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ONTOLOGY REPORT - ANNOTATIONS


Term:heterochromatin assembly
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Accession:GO:0031507 term browser browse the term
Definition:The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.
Synonyms:exact_synonym: establishment of heterochromatin architecture;   heterochromatin formation
 narrow_synonym: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region;   heterochromatin assembly involved in chromatin silencing at pericentric region;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region;   heterochromatin formation involved in chromatin silencing at pericentric region
 related_synonym: establishment of chromatin silencing;   establishment of heterochromatic silencing;   heterochromatin assembly involved in chromatin silencing;   heterochromatin formation involved in chromatin silencing
 alt_id: GO:0006343;   GO:0070869;   GO:1904497


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heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAHD1 bromo adjacent homology domain containing 1 JBrowse link 1 130,849,835 130,874,735 RGD:14298760
G BAZ2A bromodomain adjacent to zinc finger domain 2A JBrowse link 5 21,932,527 21,983,033 RGD:9068941
G EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit JBrowse link 12 20,107,744 20,139,764 RGD:9068941
G HMGA2 high mobility group AT-hook 2 JBrowse link 5 30,188,521 30,329,635 RGD:9068941
G POLE3 DNA polymerase epsilon 3, accessory subunit JBrowse link 1 254,033,378 254,036,224 RGD:14298760
G SIRT1 sirtuin 1 JBrowse link 14 71,091,167 71,126,351 RGD:9068941
DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DNMT3A DNA methyltransferase 3 alpha JBrowse link 3 113,501,972 113,609,148 RGD:14298760
G DNMT3B DNA methyltransferase 3 beta JBrowse link 17 36,345,715 36,386,076 RGD:9068941
G HDAC1 histone deacetylase 1 JBrowse link 6 88,749,611 88,785,220 RGD:14298760
G HELLS helicase, lymphoid specific JBrowse link 14 105,923,727 105,967,003 RGD:14298760
G MBD2 methyl-CpG binding domain protein 2 JBrowse link 1 103,683,077 103,768,372 RGD:14298760
G MBD3 methyl-CpG binding domain protein 3 JBrowse link 2 76,913,880 76,923,435 RGD:14298760
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 2 69,717,175 69,810,301 RGD:9068941
heterochromatin assembly by small RNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FAM172A family with sequence similarity 172 member A JBrowse link 2 100,477,770 100,893,594 RGD:14298760
G NRDE2 NRDE-2, necessary for RNA interference, domain containing JBrowse link 7 112,039,949 112,090,632 RGD:14298760
G TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit JBrowse link 13 157,495,075 157,522,349 RGD:14298760
G ZNFX1 zinc finger NFX1-type containing 1 JBrowse link 17 50,925,789 50,958,722 RGD:14298760
inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 6 103,809,732 103,986,057 RGD:14298760
negative regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AICDA activation induced cytidine deaminase JBrowse link 5 62,777,236 62,787,342 RGD:9068941
G APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 JBrowse link 5 62,811,819 62,820,532 RGD:14298760
G TET1 tet methylcytosine dioxygenase 1 JBrowse link 14 71,675,671 71,812,732 RGD:14298760
negative regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PHF2 PHD finger protein 2 JBrowse link 3 42,988,607 43,078,811 RGD:14298760
G PHF8 PHD finger protein 8 JBrowse link X 46,648,164 46,761,192 RGD:14298760
pericentric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CENPV centromere protein V JBrowse link 12 59,200,041 59,215,941 RGD:14298760
G DICER1 dicer 1, ribonuclease III JBrowse link 7 116,361,630 116,436,471 RGD:9068941
G H3-3A H3 histone, family 3A JBrowse link 10 13,939,938 13,947,976 RGD:14298760
G HELLS helicase, lymphoid specific JBrowse link 14 105,923,727 105,967,003 RGD:14298760
G LOC100521680 histone H3.3 JBrowse link 12 5,632,326 5,634,977 RGD:14298760
G ZNFX1 zinc finger NFX1-type containing 1 JBrowse link 17 50,925,789 50,958,722 RGD:14298760
positive regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATF7IP activating transcription factor 7 interacting protein JBrowse link 5 58,022,734 58,149,980 RGD:14298760
G DNMT1 DNA methyltransferase 1 JBrowse link 2 68,981,564 69,040,364 RGD:14298760
G MORC2 MORC family CW-type zinc finger 2 JBrowse link 14 47,755,264 47,800,432 RGD:14298760
G MPHOSPH8 M-phase phosphoprotein 8 JBrowse link 11 447,019 480,121 RGD:14298760
G PPHLN1 periphilin 1 JBrowse link 5 73,556,205 73,696,403 RGD:14298760
G RESF1 retroelement silencing factor 1 JBrowse link 5 42,263,560 42,299,596 RGD:9068941
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 JBrowse link 4 98,259,801 98,293,238 RGD:14298760
G TASOR transcription activation suppressor JBrowse link 13 38,491,048 38,557,256 RGD:14298760
G TRIM28 tripartite motif containing 28 JBrowse link 6 63,094,382 63,101,532 RGD:14298760
G ZNF304 zinc finger protein 304 JBrowse link 6 61,740,677 61,790,290 RGD:9068941
