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ONTOLOGY REPORT - ANNOTATIONS


Term:histone demethylase activity
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Accession:GO:0032452 term browser browse the term
Definition:Catalysis of the removal of a methyl group from a histone.
Synonyms:xref: Reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3";   reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3";   reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3";   reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3";   reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3";   reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3";   reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3";   reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3";   reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4";   reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters";   reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters";   reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters";   reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3";   reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3";   reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3";   reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3";   reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3";   reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3";   reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4";   reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4"


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histone demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jarid2 jumonji and AT-rich interaction domain containing 2 NOT ISO
IBA
(MGI:MGI:4436818|PMID:20064376)
PMID:21873635
RGD PMID:20064376, PMID:21873635 MGI:MGI:4436818, RGD:13792537 NCBI chr17:20,183,440...20,365,219
Ensembl chr17:20,184,245...20,364,714
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISS
ISO
GO_REF:0000024
(PMID:24498420)
UniProt
RGD
PMID:24498420 GO_REF:0000024 NCBI chr10:105,781,752...105,787,803
Ensembl chr10:105,781,753...105,787,803
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:16079795), (PMID:18066052), (PMID:19497860) RGD PMID:16079795, PMID:18066052, PMID:19497860 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kdm4a lysine demethylase 4A ISO
IBA
(MGI:MGI:3845989|PMID:19144645)
PMID:21873635
RGD PMID:19144645, PMID:21873635 MGI:MGI:3845989, RGD:13792537 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430
JBrowse link
G Kdm4b lysine demethylase 4B ISO
IBA
(MGI:MGI:3845989|PMID:19144645)
PMID:21873635
RGD PMID:19144645, PMID:21873635 MGI:MGI:3845989, RGD:13792537 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Kdm4c lysine demethylase 4C ISO
IBA
(MGI:MGI:3845989|PMID:19144645)
PMID:21873635
(PMID:18066052)
RGD PMID:18066052, PMID:19144645, PMID:21873635 MGI:MGI:3845989, RGD:13792537 NCBI chr 5:90,800,139...91,012,662
Ensembl chr 5:90,800,082...91,012,659
JBrowse link
G Kdm4d lysine demethylase 4D ISO
IBA
(MGI:MGI:3845989|PMID:19144645)
PMID:21873635
RGD PMID:19144645, PMID:21873635 MGI:MGI:3845989, RGD:13792537 NCBI chr 8:12,968,192...12,993,651
Ensembl chr 8:13,511,805...13,513,337
JBrowse link
G Kdm5a lysine demethylase 5A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:152,892,388...152,972,196
Ensembl chr 4:152,892,388...152,972,201
JBrowse link
G Kdm5b lysine demethylase 5B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
G Kdm5c lysine demethylase 5C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:22,302,664...22,349,298
Ensembl chr  X:22,302,485...22,348,627
JBrowse link
G Kdm5d lysine demethylase 5D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  Y:501,058...589,267
Ensembl chr  Y:505,996...589,267
