ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein binding
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Accession:GO:0032091 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
Synonyms:exact_synonym: down regulation of protein binding;   downregulation of protein binding
 narrow_synonym: inhibition of protein binding


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negative regulation of protein binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1624291
RGD:1600115
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:1624291
RGD:1600115
G Adnp activity-dependent neuroprotector homeobox JBrowse link 3 164,937,188 164,964,819 RGD:2312790
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1600115
RGD:1624291
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:1600115
RGD:1624291
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:1624291
RGD:1600115
G Bag2 Bcl2-associated athanogene 2 JBrowse link 9 38,456,487 38,467,120 RGD:1624291
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Camk1 calcium/calmodulin-dependent protein kinase I JBrowse link 4 145,289,300 145,300,146 RGD:1624291
RGD:1600115
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:1624291
RGD:1600115
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Ccm2l CCM2 like scaffold protein JBrowse link 3 148,541,404 148,557,464 RGD:1624291
RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cfhr1 complement factor H-related 1 JBrowse link 13 56,862,666 56,877,650 RGD:1624291
G Ckmt1 creatine kinase, mitochondrial 1 JBrowse link 3 113,318,559 113,324,459 RGD:1624291
RGD:1600115
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:1624291
G Ctnnbip1 catenin, beta-interacting protein 1 JBrowse link 5 166,464,170 166,513,030 RGD:1624291
RGD:1600115
G Ctsz cathepsin Z JBrowse link 3 172,527,107 172,537,877 RGD:1624291
RGD:1600115
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
RGD:1600115
G Dact1 dishevelled-binding antagonist of beta-catenin 1 JBrowse link 6 93,740,440 93,751,003 RGD:1624291
RGD:1600115
G Ddx11 DEAD/H-box helicase 11 JBrowse link 9 114,113,642 114,133,908 RGD:1624291
RGD:1600115
G Disc1 DISC1 scaffold protein JBrowse link 19 57,818,838 58,069,992 RGD:1624291
RGD:1600115
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 9 82,436,453 82,444,669 RGD:1624291
RGD:1600115
G Dtnbp1 dystrobrevin binding protein 1 JBrowse link 17 20,090,136 20,182,332 RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
RGD:1600115
G Dysf dysferlin JBrowse link 4 115,700,942 115,901,873 RGD:1624291
G Efhb EF hand domain family, member B JBrowse link 9 47,988 120,800 RGD:1600115
RGD:1624291
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 JBrowse link 13 35,622,472 35,673,449 RGD:1624291
RGD:1600115
G Fam192a family with sequence similarity 192, member A JBrowse link 19 10,827,057 10,856,747 RGD:1600115
RGD:1624291
G Frmd7 FERM domain containing 7 JBrowse link X 138,095,707 138,149,702 RGD:1624291
RGD:1600115
G Gnl3l G protein nucleolar 3 like JBrowse link X 20,037,558 20,070,505 RGD:1624291
RGD:1600115
G Golga2 golgin A2 JBrowse link 3 11,317,328 11,337,569 RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
RGD:1600115
G Gtf2f1 general transcription factor IIF subunit 1 JBrowse link 9 10,032,806 10,042,392 RGD:1600115
RGD:1624291
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:2303817
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 3 148,214,623 148,216,715 RGD:9686139
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 JBrowse link 1 252,894,663 252,900,727 RGD:1624291
RGD:1600115
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
RGD:1600115
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:1624291
RGD:1600115
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:1600115
RGD:1624291
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:12789709
G Mitd1 microtubule interacting and trafficking domain containing 1 JBrowse link 9 44,472,364 44,483,723 RGD:1624291
RGD:1600115
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:1624291
G Nes nestin JBrowse link 2 187,343,109 187,352,972 RGD:1624291
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1600115
RGD:1624291
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1600115
RGD:1624291
G Pex14 peroxisomal biogenesis factor 14 JBrowse link 5 165,782,895 165,918,445 RGD:1624291
RGD:1600115
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:1624291
RGD:1600115
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:1624291
RGD:1600115
G Plscr1 phospholipid scramblase 1 JBrowse link 8 99,625,523 99,645,882 RGD:1624291
RGD:1600115
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:5687133
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 JBrowse link 11 72,748,789 73,034,683 RGD:1299366
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:1600115
RGD:1624291
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1600115
RGD:1624291
G Senp2 SUMO specific peptidase 2 JBrowse link 11 82,627,973 82,664,702 RGD:1299408
G Slpi secretory leukocyte peptidase inhibitor JBrowse link 3 160,799,979 160,802,228 RGD:1624291
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
RGD:1600115
G Styx serine/threonine/tyrosine interacting protein JBrowse link 15 19,690,079 19,720,683 RGD:1624291
RGD:13792537
G Sympk symplekin JBrowse link 1 79,931,097 79,959,461 RGD:1600115
RGD:1624291
G Tdg thymine-DNA glycosylase JBrowse link 7 27,194,000 27,213,676 RGD:1624291
