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ONTOLOGY REPORT - ANNOTATIONS


Term:TOR signaling
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Accession:GO:0031929 term browser browse the term
Definition:A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Comment:Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
Synonyms:exact_synonym: TOR signal transduction;   TOR signaling pathway;   TOR signalling pathway;   target of rapamycin signaling pathway;   target of rapamycin signalling pathway
 related_synonym: TOR signaling cascade


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TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc88a coiled-coil domain containing 88A ISO (MGI:MGI:4411937|PMID:19778506) UniProtKB PMID:19778506 MGI:MGI:4411937 NCBI chrNW_004936491:1,670,192...1,804,056 JBrowse link
G Csf2 colony stimulating factor 2 ISO (PMID:24520418) AgBase PMID:24520418 NCBI chrNW_004936647:3,081,896...3,083,864 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO (PMID:12150926), (PMID:22578813) UniProtKB PMID:12150926, PMID:22578813 NCBI chrNW_004936710:1,446,030...1,461,945 JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 ISO (MGI:MGI:4820682|PMID:20347422) UniProtKB PMID:20347422 MGI:MGI:4820682 NCBI chrNW_004936521:8,182,740...8,207,466 JBrowse link
G Flcn folliculin ISO (PMID:17028174) UniProtKB PMID:17028174 NCBI chrNW_004936741:881,150...901,296 JBrowse link
G Fnip1 folliculin interacting protein 1 ISO (PMID:17028174) UniProtKB PMID:17028174 NCBI chrNW_004936647:3,329,097...3,428,170 JBrowse link
G Gata3 GATA binding protein 3 ISO (MGI:MGI:5285154|PMID:20696860) UniProtKB PMID:20696860 MGI:MGI:5285154 NCBI chrNW_004936484:6,780,692...6,800,883 JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISO (MGI:MGI:5500993|PMID:23686339) MGI PMID:23686339 MGI:MGI:5500993 NCBI chrNW_004936623:1,079,474...1,087,728 JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator ISO (PMID:24532714) UniProtKB PMID:24532714 NCBI chrNW_004936515:8,039,887...8,125,006 JBrowse link
G LOC101959679 disrupted in schizophrenia 1 protein ISO (MGI:MGI:4411937|PMID:19778506) UniProtKB PMID:19778506 MGI:MGI:4411937 NCBI chrNW_004936484:19,151,752...19,237,435 JBrowse link
G Meak7 MTOR associated protein, eak-7 homolog ISO (PMID:29750193) UniProt PMID:29750193 NCBI chrNW_004936641:3,490,531...3,498,615 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (PMID:15467718), (PMID:17028174), (PMID:18762023), (PMID:26018084), (PMID:29750193)
(MGI:MGI:5825416|PMID:26160071)
UniProt
BHF-UCL
PMID:15467718, PMID:17028174, PMID:18762023, PMID:26018084, PMID:26160071, PMID:29750193 MGI:MGI:5825416 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Rhebl1 RHEB like 1 ISO (PMID:12869548) UniProtKB PMID:12869548 NCBI chrNW_004936512:6,864,843...6,868,045 JBrowse link
G Rps6 ribosomal protein S6 ISO (PMID:16428328) UniProtKB PMID:16428328 NCBI chrNW_004936652:1,252,986...1,255,987 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO (PMID:12150926)
(PMID:28178239), (PMID:29750193)
UniProtKB
UniProt
PMID:12150926, PMID:28178239, PMID:29750193 NCBI chrNW_004936490:3,441,046...3,492,917 JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 ISO (PMID:29750193) UniProt PMID:29750193 NCBI chrNW_004936599:2,315,146...2,321,127 JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chrNW_004936594:4,427,225...4,758,081 JBrowse link
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A ISO (PMID:28223137) UniProtKB PMID:28223137 NCBI chrNW_004936530:9,089,478...9,264,563 JBrowse link