JBrowse link
G LOC108348070 lysine-specific demethylase 4D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:13,511,349...13,513,661
Ensembl chr 8:12,968,193...12,993,651
Ensembl chr 8:12,968,193...12,993,651
JBrowse link
G Phf2 PHD finger protein 2 NOT ISO (PMID:21167174) RGD PMID:21167174 NCBI chr17:16,240,458...16,274,626
Ensembl chr17:16,204,427...16,274,624
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:19843542) RGD PMID:19843542 NCBI chr  X:21,063,487...21,168,750
Ensembl chr  X:21,063,562...21,168,750
JBrowse link
histone demethylase activity (H3-dimethyl-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO
IBA
(PMID:20228790)
(MGI:MGI:5574544|PMID:24843136), (MGI:MGI:6115671|PMID:29370269)
PMID:21873635
RGD PMID:20228790, PMID:24843136, PMID:29370269, PMID:21873635 MGI:MGI:5574544, MGI:MGI:6115671, RGD:13792537 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kdm1b lysine demethylase 1B ISO
IBA
(PMID:23266887)
PMID:21873635
(MGI:MGI:4352982|PMID:19407342), (MGI:MGI:4358629|PMID:19727073)
RGD PMID:19407342, PMID:19727073, PMID:23266887, PMID:21873635 MGI:MGI:4352982, MGI:MGI:4358629, RGD:13792537 NCBI chr17:17,987,972...18,028,808
Ensembl chr17:17,987,972...18,028,808
JBrowse link
G Kdm5a lysine demethylase 5A ISO (PMID:18270511) RGD PMID:18270511 NCBI chr 4:152,892,388...152,972,196
Ensembl chr 4:152,892,388...152,972,201
JBrowse link
G Kdm5b lysine demethylase 5B ISO (PMID:20228790) RGD PMID:20228790 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
histone demethylase activity (H3-K27 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A ISO
IBA
(MGI:MGI:5448135|PMID:22949634)
PMID:21873635
RGD PMID:22949634, PMID:21873635 MGI:MGI:5448135, RGD:13792537 NCBI chr  X:4,805,493...4,945,788
Ensembl chr  X:4,806,277...4,945,944
JBrowse link
G Kdm6b lysine demethylase 6B ISO
IBA
(MGI:MGI:5574281|PMID:23856522)
(PMID:28262558)
PMID:21873635
RGD PMID:23856522, PMID:28262558, PMID:21873635 MGI:MGI:5574281, RGD:13792537 NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885
JBrowse link
G Kdm7a lysine demethylase 7A ISO (MGI:MGI:4437342|PMID:20194436)
(PMID:20023638), (PMID:20194436), (PMID:20622853)
RGD PMID:20023638, PMID:20194436, PMID:20622853 MGI:MGI:4437342 NCBI chr 4:66,915,603...66,957,971
Ensembl chr 4:66,922,013...66,955,732
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20622853), (PMID:20622854) RGD PMID:20622853, PMID:20622854 NCBI chr  X:21,063,487...21,168,750
Ensembl chr  X:21,063,562...21,168,750
JBrowse link
histone demethylase activity (H3-K36 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm2a lysine demethylase 2A ISO (PMID:28262558) RGD PMID:28262558 NCBI chr 1:219,566,130...219,642,294
Ensembl chr 1:219,566,156...219,640,294
JBrowse link
G Kdm2b lysine demethylase 2B ISO (PMID:26237645) RGD PMID:26237645 NCBI chr12:39,021,924...39,161,954
Ensembl chr12:39,078,119...39,161,956
JBrowse link
G Kdm4a lysine demethylase 4A ISO
IBA
(PMID:16024779), (PMID:21914792)
PMID:21873635
RGD PMID:16024779, PMID:21914792, PMID:21873635 RGD:13792537 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430
JBrowse link
G Kdm4b lysine demethylase 4B ISO (PMID:21914792) RGD PMID:21914792 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Kdm4c lysine demethylase 4C ISO
IBA
(PMID:21914792)
PMID:21873635
RGD PMID:21914792, PMID:21873635 RGD:13792537 NCBI chr 5:90,800,139...91,012,662
Ensembl chr 5:90,800,082...91,012,659
JBrowse link
G Kdm7a lysine demethylase 7A ISO (PMID:20622853) RGD PMID:20622853 NCBI chr 4:66,915,603...66,957,971
Ensembl chr 4:66,922,013...66,955,732
JBrowse link
G Kdm8 lysine demethylase 8 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:20457893)
Ensembl
UniProt
RGD
PMID:20457893, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 1:196,838,460...196,854,192
