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ONTOLOGY REPORT - ANNOTATIONS


Term:TOR signaling
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Accession:GO:0031929 term browser browse the term
Definition:A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Comment:Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
Synonyms:exact_synonym: TOR signal transduction;   TOR signaling pathway;   TOR signalling pathway;   target of rapamycin signaling pathway;   target of rapamycin signalling pathway
 related_synonym: TOR signaling cascade


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TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCDC88A coiled-coil domain containing 88A ISO (MGI:MGI:4411937|PMID:19778506) UniProtKB PMID:19778506 MGI:MGI:4411937 NCBI chr2A:55,445,060...55,576,479
Ensembl chr2A:56,589,221...56,715,362
JBrowse link
G CSF2 colony stimulating factor 2 ISO (PMID:24520418) AgBase PMID:24520418 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146
JBrowse link
G DISC1 DISC1 scaffold protein ISO (MGI:MGI:4411937|PMID:19778506) UniProtKB PMID:19778506 MGI:MGI:4411937 NCBI chr 1:207,180,513...207,594,684
Ensembl chr 1:212,265,520...212,612,079
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 ISO (PMID:12150926), (PMID:22578813) UniProtKB PMID:12150926, PMID:22578813 NCBI chr 8:37,336,698...37,362,768
Ensembl chr 8:34,513,359...34,538,936
JBrowse link
G EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 ISO (MGI:MGI:4820682|PMID:20347422) UniProtKB PMID:20347422 MGI:MGI:4820682 NCBI chr10:66,879,744...66,903,027 JBrowse link
G FLCN folliculin ISO (PMID:17028174) UniProtKB PMID:17028174 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link
G FNIP1 folliculin interacting protein 1 ISO (PMID:17028174) UniProtKB PMID:17028174 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
JBrowse link
G GATA3 GATA binding protein 3 ISO (MGI:MGI:5285154|PMID:20696860) UniProtKB PMID:20696860 MGI:MGI:5285154 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272
JBrowse link
G ICMT isoprenylcysteine carboxyl methyltransferase ISO (MGI:MGI:5500993|PMID:23686339) MGI PMID:23686339 MGI:MGI:5500993 NCBI chr 1:4,987,384...5,002,213
Ensembl chr 1:6,246,570...6,258,746
JBrowse link
G LARP1 La ribonucleoprotein 1, translational regulator ISO (PMID:24532714) UniProtKB PMID:24532714 NCBI chr 5:150,086,829...150,221,401
Ensembl chr 5:156,112,358...156,216,706
JBrowse link
G MEAK7 MTOR associated protein, eak-7 homolog ISO (PMID:29750193) UniProt PMID:29750193 NCBI chr16:65,141,319...65,167,898
Ensembl chr16:84,482,997...84,509,530
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO (PMID:15467718), (PMID:17028174), (PMID:18762023), (PMID:26018084), (PMID:29750193)
(MGI:MGI:5825416|PMID:26160071)
UniProt
BHF-UCL
PMID:15467718, PMID:17028174, PMID:18762023, PMID:26018084, PMID:26160071, PMID:29750193 MGI:MGI:5825416 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
JBrowse link
G RHEBL1 RHEB like 1 ISO (PMID:12869548) UniProtKB PMID:12869548 NCBI chr12:39,680,095...39,686,152
Ensembl chr12:40,560,179...40,565,758
JBrowse link
G RPS6 ribosomal protein S6 ISO (PMID:16428328) UniProtKB PMID:16428328 NCBI chr 9:19,185,455...19,189,504
Ensembl chr 9:19,674,380...19,677,722
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO (PMID:12150926)
(PMID:28178239), (PMID:29750193)
UniProtKB
UniProt
PMID:12150926, PMID:28178239, PMID:29750193 NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653
JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 ISO (PMID:29750193) UniProt PMID:29750193 NCBI chr11:62,786,866...62,793,826
Ensembl chr11:66,099,553...66,105,967
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708
JBrowse link
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC16A C-type lectin domain containing 16A ISO (PMID:28223137) UniProtKB PMID:28223137 NCBI chr16:9,887,877...10,124,500
Ensembl chr16:11,109,869...11,343,512
JBrowse link
negative regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1S1 AKT1 substrate 1 ISO (PMID:17386266) UniProtKB PMID:17386266 NCBI chr19:46,882,073...46,890,404
Ensembl chr19:55,797,927...55,806,256
JBrowse link
G ARNTL aryl hydrocarbon receptor nuclear translocator like ISO (MGI:MGI:5553401|PMID:24481314) UniProtKB PMID:24481314 MGI:MGI:5553401 NCBI chr11:13,436,580...13,547,135
Ensembl chr11:13,163,028...13,240,376
JBrowse link
G CRYBA1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chr17:27,522,647...27,530,767
Ensembl chr17:28,032,809...28,040,525
JBrowse link
G DDIT4 DNA damage inducible transcript 4 ISO PMID:21368030
(MGI:MGI:3773582|PMID:18198340)
(PMID:20166753)
UniProt
MGI
UniProtKB
PMID:18198340, PMID:20166753, PMID:21368030 MGI:MGI:3773582, RGD:8554300 NCBI chr10:68,796,712...68,798,840
Ensembl chr10:71,264,029...71,266,149
JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit ISO (PMID:23723238) SGD PMID:23723238 NCBI chr22:12,774,147...12,929,261 JBrowse link
G DEPTOR DEP domain containing MTOR interacting protein ISO (PMID:19446321) UniProtKB PMID:19446321 NCBI chr 8:116,563,935...116,743,843
Ensembl chr 8:119,311,942...119,492,127
JBrowse link
G EPM2A EPM2A glucan phosphatase, laforin ISO (PMID:20453062) MGI PMID:20453062 NCBI chr 6:143,179,097...143,525,223 JBrowse link
G FLCN folliculin ISO (MGI:MGI:5050037|PMID:21258407)
(MGI:MGI:3829339|PMID:18974783)
(MGI:MGI:3772618|PMID:18182616)
MGI PMID:18182616, PMID:18974783, PMID:21258407 MGI:MGI:3772618, MGI:MGI:3829339, MGI:MGI:5050037 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link
G FNIP1 folliculin interacting protein 1 ISO (MGI:MGI:5436190|PMID:22608497) MGI PMID:22608497 MGI:MGI:5436190 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha ISO (MGI:MGI:4829580|PMID:20516643) BHF-UCL PMID:20516643 MGI:MGI:4829580 NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO (MGI:MGI:5825416|PMID:26160071) BHF-UCL PMID:26160071 MGI:MGI:5825416 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO (MGI:MGI:4830408|PMID:20808783) MGI PMID:20808783 MGI:MGI:4830408 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 ISO (MGI:MGI:5306547|PMID:21336308) UniProt PMID:21336308 MGI:MGI:5306547 NCBI chr12:109,416,610...109,471,729
Ensembl chr12:112,812,769...112,863,595
JBrowse link
G MINAR1 membrane integral NOTCH2 associated receptor 1 ISO PMID:30080879
(PMID:30080879)
UniProt PMID:30080879 RGD:13825189 NCBI chr15:58,402,688...58,445,461
Ensembl chr15:77,361,433...77,402,124
JBrowse link
G MTM1 myotubularin 1 ISO (MGI:MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:MGI:5510937 NCBI chr  X:140,218,742...140,323,495
Ensembl chr  X:150,174,758...150,255,381
JBrowse link
G NPRL2 NPR2 like, GATOR1 complex subunit ISO (PMID:23723238) SGD PMID:23723238 NCBI chr 3:50,273,611...50,277,175
Ensembl chr 3:51,508,932...51,512,776
JBrowse link
G NPRL3 NPR3 like, GATOR1 complex subunit ISO (PMID:23723238) SGD PMID:23723238 Ensembl chr16:75,187...129,220 JBrowse link