negative regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 ISO (PMID:17386266) UniProtKB PMID:17386266 NCBI chrNW_004936664:3,657,170...3,664,375 JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator like ISO (MGI:MGI:5553401|PMID:24481314) UniProtKB PMID:24481314 MGI:MGI:5553401 NCBI chrNW_004936528:5,167,611...5,239,128 JBrowse link
G Cryba1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chrNW_004936538:5,392,159...5,400,583 JBrowse link
G Ddit4 DNA damage inducible transcript 4 ISO PMID:21368030
(MGI:MGI:3773582|PMID:18198340)
(PMID:20166753)
UniProt
MGI
UniProtKB
PMID:18198340, PMID:20166753, PMID:21368030 MGI:MGI:3773582, RGD:8554300 NCBI chrNW_004936521:6,646,864...6,648,982 JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004936755:871,935...1,024,538 JBrowse link
G Deptor DEP domain containing MTOR interacting protein ISO (PMID:19446321) UniProtKB PMID:19446321 NCBI chrNW_004936470:26,698,707...26,837,470 JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin ISO (PMID:20453062) MGI PMID:20453062 NCBI chrNW_004936625:761,013...819,826 JBrowse link
G Flcn folliculin ISO (MGI:MGI:3772618|PMID:18182616)
(MGI:MGI:5050037|PMID:21258407)
(MGI:MGI:3829339|PMID:18974783)
MGI PMID:18182616, PMID:18974783, PMID:21258407 MGI:MGI:3772618, MGI:MGI:3829339, MGI:MGI:5050037 NCBI chrNW_004936741:881,150...901,296 JBrowse link
G Fnip1 folliculin interacting protein 1 ISO (MGI:MGI:5436190|PMID:22608497) MGI PMID:22608497 MGI:MGI:5436190 NCBI chrNW_004936647:3,329,097...3,428,170 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO (MGI:MGI:4829580|PMID:20516643) BHF-UCL PMID:20516643 MGI:MGI:4829580 NCBI chrNW_004936706:266,462...277,256 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO (MGI:MGI:5825416|PMID:26160071) BHF-UCL PMID:26160071 MGI:MGI:5825416 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (MGI:MGI:4830408|PMID:20808783) MGI PMID:20808783 MGI:MGI:4830408 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G LOC101964565 TBC1 domain family member 7 ISO (MGI:MGI:5437552|PMID:22795129)
(PMID:22795129)
UniProtKB PMID:22795129 MGI:MGI:5437552 NCBI chrNW_004936534:8,104...17,056 JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 ISO (MGI:MGI:5306547|PMID:21336308) UniProt PMID:21336308 MGI:MGI:5306547 NCBI chrNW_004936558:4,414,283...4,448,291 JBrowse link
G Minar1 membrane integral NOTCH2 associated receptor 1 ISO (PMID:30080879) UniProt PMID:30080879 RGD:13825189 NCBI chrNW_004936471:37,573,475...37,607,329 JBrowse link
G Mtm1 myotubularin 1 ISO (MGI:MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:MGI:5510937 NCBI chrNW_004936714:1,792,893...1,870,338 JBrowse link
G Nprl2 NPR2 like, GATOR1 complex subunit ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004939530:1,745...5,100 JBrowse link
G Nprl3 NPR3 like, GATOR1 complex subunit ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004936501:747,806...783,479 JBrowse link
G Pdcd6 programmed cell death 6 ISO (PMID:21893193) UniProtKB PMID:21893193 NCBI chrNW_004936815:1,129,367...1,144,020 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO (MGI:MGI:3796765|PMID:18439900) UniProtKB PMID:18439900 MGI:MGI:3796765 NCBI chrNW_004936518:1,817,051...1,843,376 JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO (MGI:MGI:3796765|PMID:18439900) UniProtKB PMID:18439900 MGI:MGI:3796765 NCBI chrNW_004936522:4,872,360...4,939,873 JBrowse link
