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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of TOR signaling
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Accession:GO:0032007 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
Synonyms:exact_synonym: down regulation of TOR signaling pathway;   downregulation of TOR signaling pathway;   negative regulation of TOR signaling pathway;   negative regulation of TOR signalling pathway;   negative regulation of target of rapamycin signaling pathway;   negative regulation of target of rapamycin signalling pathway
 narrow_synonym: inhibition of TOR signaling pathway
 related_synonym: negative regulation of TOR signaling cascade


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negative regulation of TOR signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07029605.1 RGD:1600115
G Akt1s1 AKT1 substrate 1 JBrowse link 1 100,845,443 100,851,961 RGD:1624291
RGD:13792537
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:1600115
RGD:1624291
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:10059647
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:1624291
RGD:13792537
RGD:1600115
RGD:8554300
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit JBrowse link 14 83,089,000 83,219,576 RGD:1624291
RGD:13792537
G Deptor DEP domain containing MTOR-interacting protein JBrowse link 7 94,795,161 95,000,750 RGD:1624291
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1600115
RGD:1624291
G Fnip1 folliculin interacting protein 1 JBrowse link 10 39,786,687 39,870,188 RGD:1624291
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:1624291
RGD:13792537
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Mapkapk5 MAPK activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:1624291
RGD:13792537
G Minar1 membrane integral NOTCH2 associated receptor 1 JBrowse link 8 96,970,556 97,008,687 RGD:1624291
RGD:13792537
RGD:13825189
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:1624291
RGD:13792537
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:1624291
RGD:13792537
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1624291
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1624291
RGD:1600115
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600115
RGD:1624291
G RGD1565472 similar to RIKEN cDNA 2310003P10 JBrowse link 11 39,765,341 39,767,938 RGD:1600115
G Sh3bp4 SH3-domain binding protein 4 JBrowse link 9 96,210,750 96,288,903 RGD:1600115
RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Tbc1d7 TBC1 domain family, member 7 JBrowse link 17 23,774,793 23,792,389 RGD:1624291
RGD:13792537
G Tmem127 transmembrane protein 127 JBrowse link 3 119,677,575 119,690,371 RGD:1624291
G Tnfaip8l1 TNF alpha induced protein 8 like 1 JBrowse link 9 10,894,949 10,905,647 RGD:1624291
RGD:13792537
RGD:1600115
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
RGD:13792537
RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580520
RGD:13792537
RGD:1624291
RGD:1600115
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:13792537
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 JBrowse link 3 112,800,557 112,910,038 RGD:1624291
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 JBrowse link 9 16,003,058 16,080,152 RGD:1624291
negative regulation of TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07029605.1 RGD:13792537
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
RGD:13792537
G Bmt2 base methyltransferase of 25S rRNA 2 homolog JBrowse link 4 40,064,131 40,136,074 RGD:1624291
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 JBrowse link 14 84,447,552 84,457,396 RGD:1624291
RGD:13792537
RGD:1600115
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 JBrowse link 12 25,595,800 25,638,806 RGD:1624291
RGD:13792537
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit JBrowse link 14 83,089,000 83,219,576 RGD:1624291
G Fnip2 folliculin interacting protein 2 JBrowse link 2 178,223,561 178,334,925 RGD:13792537
G Itfg2 integrin alpha FG-GAP repeat containing 2 JBrowse link 4 161,730,643 161,744,281 RGD:1624291
G Kptn kaptin (actin binding protein) JBrowse link 1 78,015,714 78,016,508 RGD:1624291
G Kptn kaptin RGD:13792537
G RGD1565498 similar to Hypothetical protein LOC270802 JBrowse link 7 63,922,871 63,937,721 RGD:1624291
RGD:13792537
G Rnf152 ring finger protein 152 JBrowse link 13 25,183,295 25,262,785 RGD:1624291
RGD:1600115
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:1624291
RGD:13792537
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
RGD:13792537
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:1624291
RGD:13792537
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Szt2 SZT2 subunit of KICSTOR complex JBrowse link 5 137,192,120 137,238,384 RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    negative regulation of biological process 5617
      negative regulation of signaling 1396
        negative regulation of signal transduction 1232
          negative regulation of intracellular signal transduction 546
            negative regulation of TOR signaling 48
              negative regulation of TORC1 signaling 18
              negative regulation of TORC2 signaling 0
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              TOR signaling 130
                regulation of TOR signaling 108
                  negative regulation of TOR signaling 48
                    negative regulation of TORC1 signaling 18
                    negative regulation of TORC2 signaling 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.