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ONTOLOGY REPORT - ANNOTATIONS


Term:TOR signaling
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Accession:GO:0031929 term browser browse the term
Definition:A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Comment:Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
Synonyms:exact_synonym: TOR signal transduction;   TOR signaling pathway;   TOR signalling pathway;   target of rapamycin signaling pathway;   target of rapamycin signalling pathway
 related_synonym: TOR signaling cascade


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TOR signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07029605.1 RGD:1600115
G Ccdc88a coiled coil domain containing 88A JBrowse link 14 113,771,093 113,936,376 RGD:1624291
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:1624291
G Disc1 DISC1 scaffold protein JBrowse link 19 57,818,838 58,069,992 RGD:1624291
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:1600115
RGD:1624291
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 JBrowse link 20 31,055,292 31,072,469 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Fnip1 folliculin interacting protein 1 JBrowse link 10 39,786,687 39,870,188 RGD:1624291
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1624291
RGD:1600115
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1624291
G Larp1 La ribonucleoprotein 1, translational regulator JBrowse link 10 43,435,738 43,501,186 RGD:1624291
G Meak7 MTOR associated protein, eak-7 homolog JBrowse link 19 52,408,700 52,430,198 RGD:1624291
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:13792537
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:1600115
G Rhebl1 RHEB like 1 JBrowse link 7 140,552,704 140,556,980 RGD:1624291
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:1600115
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:1624291
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:1600115
RGD:1624291
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:1624291
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1624291
RGD:13792537
G Tiprl TOR signaling pathway regulator JBrowse link 13 83,478,966 83,504,448 RGD:13792537
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
negative regulation of TOR signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07029605.1 RGD:1600115
G Akt1s1 AKT1 substrate 1 JBrowse link 1 100,845,443 100,851,961 RGD:1624291
RGD:13792537
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:1600115
RGD:1624291
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:10059647
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:1624291
RGD:13792537
RGD:1600115
RGD:8554300
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit JBrowse link 14 83,089,000 83,219,576 RGD:1624291
RGD:13792537
G Deptor DEP domain containing MTOR-interacting protein JBrowse link 7 94,795,161 95,000,750 RGD:1624291
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1600115
RGD:1624291
G Fnip1 folliculin interacting protein 1 JBrowse link 10 39,786,687 39,870,188 RGD:1624291
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:1624291
RGD:13792537
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Mapkapk5 MAPK activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:1624291
RGD:13792537
G Minar1 membrane integral NOTCH2 associated receptor 1 JBrowse link 8 96,970,556 97,008,687 RGD:1624291
RGD:1600115
RGD:13792537
RGD:13825189
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:1624291
RGD:13792537
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:1624291
RGD:13792537
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1624291
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1624291
RGD:1600115
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600115
RGD:1624291
G RGD1565472 similar to RIKEN cDNA 2310003P10 JBrowse link 11 39,765,341 39,767,938 RGD:1600115
G Sh3bp4 SH3-domain binding protein 4 JBrowse link 9 96,210,750 96,288,903 RGD:1600115
RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Tbc1d7 TBC1 domain family, member 7 JBrowse link 17 23,774,793 23,792,389 RGD:1624291
RGD:13792537
G Tmem127 transmembrane protein 127 JBrowse link 3 119,677,575 119,690,371 RGD:1624291
G Tnfaip8l1 TNF alpha induced protein 8 like 1 JBrowse link 9 10,894,949 10,905,647 RGD:1624291
RGD:13792537
RGD:1600115
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
RGD:13792537
RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580520
RGD:13792537
RGD:1624291
RGD:1600115
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:13792537
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 JBrowse link 3 112,800,557 112,910,038 RGD:1624291
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 JBrowse link 9 16,003,058 16,080,152 RGD:1624291
negative regulation of TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
RGD:13792537
G Bmt2 base methyltransferase of 25S rRNA 2 homolog JBrowse link 4 40,064,131 40,136,074 RGD:1624291
