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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of myelination
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Accession:GO:0031642 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Synonyms:exact_synonym: down regulation of myelination;   downregulation of myelination
 narrow_synonym: inhibition of myelination


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negative regulation of myelination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C ISO MGI:MGI:5910745 (MGI:MGI:5904382|PMID:28251676) RGD PMID:28251676 MGI:MGI:5904382 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO MGI:MGI:2177666 (MGI:MGI:3583403|PMID:15911877) RGD PMID:15911877 MGI:MGI:3583403 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Fig4 FIG4 phosphoinositide 5-phosphatase ISO MGI:MGI:1924366|MGI:MGI:3716838 (MGI:MGI:5296993|PMID:22028665) RGD PMID:22028665 MGI:MGI:5296993 NCBI chr20:45,922,806...46,044,754
Ensembl chr20:45,922,806...46,044,738
JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:3583403|PMID:15911877) RGD PMID:15911877 MGI:MGI:3583403 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jam2 junctional adhesion molecule 2 ISO (MGI:MGI:5883159|PMID:27499083) RGD PMID:27499083 MGI:MGI:5883159 NCBI chr11:24,235,310...24,285,279
Ensembl chr11:24,266,345...24,285,275
JBrowse link
G Klk8 kallikrein related-peptidase 8 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3766680|PMID:17629414)
Ensembl
UniProt
RGD
PMID:17629414 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3766680 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
JBrowse link
G Lpin1 lipin 1 IDA RGD PMID:21715287 RGD:38599010 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Mtmr2 myotubularin related protein 2 ISO MGI:MGI:2143585|MGI:MGI:3513454 (MGI:MGI:4352761|PMID:19587293), (MGI:MGI:5296993|PMID:22028665) RGD PMID:19587293, PMID:22028665 MGI:MGI:4352761, MGI:MGI:5296993 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:MGI:4454957|PMID:20448149) RGD PMID:20448149 MGI:MGI:4454957 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Tmem98 transmembrane protein 98 ISS
ISO
GO_REF:0000024
(MGI:MGI:6258499|PMID:30249802)
UniProt
RGD
PMID:30249802 GO_REF:0000024, MGI:MGI:6258499 NCBI chr10:68,173,380...68,184,289
Ensembl chr10:68,173,369...68,184,320
JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:23982745 RGD:10450590 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 ISO
IBA
(PMID:21725297)
PMID:21873635
RGD PMID:21725297, PMID:21873635 RGD:13792537 NCBI chr 9:20,546,159...20,621,051
Ensembl chr 9:20,546,159...20,621,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    negative regulation of biological process 5696
      negative regulation of cellular process 5144
        negative regulation of myelination 12
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            nervous system development 2716
              ensheathment of neurons 177
                axon ensheathment 177
                  myelination 175
                    regulation of myelination 61
                      negative regulation of myelination 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.