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ONTOLOGY REPORT - ANNOTATIONS


Term:peptidyl-proline dioxygenase activity
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Accession:GO:0031543 term browser browse the term
Definition:Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.
Synonyms:broad_synonym: proline hydroxylase activity;   proline,2-oxoglutarate 4-dioxygenase activity;   prolyl 4-hydroxylase activity;   prolyl hydroxylase activity


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peptidyl-proline dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07004992.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:173,275,336...173,284,941 JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:20308610, PMID:21873635, PMID:18640395 RGD:6483365, RGD:13792537, RGD:6483450 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISO
IBA
(MGI:MGI:5574277|PMID:24030251)
PMID:21873635
RGD PMID:24030251, PMID:21873635 MGI:MGI:5574277, RGD:13792537 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 ISO
IBA
(PMID:24550447)
PMID:21873635
RGD PMID:24550447, PMID:21873635 RGD:13792537 NCBI chr19:11,425,301...11,451,085
Ensembl chr19:11,425,105...11,451,278
JBrowse link
peptidyl-proline 3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 ISO (PMID:24550462) RGD PMID:24550462 NCBI chr19:11,425,301...11,451,085
Ensembl chr19:11,425,105...11,451,278
JBrowse link
peptidyl-proline 4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07004992.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:173,275,336...173,284,941 JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 ISO
IBA
(PMID:11598268), (PMID:12615973), (PMID:12788921), (PMID:22286099)
PMID:21873635
RGD PMID:11598268, PMID:12615973, PMID:12788921, PMID:22286099, PMID:21873635 RGD:13792537 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 IDA
IBA
ISO
PMID:15925519
PMID:21873635
(PMID:11598268), (PMID:12039559)
RGD PMID:11598268, PMID:12039559, PMID:15925519, PMID:21873635 RGD:13602003, RGD:13792537 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:11598268), (PMID:12615973), (PMID:12788921), (PMID:22286099)
Ensembl
RGD
PMID:11598268, PMID:12615973, PMID:12788921, PMID:22286099, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
procollagen-proline 3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P3h1 prolyl 3-hydroxylase 1 IBA
IEA
PMID:21873635
GO_REF:0000003
UniProt PMID:21873635 GO_REF:0000003, RGD:13792537 NCBI chr 5:138,279,597...138,294,280
Ensembl chr 5:138,279,506...138,294,262
JBrowse link
G P3h2 prolyl 3-hydroxylase 2 IDA
IEA
IBA
ISS
ISO
PMID:21757687
GO_REF:0000003
PMID:21873635
GO_REF:0000024
(PMID:18487197)
UniProt
RGD
PMID:18487197, PMID:21757687, PMID:21873635 GO_REF:0000003, GO_REF:0000024, RGD:8553392, RGD:13792537 NCBI chr11:78,028,885...78,169,746
Ensembl chr11:78,029,038...78,169,648
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:157,359,331...157,375,186
Ensembl chr 4:157,359,332...157,372,861
JBrowse link
procollagen-proline 4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 contributes_to TAS
IBA
ISO
PMID:21873635
(MGI:MGI:72931|PMID:7753822)
MGI:MGI:3706369 (MGI:MGI:3706231|PMID:17135260)
RGD PMID:7753822, PMID:17135260, PMID:11997102, PMID:21873635 MGI:MGI:3706231, MGI:MGI:72931, RGD:625562, RGD:13792537 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 contributes_to ISO
IBA
(MGI:MGI:72931|PMID:7753822)
PMID:21873635
RGD PMID:7753822, PMID:21873635 MGI:MGI:72931, RGD:13792537 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G P4ha3 prolyl 4-hydroxylase subunit alpha 3 IMP
IEA
GO_REF:0000003 UniProt PMID:14500733 GO_REF:0000003, RGD:731224 NCBI chr 1:165,295,835...165,330,922
Ensembl chr 1:165,295,847...165,330,322
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta contributes_to ISO (PMID:7753822) RGD PMID:7753822 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G P4htm prolyl 4-hydroxylase, transmembrane contributes_to IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:117,364,895...117,383,275
Ensembl chr 8:117,365,101...117,382,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      catalytic activity, acting on a protein 2312
        peptidyl-proline dioxygenase activity 13
          peptidyl-proline 3-dioxygenase activity + 4
          peptidyl-proline 4-dioxygenase activity + 9
          procollagen-proline dioxygenase activity + 8
Path 2
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      oxidoreductase activity 877
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 223
          2-oxoglutarate-dependent dioxygenase activity 50
            peptidyl-proline dioxygenase activity 13
              peptidyl-proline 3-dioxygenase activity + 4
              peptidyl-proline 4-dioxygenase activity + 9
              procollagen-proline dioxygenase activity + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.