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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
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Accession:GO:0032436 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms:exact_synonym: up regulation of proteasomal ubiquitin-dependent protein catabolic process;   upregulation of proteasomal ubiquitin-dependent protein catabolic process
 narrow_synonym: activation of proteasomal ubiquitin-dependent protein catabolic process;   stimulation of proteasomal ubiquitin-dependent protein catabolic process


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positive regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC135026.1 RGD:13792537
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Ankib1 ankyrin repeat and IBR domain containing 1 JBrowse link 4 27,473,477 27,597,206 RGD:13792537
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 JBrowse link 8 64,166,359 64,268,555 RGD:13792537
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 JBrowse link 8 117,387,004 117,446,085 RGD:13792537
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1624291
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:1624291
RGD:1600115
G Axin1 axin 1 RGD:1624291
G Bag2 BAG cochaperone 2 JBrowse link 9 38,456,487 38,467,120 RGD:1624291
G Bbs7 Bardet-Biedl syndrome 7 JBrowse link 2 123,283,402 123,322,991 RGD:1624291
G Cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 JBrowse link 19 55,438,409 55,510,652 RGD:1624291
G Chfr checkpoint with forkhead and ring finger domains JBrowse link 12 52,562,594 52,596,162 RGD:1624291
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:1600115
RGD:13792537
RGD:1624291
G Cop1 COP1, E3 ubiquitin ligase JBrowse link 13 76,942,883 77,076,015 RGD:1624291
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:1600115
RGD:1624291
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:1624291
RGD:13792537
RGD:1600115
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
RGD:1600115
G Dda1 DET1 and DDB1 associated 1 JBrowse link 16 19,877,873 19,885,501 RGD:13792537
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1624291
G Det1 DET1 partner of COP1 E3 ubiquitin ligase JBrowse link 1 140,519,755 140,535,969 RGD:1624291
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 9 82,436,453 82,444,669 RGD:1624291
RGD:13792537
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
G Fam122a family with sequence similarity 122A JBrowse link 1 242,372,458 242,373,764 RGD:1600115
RGD:1624291
G Fbxo22 F-box protein 22 JBrowse link 8 59,770,032 59,786,061 RGD:1624291
RGD:13792537
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:1624291
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
RGD:1600115
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
RGD:13792537
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
RGD:13792537
G Hspbp1 HSPA (Hsp70) binding protein 1 JBrowse link 1 72,732,418 72,756,087 RGD:1624291
G Il33 interleukin 33 JBrowse link 1 248,112,611 248,147,030 RGD:1624291
RGD:1600115
G Klhl40 kelch-like family member 40 JBrowse link 8 130,416,265 130,421,871 RGD:1624291
G LOC108348108 heat shock 70 kDa protein 1A JBrowse link 20 2,699,707 2,701,856 RGD:13792537
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Nkd2 NKD inhibitor of WNT signaling pathway 2 JBrowse link 1 32,054,390 32,085,416 RGD:1624291
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
G Nub1 negative regulator of ubiquitin-like proteins 1 JBrowse link 4 6,950,870 6,981,400 RGD:1624291
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:1624291
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:1600115
RGD:1624291
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:7241135
G Prickle1 prickle planar cell polarity protein 1 JBrowse link 7 134,702,964 134,799,437 RGD:1624291
RGD:1600115
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
RGD:13792537
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:1624291
RGD:1600115
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
RGD:1600115
G Rad23a RAD23 homolog A, nucleotide excision repair protein JBrowse link 19 25,949,488 25,956,677 RGD:1624291
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:1624291
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link 14 17,615,968 17,631,715 RGD:1624291
G Rnf14 ring finger protein 14 JBrowse link 18 31,443,424 31,468,641 RGD:13792537
G Rnf144a ring finger protein 144A JBrowse link 6 45,509,895 45,629,233 RGD:13792537
G Rnf144b ring finger protein 144B JBrowse link 17 17,817,122 17,947,777 RGD:13792537
G Rnf180 ring finger protein 180 JBrowse link 2 35,718,100 35,892,578 RGD:1624291
RGD:1600115
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase JBrowse link 7 75,058,758 75,098,331 RGD:13792537
G Rnf19b ring finger protein 19B JBrowse link 5 147,246,032 147,270,892 RGD:13792537
