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ONTOLOGY REPORT - ANNOTATIONS


Term:TOR signaling
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Accession:GO:0031929 term browser browse the term
Definition:A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Comment:Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
Synonyms:exact_synonym: TOR signal transduction;   TOR signaling pathway;   TOR signalling pathway;   target of rapamycin signaling pathway;   target of rapamycin signalling pathway
 related_synonym: TOR signaling cascade


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TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCDC88A coiled-coil domain containing 88A IEA Ensembl GO_REF:0000107 NCBI chr 3:85,811,043...85,971,162
Ensembl chr 3:85,811,106...85,941,868
JBrowse link
G COPS3 COP9 signalosome subunit 3 IEA Ensembl GO_REF:0000107 NCBI chr12:61,000,562...61,023,920
Ensembl chr12:60,994,310...61,045,396
JBrowse link
G CSF2 colony stimulating factor 2 IMP (PMID:24520418) AgBase PMID:24520418 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G DISC1 DISC1 scaffold protein ISO (MGI:MGI:4411937|PMID:19778506) UniProtKB PMID:19778506 MGI:MGI:4411937 NCBI chr14:58,606,441...58,963,954
Ensembl chr14:58,604,784...59,058,289
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 IEA Ensembl GO_REF:0000107 NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399
JBrowse link
G EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 IEA Ensembl GO_REF:0000107 NCBI chr14:73,323,609...73,355,443
Ensembl chr14:73,323,642...73,349,291
JBrowse link
G FLCN folliculin ISO (PMID:17028174) UniProtKB PMID:17028174 NCBI chr12:61,029,186...61,045,400 JBrowse link
G FNIP1 folliculin interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,958,114...134,093,413
JBrowse link
G GATA3 GATA binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,660...63,388,859
JBrowse link
G ICMT isoprenylcysteine carboxyl methyltransferase ISO (MGI:MGI:5500993|PMID:23686339) MGI PMID:23686339 MGI:MGI:5500993 NCBI chr 6:67,116,943...67,125,908
Ensembl chr 6:67,092,517...67,126,639
JBrowse link
G LARP1 La ribonucleoprotein 1, translational regulator ISO (PMID:24532714) UniProtKB PMID:24532714 NCBI chr16:68,390,879...68,451,605
Ensembl chr16:68,390,875...68,484,918
JBrowse link
G MEAK7 MTOR associated protein, eak-7 homolog IEA Ensembl GO_REF:0000107 NCBI chr 6:4,169,840...4,226,798
Ensembl chr 6:4,204,078...4,228,590
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:39,778,746...39,786,206
Ensembl chr 3:39,778,754...39,788,309
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO (PMID:15467718), (PMID:17028174), (PMID:18762023), (PMID:26018084), (PMID:29750193)
(MGI:MGI:5825416|PMID:26160071)
UniProt
BHF-UCL
PMID:15467718, PMID:17028174, PMID:18762023, PMID:26018084, PMID:26160071, PMID:29750193 MGI:MGI:5825416 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G RHEBL1 RHEB like 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:15,094,398...15,097,785
Ensembl chr 5:15,094,603...15,097,665
JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 IEA InterPro GO_REF:0000002 NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,934...24,311,231
JBrowse link
G RPS6 ribosomal protein S6 IEA Ensembl GO_REF:0000107 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO (PMID:28178239), (PMID:29750193)
(PMID:12150926)
UniProt
UniProtKB
PMID:12150926, PMID:28178239, PMID:29750193 NCBI chr12:36,111,584...36,159,287 JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 IEA Ensembl GO_REF:0000107 NCBI chr 2:5,089,466...5,095,591
Ensembl chr 2:5,089,469...5,095,576
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr12:1,709,121...1,991,844
Ensembl chr12:1,709,126...1,991,560
JBrowse link
G TIPRL TOR signaling pathway regulator IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:82,759,305...82,794,765
Ensembl chr 4:82,756,044...82,794,715
JBrowse link
