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Term:wybutosine biosynthetic process
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Accession:GO:0031591 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.
Comment:Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
Synonyms:exact_synonym: yW biosynthesis;   yW biosynthetic process

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wybutosine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lcmt2 leucine carboxyl methyltransferase 2 JBrowse link 3 113,089,646 113,091,770 RGD:13792537
G Trmt12 tRNA methyltransferase 12 JBrowse link 7 98,748,547 98,750,173 RGD:13792537
G Tyw1 tRNA-yW synthesizing protein 1 homolog JBrowse link 12 29,824,990 29,919,240 RGD:13792537
G Tyw3 tRNA-yW synthesizing protein 3 homolog JBrowse link 2 260,861,825 260,884,270 RGD:13792537
G Tyw5 tRNA-yW synthesizing protein 5 JBrowse link 9 64,077,841 64,096,265 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      nitrogen compound metabolic process 10025
        organonitrogen compound metabolic process 6969
          organonitrogen compound biosynthetic process 1973
            wybutosine biosynthetic process 5
Path 2
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      cellular metabolic process 10737
        heterocycle metabolic process 5428
          nucleobase-containing compound metabolic process 5276
            nucleic acid metabolic process 4782
              RNA metabolic process 4290
                ncRNA metabolic process 489
                  ncRNA processing 390
                    tRNA processing 117
                      tRNA modification 84
                        wybutosine biosynthetic process 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.