G PDCD6 programmed cell death 6 ISO (PMID:21893193) UniProtKB PMID:21893193 NCBI chr 5:250,025...291,055 JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO (MGI:MGI:3796765|PMID:18439900) UniProtKB PMID:18439900 MGI:MGI:3796765 NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO (MGI:MGI:3796765|PMID:18439900) UniProtKB PMID:18439900 MGI:MGI:3796765 NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227
JBrowse link
G SH3BP4 SH3 domain binding protein 4 ISO (PMID:22575674) UniProtKB PMID:22575674 NCBI chr2B:122,179,431...122,284,430
Ensembl chr2B:241,089,624...241,149,524
JBrowse link
G SIRT1 sirtuin 1 ISO (MGI:MGI:4437499|PMID:20169165)
(PMID:20169165)
UniProtKB PMID:20169165 MGI:MGI:4437499 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G TBC1D7 TBC1 domain family member 7 ISO (PMID:22795129)
(MGI:MGI:5437552|PMID:22795129)
UniProtKB PMID:22795129 MGI:MGI:5437552 NCBI chr 6:13,150,677...13,174,661
Ensembl chr 6:13,491,734...13,546,853
JBrowse link
G TMEM127 transmembrane protein 127 ISO (PMID:20154675) UniProtKB PMID:20154675 NCBI chr2A:103,049,655...103,065,116
Ensembl chr2A:97,174,322...97,189,171
JBrowse link
G TNFAIP8L1 TNF alpha induced protein 8 like 1 ISO (MGI:MGI:5582156|PMID:21600655) UniProtKB PMID:21600655 MGI:MGI:5582156 NCBI chr19:3,658,205...3,674,237
Ensembl chr19:4,621,902...4,622,462
JBrowse link
G TSC1 TSC complex subunit 1 ISO PMID:23435171
(PMID:17308101), (PMID:28215400)
ParkinsonsUK-UCL
UniProtKB
PMID:17308101, PMID:23435171, PMID:28215400 RGD:10448950 NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3773582|PMID:18198340)
(MGI:MGI:5819337|PMID:23778976)
(PMID:23778976)
MGI
ParkinsonsUK-UCL
RGD
PMID:12869586, PMID:18198340, PMID:23778976 MGI:MGI:3773582, MGI:MGI:5819337, RGD:1580520 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569
JBrowse link
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 ISO (PMID:20298436) UniProtKB PMID:20298436 NCBI chr15:21,899,611...22,064,606
Ensembl chr15:40,060,111...40,221,725
JBrowse link
G UBR2 ubiquitin protein ligase E3 component n-recognin 2 ISO (PMID:20298436) UniProtKB PMID:20298436 NCBI chr 6:42,150,409...42,282,486
Ensembl chr 6:43,449,154...43,579,224
JBrowse link
negative regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALG13 ALG13 UDP-N-acetylglucosaminyltransferase subunit ISO (MGI:MGI:6306805|PMID:30872163) MGI PMID:30872163 MGI:MGI:6306805 NCBI chr  X:100,794,882...100,874,083
Ensembl chr  X:111,253,717...111,332,534
JBrowse link
G ATM ATM serine/threonine kinase ISO (PMID:23878245)
(MGI:MGI:5509101|PMID:23878245)
ParkinsonsUK-UCL PMID:23878245 MGI:MGI:5509101 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G BMT2 base methyltransferase of 25S rRNA 2 homolog ISO (PMID:29123071) UniProtKB PMID:29123071 NCBI chr 7:104,786,390...104,905,357
Ensembl chr 7:117,488,026...117,607,033
JBrowse link
G C12H12orf66 chromosome 12 C12orf66 homolog ISO (PMID:28199306) UniProtKB PMID:28199306 NCBI chr12:24,691,658...24,721,618
Ensembl chr12:25,174,580...25,219,830
JBrowse link
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 ISO (PMID:26972053) UniProtKB PMID:26972053 NCBI chr22:11,321,259...11,325,787
Ensembl chr22:29,123,198...29,127,736
JBrowse link
G CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 ISO (PMID:26972053) UniProtKB PMID:26972053 Ensembl chr 7:82,068,521...82,075,387 JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit ISO (PMID:25457612), (PMID:29769719) UniProtKB PMID:25457612, PMID:29769719 NCBI chr22:12,774,147...12,929,261 JBrowse link