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC16A C-type lectin domain containing 16A IEA Ensembl GO_REF:0000107 NCBI chr 3:31,938,133...32,158,343
Ensembl chr 3:31,938,135...32,158,558
JBrowse link
negative regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1S1 AKT1 substrate 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:54,881,581...54,890,917
Ensembl chr 6:54,881,584...54,889,954
JBrowse link
G ARNTL aryl hydrocarbon receptor nuclear translocator like IEA Ensembl GO_REF:0000107 NCBI chr 2:45,895,637...46,025,174
Ensembl chr 2:45,895,289...46,025,165
JBrowse link
G COPS3 COP9 signalosome subunit 3 IEA Ensembl GO_REF:0000107 NCBI chr12:61,000,562...61,023,920
Ensembl chr12:60,994,310...61,045,396
JBrowse link
G CRYBA1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chr12:45,466,051...45,473,110
Ensembl chr12:45,368,561...45,473,100
JBrowse link
G DDIT4 DNA damage inducible transcript 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:75,117,708...75,119,907
Ensembl chr14:75,117,707...75,119,903
JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:48,421,788...48,523,530 JBrowse link
G DEPTOR DEP domain containing MTOR interacting protein IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 4:18,969,509...19,180,131
Ensembl chr 4:18,908,686...19,180,117
JBrowse link
G EPM2A EPM2A glucan phosphatase, laforin ISO (PMID:20453062) MGI PMID:20453062 NCBI chr 1:19,806,363...19,893,350
Ensembl chr 1:19,755,720...20,024,398
JBrowse link
G FLCN folliculin IEA Ensembl GO_REF:0000107 NCBI chr12:61,029,186...61,045,400 JBrowse link
G FNIP1 folliculin interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,958,114...134,093,413
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 6:49,690,319...49,700,735
Ensembl chr 6:49,690,370...49,700,735
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO (MGI:MGI:5825416|PMID:26160071) BHF-UCL PMID:26160071 MGI:MGI:5825416 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,574
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha IEA Ensembl GO_REF:0000107 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 ISO (MGI:MGI:5306547|PMID:21336308) UniProt PMID:21336308 MGI:MGI:5306547 NCBI chr14:39,852,537...39,885,898
Ensembl chr14:39,846,606...39,886,455
JBrowse link
G MINAR1 membrane integral NOTCH2 associated receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:48,501,067...48,539,300
Ensembl chr 7:48,501,078...48,539,315
JBrowse link
G MTM1 myotubularin 1 IEA Ensembl GO_REF:0000107 NCBI chr  X:122,286,904...122,379,302
Ensembl chr  X:122,286,916...122,379,299
JBrowse link
G NPRL2 NPR2 like, GATOR1 complex subunit ISO (PMID:23723238) SGD PMID:23723238 NCBI chr13:32,830,895...32,834,205 JBrowse link
G NPRL3 NPR3 like, GATOR1 complex subunit IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 3:41,478,465...41,540,719
Ensembl chr 3:41,479,193...41,545,023
JBrowse link
G PDCD6 programmed cell death 6 ISO (PMID:21893193) UniProtKB PMID:21893193 NCBI chr16:79,818,960...79,832,272
Ensembl chr16:79,818,956...79,832,497
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,321...25,783,610
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:155,683,392...155,754,283
Ensembl chr 6:155,681,781...155,754,272
JBrowse link
G SH3BP4 SH3 domain binding protein 4 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr15:135,003,501...135,094,801
Ensembl chr15:135,003,511...135,106,622
JBrowse link
G SIRT1 sirtuin 1 IEA Ensembl GO_REF:0000107 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,157...71,123,299
JBrowse link
G TBC1D7 TBC1 domain family member 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:9,685,273...9,708,781
Ensembl chr 7:9,685,259...9,708,781
JBrowse link
G TMEM127 transmembrane protein 127 IEA Ensembl GO_REF:0000107 NCBI chr 3:46,966,858...47,017,659
Ensembl chr 3:46,966,890...47,017,659
JBrowse link
G TNFAIP8L1 TNF alpha induced protein 8 like 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:74,203,753...74,220,811