Ensembl chr 1:196,839,321...196,854,180
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20208542), (PMID:20622853) RGD PMID:20208542, PMID:20622853 NCBI chr  X:21,063,487...21,168,750
Ensembl chr  X:21,063,562...21,168,750
JBrowse link
G Riox1 ribosomal oxygenase 1 ISO
IBA
(MGI:MGI:4418587|PMID:19927124)
PMID:21873635
RGD PMID:19927124, PMID:21873635 MGI:MGI:4418587, RGD:13792537 NCBI chr 6:107,428,508...107,431,126
Ensembl chr 6:107,428,508...107,431,116
JBrowse link
G Riox2 ribosomal oxygenase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
G Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked ISO (MGI:MGI:5305502|PMID:22192413) RGD PMID:22192413 MGI:MGI:5305502 NCBI chr  Y:1,065,274...1,206,127
Ensembl chr  Y:989,240...1,206,096
JBrowse link
histone demethylase activity (H3-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO (PMID:15620353) RGD PMID:15620353 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kdm5b lysine demethylase 5B ISO (MGI:MGI:3715069|PMID:17320160)
(PMID:18048344), (PMID:24952722), (PMID:27214403), (PMID:28262558)
RGD PMID:17320160, PMID:18048344, PMID:24952722, PMID:27214403, PMID:28262558 MGI:MGI:3715069 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
G Kdm5c lysine demethylase 5C ISO (PMID:17320160), (PMID:28262558) RGD PMID:17320160, PMID:28262558 NCBI chr  X:22,302,664...22,349,298
Ensembl chr  X:22,302,485...22,348,627
JBrowse link
G Kdm5d lysine demethylase 5D ISO (PMID:17320160) RGD PMID:17320160 NCBI chr  Y:501,058...589,267
Ensembl chr  Y:505,996...589,267
JBrowse link
G Riox1 ribosomal oxygenase 1 ISO
IBA
(MGI:MGI:4418587|PMID:19927124)
PMID:21873635
RGD PMID:19927124, PMID:21873635 MGI:MGI:4418587, RGD:13792537 NCBI chr 6:107,428,508...107,431,126
Ensembl chr 6:107,428,508...107,431,116
JBrowse link
G Riox2 ribosomal oxygenase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
histone demethylase activity (H3-K9 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hr HR, lysine demethylase and nuclear receptor corepressor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276
JBrowse link
G Jmjd1c jumonji domain containing 1C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:22,751,743...22,914,080
Ensembl chr20:22,751,743...22,882,672
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:16079795), (PMID:20228790) RGD PMID:16079795, PMID:20228790 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kdm3a lysine demethylase 3A IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:28262558)
Ensembl
RGD
PMID:28262558, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kdm3b lysine demethylase 3B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:27,593,823...27,631,129
Ensembl chr18:27,576,129...27,631,088
JBrowse link
G Kdm4a lysine demethylase 4A ISO
IBA
(PMID:21914792)
PMID:21873635
RGD PMID:21914792, PMID:21873635 RGD:13792537 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430
JBrowse link
G Kdm4b lysine demethylase 4B ISO
IBA
(MGI:MGI:3629551|PMID:16738407)
PMID:21873635
(PMID:21914792), (PMID:28262558)
RGD PMID:16738407, PMID:21914792, PMID:28262558, PMID:21873635 MGI:MGI:3629551, RGD:13792537 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Kdm4c lysine demethylase 4C ISO
IBA
(PMID:17277772), (PMID:18066052), (PMID:21914792), (PMID:28262558)
PMID:21873635
RGD PMID:17277772, PMID:18066052, PMID:21914792, PMID:28262558, PMID:21873635 RGD:13792537 NCBI chr 5:90,800,139...91,012,662
Ensembl chr 5:90,800,082...91,012,659
JBrowse link
G Kdm4d lysine demethylase 4D ISO
IBA
(MGI:MGI:5552986|PMID:24550317)
PMID:21873635
(PMID:21914792), (PMID:25124442)
RGD PMID:21914792, PMID:24550317, PMID:25124442, PMID:21873635 MGI:MGI:5552986, RGD:13792537 NCBI chr 8:12,968,192...12,993,651