G FNIP1 folliculin interacting protein 1 ISO (MGI:MGI:5635927|PMID:25775561) MGI PMID:25775561 MGI:MGI:5635927 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
JBrowse link
G FNIP2 folliculin interacting protein 2 ISO (MGI:MGI:5635927|PMID:25775561) MGI PMID:25775561 MGI:MGI:5635927 NCBI chr 4:151,086,854...151,224,192
Ensembl chr 4:162,896,805...163,032,167
JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 ISO (PMID:28199306) UniProtKB PMID:28199306 NCBI chr12:2,933,227...2,980,509
Ensembl chr12:2,865,297...2,877,555
JBrowse link
G KPTN kaptin, actin binding protein ISO (PMID:28199306) UniProtKB PMID:28199306 NCBI chr19:44,467,344...44,478,150
Ensembl chr19:53,122,663...53,131,805
JBrowse link
G RNF152 ring finger protein 152 ISO (MGI:MGI:5644195|PMID:25936802)
(PMID:25936802)
UniProtKB PMID:25936802 MGI:MGI:5644195 NCBI chr18:55,180,955...55,264,164
Ensembl chr18:58,507,684...58,508,295
JBrowse link
G SESN1 sestrin 1 ISO (MGI:MGI:5604284|PMID:25259925)
(PMID:18692468), (PMID:25263562)
UniProtKB PMID:18692468, PMID:25259925, PMID:25263562 MGI:MGI:5604284 NCBI chr 6:106,789,911...106,896,382
Ensembl chr 6:110,839,631...110,946,276
JBrowse link
G SESN2 sestrin 2 ISO (PMID:18692468), (PMID:24947615), (PMID:25263562), (PMID:25457612), (PMID:26449471), (PMID:26586190), (PMID:26612684)
(MGI:MGI:5604284|PMID:25259925), (MGI:MGI:5688277|PMID:24947615)
UniProtKB PMID:18692468, PMID:24947615, PMID:25259925, PMID:25263562, PMID:25457612, PMID:26449471, PMID:26586190, PMID:26612684 MGI:MGI:5604284, MGI:MGI:5688277 NCBI chr 1:27,518,248...27,541,264
Ensembl chr 1:28,555,072...28,577,931
JBrowse link
G SESN3 sestrin 3 ISO (MGI:MGI:5604284|PMID:25259925)
(PMID:25263562)
UniProtKB PMID:25259925, PMID:25263562 MGI:MGI:5604284 NCBI chr11:90,184,571...90,249,825
Ensembl chr11:93,714,916...93,773,679
JBrowse link
G SPAAR small regulatory polypeptide of amino acid response ISO (PMID:28024296)
(MGI:MGI:5822922|PMID:28024296)
UniProtKB PMID:28024296 MGI:MGI:5822922 NCBI chr 9:35,760,064...35,762,224
Ensembl chr 9:36,563,148...36,563,420
JBrowse link
G STK11 serine/threonine kinase 11 ISO (PMID:23878245) ParkinsonsUK-UCL PMID:23878245 Ensembl chr19:1,188,537...1,210,677 JBrowse link
G SZT2 SZT2 subunit of KICSTOR complex ISO (MGI:MGI:5883356|PMID:28199306), (MGI:MGI:5897504|PMID:28199315)
(PMID:28199306), (PMID:28199315)
UniProtKB PMID:28199306, PMID:28199315 MGI:MGI:5883356, MGI:MGI:5897504 NCBI chr 1:42,691,292...42,754,046
Ensembl chr 1:44,068,998...44,129,456
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:5509101|PMID:23878245) ParkinsonsUK-UCL PMID:23878245 MGI:MGI:5509101 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569
JBrowse link
positive regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT3 AKT serine/threonine kinase 3 ISO (MGI:MGI:3531618|PMID:15713641) MGI PMID:15713641 MGI:MGI:3531618 NCBI chr 1:219,107,482...219,463,140
Ensembl chr 1:224,480,784...224,824,838
JBrowse link
G FLCN folliculin ISO (PMID:24081491), (PMID:24095279), (PMID:31672913), (PMID:31704029)
(MGI:MGI:3841511|PMID:19234517)
UniProt
MGI
PMID:19234517, PMID:24081491, PMID:24095279, PMID:31672913, PMID:31704029 MGI:MGI:3841511 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link
G FNIP1 folliculin interacting protein 1 ISO (PMID:24081491) UniProt PMID:24081491 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
JBrowse link
G GOLPH3 golgi phosphoprotein 3 ISO (PMID:19553991) UniProtKB PMID:19553991 NCBI chr 5:78,157,724...78,215,933
