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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase D-activating G protein-coupled receptor signaling pathway
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Accession:GO:0031583 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).
Comment:This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation.
Synonyms:exact_synonym: G-protein signalling, phospholipase D activating pathway
 related_synonym: activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway


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phospholipase D-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:1624291
RGD:1600115
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:1598460

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Path 1
Term Annotations click to browse term
  biological_process 18166
    signaling 7108
      signal transduction 6597
        G protein-coupled receptor signaling pathway 2395
          phospholipase D-activating G protein-coupled receptor signaling pathway 2
Path 2
Term Annotations click to browse term
  biological_process 18166
    biological regulation 12793
      regulation of biological process 12128
        regulation of cellular process 11458
          signal transduction 6597
            G protein-coupled receptor signaling pathway 2395
              phospholipase D-activating G protein-coupled receptor signaling pathway 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.