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ONTOLOGY REPORT - ANNOTATIONS


Term:histone demethylase activity
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Accession:GO:0032452 term browser browse the term
Definition:Catalysis of the removal of a methyl group from a histone.
Synonyms:xref: Reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3";   reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3";   reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3";   reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3";   reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3";   reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3";   reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3";   reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3";   reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4";   reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters";   reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters";   reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters";   reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3";   reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3";   reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3";   reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3";   reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3";   reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3";   reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4";   reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4"


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histone demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jarid2 jumonji and AT-rich interaction domain containing 2 NOT ISO (MGI:MGI:4436818|PMID:20064376) UniProtKB PMID:20064376 MGI:MGI:4436818 NCBI chrNW_004955590:383,810...512,854
Ensembl chrNW_004955590:384,817...626,684
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISO (PMID:24498420) UniProt PMID:24498420 NCBI chrNW_004955506:5,577,735...5,588,307
Ensembl chrNW_004955506:5,577,437...5,588,372
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:19497860)
(PMID:16079795), (PMID:18066052)
BHF-UCL
Reactome
PMID:16079795, PMID:18066052, PMID:19497860 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G Kdm4a lysine demethylase 4A ISO (MGI:MGI:3845989|PMID:19144645) MGI PMID:19144645 MGI:MGI:3845989 NCBI chrNW_004955537:3,199,394...3,255,945 JBrowse link
G Kdm4b lysine demethylase 4B ISO (MGI:MGI:3845989|PMID:19144645) MGI PMID:19144645 MGI:MGI:3845989 NCBI chrNW_004955495:4,019,066...4,101,577
Ensembl chrNW_004955495:4,018,770...4,114,604
JBrowse link
G Kdm4c lysine demethylase 4C ISO (PMID:18066052)
(MGI:MGI:3845989|PMID:19144645)
Reactome
MGI
PMID:18066052, PMID:19144645 MGI:MGI:3845989 NCBI chrNW_004955434:10,646,524...11,000,589
Ensembl chrNW_004955434:10,685,704...11,000,644
JBrowse link
G Kdm4d lysine demethylase 4D ISO (MGI:MGI:3845989|PMID:19144645) MGI PMID:19144645 MGI:MGI:3845989 NCBI chrNW_004955605:7,585...32,650
Ensembl chrNW_004955605:8,977...10,539
JBrowse link
G Phf2 PHD finger protein 2 NOT ISO (PMID:21167174) UniProtKB PMID:21167174 NCBI chrNW_004955515:4,428,068...4,471,642
Ensembl chrNW_004955515:4,429,957...4,471,641
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:19843542) UniProtKB PMID:19843542 NCBI chrNW_004955475:1,105,619...1,230,758
Ensembl chrNW_004955475:1,105,619...1,230,756
JBrowse link
histone demethylase activity (H3-dimethyl-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO (MGI:MGI:6115671|PMID:29370269)
(MGI:MGI:5574544|PMID:24843136)
(PMID:20228790)
CACAO
MGI
UniProtKB
PMID:20228790, PMID:24843136, PMID:29370269 MGI:MGI:5574544, MGI:MGI:6115671 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G Kdm1b lysine demethylase 1B ISO (MGI:MGI:4352982|PMID:19407342), (MGI:MGI:4358629|PMID:19727073)
(PMID:23266887)
MGI
UniProtKB