G Rnf217 ring finger protein 217 JBrowse link 1 28,301,960 28,391,582 RGD:13792537
G Sh3rf2 SH3 domain containing ring finger 2 JBrowse link 18 36,371,041 36,471,020 RGD:13673844
RGD:1624291
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:1624291
RGD:1600115
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1624291
RGD:1600115
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
G Sumo1 small ubiquitin-like modifier 1 JBrowse link 9 66,453,428 66,483,614 RGD:1624291
G Sumo2 small ubiquitin-like modifier 2 JBrowse link 10 104,085,401 104,097,983 RGD:1624291
G Taf1 TATA-box binding protein associated factor 1 JBrowse link X 71,412,291 71,486,456 RGD:1624291
G Trib1 tribbles pseudokinase 1 JBrowse link 7 99,954,492 99,961,026 RGD:1624291
RGD:13792537
G Trib2 tribbles pseudokinase 2 JBrowse link 6 41,016,722 41,040,972 RGD:1624291
RGD:13792537
G Trib3 tribbles pseudokinase 3 JBrowse link 3 147,814,056 147,819,650 RGD:13792537
G Ube2v2 ubiquitin conjugating enzyme E2 V2 JBrowse link 11 89,557,273 89,591,175 RGD:1299567
G Usp5 ubiquitin specific peptidase 5 JBrowse link 4 157,332,735 157,347,803 RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1599730
RGD:1624291
G Zer1 zyg-11 related, cell cycle regulator JBrowse link 3 8,662,579 8,690,486 RGD:1624291
G Zfand2a zinc finger AN1-type containing 2A JBrowse link 12 17,252,093 17,263,477 RGD:1624291
G Zyg11b zyg-11 family member B, cell cycle regulator JBrowse link 5 127,844,062 127,878,792 RGD:1624291
positive regulation of anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc20 cell division cycle 20 JBrowse link 5 137,260,728 137,264,931 RGD:13792537
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:13792537
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcap31 B-cell receptor-associated protein 31 JBrowse link X 157,094,365 157,126,397 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1600115
RGD:1624291
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:10047316
RGD:1624291
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 7 11,521,949 11,538,691 RGD:1624291
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1600115
RGD:1624291
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plk3 polo-like kinase 3 JBrowse link 5 135,997,725 136,002,900 RGD:1624291
RGD:1600115
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:1600115
RGD:1624291
positive regulation of transcription factor catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxw8 F-box and WD repeat domain containing 8 JBrowse link 12 44,046,204 44,138,138 RGD:1624291
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:1624291
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:1600115
RGD:1624291
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      primary metabolic process 10563
        protein metabolic process 6070
          protein catabolic process 970
            proteasomal protein catabolic process 478
              proteasome-mediated ubiquitin-dependent protein catabolic process 412
                positive regulation of proteasomal ubiquitin-dependent protein catabolic process 89
                  positive regulation of ER-associated ubiquitin-dependent protein catabolic process 6
                  positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                  positive regulation of anaphase-promoting complex-dependent catabolic process 2
                  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia 2
                  positive regulation of transcription factor catabolic process 4
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      organic substance metabolic process 11299
        macromolecule metabolic process 9767
          macromolecule catabolic process 1309
            protein catabolic process 970
              cellular protein catabolic process 804
                proteolysis involved in cellular protein catabolic process 751
                  modification-dependent protein catabolic process 639
                    ubiquitin-dependent protein catabolic process 628
                      proteasome-mediated ubiquitin-dependent protein catabolic process 412
                        regulation of proteasomal ubiquitin-dependent protein catabolic process 131
                          positive regulation of proteasomal ubiquitin-dependent protein catabolic process 89
                            positive regulation of ER-associated ubiquitin-dependent protein catabolic process 6
                            positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                            positive regulation of anaphase-promoting complex-dependent catabolic process 2
                            positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia 2
                            positive regulation of transcription factor catabolic process 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.