Ensembl chr 5:83,536,242...83,596,639
JBrowse link
G HDAC3 histone deacetylase 3 ISO (PMID:25190803) UniProtKB PMID:25190803 NCBI chr 5:136,981,790...136,997,786
Ensembl chr 5:143,094,406...143,110,322
JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 ISO (MGI:MGI:5607214|PMID:23027611)
(PMID:23027611)
UniProtKB PMID:23027611 MGI:MGI:5607214 NCBI chr 1:18,619,683...18,635,822
Ensembl chr 1:19,662,978...19,678,680
JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chr11:67,177,580...67,183,631
Ensembl chr11:70,390,141...70,407,246
JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chr 1:131,396,937...131,400,695
Ensembl chr 1:135,226,400...135,230,167
JBrowse link
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chr 4:92,304,115...92,317,461
Ensembl chr 4:102,965,111...102,978,205
JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO (PMID:22980980) UniProtKB PMID:22980980 NCBI chr 7:92,183,617...92,188,967 JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO (PMID:22980980) UniProtKB PMID:22980980 NCBI chr 1:113,050,671...113,057,368
Ensembl chr 1:127,285,553...127,292,233
JBrowse link
G LARS1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) CAFA PMID:22424946 NCBI chr 5:141,562,798...141,631,388
Ensembl chr 5:147,578,042...147,646,834
JBrowse link
G LEP leptin ISO (PMID:25060689) UniProtKB PMID:25060689 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G LIN28A lin-28 homolog A ISO (MGI:MGI:5294254|PMID:21962509) BHF-UCL PMID:21962509 MGI:MGI:5294254 NCBI chr 1:25,674,751...25,693,684
Ensembl chr 1:26,739,268...26,758,028
JBrowse link
G MIOS meiosis regulator for oocyte development ISO (PMID:23723238) SGD PMID:23723238 NCBI chr 7:8,291,307...8,346,822
Ensembl chr 7:7,643,780...7,684,246
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog ISO (PMID:15467718) UniProtKB PMID:15467718 NCBI chr16:1,063,534...1,067,706
Ensembl chr16:2,306,451...2,310,828
JBrowse link
G RELN reelin ISO (MGI:MGI:5286805|PMID:21664258) BHF-UCL PMID:21664258 MGI:MGI:5286805 NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037
JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO (MGI:MGI:5306547|PMID:21336308)
(PMID:20381137)
UniProtKB PMID:20381137, PMID:21336308 MGI:MGI:5306547 NCBI chr 7:143,054,747...143,108,011 JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 ISO (PMID:15467718) UniProtKB PMID:15467718 NCBI chr 5:71,299,215...71,435,290
Ensembl chr 5:76,389,130...76,469,830
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 ISO (PMID:12150926), (PMID:18439900) UniProtKB PMID:12150926, PMID:18439900 NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708
JBrowse link
G RRAGB Ras related GTP binding B ISO (PMID:22575674) UniProtKB PMID:22575674 NCBI chr  X:48,003,566...48,042,285
Ensembl chr  X:56,155,662...56,194,335
JBrowse link
G SEC13 SEC13 homolog, nuclear pore and COPII coat complex component ISO (PMID:23723238) SGD PMID:23723238 NCBI chr 3:10,237,101...10,257,694
Ensembl chr 3:10,588,644...10,608,754
JBrowse link
G SEH1L SEH1 like nucleoporin ISO (PMID:23723238) SGD PMID:23723238 NCBI chr18:1,342,928...1,379,719
Ensembl chr18:16,464,446...16,500,693
JBrowse link
G SLC38A9 solute carrier family 38 member 9 ISO (PMID:25561175), (PMID:25567906) UniProtKB PMID:25561175, PMID:25567906 NCBI chr 5:58,312,101...58,397,365
Ensembl chr 5:59,944,034...60,020,769
JBrowse link
G SMCR8 SMCR8-C9orf72 complex subunit ISO (PMID:28195531) HGNC PMID:28195531 NCBI chr17:32,858,205...32,871,132