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 JBrowse link 14 84,447,552 84,457,396 RGD:1624291
RGD:13792537
RGD:1600115
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 JBrowse link 12 25,595,800 25,638,806 RGD:1624291
RGD:13792537
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit JBrowse link 14 83,089,000 83,219,576 RGD:1624291
G Fnip1 folliculin interacting protein 1 JBrowse link 10 39,786,687 39,870,188 RGD:1624291
G Fnip2 folliculin interacting protein 2 JBrowse link 2 178,223,561 178,334,925 RGD:1624291
G Itfg2 integrin alpha FG-GAP repeat containing 2 JBrowse link 4 161,730,643 161,744,281 RGD:1624291
G Kptn kaptin (actin binding protein) JBrowse link 1 78,015,714 78,016,508 RGD:1624291
G Kptn kaptin RGD:1600115
G RGD1565498 similar to Hypothetical protein LOC270802 JBrowse link 7 63,922,871 63,937,721 RGD:1624291
RGD:13792537
G Rnf152 ring finger protein 152 JBrowse link 13 25,183,295 25,262,785 RGD:1624291
RGD:1600115
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:1624291
RGD:13792537
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
RGD:13792537
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:1624291
RGD:13792537
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Szt2 SZT2 subunit of KICSTOR complex JBrowse link 5 137,192,120 137,238,384 RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
positive regulation of TOR signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:1624291
RGD:1600115
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:8554638
G Golph3 golgi phosphoprotein 3 JBrowse link 2 62,360,754 62,388,773 RGD:1600115
RGD:1624291
G Hdac3 histone deacetylase 3 JBrowse link 18 31,073,057 31,094,347 RGD:1600115
RGD:1624291
G Htr6 5-hydroxytryptamine receptor 6 JBrowse link 5 157,501,202 157,518,870 RGD:1624291
RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 JBrowse link 1 166,991,474 166,997,045 RGD:1624291
RGD:1600115
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 JBrowse link 2 187,911,530 187,914,930 RGD:1624291
RGD:13792537
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 JBrowse link 2 243,160,821 243,173,057 RGD:1624291
RGD:13792537
RGD:1600115
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 JBrowse link 12 19,573,909 19,577,625 RGD:1624291
RGD:13792537
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 JBrowse link 2 210,034,095 210,039,451 RGD:1624291
G Lars1 leucyl-tRNA synthetase 1 JBrowse link 18 36,524,013 36,579,471 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:13792537
RGD:1600115
G Lin28a lin-28 homolog A JBrowse link 5 152,230,343 152,247,873 RGD:1624291
G LOC100361543 RhoA activator C11orf59-like JBrowse link X 37,261,428 37,262,470 RGD:1600115
G LOC108348096 ras-related GTP-binding protein B JBrowse link X 19,336,382 19,369,872 RGD:1600115
RGD:13792537
G Mios meiosis regulator for oocyte development JBrowse link 4 34,238,370 34,264,015 RGD:1624291
RGD:13792537
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:1624291
RGD:1600115
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:1624291
RGD:1600115
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:1600115
RGD:1624291
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:1624291
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1624291
G Rraga Ras-related GTP binding A JBrowse link 5 104,941,067 104,942,662 RGD:13792537
G RragB Ras-related GTP binding B JBrowse link X 19,085,913 19,135,049 RGD:1624291
RGD:13792537
RGD:1600115
G Rragc Ras-related GTP binding C JBrowse link 5 141,572,536 141,590,784 RGD:13792537
G Rragd Ras-related GTP binding D JBrowse link 5 48,224,994 48,260,691 RGD:13792537
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:1624291
G Seh1l SEH1-like nucleoporin JBrowse link 18 63,545,150 63,568,101 RGD:1624291
G Slc38a9 solute carrier family 38, member 9 JBrowse link 2 44,512,556 44,592,793 RGD:1600115
RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Wdr24 WD repeat domain 24 JBrowse link 10 15,191,078 15,195,860 RGD:1624291
G Wdr59 WD repeat domain 59 JBrowse link 19 43,651,686 43,714,391 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
positive regulation of TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07041481.1 RGD:1600115
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:13792537
G Gpr137b G protein-coupled receptor 137B JBrowse link 17 90,670,852 90,709,003 RGD:1624291
RGD:1600115
G Klhl22 kelch-like family member 22 JBrowse link 11 87,646,489 87,718,808 RGD:1600115
RGD:1624291
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 JBrowse link 2 210,034,095 210,039,451 RGD:13792537
G Lars1 leucyl-tRNA synthetase 1 JBrowse link 18 36,524,013 36,579,471 RGD:1624291
G Pih1d1 PIH1 domain containing 1 JBrowse link 1 101,151,240 101,156,806 RGD:1624291
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 JBrowse link 15 27,852,152 27,855,999 RGD:1624291
RGD:1600115
G Rraga Ras-related GTP binding A JBrowse link 5 104,941,067 104,942,662 RGD:1624291
