RNA metabolic process 3251
                  negative regulation of RNA metabolic process 1379
                    negative regulation of RNA biosynthetic process 1279
                      negative regulation of nucleic acid-templated transcription 1277
                        negative regulation of transcription, DNA-templated 1265
                          chromatin organization involved in negative regulation of transcription 132
                            heterochromatin assembly 48
                              DNA methylation-dependent heterochromatin assembly + 21
                              heterochromatin assembly by small RNA + 3
                              heterochromatin domain assembly + 0
                              heterochromatin island assembly + 0
                              inactivation of X chromosome by heterochromatin assembly 1
                              negative regulation of heterochromatin assembly + 5
                              pericentric heterochromatin assembly + 5
                              positive regulation of heterochromatin assembly + 12
                              rDNA heterochromatin assembly + 11
                              regulation of heterochromatin assembly + 20
                              senescence-associated heterochromatin focus assembly 3
                              silent mating-type cassette heterochromatin assembly + 0
                              subtelomeric heterochromatin assembly + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.