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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of nuclease activity
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Accession:GO:0032069 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.
Synonyms:related_synonym: nuclease regulator activity


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negative regulation of deoxyribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha ISO (PMID:19944011) RGD PMID:19944011 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
negative regulation of endodeoxyribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzma granzyme A ISO (PMID:12524539) RGD PMID:12524539 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
negative regulation of endoribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 ISO (PMID:7539425) RGD PMID:7539425 NCBI chr19:31,867,960...31,892,863
Ensembl chr19:31,867,981...31,892,863
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 ISO
IEA
(PMID:19328063)
GO_REF:0000107
(MGI:MGI:3840374|PMID:19328063)
RGD
Ensembl
PMID:19328063 GO_REF:0000107, MGI:MGI:3840374 NCBI chr 7:141,039,433...141,070,269
Ensembl chr 7:141,034,982...141,069,989
JBrowse link
negative regulation of exonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf1 telomeric repeat binding factor 1 ISO
IBA
(PMID:15200954)
PMID:21873635
RGD PMID:15200954, PMID:21873635 RGD:13792537 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Terf2 telomeric repeat binding factor 2 ISO (PMID:15200954) RGD PMID:15200954 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
negative regulation of nuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neil1 nei-like DNA glycosylase 1 ISO (PMID:17611195) RGD PMID:17611195 NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102
JBrowse link
positive regulation of deoxyribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcna proliferating cell nuclear antigen ISO
ISS
(PMID:19443450)
GO_REF:0000024
RGD
UniProt
PMID:19443450 GO_REF:0000024 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
positive regulation of endodeoxyribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:20605787) RGD PMID:20605787 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ddx11 DEAD/H-box helicase 11 ISO (PMID:18499658) RGD PMID:18499658 NCBI chr 9:114,113,642...114,133,908
Ensembl chr 9:114,111,580...114,132,492
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
(PMID:19059439)
GO_REF:0000107
RGD
Ensembl
PMID:19059439 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Rps3 ribosomal protein S3 ISO (PMID:18973764) RGD PMID:18973764 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
positive regulation of endoribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
positive regulation of exoribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tcea1 transcription elongation factor A1 IDA RGD PMID:16046193 RGD:9693728 NCBI chr 5:14,511,183...14,548,494
Ensembl chr 5:14,511,183...14,548,429
JBrowse link
positive regulation of nuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb2 high mobility group box 2 ISO (PMID:978439) RGD PMID:978439 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
regulation of endodeoxyribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npm1 nucleophosmin 1 ISO
ISS
(PMID:19188445)
GO_REF:0000024
RGD
UniProt
PMID:19188445 GO_REF:0000024 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:19934257)
GO_REF:0000107
RGD
Ensembl
PMID:19934257 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
regulation of endoribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npm1 nucleophosmin 1 ISO
ISS
(PMID:19188445)
GO_REF:0000024
RGD
UniProt
PMID:19188445 GO_REF:0000024 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
regulation of restriction endodeoxyribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 ISO (PMID:17803946) RGD PMID:17803946 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
regulation of ribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103689988 2'-5'-oligoadenylate synthase 1A-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:42,367,110...42,376,531
Ensembl chr12:42,367,535...42,376,426
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A ISO
IBA
(PMID:19923450)
PMID:21873635
RGD PMID:19923450, PMID:21873635 RGD:13792537 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas1b 2-5 oligoadenylate synthetase 1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,255,762...41,266,430
Ensembl chr12:41,227,825...41,307,352
JBrowse link
G Oas1e 2'-5' oligoadenylate synthetase 1E IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,281,479...41,290,500
Ensembl chr12:41,281,559...41,290,497
JBrowse link
G Oas1g 2'-5' oligoadenylate synthetase 1G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:42,343,103...42,355,139
Ensembl chr12:42,343,123...42,355,131
JBrowse link
G Oas1h 2 ' -5 ' oligoadenylate synthetase 1H IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,214,587...41,224,254
Ensembl chr12:41,214,587...41,224,254
JBrowse link
G Oas1i 2 ' -5 ' oligoadenylate synthetase 1I IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,155,489...41,167,501
Ensembl chr12:41,155,497...41,167,505
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 ISO
IEA
IBA
(PMID:19923450)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:19923450, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Oasl2 2'-5' oligoadenylate synthetase-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:47,470,074...47,483,131
Ensembl chr12:47,469,598...47,482,961
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    regulation of biological process 13075
      regulation of metabolic process 6985
        regulation of macromolecule metabolic process 6491
          regulation of nuclease activity 30
            negative regulation of nuclease activity + 7
            positive regulation of nuclease activity + 9
            regulation of deoxyribonuclease activity + 10
            regulation of exonuclease activity + 3
            regulation of ribonuclease activity + 17
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of metabolic process 6985
          regulation of macromolecule metabolic process 6491
            regulation of nuclease activity 30
              negative regulation of nuclease activity + 7
              positive regulation of nuclease activity + 9
              regulation of deoxyribonuclease activity + 10
              regulation of exonuclease activity + 3
              regulation of ribonuclease activity + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.