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ONTOLOGY REPORT - ANNOTATIONS


Term:icosanoid secretion
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Accession:GO:0032309 term browser browse the term
Definition:The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.
Synonyms:exact_synonym: eicosanoid secretion


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arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO
IEA
(PMID:17077303)
GO_REF:0000107
RGD
Ensembl
PMID:17077303 GO_REF:0000107 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Anxa1 annexin A1 IBA
ISO
PMID:21873635
MGI:2449710 (MGI:2661244|PMID:12553880)
RGD PMID:12553880, PMID:21873635 MGI:2661244, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO
IEA
(PMID:17077303)
GO_REF:0000107
RGD
Ensembl
PMID:17077303 GO_REF:0000107 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Drd2 dopamine receptor D2 ISO (PMID:8301582) RGD PMID:8301582 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 ISO (PMID:8301582) RGD PMID:8301582 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 ISO
IEA
(PMID:7512953)
GO_REF:0000107
RGD
Ensembl
PMID:7512953 GO_REF:0000107 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Kiss1r KISS1 receptor IDA RGD PMID:11457843 RGD:1357971 NCBI chr 7:12,606,210...12,609,868
Ensembl chr 7:12,606,210...12,609,868
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor IDA RGD PMID:9291830 RGD:1600299 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G LOC102546467 HERV-H LTR-associating protein 1-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:106,442,364...106,485,324
Ensembl chr 7:106,441,257...106,465,830
JBrowse link
G Nmb neuromedin B IDA stimulates RGD PMID:8532598 RGD:1642335 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nmur2 neuromedin U receptor 2 ISO (PMID:10887190) RGD PMID:10887190 NCBI chr10:41,392,663...41,408,518
Ensembl chr10:41,392,666...41,408,518
JBrowse link
G Oc90 otoconin 90 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:106,615,859...106,697,089
Ensembl chr 7:106,619,326...106,653,567
JBrowse link
G Pla2g10 phospholipase A2, group X IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Pla2g12a phospholipase A2, group XIIA IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Pla2g12b phospholipase A2, group XIIB IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:28,989,440...29,007,967
Ensembl chr20:28,989,491...29,007,968
JBrowse link
G Pla2g1b phospholipase A2 group IB NOT IEA
ISO
GO_REF:0000002
(PMID:15528384)
InterPro
RGD
PMID:15528384 GO_REF:0000002 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g2a phospholipase A2 group IIA IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g2c phospholipase A2, group IIC IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:157,163,672...157,187,654
Ensembl chr 5:157,165,341...157,187,643
JBrowse link
G Pla2g2d phospholipase A2, group IID IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:157,222,636...157,228,795
Ensembl chr 5:157,222,636...157,228,791
JBrowse link
G Pla2g2f phospholipase A2, group IIF IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:157,192,047...157,217,265
Ensembl chr 5:157,193,053...157,199,441
JBrowse link
G Pla2g3 phospholipase A2, group III IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pla2g4a phospholipase A2 group IVA IEA
ISO
GO_REF:0000107
(MGI:3709446|PMID:17293613), (MGI:5297793|PMID:10946309)
Ensembl
RGD
PMID:10946309, PMID:17293613 GO_REF:0000107, MGI:3709446, MGI:5297793 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Pla2g4f phospholipase A2, group IVF ISO (MGI:3709446|PMID:17293613) RGD PMID:17293613 MGI:3709446 NCBI chr 3:112,068,617...112,083,978
Ensembl chr 3:112,072,330...112,084,144
JBrowse link
G Pla2g5 phospholipase A2, group V IDA
ISO
IBA
(MGI:5297792|PMID:11830583)
PMID:21873635
RGD PMID:11830583, PMID:11106649, PMID:21873635 MGI:5297792, RGD:2303037, RGD:13792537 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 ISO (PMID:10833412), (PMID:15695510) RGD PMID:10833412, PMID:15695510 NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785
JBrowse link
G Proca1 protein interacting with cyclin A1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:65,454,451...65,469,491
Ensembl chr10:65,454,658...65,469,490
JBrowse link
negative regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5pf ATP synthase peripheral stalk subunit F6 IDA RGD PMID:9822642 RGD:13800919 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Hrh2 histamine receptor H 2 IDA RGD PMID:1313563 RGD:9685527 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 ISO (MGI:5297792|PMID:11830583) RGD PMID:11830583 MGI:5297792 NCBI chr 3:46,488,963...46,621,873
Ensembl chr 3:46,488,186...46,621,873
JBrowse link
negative regulation of icosanoid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:18799632 RGD:2313549 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
negative regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 ISO (PMID:21242590) RGD PMID:21242590 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 IMP
IDA
RGD PMID:19474762, PMID:11581303 RGD:13800898, RGD:13800911 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