Ensembl chr 2:74,203,766...74,220,816
JBrowse link
G TSC1 TSC complex subunit 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,952
JBrowse link
G TSC2 TSC complex subunit 2 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,922...39,937,371
JBrowse link
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:128,319,311...128,474,330
Ensembl chr 1:128,319,310...128,474,330
JBrowse link
G UBR2 ubiquitin protein ligase E3 component n-recognin 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:37,655,808...37,785,301
Ensembl chr 7:37,655,847...37,784,359
JBrowse link
negative regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALG13 ALG13 UDP-N-acetylglucosaminyltransferase subunit ISO (MGI:MGI:6306805|PMID:30872163) MGI PMID:30872163 MGI:MGI:6306805 NCBI chr  X:91,644,586...91,708,695 JBrowse link
G ATM ATM serine/threonine kinase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,554
JBrowse link
G BMT2 base methyltransferase of 25S rRNA 2 homolog IEA Ensembl GO_REF:0000107 NCBI chr18:32,798,278...32,900,769
Ensembl chr18:32,798,289...32,900,767
JBrowse link
G C5H12orf66 chromosome 5 C12orf66 homolog IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:28,656,227...28,679,095
Ensembl chr 5:28,600,318...28,678,840
JBrowse link
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:47,261,905...47,266,729
Ensembl chr14:47,261,908...47,266,811
JBrowse link
G CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:11,956,289...12,039,913
Ensembl chr 3:11,956,290...12,039,562
JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit ISO (PMID:25457612), (PMID:29769719) UniProtKB PMID:25457612, PMID:29769719 NCBI chr14:48,421,788...48,523,530 JBrowse link
G FNIP1 folliculin interacting protein 1 ISO (MGI:MGI:5635927|PMID:25775561) MGI PMID:25775561 MGI:MGI:5635927 NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,958,114...134,093,413
JBrowse link
G FNIP2 folliculin interacting protein 2 ISO (MGI:MGI:5635927|PMID:25775561) MGI PMID:25775561 MGI:MGI:5635927 NCBI chr 8:47,702,877...47,838,541
Ensembl chr 8:47,702,578...47,838,521
JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:67,292,901...67,306,208
Ensembl chr 5:67,291,771...67,305,758
JBrowse link
G KPTN kaptin, actin binding protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:53,238,650...53,246,458
Ensembl chr 6:53,238,666...53,249,163
JBrowse link
G RNF152 ring finger protein 152 IEA Ensembl GO_REF:0000107 NCBI chr 1:159,529,879...159,606,031
Ensembl chr 1:159,530,623...159,601,981
JBrowse link
G SESN1 sestrin 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:75,056,731...75,170,374
Ensembl chr 1:75,033,098...75,169,987
JBrowse link
G SESN2 sestrin 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:85,321,982...85,348,044
Ensembl chr 6:85,324,228...85,348,044
JBrowse link
G SESN3 sestrin 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:27,207,239...27,279,205
Ensembl chr 9:27,207,236...27,298,628
JBrowse link
G STK11 serine/threonine kinase 11 IEA Ensembl GO_REF:0000107 NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327
JBrowse link
G SZT2 SZT2 subunit of KICSTOR complex IEA Ensembl GO_REF:0000107 NCBI chr 6:167,811,589...167,861,321
Ensembl chr 6:167,811,594...167,861,307
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:5509101|PMID:23878245) ParkinsonsUK-UCL PMID:23878245 MGI:MGI:5509101 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,922...39,937,371
JBrowse link
positive regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT3 AKT serine/threonine kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr10:16,441,465...16,741,745
Ensembl chr10:16,441,447...16,741,339
JBrowse link
G FLCN folliculin IEA Ensembl GO_REF:0000107 NCBI chr12:61,029,186...61,045,400 JBrowse link
G FNIP1 folliculin interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,958,114...134,093,413
JBrowse link
G GAS6 growth arrest specific 6 ISO PMID:18374201 UniProt PMID:18374201 RGD:8554638 NCBI chr11:78,848,797...78,880,733