G Sh3bp4 SH3 domain binding protein 4 ISO (PMID:22575674) UniProtKB PMID:22575674 NCBI chrNW_004936525:2,693,828...2,757,480 JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:4437499|PMID:20169165)
(PMID:20169165)
UniProtKB PMID:20169165 MGI:MGI:4437499 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Tmem127 transmembrane protein 127 ISO (PMID:20154675) UniProtKB PMID:20154675 NCBI chrNW_004936744:344,356...359,086 JBrowse link
G Tnfaip8l1 TNF alpha induced protein 8 like 1 ISO (MGI:MGI:5582156|PMID:21600655) UniProtKB PMID:21600655 MGI:MGI:5582156 NCBI chrNW_004936588:2,695,818...2,706,089 JBrowse link
G Tsc1 TSC complex subunit 1 ISO (PMID:17308101), (PMID:28215400)
PMID:23435171
UniProtKB
ParkinsonsUK-UCL
PMID:17308101, PMID:23435171, PMID:28215400 RGD:10448950 NCBI chrNW_004936487:19,331,183...19,386,841 JBrowse link
G Tsc2 TSC complex subunit 2 ISO (MGI:MGI:3773582|PMID:18198340)
(PMID:23778976)
(MGI:MGI:5819337|PMID:23778976)
MGI
ParkinsonsUK-UCL
RGD
PMID:12869586, PMID:18198340, PMID:23778976 MGI:MGI:3773582, MGI:MGI:5819337, RGD:1580520 NCBI chrNW_004936694:1,958,152...1,993,373 JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 ISO (PMID:20298436) UniProtKB PMID:20298436 NCBI chrNW_004936471:6,171,655...6,313,853 JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 ISO (PMID:20298436) UniProtKB PMID:20298436 NCBI chrNW_004936476:17,178,981...17,322,600 JBrowse link
negative regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alg13 ALG13 UDP-N-acetylglucosaminyltransferase subunit ISO (MGI:MGI:6306805|PMID:30872163) MGI PMID:30872163 MGI:MGI:6306805 NCBI chrNW_004936499:3,558,273...3,629,570 JBrowse link
G Atm ATM serine/threonine kinase ISO (PMID:23878245)
(MGI:MGI:5509101|PMID:23878245)
ParkinsonsUK-UCL PMID:23878245 MGI:MGI:5509101 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Bmt2 base methyltransferase of 25S rRNA 2 homolog ISO (PMID:29123071) UniProtKB PMID:29123071 NCBI chrNW_004936589:5,578,566...5,657,093 JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 ISO (PMID:26972053) UniProtKB PMID:26972053 NCBI chrNW_004936904:372,609...376,878 JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 ISO (PMID:26972053) UniProtKB PMID:26972053 NCBI chrNW_004936543:3,692,040...3,709,658 JBrowse link
G CUNH12orf66 chromosome unknown C12orf66 homolog ISO (PMID:28199306) UniProtKB PMID:28199306 NCBI chrNW_004936545:2,577,388...2,602,698 JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO (PMID:25457612), (PMID:29769719) UniProtKB PMID:25457612, PMID:29769719 NCBI chrNW_004936755:871,935...1,024,538 JBrowse link
G Fnip1 folliculin interacting protein 1 ISO (MGI:MGI:5635927|PMID:25775561) MGI PMID:25775561 MGI:MGI:5635927 NCBI chrNW_004936647:3,329,097...3,428,170 JBrowse link
G Fnip2 folliculin interacting protein 2 ISO (MGI:MGI:5635927|PMID:25775561) MGI PMID:25775561 MGI:MGI:5635927 NCBI chrNW_004936576:5,221,619...5,335,133 JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 ISO (PMID:28199306) UniProtKB PMID:28199306 NCBI chrNW_004936606:3,144,616...3,158,825 JBrowse link
G Kptn kaptin, actin binding protein ISO (PMID:28199306) UniProtKB PMID:28199306 NCBI chrNW_004936664:1,146,003...1,155,571 JBrowse link
G Rnf152 ring finger protein 152 ISO (MGI:MGI:5644195|PMID:25936802)
(PMID:25936802)
UniProtKB PMID:25936802 MGI:MGI:5644195 NCBI chrNW_004936497:3,357,464...3,421,813 JBrowse link
G Sesn1 sestrin 1 ISO (MGI:MGI:5604284|PMID:25259925)
(PMID:18692468), (PMID:25263562)