RGD:1600115
G RragB Ras-related GTP binding B JBrowse link X 19,085,913 19,135,049 RGD:1624291
G Rragd Ras-related GTP binding D JBrowse link 5 48,224,994 48,260,691 RGD:1624291
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:1600115
G Seh1l SEH1-like nucleoporin JBrowse link 18 63,545,150 63,568,101 RGD:1624291
G Sik3 SIK family kinase 3 JBrowse link 8 50,310,263 50,520,284 RGD:1624291
G Telo2 telomere maintenance 2 JBrowse link 10 14,461,581 14,476,812 RGD:1624291
positive regulation of TORC2 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sik3 SIK family kinase 3 JBrowse link 8 50,310,263 50,520,284 RGD:1624291
G Telo2 telomere maintenance 2 JBrowse link 10 14,461,581 14,476,812 RGD:1624291
regulation of TOR signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 1,369,534 1,391,603 RGD:1624291
RGD:1600115
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:13792537
G Fam83d family with sequence similarity 83, member D JBrowse link 3 155,269,344 155,288,612 RGD:1624291
G Fbxo9 f-box protein 9 JBrowse link 8 85,388,331 85,413,896 RGD:1624291
RGD:1600115
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:1624291
RGD:1600115
G Gpat3 glycerol-3-phosphate acyltransferase 3 JBrowse link 14 10,343,287 10,396,565 RGD:1624291
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link 9 26,164,969 26,736,704 RGD:1624291
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:1624291
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase JBrowse link 20 33,100,190 33,323,544 RGD:1624291
RGD:13792537
RGD:1600115
G RragB Ras-related GTP binding B JBrowse link X 19,085,913 19,135,049 RGD:1624291
G Rragc Ras-related GTP binding C JBrowse link 5 141,572,536 141,590,784 RGD:1624291
G Slc7a1 solute carrier family 7 member 1 JBrowse link 12 8,032,775 8,108,972 RGD:1642930
G Slc7a3 solute carrier family 7 member 3 JBrowse link X 70,972,767 70,979,466 RGD:1642930
G Tbck TBC1 domain containing kinase JBrowse link 2 237,751,646 237,958,497 RGD:1624291
G Telo2 telomere maintenance 2 JBrowse link 10 14,461,581 14,476,812 RGD:1624291
G Tmem127 transmembrane protein 127 JBrowse link 3 119,677,575 119,690,371 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Tti1 TELO2 interacting protein 1 JBrowse link 3 154,463,108 154,506,955 RGD:1624291
RGD:13792537
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:1624291
regulation of TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgkq diacylglycerol kinase, theta JBrowse link 14 2,069,409 2,083,370 RGD:1624291
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 JBrowse link 13 47,906,230 47,916,877 RGD:1600115
RGD:1624291
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:1600115
RGD:1624291
G Rraga Ras-related GTP binding A JBrowse link 5 104,941,067 104,942,662 RGD:1600115
G Rragc Ras-related GTP binding C JBrowse link 5 141,572,536 141,590,784 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
regulation of TORC2 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pih1d1 PIH1 domain containing 1 JBrowse link 1 101,151,240 101,156,806 RGD:1624291
TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Larp1 La ribonucleoprotein 1, translational regulator JBrowse link 10 43,435,738 43,501,186 RGD:1624291
G Mfsd8 major facilitator superfamily domain containing 8 JBrowse link 2 127,706,618 127,784,129 RGD:1624291
RGD:1600115
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:1624291
RGD:1600115
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:13792537
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:13792537
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1624291
TORC2 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07051501.1 RGD:13792537
G Mapkap1 MAPK associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:13792537
G Prr5 proline rich 5 JBrowse link 7 125,569,791 125,609,340 RGD:13792537
G Prr5l proline rich 5 like JBrowse link 3 91,290,207 91,461,208 RGD:1600115
RGD:13792537
RGD:1624291
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:1624291
G Syap1 synapse associated protein 1 JBrowse link X 33,528,071 33,562,584 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      signal transduction 6872
        intracellular signal transduction 2584
          TOR signaling 128
            TORC1 signaling + 46
            TORC2 signaling + 9
            negative regulation of TOR signaling + 48
            positive regulation of TOR signaling + 43
            regulation of TOR signaling + 106
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11994
          signal transduction 6872
            intracellular signal transduction 2584
              TOR signaling 128
                TORC1 signaling + 46
                TORC2 signaling + 9
                negative regulation of TOR signaling + 48
                positive regulation of TOR signaling + 43
                regulation of TOR signaling + 106
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.