positive regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1b arginine vasopressin receptor 1B ISO (PMID:9322919) RGD PMID:9322919 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Mif macrophage migration inhibitory factor ISO (MGI:4437204|PMID:10364264) RGD PMID:10364264 MGI:4437204 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:11852105 RGD:9743869 NCBI chr 3:175,982,313...176,046,345
Ensembl chr 3:175,885,894...176,046,345
JBrowse link
G Pla2g10 phospholipase A2, group X IEA
ISO
GO_REF:0000107
(MGI:5051938|PMID:20844270)
Ensembl
RGD
PMID:20844270 GO_REF:0000107, MGI:5051938 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Pla2g6 phospholipase A2 group VI IMP
IDA
RGD PMID:20732873, PMID:15576376 RGD:6482749, RGD:6482753 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 ISS
ISO
GO_REF:0000024
(MGI:5297793|PMID:10946309)
UniProt
RGD
PMID:10946309 GO_REF:0000024, MGI:5297793 NCBI chr 3:46,488,963...46,621,873
Ensembl chr 3:46,488,186...46,621,873
JBrowse link
G Sstr4 somatostatin receptor 4 IDA RGD PMID:8175684 RGD:2325010 NCBI chr 3:142,739,781...142,741,644
Ensembl chr 3:142,739,781...142,741,644
JBrowse link
positive regulation of fever generation by positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11a TNF receptor superfamily member 11A ISO (MGI:4413614|PMID:19940926) RGD PMID:19940926 MGI:4413614 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO (MGI:4413614|PMID:19940926) RGD PMID:19940926 MGI:4413614 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
positive regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 IDA RGD PMID:1324048 RGD:8662308 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Il1a interleukin 1 alpha IDA RGD PMID:8612624 RGD:7800677 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta IEA
ISO
GO_REF:0000107
(MGI:4413614|PMID:19940926)
Ensembl
RGD
PMID:19940926 GO_REF:0000107, MGI:4413614 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IMP RGD PMID:12649265 RGD:7495834 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:9786861 RGD:2304243 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:9575824 RGD:2304227 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO MGI:2386080 (MGI:3616954|PMID:16269410) RGD PMID:16269410 MGI:3616954 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA RGD PMID:15840771 RGD:2316683 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Pla2g10 phospholipase A2, group X ISO
IEA
(PMID:18511424)
GO_REF:0000107
RGD
Ensembl
PMID:18511424 GO_REF:0000107 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Pla2g3 phospholipase A2, group III ISO MGI:4461174 (MGI:6108995|PMID:28947740) RGD PMID:28947740 MGI:6108995 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pla2g4a phospholipase A2 group IVA IEA
ISO
GO_REF:0000107
MGI:2385582 (MGI:5779244|PMID:26828067)
Ensembl
RGD
PMID:26828067 GO_REF:0000107, MGI:5779244 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Ptges prostaglandin E synthase ISO MGI:3051640 (MGI:5779244|PMID:26828067) RGD PMID:26828067 MGI:5779244 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO (PMID:19790068) RGD PMID:19790068 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
positive regulation of prostaglandin secretion involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mif macrophage migration inhibitory factor ISO (MGI:2156302|PMID:11756671) RGD PMID:11756671 MGI:2156302 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 ISO (PMID:25173977) RGD PMID:25173977 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Lep leptin ISO
ISS
(PMID:19688109)
GO_REF:0000024
RGD
UniProt
PMID:19688109 GO_REF:0000024 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nos2 nitric oxide synthase 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19688109)
Ensembl
UniProt
RGD
PMID:19688109 GO_REF:0000024, GO_REF:0000107 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
regulation of arachidonic acid secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syk spleen associated tyrosine kinase IEA
ISO
ISS
GO_REF:0000107
(MGI:87668|PMID:9171347)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9171347 GO_REF:0000024, GO_REF:0000107, MGI:87668 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
regulation of prostaglandin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 ISO (PMID:18703674) RGD PMID:18703674 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          secretion 1152
            icosanoid secretion 53
              arachidonic acid secretion + 35
              negative regulation of icosanoid secretion + 5
              positive regulation of icosanoid secretion + 21
              prostaglandin secretion + 22
              regulation of icosanoid secretion + 27
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          ion transport 3500
            anion transport 2681
              organic substance transport 2558
                organic anion transport 384
                  carboxylic acid transport 299
                    icosanoid transport 58
                      icosanoid secretion 53
                        arachidonic acid secretion + 35
                        negative regulation of icosanoid secretion + 5
                        positive regulation of icosanoid secretion + 21
                        prostaglandin secretion + 22
                        regulation of icosanoid secretion + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.