Ensembl chr11:78,848,794...78,881,272
JBrowse link
G HDAC3 histone deacetylase 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:143,273,188...143,287,421
Ensembl chr 2:143,273,191...143,287,387
JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 ISO (MGI:MGI:5607214|PMID:23027611)
(PMID:23027611)
UniProtKB PMID:23027611 MGI:MGI:5607214 NCBI chr 6:78,077,358...78,092,211 JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,116...41,856,339
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 9:6,674,045...6,680,067
Ensembl chr 9:6,672,475...6,680,053
JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 4:93,972,112...93,975,561
Ensembl chr 4:93,968,960...93,976,304
JBrowse link
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:120,625,897...120,642,630
Ensembl chr 8:120,623,550...120,643,112
JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
InterPro
PMID:21873635 GO_REF:0000002, GO_REF:0000107 NCBI chr 3:8,119,338...8,171,790
Ensembl chr 3:8,155,188...8,164,721
JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISS UniProt GO_REF:0000024 NCBI chr 4:109,722,664...109,728,278
Ensembl chr 4:109,721,910...109,728,257
JBrowse link
G LARS1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) CAFA PMID:22424946 NCBI chr 2:147,480,132...147,554,197
Ensembl chr 2:147,477,378...147,554,196
JBrowse link
G LEP leptin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G LIN28A lin-28 homolog A IEA Ensembl GO_REF:0000107 NCBI chr 6:83,806,178...83,818,550
Ensembl chr 6:83,806,122...83,818,631
JBrowse link
G LOC110257335 Golgi phosphoprotein 3 ISO (PMID:19553991) UniProtKB PMID:19553991 NCBI chr16:18,367,264...18,416,496
Ensembl chr16:18,367,282...18,416,501
JBrowse link
G MIOS meiosis regulator for oocyte development IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 9:77,851,764...77,892,417
Ensembl chr 9:77,851,763...77,893,964
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog IEA Ensembl GO_REF:0000107 NCBI chr 3:39,778,746...39,786,206
Ensembl chr 3:39,778,754...39,788,309
JBrowse link
G MYCBP MYC binding protein IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr 6:94,805,649...94,814,443
Ensembl chr 6:94,785,910...94,814,537
JBrowse link
G RELN reelin IEA Ensembl GO_REF:0000107 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,857...103,963,965
JBrowse link
G RHEB Ras homolog, mTORC1 binding IEA InterPro GO_REF:0000002 NCBI chr18:5,779,439...5,821,839
Ensembl chr18:5,779,212...5,822,257
JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 IEA Ensembl GO_REF:0000107 NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,934...24,311,231
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 IEA Ensembl GO_REF:0000107 NCBI chr12:1,709,121...1,991,844
Ensembl chr12:1,709,126...1,991,560
JBrowse link
G RRAGA Ras related GTP binding A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:203,772,063...203,774,580
Ensembl chr 1:203,772,759...203,774,577
JBrowse link
G RRAGB Ras related GTP binding B IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr  X:48,286,584...48,330,196
Ensembl chr  X:48,286,592...48,330,195
JBrowse link
G RRAGC Ras related GTP binding C IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr 6:94,785,906...94,803,017
Ensembl chr 6:94,785,910...94,814,537
JBrowse link
G RRAGD Ras related GTP binding D IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr 1:57,374,047...57,424,058
Ensembl chr 1:57,374,051...57,424,061
JBrowse link
G SEC13 SEC13 homolog, nuclear pore and COPII coat complex component ISO (PMID:23723238) SGD PMID:23723238 NCBI chr13:66,483,620...66,524,411
Ensembl chr13:66,480,151...66,524,344
JBrowse link
G SLC38A9 solute carrier family 38 member 9 IEA Ensembl GO_REF:0000107 NCBI chr16:34,639,575...34,858,827
Ensembl chr16:34,738,194...34,858,735
JBrowse link
G SMCR8 SMCR8-C9orf72 complex subunit IEA Ensembl GO_REF:0000107 NCBI chr12:60,435,276...60,443,525