UniProtKB PMID:18692468, PMID:25259925, PMID:25263562 MGI:MGI:5604284 NCBI chrNW_004936564:5,187,152...5,291,201 JBrowse link
G Sesn2 sestrin 2 ISO (PMID:18692468), (PMID:24947615), (PMID:25263562), (PMID:25457612), (PMID:26449471), (PMID:26586190), (PMID:26612684)
(MGI:MGI:5604284|PMID:25259925), (MGI:MGI:5688277|PMID:24947615)
UniProtKB PMID:18692468, PMID:24947615, PMID:25259925, PMID:25263562, PMID:25457612, PMID:26449471, PMID:26586190, PMID:26612684 MGI:MGI:5604284, MGI:MGI:5688277 NCBI chrNW_004936474:12,416,652...12,436,799 JBrowse link
G Sesn3 sestrin 3 ISO (PMID:25263562)
(MGI:MGI:5604284|PMID:25259925)
UniProtKB PMID:25259925, PMID:25263562 MGI:MGI:5604284 NCBI chrNW_004936700:2,429,535...2,491,752 JBrowse link
G Stk11 serine/threonine kinase 11 ISO (PMID:23878245) ParkinsonsUK-UCL PMID:23878245 NCBI chrNW_004936588:579,816...601,033 JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex ISO (PMID:28199306), (PMID:28199315)
(MGI:MGI:5883356|PMID:28199306), (MGI:MGI:5897504|PMID:28199315)
UniProtKB PMID:28199306, PMID:28199315 MGI:MGI:5883356, MGI:MGI:5897504 NCBI chrNW_004936474:24,788,175...24,837,471 JBrowse link
G Tsc2 TSC complex subunit 2 ISO (MGI:MGI:5509101|PMID:23878245) ParkinsonsUK-UCL PMID:23878245 MGI:MGI:5509101 NCBI chrNW_004936694:1,958,152...1,993,373 JBrowse link
positive regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt3 AKT serine/threonine kinase 3 ISO (MGI:MGI:3531618|PMID:15713641) MGI PMID:15713641 MGI:MGI:3531618 NCBI chrNW_004936526:6,944,056...7,201,226 JBrowse link
G Flcn folliculin ISO (PMID:24081491), (PMID:24095279), (PMID:31672913), (PMID:31704029)
(MGI:MGI:3841511|PMID:19234517)
UniProt
MGI
PMID:19234517, PMID:24081491, PMID:24095279, PMID:31672913, PMID:31704029 MGI:MGI:3841511 NCBI chrNW_004936741:881,150...901,296 JBrowse link
G Fnip1 folliculin interacting protein 1 ISO (PMID:24081491) UniProt PMID:24081491 NCBI chrNW_004936647:3,329,097...3,428,170 JBrowse link
G Gas6 growth arrest specific 6 ISO PMID:18374201 UniProt PMID:18374201 RGD:8554638 NCBI chrNW_004936472:27,116...57,158 JBrowse link
G Golph3 golgi phosphoprotein 3 ISO (PMID:19553991) UniProtKB PMID:19553991 NCBI chrNW_004936518:8,602,367...8,635,665 JBrowse link
G Hdac3 histone deacetylase 3 ISO (PMID:25190803) UniProtKB PMID:25190803 NCBI chrNW_004936504:12,530,546...12,546,556 JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 ISO (MGI:MGI:5607214|PMID:23027611)
(PMID:23027611)
UniProtKB PMID:23027611 MGI:MGI:5607214 NCBI chrNW_004936474:5,848,719...5,858,520 JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chrNW_004936498:1,446,794...1,459,590 JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chrNW_004936580:5,316,748...5,320,364 JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO (PMID:20381137) UniProtKB PMID:20381137 NCBI chrNW_004936520:3,113,178...3,128,333 JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO (PMID:22980980) UniProtKB PMID:22980980 NCBI chrNW_004936543:408,345...411,723 JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO (PMID:22980980) UniProtKB PMID:22980980 NCBI chrNW_004936704:1,830,470...1,835,966 JBrowse link
G Lars1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) CAFA PMID:22424946 NCBI chrNW_004936504:8,500,024...8,568,477 JBrowse link
G Lep leptin ISO (PMID:25060689) UniProtKB PMID:25060689 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G Lin28a lin-28 homolog A ISO (MGI:MGI:5294254|PMID:21962509) BHF-UCL PMID:21962509 MGI:MGI:5294254 NCBI chrNW_004936474:10,896,153...10,909,247 JBrowse link