positive regulation of heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TPR translocated promoter region, nuclear basket protein JBrowse link 9 127,481,678 127,540,393 RGD:14298760
positive regulation of subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SIRT6 sirtuin 6 JBrowse link 2 74,568,539 74,577,774 RGD:14298760
rDNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAZ2A bromodomain adjacent to zinc finger domain 2A JBrowse link 5 21,932,527 21,983,033 RGD:9068941
G BEND3 BEN domain containing 3 JBrowse link 1 73,184,745 73,224,663 RGD:14298760
G RRP8 ribosomal RNA processing 8 JBrowse link 9 3,152,162 3,169,380 RGD:14298760
G SIRT1 sirtuin 1 JBrowse link 14 71,091,167 71,126,351 RGD:14298760
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 JBrowse link 8 84,184,572 84,224,943 RGD:14298760
G SUV39H1 suppressor of variegation 3-9 homolog 1 JBrowse link X 42,797,309 42,811,457 RGD:14298760
G UBTF upstream binding transcription factor JBrowse link 12 18,989,833 19,006,145 RGD:9068941
regulation of DNA methylation-dependent heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G POU5F1 POU class 5 homeobox 1 JBrowse link 7 23,564,654 23,570,691 RGD:9068941
regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G H2AFY H2A histone family, member Y JBrowse link 2 137,535,128 137,623,886 RGD:9068941
G NAA40 N-alpha-acetyltransferase 40, NatD catalytic subunit JBrowse link 2 8,115,288 8,130,075 RGD:14298760
senescence-associated heterochromatin focus assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGA1 high mobility group AT-hook 1 JBrowse link 7 30,320,090 30,329,413 RGD:9068941
G HMGA2 high mobility group AT-hook 2 JBrowse link 5 30,188,521 30,329,635 RGD:9068941
G P14ARF p14ARF protein JBrowse link 1 200,774,496 200,799,149 RGD:14298760
subtelomeric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G H3-3A H3 histone, family 3A JBrowse link 10 13,939,938 13,947,976 RGD:14298760
G LOC100521680 histone H3.3 JBrowse link 12 5,632,326 5,634,977 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16412
    cellular process 15625
      cellular component organization or biogenesis 5902
        cellular component organization 5740
          chromatin organization 687
            chromatin remodeling 166
              heterochromatin assembly 49
                DNA methylation-dependent heterochromatin assembly + 21
                heterochromatin assembly by small RNA + 4
                heterochromatin domain assembly + 0
                heterochromatin island assembly + 0
                inactivation of X chromosome by heterochromatin assembly 1
                negative regulation of heterochromatin assembly + 5
                pericentric heterochromatin assembly + 6
                positive regulation of heterochromatin assembly + 12
                rDNA heterochromatin assembly + 11
                regulation of heterochromatin assembly + 20
                senescence-associated heterochromatin focus assembly 3
                silent mating-type cassette heterochromatin assembly + 0
                subtelomeric heterochromatin assembly + 3
Path 2
Term Annotations click to browse term
  biological_process 16412
    metabolic process 10434
      cellular metabolic process 9428
        cellular aromatic compound metabolic process 4993
          nucleobase-containing compound metabolic process 4795
            nucleic acid metabolic process 4388
              RNA metabolic process 3922
                regulation of RNA metabolic process 3240
                  negative regulation of RNA metabolic process 1342
                    negative regulation of RNA biosynthetic process 1244
                      negative regulation of nucleic acid-templated transcription 1242
                        negative regulation of transcription, DNA-templated 1218
                          chromatin organization involved in negative regulation of transcription 101
                            heterochromatin assembly 49
                              DNA methylation-dependent heterochromatin assembly + 21
                              heterochromatin assembly by small RNA + 4
                              heterochromatin domain assembly + 0
                              heterochromatin island assembly + 0
                              inactivation of X chromosome by heterochromatin assembly 1
                              negative regulation of heterochromatin assembly + 5
                              pericentric heterochromatin assembly + 6
                              positive regulation of heterochromatin assembly + 12
                              rDNA heterochromatin assembly + 11
                              regulation of heterochromatin assembly + 20
                              senescence-associated heterochromatin focus assembly 3
                              silent mating-type cassette heterochromatin assembly + 0
                              subtelomeric heterochromatin assembly + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.