Ensembl chr12:60,435,273...60,443,520
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:5906931|PMID:28802038) ARUK-UCL PMID:28802038 MGI:MGI:5906931 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,464,034...36,471,516
JBrowse link
G WDR24 WD repeat domain 24 IEA Ensembl
InterPro
GO_REF:0000002, GO_REF:0000107 NCBI chr 3:41,085,415...41,090,628
Ensembl chr 3:41,085,442...41,090,631
JBrowse link
G WDR59 WD repeat domain 59 IEA Ensembl GO_REF:0000107 NCBI chr 6:12,682,166...12,769,339
Ensembl chr 6:12,681,898...12,771,481
JBrowse link
G XBP1 X-box binding protein 1 ISO (PMID:25190803) UniProtKB PMID:25190803 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link
positive regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEP192 centrosomal protein 192 IEA InterPro GO_REF:0000002 NCBI chr 6:96,611,560...96,733,800
Ensembl chr 6:96,611,564...96,733,799
JBrowse link
G CLEC16A C-type lectin domain containing 16A IEA Ensembl GO_REF:0000107 NCBI chr 3:31,938,133...32,158,343
Ensembl chr 3:31,938,135...32,158,558
JBrowse link
G COPS3 COP9 signalosome subunit 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:61,000,562...61,023,920
Ensembl chr12:60,994,310...61,045,396
JBrowse link
G GPR137 G protein-coupled receptor 137 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:7,826,454...7,831,010
Ensembl chr 2:7,826,454...7,830,969
JBrowse link
G GPR137B G protein-coupled receptor 137B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:55,125,405...55,181,688
Ensembl chr14:55,125,409...55,181,687
JBrowse link
G GPR137C G protein-coupled receptor 137C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:182,203,185...182,263,753
Ensembl chr 1:182,202,767...182,261,517
JBrowse link
G KLHL22 kelch like family member 22 IEA Ensembl GO_REF:0000107 NCBI chr14:50,773,917...50,809,991 JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:109,722,664...109,728,278
Ensembl chr 4:109,721,910...109,728,257
JBrowse link
G LARS1 leucyl-tRNA synthetase 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:147,480,132...147,554,197
Ensembl chr 2:147,477,378...147,554,196
JBrowse link
G PIH1D1 PIH1 domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:54,524,172...54,529,700
Ensembl chr 6:54,524,172...54,537,588
JBrowse link
G PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:78,447,323...78,451,761
Ensembl chr 7:78,447,369...78,451,846
JBrowse link
G RRAGA Ras related GTP binding A IEA Ensembl GO_REF:0000107 NCBI chr 1:203,772,063...203,774,580
Ensembl chr 1:203,772,759...203,774,577
JBrowse link
G RRAGB Ras related GTP binding B IEA Ensembl GO_REF:0000107 NCBI chr  X:48,286,584...48,330,196
Ensembl chr  X:48,286,592...48,330,195
JBrowse link
G RRAGD Ras related GTP binding D IEA Ensembl GO_REF:0000107 NCBI chr 1:57,374,047...57,424,058
Ensembl chr 1:57,374,051...57,424,061
JBrowse link
G SEC13 SEC13 homolog, nuclear pore and COPII coat complex component IEA InterPro GO_REF:0000002 NCBI chr13:66,483,620...66,524,411
Ensembl chr13:66,480,151...66,524,344
JBrowse link
G SIK3 SIK family kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:44,223,227...44,471,689
Ensembl chr 9:44,223,227...44,513,822
JBrowse link
G TELO2 telomere maintenance 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:40,372,215...40,386,777
Ensembl chr 3:40,362,208...40,386,777
JBrowse link
positive regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIK3 SIK family kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:44,223,227...44,471,689
Ensembl chr 9:44,223,227...44,513,822
JBrowse link
G TELO2 telomere maintenance 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:40,372,215...40,386,777
Ensembl chr 3:40,362,208...40,386,777
JBrowse link
regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARAF A-Raf proto-oncogene, serine/threonine kinase ISO (PMID:22609986) UniProtKB PMID:22609986 NCBI chr  X:42,078,202...42,090,250
Ensembl chr  X:42,078,195...42,090,247
JBrowse link