Ensembl chr17:37,884,037...37,896,972
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:5906931|PMID:28802038) ARUK-UCL PMID:28802038 MGI:MGI:5906931 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578
JBrowse link
G WDR24 WD repeat domain 24 ISO (PMID:23723238), (PMID:27166823) UniProtKB PMID:23723238, PMID:27166823 Ensembl chr16:699,142...704,869 JBrowse link
G WDR59 WD repeat domain 59 ISO (PMID:23723238) SGD PMID:23723238 NCBI chr16:55,438,945...55,553,937
Ensembl chr16:74,792,207...74,905,582
JBrowse link
G XBP1 X-box binding protein 1 ISO (PMID:25190803) UniProtKB PMID:25190803 NCBI chr22:9,863,479...9,869,491 JBrowse link
positive regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC16A C-type lectin domain containing 16A ISO (PMID:28223137) UniProtKB PMID:28223137 NCBI chr16:9,887,877...10,124,500
Ensembl chr16:11,109,869...11,343,512
JBrowse link
G GPR137B G protein-coupled receptor 137B ISO (PMID:31036939) UniProt PMID:31036939 NCBI chr 1:211,709,507...211,775,846
Ensembl chr 1:216,696,105...216,778,370
JBrowse link
G KLHL22 kelch like family member 22 ISO (PMID:29769719)
(MGI:MGI:6162296|PMID:29769719)
UniProtKB PMID:29769719 MGI:MGI:6162296 Ensembl chr22:19,122,875...19,174,842 JBrowse link
G LARS1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) CAFA PMID:22424946 NCBI chr 5:141,562,798...141,631,388
Ensembl chr 5:147,578,042...147,646,834
JBrowse link
G PIH1D1 PIH1 domain containing 1 ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chr19:46,459,855...46,465,882
Ensembl chr19:55,381,803...55,387,664
JBrowse link
G PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 ISO (PMID:29644770)
(MGI:MGI:6304515|PMID:29644770)
UniProt PMID:29644770 MGI:MGI:6304515 NCBI chr14:1,332,403...1,336,157
Ensembl chr14:19,384,634...19,388,140
JBrowse link
G RRAGA Ras related GTP binding A ISO (PMID:25936802) UniProtKB PMID:25936802 NCBI chr 9:18,868,781...18,870,356
Ensembl chr 9:19,362,599...19,363,540
JBrowse link
G RRAGB Ras related GTP binding B ISO (PMID:22424946) CAFA PMID:22424946 NCBI chr  X:48,003,566...48,042,285
Ensembl chr  X:56,155,662...56,194,335
JBrowse link
G RRAGD Ras related GTP binding D ISO (PMID:22424946) CAFA PMID:22424946 NCBI chr 6:87,237,442...87,285,579
Ensembl chr 6:90,511,250...90,558,822
JBrowse link
G SEH1L SEH1 like nucleoporin ISO (PMID:25457612) UniProtKB PMID:25457612 NCBI chr18:1,342,928...1,379,719
Ensembl chr18:16,464,446...16,500,693
JBrowse link
G SIK3 SIK family kinase 3 ISO (PMID:30232230) UniProt PMID:30232230 NCBI chr11:111,680,884...111,932,424
Ensembl chr11:115,613,478...115,730,158
JBrowse link
G TELO2 telomere maintenance 2 ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chr16:112,856...130,175
Ensembl chr16:1,548,212...1,566,337
JBrowse link
positive regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIK3 SIK family kinase 3 ISO (PMID:30232230) UniProt PMID:30232230 NCBI chr11:111,680,884...111,932,424
Ensembl chr11:115,613,478...115,730,158
JBrowse link
G TELO2 telomere maintenance 2 ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chr16:112,856...130,175
Ensembl chr16:1,548,212...1,566,337
JBrowse link
regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARAF A-Raf proto-oncogene, serine/threonine kinase ISO (PMID:22609986) UniProtKB PMID:22609986 NCBI chr  X:39,997,026...40,007,783
Ensembl chr  X:47,893,153...47,904,643
JBrowse link
G FAM83D family with sequence similarity 83 member D ISO (PMID:24344117) UniProtKB PMID:24344117 NCBI chr20:35,251,338...35,278,057
