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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase D-activating G protein-coupled receptor signaling pathway
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Accession:GO:0031583 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).
Comment:This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation.
Synonyms:exact_synonym: G-protein signalling, phospholipase D activating pathway
 related_synonym: activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway


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phospholipase D-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO (MGI:84748|PMID:8978712) RGD PMID:8978712 MGI:84748 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G Htr2c 5-hydroxytryptamine receptor 2C IMP RGD PMID:12435801 RGD:1598460 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          phospholipase D-activating G protein-coupled receptor signaling pathway 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            G protein-coupled receptor signaling pathway 2509
              phospholipase D-activating G protein-coupled receptor signaling pathway 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.