G LOC101966958 GATOR complex protein WDR59 ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004936475:23,754,525...23,803,942 JBrowse link
G Mios meiosis regulator for oocyte development ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004936585:2,296,713...2,331,737 JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO (PMID:15467718) UniProtKB PMID:15467718 NCBI chrNW_004936694:1,839,135...1,849,307 JBrowse link
G Reln reelin ISO (MGI:MGI:5286805|PMID:21664258) BHF-UCL PMID:21664258 MGI:MGI:5286805 NCBI chrNW_004936479:19,628,488...20,088,278 JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO (PMID:20381137)
(MGI:MGI:5306547|PMID:21336308)
UniProtKB PMID:20381137, PMID:21336308 MGI:MGI:5306547 NCBI chrNW_004936527:6,832,286...6,877,938 JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 ISO (PMID:15467718) UniProtKB PMID:15467718 NCBI chrNW_004936518:3,198,312...3,314,393 JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 ISO (PMID:12150926), (PMID:18439900) UniProtKB PMID:12150926, PMID:18439900 NCBI chrNW_004936594:4,427,225...4,758,081 JBrowse link
G Rragb Ras related GTP binding B ISO (PMID:22575674) UniProtKB PMID:22575674 NCBI chrNW_004936819:946,874...988,531 JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004936602:3,013,490...3,030,489 JBrowse link
G Seh1l SEH1 like nucleoporin ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004936626:2,538,655...2,562,468 JBrowse link
G Slc38a9 solute carrier family 38 member 9 ISO (PMID:25561175), (PMID:25567906) UniProtKB PMID:25561175, PMID:25567906 NCBI chrNW_004936480:12,103,697...12,198,592 JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit ISO (PMID:28195531) HGNC PMID:28195531 NCBI chrNW_004936741:1,838,974...1,848,742 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:5906931|PMID:28802038) ARUK-UCL PMID:28802038 MGI:MGI:5906931 NCBI chrNW_004936476:18,659,725...18,665,406 JBrowse link
G Wdr24 WD repeat domain 24 ISO (PMID:23723238), (PMID:27166823) UniProtKB PMID:23723238, PMID:27166823 NCBI chrNW_004936501:321,877...326,984 JBrowse link
G Xbp1 X-box binding protein 1 ISO (PMID:25190803) UniProtKB PMID:25190803 NCBI chrNW_004936657:2,891,171...2,895,409 JBrowse link
positive regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A ISO (PMID:28223137) UniProtKB PMID:28223137 NCBI chrNW_004936530:9,089,478...9,264,563 JBrowse link
G Gpr137b G protein-coupled receptor 137B ISO (PMID:31036939) UniProt PMID:31036939 NCBI chrNW_004936484:16,539,076...16,578,606 JBrowse link
G Klhl22 kelch like family member 22 ISO (MGI:MGI:6162296|PMID:29769719)
(PMID:29769719)
UniProtKB PMID:29769719 MGI:MGI:6162296 NCBI chrNW_004936619:2,854,915...2,899,386 JBrowse link
G Lars1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) CAFA PMID:22424946 NCBI chrNW_004936504:8,500,024...8,568,477 JBrowse link
G Pih1d1 PIH1 domain containing 1 ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chrNW_004936664:3,321,278...3,326,720 JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 ISO (MGI:MGI:6304515|PMID:29644770)
(PMID:29644770)
UniProt PMID:29644770 MGI:MGI:6304515 NCBI chrNW_004936877:669,407...673,004 JBrowse link
G Rraga Ras related GTP binding A ISO (PMID:25936802) UniProtKB PMID:25936802 NCBI chrNW_004936652:991,832...993,439 JBrowse link
G Rragb Ras related GTP binding B ISO (PMID:22424946) CAFA PMID:22424946 NCBI chrNW_004936819:946,874...988,531 JBrowse link
