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ONTOLOGY REPORT - ANNOTATIONS


Term:Mis6-Sim4 complex
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Accession:GO:0031511 term browser browse the term
Definition:A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
Synonyms:exact_synonym: Mis6-Mal2-Sim4 centromere complex;   Sim4 complex
 narrow_synonym: Mis6 centromere subcomplex


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Mis6-Sim4 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cenpo centromere protein O JBrowse link 6 28,648,804 28,663,527 RGD:13792537

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Path 1
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  cellular_component 19951
    protein-containing complex 5828
      Mis6-Sim4 complex 1
Path 2
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  cellular_component 19951
    cellular anatomical entity 19598
      organelle 12670
        non-membrane-bounded organelle 4661
          intracellular non-membrane-bounded organelle 4642
            chromosome 1109
              chromosomal region 290
                chromosome, centromeric region 186
                  kinetochore 127
                    condensed chromosome kinetochore 64
                      condensed chromosome inner kinetochore 5
                        Mis6-Sim4 complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.