Ensembl chr20:36,357,610...36,384,355
JBrowse link
G FBXO9 F-box protein 9 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chr 6:52,621,036...52,652,980
Ensembl chr 6:54,259,044...54,291,207
JBrowse link
G FLCN folliculin ISO (MGI:MGI:4461845|PMID:19843504) MGI PMID:19843504 MGI:MGI:4461845 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link
G GNA12 G protein subunit alpha 12 ISO (MGI:MGI:5448916|PMID:22609986)
(PMID:22609986)
UniProtKB PMID:22609986 MGI:MGI:5448916 NCBI chr 7:2,989,832...3,104,848 JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 ISO (PMID:17002884) UniProtKB PMID:17002884 NCBI chr 4:40,590,801...40,660,527
Ensembl chr 4:46,438,848...46,506,455
JBrowse link
G PKHD1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin ISO (PMID:19524688) UniProtKB PMID:19524688 NCBI chr 6:51,166,516...51,635,057
Ensembl chr 6:52,435,462...52,903,309
JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO (MGI:MGI:4367675|PMID:19258434) CACAO PMID:19258434 MGI:MGI:4367675 NCBI chr 7:143,054,747...143,108,011 JBrowse link
G ROS1 ROS proto-oncogene 1, receptor tyrosine kinase ISO (PMID:16885344) UniProtKB PMID:16885344 NCBI chr 6:115,095,753...115,234,525
Ensembl chr 6:119,238,419...119,376,053
JBrowse link
G RRAGB Ras related GTP binding B ISO (PMID:23723238) UniProtKB PMID:23723238 NCBI chr  X:48,003,566...48,042,285
Ensembl chr  X:56,155,662...56,194,335
JBrowse link
G RRAGC Ras related GTP binding C ISO (PMID:23723238) UniProtKB PMID:23723238 NCBI chr 1:38,110,578...38,132,179
Ensembl chr 1:39,456,768...39,478,244
JBrowse link
G SLC7A1 solute carrier family 7 member 1 ISO RGD PMID:17234578 RGD:1642930 NCBI chr13:10,791,600...10,877,082
Ensembl chr13:28,837,200...28,907,403
JBrowse link
G SLC7A3 solute carrier family 7 member 3 ISO RGD PMID:17234578 RGD:1642930 NCBI chr  X:60,193,997...60,199,564
Ensembl chr  X:70,253,441...70,258,991
JBrowse link
G TBCK TBC1 domain containing kinase ISO (PMID:23977024) UniProtKB PMID:23977024 NCBI chr 4:98,515,422...98,797,701
Ensembl chr 4:109,126,999...109,403,946
JBrowse link
G TELO2 telomere maintenance 2 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chr16:112,856...130,175
Ensembl chr16:1,548,212...1,566,337
JBrowse link
G TMEM127 transmembrane protein 127 ISO (MGI:MGI:5565633|PMID:24334765) MGI PMID:24334765 MGI:MGI:5565633 NCBI chr2A:103,049,655...103,065,116
Ensembl chr2A:97,174,322...97,189,171
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:5906931|PMID:28802038) ARUK-UCL PMID:28802038 MGI:MGI:5906931 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578
JBrowse link
G TTI1 TELO2 interacting protein 1 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chr20:34,304,137...34,354,615
Ensembl chr20:35,417,502...35,467,918
JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 ISO (MGI:MGI:3797328|PMID:18443001) MGI PMID:18443001 MGI:MGI:3797328 NCBI chr 1:39,545,264...39,589,721
Ensembl chr 1:40,869,076...40,912,747
JBrowse link
regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C9orf72 C9orf72-SMCR8 complex subunit ISO (MGI:MGI:5811684|PMID:27875531)
(PMID:27559131)
UniProtKB PMID:27559131, PMID:27875531 MGI:MGI:5811684 NCBI chr 9:27,395,054...27,422,282
Ensembl chr 9:28,001,813...28,022,066
JBrowse link
G DGKQ diacylglycerol kinase theta ISO (PMID:23767959) ParkinsonsUK-UCL PMID:23767959 NCBI chr 4:1,075,133...1,090,081
Ensembl chr 4:994,985...1,007,724
JBrowse link
G DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 ISO (PMID:23415227) UniProtKB PMID:23415227 NCBI chr 1:182,237,556...182,255,984
Ensembl chr 1:186,517,041...186,530,272
JBrowse link
G RRAGC Ras related GTP binding C ISO (PMID:27222292) UniProtKB PMID:27222292 NCBI chr 1:38,110,578...38,132,179
Ensembl chr 1:39,456,768...39,478,244
JBrowse link
G SMCR8 SMCR8-C9orf72 complex subunit ISO (PMID:27559131) UniProtKB PMID:27559131 NCBI chr17:32,858,205...32,871,132
Ensembl chr17:37,884,037...37,896,972
JBrowse link
regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIH1D1 PIH1 domain containing 1 NOT ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chr19:46,459,855...46,465,882
Ensembl chr19:55,381,803...55,387,664
JBrowse link
TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARD11 caspase recruitment domain family member 11 ISO (PMID:28628108) UniProtKB PMID:28628108 NCBI chr 7:3,166,788...3,304,729
Ensembl chr 7:3,258,736...3,332,999
JBrowse link
G LARP1 La ribonucleoprotein 1, translational regulator ISO (PMID:25940091) UniProtKB PMID:25940091 NCBI chr 5:150,086,829...150,221,401
Ensembl chr 5:156,112,358...156,216,706
JBrowse link
G MFSD8 major facilitator superfamily domain containing 8 ISO (MGI:MGI:6155546|PMID:29514215) MGI PMID:29514215 MGI:MGI:6155546 NCBI chr 4:120,087,477...120,137,550
Ensembl chr 4:131,391,361...131,439,590
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog ISO (PMID:12718876) WormBase PMID:12718876 NCBI chr16:1,063,534...1,067,706
Ensembl chr16:2,306,451...2,310,828
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO (PMID:28223137)
(PMID:12718876), (PMID:22424946)
UniProtKB
CAFA
PMID:12718876, PMID:22424946, PMID:28223137 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 ISO (PMID:12718876) WormBase PMID:12718876 NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708
JBrowse link
TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRR5L proline rich 5 like ISO (MGI:MGI:5448916|PMID:22609986)
(PMID:22609986)
UniProtKB PMID:22609986 MGI:MGI:5448916 NCBI chr11:36,269,291...36,438,954
Ensembl chr11:36,223,385...36,311,659
JBrowse link
G SESN3 sestrin 3 ISO (MGI:MGI:5779633|PMID:25377878) UniProtKB PMID:25377878 MGI:MGI:5779633 NCBI chr11:90,184,571...90,249,825
Ensembl chr11:93,714,916...93,773,679
JBrowse link
G SYAP1 synapse associated protein 1 ISO (MGI:MGI:6114863|PMID:23300339)
(PMID:23300339)
UniProtKB PMID:23300339 MGI:MGI:6114863 NCBI chr  X:9,339,052...9,384,940
Ensembl chr  X:16,706,612...16,747,610
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12524
    signaling 4286
      signal transduction 3809
        intracellular signal transduction 2043
          TOR signaling 116
            TORC1 signaling + 42
            TORC2 signaling + 6
            negative regulation of TOR signaling + 45
            positive regulation of TOR signaling + 39
            regulation of TOR signaling + 98
Path 2
Term Annotations click to browse term
  biological_process 12524
    biological regulation 9129
      regulation of biological process 8652
        regulation of cellular process 8181
          signal transduction 3809
            intracellular signal transduction 2043
              TOR signaling 116
                TORC1 signaling + 42
                TORC2 signaling + 6
                negative regulation of TOR signaling + 45
                positive regulation of TOR signaling + 39
                regulation of TOR signaling + 98
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.