G DDIT4 DNA damage inducible transcript 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:75,117,708...75,119,907
Ensembl chr14:75,117,707...75,119,903
JBrowse link
G FAM83D family with sequence similarity 83 member D IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr17:41,868,982...41,892,222
Ensembl chr17:41,869,051...41,895,625
JBrowse link
G FBXO9 F-box protein 9 IEA Ensembl GO_REF:0000107 NCBI chr 7:46,723,579...46,748,132
Ensembl chr 7:46,723,593...46,761,484
JBrowse link
G FLCN folliculin ISO (MGI:MGI:4461845|PMID:19843504) MGI PMID:19843504 MGI:MGI:4461845 NCBI chr12:61,029,186...61,045,400 JBrowse link
G GBA glucosylceramidase beta ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 4:94,583,905...94,606,689
Ensembl chr 4:94,584,196...94,609,745
JBrowse link
G GNA12 G protein subunit alpha 12 IEA Ensembl GO_REF:0000107 NCBI chr 3:2,002,494...2,105,937
Ensembl chr 3:2,000,863...2,105,949
JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 IEA Ensembl GO_REF:0000107 NCBI chr 8:134,912,493...135,002,140
Ensembl chr 8:134,912,491...134,977,395
JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:67,292,901...67,306,208
Ensembl chr 5:67,291,771...67,305,758
JBrowse link
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 IEA InterPro GO_REF:0000002 NCBI chr 8:120,625,897...120,642,630
Ensembl chr 8:120,623,550...120,643,112
JBrowse link
G PKHD1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin IEA Ensembl GO_REF:0000107 NCBI chr 7:45,447,354...45,925,141
Ensembl chr 7:45,447,357...45,925,113
JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO (MGI:MGI:4367675|PMID:19258434) CACAO PMID:19258434 MGI:MGI:4367675 NCBI chr18:5,779,439...5,821,839
Ensembl chr18:5,779,212...5,822,257
JBrowse link
G ROS1 ROS proto-oncogene 1, receptor tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr 1:44,409,877...44,535,784
Ensembl chr 1:44,409,931...44,534,874
JBrowse link
G RRAGB Ras related GTP binding B ISO (PMID:23723238) UniProtKB PMID:23723238 NCBI chr  X:48,286,584...48,330,196
Ensembl chr  X:48,286,592...48,330,195
JBrowse link
G RRAGC Ras related GTP binding C ISO (PMID:23723238) UniProtKB PMID:23723238 NCBI chr 6:94,785,906...94,803,017
Ensembl chr 6:94,785,910...94,814,537
JBrowse link
G SLC7A1 solute carrier family 7 member 1 ISO RGD PMID:17234578 RGD:1642930 NCBI chr11:6,538,053...6,604,654
Ensembl chr11:6,538,055...6,596,878
JBrowse link
G SLC7A3 solute carrier family 7 member 3 ISO RGD PMID:17234578 RGD:1642930 NCBI chr  X:56,937,081...56,942,331
Ensembl chr  X:56,937,082...56,942,357
JBrowse link
G TBCK TBC1 domain containing kinase IEA Ensembl GO_REF:0000107 NCBI chr 8:115,476,776...115,703,011
Ensembl chr 8:115,476,648...115,709,051
JBrowse link
G TELO2 telomere maintenance 2 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chr 3:40,372,215...40,386,777
Ensembl chr 3:40,362,208...40,386,777
JBrowse link
G TMEM127 transmembrane protein 127 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:46,966,858...47,017,659
Ensembl chr 3:46,966,890...47,017,659
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:5906931|PMID:28802038) ARUK-UCL PMID:28802038 MGI:MGI:5906931 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,464,034...36,471,516
JBrowse link
G TTI1 TELO2 interacting protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:41,047,408...41,094,038
Ensembl chr17:41,047,408...41,078,506
JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 IEA Ensembl GO_REF:0000107 NCBI chr 6:96,008,307...96,057,131
Ensembl chr 6:96,008,455...96,062,951
JBrowse link
regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C10H9orf72 chromosome 10 C9orf72 homolog IEA Ensembl GO_REF:0000107 NCBI chr10:38,389,366...38,415,903
Ensembl chr10:38,389,331...38,415,903
JBrowse link
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 IEA InterPro GO_REF:0000002 NCBI chr14:47,261,905...47,266,729
Ensembl chr14:47,261,908...47,266,811
JBrowse link