Ensembl chr 8:13,511,805...13,513,337
JBrowse link
G Kdm7a lysine demethylase 7A ISO (MGI:MGI:4437342|PMID:20194436)
(PMID:20023638), (PMID:20194436), (PMID:20622853)
RGD PMID:20023638, PMID:20194436, PMID:20622853 MGI:MGI:4437342 NCBI chr 4:66,915,603...66,957,971
Ensembl chr 4:66,922,013...66,955,732
JBrowse link
G LOC108348070 lysine-specific demethylase 4D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:13,511,349...13,513,661
Ensembl chr 8:12,968,193...12,993,651
Ensembl chr 8:12,968,193...12,993,651
JBrowse link
G Phf2 PHD finger protein 2 ISO (PMID:21532585) RGD PMID:21532585 NCBI chr17:16,240,458...16,274,626
Ensembl chr17:16,204,427...16,274,624
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20023638), (PMID:20208542), (PMID:20346720), (PMID:20622853), (PMID:20622854) RGD PMID:20023638, PMID:20208542, PMID:20346720, PMID:20622853, PMID:20622854 NCBI chr  X:21,063,487...21,168,750
Ensembl chr  X:21,063,562...21,168,750
JBrowse link
histone demethylase activity (H3-monomethyl-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO (MGI:MGI:6115671|PMID:29370269) RGD PMID:29370269 MGI:MGI:6115671 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kdm1b lysine demethylase 1B ISO (PMID:23266887)
(MGI:MGI:4352982|PMID:19407342), (MGI:MGI:4358629|PMID:19727073)
RGD PMID:19407342, PMID:19727073, PMID:23266887 MGI:MGI:4352982, MGI:MGI:4358629 NCBI chr17:17,987,972...18,028,808
Ensembl chr17:17,987,972...18,028,808
JBrowse link
histone demethylase activity (H3-R2 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISO
ISS
(PMID:17947579)
GO_REF:0000024
RGD
UniProt
PMID:17947579 GO_REF:0000024 NCBI chr10:105,781,752...105,787,803
Ensembl chr10:105,781,753...105,787,803
JBrowse link
histone demethylase activity (H3-trimethyl-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jarid2 jumonji and AT-rich interaction domain containing 2 NOT IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:20,183,440...20,365,219
Ensembl chr17:20,184,245...20,364,714
JBrowse link
G Kdm1b lysine demethylase 1B NOT ISO (MGI:MGI:4352982|PMID:19407342), (MGI:MGI:4358629|PMID:19727073) RGD PMID:19407342, PMID:19727073 MGI:MGI:4352982, MGI:MGI:4358629 NCBI chr17:17,987,972...18,028,808
Ensembl chr17:17,987,972...18,028,808
JBrowse link
G Kdm5a lysine demethylase 5A ISO
IBA
(PMID:18270511)
PMID:21873635
RGD PMID:18270511, PMID:21873635 RGD:13792537 NCBI chr 4:152,892,388...152,972,196
Ensembl chr 4:152,892,388...152,972,201
JBrowse link
G Kdm5b lysine demethylase 5B ISO
IBA
(PMID:20228790), (PMID:20403335)
PMID:21873635
RGD PMID:20228790, PMID:20403335, PMID:21873635 RGD:13792537 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
G Kdm5c lysine demethylase 5C IBA
IEA
PMID:21873635
GO_REF:0000003
UniProt PMID:21873635 GO_REF:0000003, RGD:13792537 NCBI chr  X:22,302,664...22,349,298
Ensembl chr  X:22,302,485...22,348,627
JBrowse link
G Kdm5d lysine demethylase 5D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  Y:501,058...589,267
Ensembl chr  Y:505,996...589,267
JBrowse link
histone demethylase activity (H4-K20 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm7a lysine demethylase 7A ISO (PMID:20622853) RGD PMID:20622853 NCBI chr 4:66,915,603...66,957,971
Ensembl chr 4:66,922,013...66,955,732
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20622853), (PMID:20622854) RGD PMID:20622853, PMID:20622854 NCBI chr  X:21,063,487...21,168,750
Ensembl chr  X:21,063,562...21,168,750
JBrowse link
histone demethylase activity (H4-R3 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISS
ISO
GO_REF:0000024
(PMID:17947579), (PMID:24360279)
UniProt
RGD
PMID:17947579, PMID:24360279 GO_REF:0000024 NCBI chr10:105,781,752...105,787,803
Ensembl chr10:105,781,753...105,787,803
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.