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ONTOLOGY REPORT - ANNOTATIONS


Term:pericentric heterochromatin assembly
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Accession:GO:0031508 term browser browse the term
Definition:The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA.
Synonyms:exact_synonym: centromere chromatin silencing;   centromeric heterochromatin biosynthesis;   centromeric heterochromatin formation;   centromeric silencing;   chromatin silencing at centromere;   heterochromatic silencing at centromere
 narrow_synonym: chromatin silencing at centromere outer repeat region
 related_synonym: centric heterochromatin formation;   chromatin silencing at pericentric region
 alt_id: GO:0030702;   GO:1990141


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pericentric heterochromatin assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPV centromere protein V ISO (PMID:18772885) UniProtKB PMID:18772885 NCBI chr17:35,247,664...35,258,656 JBrowse link
G DICER1 dicer 1, ribonuclease III ISO (MGI:MGI:3528782|PMID:15713842) MGI PMID:15713842 MGI:MGI:3528782 NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940
JBrowse link
G HELLS helicase, lymphoid specific ISO (MGI:MGI:3041983|PMID:14612388) UniProtKB PMID:14612388 MGI:MGI:3041983 NCBI chr10:91,282,330...91,344,156
Ensembl chr10:94,790,292...94,847,209
JBrowse link
G LOC100970414 histone H3.3A ISO (MGI:MGI:5694896|PMID:26159997) MGI PMID:26159997 MGI:MGI:5694896 NCBI chr 1:201,523,670...201,533,005
Ensembl chr 1:206,520,109...206,529,447
JBrowse link
G LOC100988671 histone H3.3A ISO (MGI:MGI:5694896|PMID:26159997) MGI PMID:26159997 MGI:MGI:5694896 NCBI chr17:69,728,165...69,730,519
Ensembl chr17:75,277,614...75,281,106
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12529
    metabolic process 7962
      negative regulation of metabolic process 2647
        negative regulation of macromolecule metabolic process 2387
          negative regulation of gene expression 1747
            pericentric heterochromatin assembly 5
              positive regulation of pericentric heterochromatin assembly 0
              regulation of pericentric heterochromatin assembly + 0
Path 2
Term Annotations click to browse term
  biological_process 12529
    metabolic process 7962
      cellular metabolic process 7310
        cellular aromatic compound metabolic process 3867
          nucleobase-containing compound metabolic process 3691
            nucleic acid metabolic process 3388
              RNA metabolic process 3006
                regulation of RNA metabolic process 2580
                  negative regulation of RNA metabolic process 1208
                    negative regulation of RNA biosynthetic process 1114
                      negative regulation of nucleic acid-templated transcription 1112
                        negative regulation of transcription, DNA-templated 1108
                          chromatin organization involved in negative regulation of transcription 61
                            heterochromatin assembly 43
                              pericentric heterochromatin assembly 5
                                positive regulation of pericentric heterochromatin assembly 0
                                regulation of pericentric heterochromatin assembly + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.