G Rragd Ras related GTP binding D ISO (PMID:22424946) CAFA PMID:22424946 NCBI chrNW_004936510:2,810,028...2,849,792 JBrowse link
G Seh1l SEH1 like nucleoporin ISO (PMID:25457612) UniProtKB PMID:25457612 NCBI chrNW_004936626:2,538,655...2,562,468 JBrowse link
G Sik3 SIK family kinase 3 ISO (PMID:30232230) UniProt PMID:30232230 NCBI chrNW_004936542:2,119,423...2,357,533 JBrowse link
G Telo2 telomere maintenance 2 ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chrNW_004936694:2,418,223...2,433,630 JBrowse link
positive regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sik3 SIK family kinase 3 ISO (PMID:30232230) UniProt PMID:30232230 NCBI chrNW_004936542:2,119,423...2,357,533 JBrowse link
G Telo2 telomere maintenance 2 ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chrNW_004936694:2,418,223...2,433,630 JBrowse link
regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase ISO (PMID:22609986) UniProtKB PMID:22609986 NCBI chrNW_004936502:13,323,365...13,335,003 JBrowse link
G Fam83d family with sequence similarity 83 member D ISO (PMID:24344117) UniProtKB PMID:24344117 NCBI chrNW_004936561:2,528,463...2,549,665 JBrowse link
G Fbxo9 F-box protein 9 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chrNW_004936476:7,769,355...7,809,688 JBrowse link
G Flcn folliculin ISO (MGI:MGI:4461845|PMID:19843504) MGI PMID:19843504 MGI:MGI:4461845 NCBI chrNW_004936741:881,150...901,296 JBrowse link
G Gba glucosylceramidase beta ISO (PMID:27378698)
(MGI:MGI:5817293|PMID:27378698)
UniProt PMID:27378698 MGI:MGI:5817293 NCBI chrNW_004936580:4,715,869...4,720,752 JBrowse link
G Gna12 G protein subunit alpha 12 ISO (MGI:MGI:5448916|PMID:22609986)
(PMID:22609986)
UniProtKB PMID:22609986 MGI:MGI:5448916 NCBI chrNW_004936823:447,979...543,134 JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 ISO (PMID:17002884) UniProtKB PMID:17002884 NCBI chrNW_004936738:1,107,725...1,166,697 JBrowse link
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin ISO (PMID:19524688) UniProtKB PMID:19524688 NCBI chrNW_004936476:8,730,766...9,160,102 JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO (MGI:MGI:4367675|PMID:19258434) CACAO PMID:19258434 MGI:MGI:4367675 NCBI chrNW_004936527:6,832,286...6,877,938 JBrowse link
G Ros1 ROS proto-oncogene 1, receptor tyrosine kinase ISO (PMID:16885344) UniProtKB PMID:16885344 NCBI chrNW_004936658:382,025...506,818 JBrowse link
G Rragb Ras related GTP binding B ISO (PMID:23723238) UniProtKB PMID:23723238 NCBI chrNW_004936819:946,874...988,531 JBrowse link
G Slc7a1 solute carrier family 7 member 1 ISO RGD PMID:17234578 RGD:1642930 NCBI chrNW_004936472:24,442,907...24,517,834 JBrowse link
G Slc7a3 solute carrier family 7 member 3 ISO RGD PMID:17234578 RGD:1642930 NCBI chrNW_004936762:661,532...667,277 JBrowse link
G Tbck TBC1 domain containing kinase ISO (PMID:23977024) UniProtKB PMID:23977024 NCBI chrNW_004936814:837,394...1,052,220 JBrowse link
G Telo2 telomere maintenance 2 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chrNW_004936694:2,418,223...2,433,630 JBrowse link
G Tmem127 transmembrane protein 127 ISO (MGI:MGI:5565633|PMID:24334765) MGI PMID:24334765 MGI:MGI:5565633 NCBI chrNW_004936744:344,356...359,086 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (MGI:MGI:5906931|PMID:28802038) ARUK-UCL PMID:28802038 MGI:MGI:5906931 NCBI chrNW_004936476:18,659,725...18,665,406 JBrowse link
