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ONTOLOGY REPORT - ANNOTATIONS


Term:pericentric heterochromatin assembly
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Accession:GO:0031508 term browser browse the term
Definition:The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA.
Synonyms:exact_synonym: centromere chromatin silencing;   centromeric heterochromatin biosynthesis;   centromeric heterochromatin formation;   centromeric silencing;   chromatin silencing at centromere;   heterochromatic silencing at centromere
 narrow_synonym: chromatin silencing at centromere outer repeat region
 related_synonym: centric heterochromatin formation;   chromatin silencing at pericentric region
 alt_id: GO:0030702;   GO:1990141


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pericentric heterochromatin assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpv centromere protein V ISO (PMID:18772885) UniProtKB PMID:18772885 NCBI chrNW_004936821:267,137...276,969 JBrowse link
G Dicer1 dicer 1, ribonuclease III ISO (MGI:MGI:3528782|PMID:15713842) MGI PMID:15713842 MGI:MGI:3528782 NCBI chrNW_004936846:528,768...584,599 JBrowse link
G Hells helicase, lymphoid specific ISO (MGI:MGI:3041983|PMID:14612388) UniProtKB PMID:14612388 MGI:MGI:3041983 NCBI chrNW_004936601:626,354...662,477 JBrowse link
G LOC101963041 histone H3.3 ISO (MGI:MGI:5694896|PMID:26159997) MGI PMID:26159997 MGI:MGI:5694896 NCBI chrNW_004936526:2,835,002...2,842,328 JBrowse link
G LOC101963257 histone H3.3 ISO (MGI:MGI:5694896|PMID:26159997) MGI PMID:26159997 MGI:MGI:5694896 NCBI chrNW_004936594:959,493...961,703 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      negative regulation of metabolic process 2541
        negative regulation of macromolecule metabolic process 2288
          negative regulation of gene expression 1673
            pericentric heterochromatin assembly 5
              positive regulation of pericentric heterochromatin assembly 0
              regulation of pericentric heterochromatin assembly + 0
Path 2
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      cellular metabolic process 7051
        cellular aromatic compound metabolic process 3743
          nucleobase-containing compound metabolic process 3574
            nucleic acid metabolic process 3288
              RNA metabolic process 2915
                regulation of RNA metabolic process 2500
                  negative regulation of RNA metabolic process 1159
                    negative regulation of RNA biosynthetic process 1068
                      negative regulation of nucleic acid-templated transcription 1066
                        negative regulation of transcription, DNA-templated 1062
                          chromatin organization involved in negative regulation of transcription 59
                            heterochromatin assembly 41
                              pericentric heterochromatin assembly 5
                                positive regulation of pericentric heterochromatin assembly 0
                                regulation of pericentric heterochromatin assembly + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.