PMID:19407342, PMID:19727073, PMID:23266887 MGI:MGI:4352982, MGI:MGI:4358629 NCBI chrNW_004955483:8,000,862...8,052,486
Ensembl chrNW_004955483:8,002,577...8,052,486
JBrowse link
G Kdm5a lysine demethylase 5A ISO (PMID:18270511) CAFA PMID:18270511 NCBI chrNW_004955454:6,774,308...6,865,047
Ensembl chrNW_004955454:6,774,476...6,865,033
JBrowse link
G Kdm5b lysine demethylase 5B ISO (PMID:20228790) UniProtKB PMID:20228790 NCBI chrNW_004955406:38,755,220...38,823,094
Ensembl chrNW_004955406:38,755,220...38,823,088
JBrowse link
histone demethylase activity (H3-K27 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A ISO (MGI:MGI:5448135|PMID:22949634) MGI PMID:22949634 MGI:MGI:5448135 NCBI chrNW_004955516:3,151,350...3,346,832
Ensembl chrNW_004955516:3,149,948...3,346,832
JBrowse link
G Kdm6b lysine demethylase 6B ISO (MGI:MGI:5574281|PMID:23856522)
(PMID:28262558)
BHF-UCL
UniProtKB
PMID:23856522, PMID:28262558 MGI:MGI:5574281 NCBI chrNW_004955467:9,085,239...9,106,658
Ensembl chrNW_004955467:9,086,204...9,094,404
JBrowse link
G Kdm7a lysine demethylase 7A ISO (MGI:MGI:4437342|PMID:20194436)
(PMID:20023638), (PMID:20194436), (PMID:20622853)
UniProtKB PMID:20023638, PMID:20194436, PMID:20622853 MGI:MGI:4437342 NCBI chrNW_004955494:3,018,395...3,110,528
Ensembl chrNW_004955494:3,030,133...3,104,215
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20622853), (PMID:20622854) UniProtKB PMID:20622853, PMID:20622854 NCBI chrNW_004955475:1,105,619...1,230,758
Ensembl chrNW_004955475:1,105,619...1,230,756
JBrowse link
histone demethylase activity (H3-K36 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm2a lysine demethylase 2A ISO (PMID:28262558) UniProtKB PMID:28262558 NCBI chrNW_004955422:18,201,243...18,308,163
Ensembl chrNW_004955422:18,200,758...18,308,163
JBrowse link
G Kdm2b lysine demethylase 2B ISO (PMID:26237645) UniProt PMID:26237645 NCBI chrNW_004955482:6,774,021...6,885,113
Ensembl chrNW_004955482:6,774,059...6,887,171
JBrowse link
G Kdm4a lysine demethylase 4A ISO (PMID:16024779), (PMID:21914792) UniProtKB PMID:16024779, PMID:21914792 NCBI chrNW_004955537:3,199,394...3,255,945 JBrowse link
G Kdm4b lysine demethylase 4B ISO (PMID:21914792) UniProtKB PMID:21914792 NCBI chrNW_004955495:4,019,066...4,101,577
Ensembl chrNW_004955495:4,018,770...4,114,604
JBrowse link
G Kdm4c lysine demethylase 4C ISO (PMID:21914792) UniProtKB PMID:21914792 NCBI chrNW_004955434:10,646,524...11,000,589
Ensembl chrNW_004955434:10,685,704...11,000,644
JBrowse link
G Kdm7a lysine demethylase 7A ISO (PMID:20622853) UniProtKB PMID:20622853 NCBI chrNW_004955494:3,018,395...3,110,528
Ensembl chrNW_004955494:3,030,133...3,104,215
JBrowse link
G Kdm8 lysine demethylase 8 ISO (PMID:20457893) UniProtKB PMID:20457893 NCBI chrNW_004955493:5,437,344...5,462,849
Ensembl chrNW_004955493:5,437,090...5,462,294
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20208542), (PMID:20622853) UniProtKB PMID:20208542, PMID:20622853 NCBI chrNW_004955475:1,105,619...1,230,758
Ensembl chrNW_004955475:1,105,619...1,230,756
JBrowse link
G Riox1 ribosomal oxygenase 1 ISO (MGI:MGI:4418587|PMID:19927124) UniProtKB PMID:19927124 MGI:MGI:4418587 NCBI chrNW_004955523:1,907,570...1,910,038
Ensembl chrNW_004955523:1,908,024...1,909,944
JBrowse link
histone demethylase activity (H3-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO (PMID:15620353) UniProtKB PMID:15620353 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G Kdm5b lysine demethylase 5B ISO (MGI:MGI:3715069|PMID:17320160)
(PMID:18048344)
(PMID:24952722), (PMID:27214403), (PMID:28262558)
MGI
CACAO
UniProtKB
PMID:17320160, PMID:18048344, PMID:24952722, PMID:27214403, PMID:28262558 MGI:MGI:3715069 NCBI chrNW_004955406:38,755,220...38,823,094
Ensembl chrNW_004955406:38,755,220...38,823,088
JBrowse link
G Kdm5c lysine demethylase 5C ISO (PMID:28262558)
(PMID:17320160)
UniProtKB
MGI