G Tti1 TELO2 interacting protein 1 ISO (PMID:23263282) UniProtKB PMID:23263282 NCBI chrNW_004936561:3,303,258...3,353,487 JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO (MGI:MGI:3797328|PMID:18443001) MGI PMID:18443001 MGI:MGI:3797328 NCBI chrNW_004936474:22,035,059...22,077,846 JBrowse link
regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C9orf72 C9orf72-SMCR8 complex subunit ISO (MGI:MGI:5811684|PMID:27875531)
(PMID:27559131)
UniProtKB PMID:27559131, PMID:27875531 MGI:MGI:5811684 NCBI chrNW_004936611:2,074,655...2,101,846 JBrowse link
G Dgkq diacylglycerol kinase theta ISO (PMID:23767959) ParkinsonsUK-UCL PMID:23767959 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 ISO (PMID:23415227) UniProtKB PMID:23415227 NCBI chrNW_004936557:5,947,157...5,956,874 JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit ISO (PMID:27559131) UniProtKB PMID:27559131 NCBI chrNW_004936741:1,838,974...1,848,742 JBrowse link
regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pih1d1 PIH1 domain containing 1 NOT ISO (PMID:24036451) UniProtKB PMID:24036451 NCBI chrNW_004936664:3,321,278...3,326,720 JBrowse link
TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family member 11 ISO (PMID:28628108) UniProtKB PMID:28628108 NCBI chrNW_004936823:580,438...621,298 JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator ISO (PMID:25940091) UniProtKB PMID:25940091 NCBI chrNW_004936515:8,039,887...8,125,006 JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 ISO (MGI:MGI:6155546|PMID:29514215) MGI PMID:29514215 MGI:MGI:6155546 NCBI chrNW_004936642:2,745,889...2,833,286 JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO (PMID:12718876) WormBase PMID:12718876 NCBI chrNW_004936694:1,839,135...1,849,307 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (PMID:28223137)
(PMID:12718876), (PMID:22424946)
UniProtKB
CAFA
PMID:12718876, PMID:22424946, PMID:28223137 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 ISO (PMID:12718876) WormBase PMID:12718876 NCBI chrNW_004936594:4,427,225...4,758,081 JBrowse link
TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prr5l proline rich 5 like ISO (PMID:22609986)
(MGI:MGI:5448916|PMID:22609986)
UniProtKB PMID:22609986 MGI:MGI:5448916 NCBI chrNW_004936533:1,895,594...1,975,442 JBrowse link
G Sesn3 sestrin 3 ISO (MGI:MGI:5779633|PMID:25377878) UniProtKB PMID:25377878 MGI:MGI:5779633 NCBI chrNW_004936700:2,429,535...2,491,752 JBrowse link
G Syap1 synapse associated protein 1 ISO (PMID:23300339)
(MGI:MGI:6114863|PMID:23300339)
UniProtKB PMID:23300339 MGI:MGI:6114863 NCBI chrNW_004936470:5,994,217...6,026,057 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    signaling 4166
      signal transduction 3695
        intracellular signal transduction 1982
          TOR signaling 116
            TORC1 signaling + 40
            TORC2 signaling + 6
            negative regulation of TOR signaling + 44
            positive regulation of TOR signaling + 40
            regulation of TOR signaling + 98
Path 2
Term Annotations click to browse term
  biological_process 11968
    biological regulation 8764
      regulation of biological process 8316
        regulation of cellular process 7896
          signal transduction 3695
            intracellular signal transduction 1982
              TOR signaling 116
                TORC1 signaling + 40
                TORC2 signaling + 6
                negative regulation of TOR signaling + 44
                positive regulation of TOR signaling + 40
                regulation of TOR signaling + 98
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.