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ONTOLOGY REPORT - ANNOTATIONS


Term:pericentric heterochromatin assembly
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Accession:GO:0031508 term browser browse the term
Definition:The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA.
Synonyms:exact_synonym: centromere chromatin silencing;   centromeric heterochromatin biosynthesis;   centromeric heterochromatin formation;   centromeric silencing;   chromatin silencing at centromere;   heterochromatic silencing at centromere
 narrow_synonym: chromatin silencing at centromere outer repeat region
 related_synonym: centric heterochromatin formation;   chromatin silencing at pericentric region
 alt_id: GO:0030702;   GO:1990141


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pericentric heterochromatin assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cenpv centromere protein V JBrowse link 10 48,846,513 48,861,893 RGD:1624291
RGD:13792537
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:1624291
G H3f3a H3 histone family member 3A JBrowse link 13 99,091,246 99,102,828 RGD:1624291
G H3f3b H3 histone family member 3B JBrowse link 10 104,573,666 104,575,890 RGD:1624291
G Hells helicase, lymphoid specific JBrowse link 1 257,901,856 257,953,889 RGD:1624291
RGD:13792537
G LOC100911660 lymphocyte-specific helicase-like JBrowse link 1 257,614,688 257,660,184 RGD:13792537
G Znfx1 zinc finger, NFX1-type containing 1 JBrowse link 3 163,787,101 163,847,671 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      negative regulation of metabolic process 3227
        negative regulation of macromolecule metabolic process 2957
          negative regulation of gene expression 2076
            pericentric heterochromatin assembly 7
              positive regulation of pericentric heterochromatin assembly 0
              regulation of pericentric heterochromatin assembly + 0
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      cellular metabolic process 10917
        cellular aromatic compound metabolic process 5567
          nucleobase-containing compound metabolic process 5344
            nucleic acid metabolic process 4850
              RNA metabolic process 4347
                regulation of RNA metabolic process 3510
                  negative regulation of RNA metabolic process 1418
                    negative regulation of RNA biosynthetic process 1316
                      negative regulation of nucleic acid-templated transcription 1314
                        negative regulation of transcription, DNA-templated 1280
                          chromatin organization involved in negative regulation of transcription 130
                            heterochromatin assembly 52
                              pericentric heterochromatin assembly 7
                                positive regulation of pericentric heterochromatin assembly 0
                                regulation of pericentric heterochromatin assembly + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.