ONTOLOGY REPORT - ANNOTATIONS


Term:intra-S DNA damage checkpoint
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Accession:GO:0031573 term browser browse the term
Definition:A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
Synonyms:exact_synonym: mitotic intra-S DNA damage checkpoint
 broad_synonym: S-phase checkpoint


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intra-S DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:1624291
RGD:1600115
G Eme1 essential meiotic structure-specific endonuclease 1 JBrowse link 10 82,366,820 82,375,510 RGD:13792537
G Eme2 essential meiotic structure-specific endonuclease subunit 2 JBrowse link 10 14,253,552 14,257,017 RGD:13792537
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:13792537
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1600115
RGD:13792537
RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1624291
RGD:1600115
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 1 220,862,474 220,867,973 RGD:13792537
G Nek11 NIMA-related kinase 11 JBrowse link 8 113,703,406 113,937,097 RGD:1624291
RGD:13792537
G Rad9a RAD9 checkpoint clamp component A JBrowse link 1 219,443,347 219,450,574 RGD:1624291
RGD:13792537
G Rad9b RAD9 checkpoint clamp component B JBrowse link 12 39,699,076 39,731,218 RGD:13792537
G Tipin timeless interacting protein JBrowse link 8 69,753,363 69,768,640 RGD:1624291
RGD:1600115
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:1624291
RGD:1600115
signal transduction involved in intra-S DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17926
    cellular process 16077
      cell cycle checkpoint 184
        DNA integrity checkpoint 122
          DNA damage checkpoint 110
            mitotic DNA damage checkpoint 59
              intra-S DNA damage checkpoint 13
                detection of DNA damage stimulus involved in intra-S DNA damage checkpoint 0
                signal transduction involved in intra-S DNA damage checkpoint 1
Path 2
Term Annotations click to browse term
  biological_process 17926
    biological regulation 12622
      regulation of biological process 11964
        negative regulation of biological process 5362
          negative regulation of cellular process 4787
            negative regulation of cell cycle 461
              cell cycle checkpoint 184
                mitotic cell cycle checkpoint 130
                  mitotic DNA integrity checkpoint 67
                    mitotic DNA damage checkpoint 59
                      intra-S DNA damage checkpoint 13
                        detection of DNA damage stimulus involved in intra-S DNA damage checkpoint 0
                        signal transduction involved in intra-S DNA damage checkpoint 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.