RGD:1600115
G Tex14 testis expressed 14, intercellular bridge forming factor JBrowse link 10 74,724,070 74,849,172 RGD:1624291
RGD:1600115
G Tfip11 tuftelin interacting protein 11 JBrowse link 12 50,320,820 50,333,052 RGD:1624291
RGD:1600115
G Tle5 TLE family member 5, transcriptional modulator JBrowse link 7 11,012,843 11,018,156 RGD:1624291
RGD:1600115
G Tmbim6 transmembrane BAX inhibitor motif containing 6 JBrowse link 7 141,039,433 141,070,269 RGD:1624291
RGD:1600115
G Tmc8 transmembrane channel-like 8 JBrowse link 10 106,784,819 106,795,307 RGD:1624291
RGD:1600115
G Ttbk1 tau tubulin kinase 1 JBrowse link 9 16,862,305 16,899,399 RGD:1624291
RGD:1600115
G Usp33 ubiquitin specific peptidase 33 JBrowse link 2 257,567,179 257,602,817 RGD:1624291
RGD:1600115
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 JBrowse link 10 15,243,429 15,245,757 RGD:1624291
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 JBrowse link 10 81,936,156 81,943,142 RGD:1624291
RGD:1600115
G Xirp1 xin actin-binding repeat containing 1 JBrowse link 8 128,694,809 128,712,092 RGD:1624291
G Zfpm1 zinc finger protein, multitype 1 JBrowse link 19 55,094,585 55,150,994 RGD:1624291
RGD:1600115
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:1624291
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5509896
RGD:1624291
negative regulation of actin filament binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crmp1 collapsin response mediator protein 1 JBrowse link 14 78,266,931 78,312,777 RGD:1624291
RGD:1600115
negative regulation of apolipoprotein binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
RGD:1600115
negative regulation of C-C chemokine binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl6 chemokine (C-C motif) ligand 6 JBrowse link 10 70,798,118 70,802,750 RGD:1624291
negative regulation of cytokine activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
RGD:1600115
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
negative regulation of estrogen receptor binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:1600115
RGD:1624291
G Nkx3-1 NK3 homeobox 1 JBrowse link 15 51,065,316 51,067,908 RGD:1624291
RGD:1600115
G Ruvbl2 RuvB-like AAA ATPase 2 JBrowse link 1 101,413,766 101,426,970 RGD:1624291
RGD:1600115
negative regulation of guanyl-nucleotide exchange factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha JBrowse link 12 37,444,136 37,452,391 RGD:1581075
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta JBrowse link 6 26,546,917 26,552,474 RGD:1581075
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:1581075
G Gpsm1 G-protein signaling modulator 1 JBrowse link 3 3,767,394 3,794,360 RGD:1624291
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1600115
RGD:1624291
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:1624291
RGD:1600115
negative regulation of low-density lipoprotein particle receptor binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 5 126,031,368 126,053,726 RGD:1624291
RGD:1600115
negative regulation of microtubule binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:13514087
G Ttbk2 tau tubulin kinase 2 JBrowse link 3 112,677,932 112,789,615 RGD:1624291
RGD:1600115
negative regulation of protein homodimerization activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1600115
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 3 148,214,623 148,216,715 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:8554127
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1624291
RGD:1600115
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:1624291
negative regulation of receptor binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam15 ADAM metallopeptidase domain 15 JBrowse link 2 188,661,831 188,672,337 RGD:1624291
RGD:1600115
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
RGD:1600115
G Crtac1 cartilage acidic protein 1 JBrowse link 1 261,527,009 261,669,614 RGD:1624291
RGD:1600115
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:1624291
RGD:1600115
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1600115
RGD:1624291
G Rgma repulsive guidance molecule BMP co-receptor a JBrowse link 1 134,699,053 134,742,512 RGD:1624291
RGD:1600115
negative regulation of Rho guanyl-nucleotide exchange factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1624291
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115

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Term Annotations click to browse term
  biological_process 17928
    biological regulation 12623
      regulation of molecular function 2872
        regulation of binding 413
          regulation of protein binding 247
            negative regulation of protein binding 110
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
              negative regulation of C-C chemokine binding 1
              negative regulation of Ras GTPase binding + 2
              negative regulation of actin binding + 1
              negative regulation of apolipoprotein binding 1
              negative regulation of guanyl-nucleotide exchange factor activity + 8
              negative regulation of heparan sulfate proteoglycan binding 0
              negative regulation of microtubule binding + 2
              negative regulation of protein homodimerization activity 5
              negative regulation of receptor binding + 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.