G DGKQ diacylglycerol kinase theta IEA Ensembl GO_REF:0000107 NCBI chr 8:313,325...325,089
Ensembl chr 8:313,327...325,095
JBrowse link
G DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:67,268,600...67,279,617
Ensembl chr 9:67,268,633...67,280,113
JBrowse link
G MYCBP MYC binding protein IEA Ensembl GO_REF:0000107 NCBI chr 6:94,805,649...94,814,443
Ensembl chr 6:94,785,910...94,814,537
JBrowse link
G RRAGC Ras related GTP binding C IEA Ensembl GO_REF:0000107 NCBI chr 6:94,785,906...94,803,017
Ensembl chr 6:94,785,910...94,814,537
JBrowse link
G SMCR8 SMCR8-C9orf72 complex subunit IEA Ensembl GO_REF:0000107 NCBI chr12:60,435,276...60,443,525
Ensembl chr12:60,435,273...60,443,520
JBrowse link
regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIH1D1 PIH1 domain containing 1 NOT ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chr 6:54,524,172...54,529,700
Ensembl chr 6:54,524,172...54,537,588
JBrowse link
TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARD11 caspase recruitment domain family member 11 IEA Ensembl GO_REF:0000107 NCBI chr 3:2,145,178...2,266,377
Ensembl chr 3:2,145,177...2,266,356
JBrowse link
G LARP1 La ribonucleoprotein 1, translational regulator IEA Ensembl GO_REF:0000107 NCBI chr16:68,390,879...68,451,605
Ensembl chr16:68,390,875...68,484,918
JBrowse link
G MFSD8 major facilitator superfamily domain containing 8 IEA Ensembl GO_REF:0000107 NCBI chr 8:96,925,063...96,972,390
Ensembl chr 8:96,925,080...96,971,339
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog IEA Ensembl GO_REF:0000107 NCBI chr 3:39,778,746...39,786,206
Ensembl chr 3:39,778,754...39,788,309
JBrowse link
G MTOR mechanistic target of rapamycin kinase IEA Ensembl GO_REF:0000107 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G NPRL3 NPR3 like, GATOR1 complex subunit IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:41,478,465...41,540,719
Ensembl chr 3:41,479,193...41,545,023
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:1,709,121...1,991,844
Ensembl chr12:1,709,126...1,991,560
JBrowse link
G SMG1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:26,653,819...26,758,268
Ensembl chr 3:26,653,792...26,754,882
JBrowse link
TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPKAP1 MAPK associated protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:266,096,192...266,346,384
Ensembl chr 1:266,096,193...266,346,210
JBrowse link
G PRR5 proline rich 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:4,467,231...4,525,610
Ensembl chr 5:4,467,232...4,525,588
JBrowse link
G PRR5L proline rich 5 like IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 2:24,646,865...24,812,642
Ensembl chr 2:24,646,867...24,812,610
JBrowse link
G SESN3 sestrin 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:27,207,239...27,279,205
Ensembl chr 9:27,207,236...27,298,628
JBrowse link
G SYAP1 synapse associated protein 1 IEA Ensembl GO_REF:0000107 NCBI chr  X:13,181,948...13,206,948
Ensembl chr  X:13,181,953...13,208,347
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16524
    signaling 6450
      signal transduction 5920
        intracellular signal transduction 2481
          TOR signaling 125
            TORC1 signaling + 49
            TORC2 signaling + 8
            negative regulation of TOR signaling + 45
            positive regulation of TOR signaling + 45
            regulation of TOR signaling + 103
Path 2
Term Annotations click to browse term
  biological_process 16524
    biological regulation 11994
      regulation of biological process 11420
        regulation of cellular process 10970
          signal transduction 5920
            intracellular signal transduction 2481
              TOR signaling 125
                TORC1 signaling + 49
                TORC2 signaling + 8
                negative regulation of TOR signaling + 45
                positive regulation of TOR signaling + 45
                regulation of TOR signaling + 103
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.