PMID:17320160, PMID:28262558 NCBI chrNW_004955475:243,666...278,064
Ensembl chrNW_004955475:243,666...278,627
JBrowse link
G Riox1 ribosomal oxygenase 1 ISO (MGI:MGI:4418587|PMID:19927124) UniProtKB PMID:19927124 MGI:MGI:4418587 NCBI chrNW_004955523:1,907,570...1,910,038
Ensembl chrNW_004955523:1,908,024...1,909,944
JBrowse link
histone demethylase activity (H3-K9 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO (PMID:16079795), (PMID:20228790) UniProtKB PMID:16079795, PMID:20228790 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G Kdm3a lysine demethylase 3A ISO (PMID:28262558) UniProtKB PMID:28262558 NCBI chrNW_004955424:1,164,384...1,218,607
Ensembl chrNW_004955424:1,171,827...1,218,607
JBrowse link
G Kdm4a lysine demethylase 4A ISO (PMID:21914792) UniProtKB PMID:21914792 NCBI chrNW_004955537:3,199,394...3,255,945 JBrowse link
G Kdm4b lysine demethylase 4B ISO (PMID:28262558)
(MGI:MGI:3629551|PMID:16738407)
(PMID:21914792)
UniProtKB
MGI
PMID:16738407, PMID:21914792, PMID:28262558 MGI:MGI:3629551 NCBI chrNW_004955495:4,019,066...4,101,577
Ensembl chrNW_004955495:4,018,770...4,114,604
JBrowse link
G Kdm4c lysine demethylase 4C ISO (PMID:17277772), (PMID:28262558)
(PMID:18066052), (PMID:21914792)
BHF-UCL
UniProtKB
PMID:17277772, PMID:18066052, PMID:21914792, PMID:28262558 NCBI chrNW_004955434:10,646,524...11,000,589
Ensembl chrNW_004955434:10,685,704...11,000,644
JBrowse link
G Kdm4d lysine demethylase 4D ISO (PMID:21914792), (PMID:25124442)
(MGI:MGI:5552986|PMID:24550317)
UniProtKB
MGI
PMID:21914792, PMID:24550317, PMID:25124442 MGI:MGI:5552986 NCBI chrNW_004955605:7,585...32,650
Ensembl chrNW_004955605:8,977...10,539
JBrowse link
G Kdm7a lysine demethylase 7A ISO (MGI:MGI:4437342|PMID:20194436)
(PMID:20023638), (PMID:20194436), (PMID:20622853)
UniProtKB PMID:20023638, PMID:20194436, PMID:20622853 MGI:MGI:4437342 NCBI chrNW_004955494:3,018,395...3,110,528
Ensembl chrNW_004955494:3,030,133...3,104,215
JBrowse link
G Phf2 PHD finger protein 2 ISO (PMID:21532585) UniProtKB PMID:21532585 NCBI chrNW_004955515:4,428,068...4,471,642
Ensembl chrNW_004955515:4,429,957...4,471,641
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20023638), (PMID:20208542), (PMID:20346720), (PMID:20622853), (PMID:20622854) UniProtKB PMID:20023638, PMID:20208542, PMID:20346720, PMID:20622853, PMID:20622854 NCBI chrNW_004955475:1,105,619...1,230,758
Ensembl chrNW_004955475:1,105,619...1,230,756
JBrowse link
histone demethylase activity (H3-monomethyl-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO (MGI:MGI:6115671|PMID:29370269) CACAO PMID:29370269 MGI:MGI:6115671 NCBI chrNW_004955452:3,044,042...3,104,650
Ensembl chrNW_004955452:3,044,264...3,104,418
JBrowse link
G Kdm1b lysine demethylase 1B ISO (MGI:MGI:4352982|PMID:19407342), (MGI:MGI:4358629|PMID:19727073)
(PMID:23266887)
MGI
UniProtKB
PMID:19407342, PMID:19727073, PMID:23266887 MGI:MGI:4352982, MGI:MGI:4358629 NCBI chrNW_004955483:8,000,862...8,052,486
Ensembl chrNW_004955483:8,002,577...8,052,486
JBrowse link
histone demethylase activity (H3-R2 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISO (PMID:17947579) UniProtKB PMID:17947579 NCBI chrNW_004955506:5,577,735...5,588,307
Ensembl chrNW_004955506:5,577,437...5,588,372
JBrowse link
histone demethylase activity (H3-trimethyl-K4 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1b lysine demethylase 1B NOT ISO (MGI:MGI:4352982|PMID:19407342), (MGI:MGI:4358629|PMID:19727073) UniProtKB PMID:19407342, PMID:19727073 MGI:MGI:4352982, MGI:MGI:4358629 NCBI chrNW_004955483:8,000,862...8,052,486
Ensembl chrNW_004955483:8,002,577...8,052,486
JBrowse link
G Kdm5a lysine demethylase 5A ISO (PMID:18270511) CAFA PMID:18270511 NCBI chrNW_004955454:6,774,308...6,865,047
Ensembl chrNW_004955454:6,774,476...6,865,033
JBrowse link
G Kdm5b lysine demethylase 5B ISO (PMID:20228790)
(PMID:20403335)
UniProtKB
CAFA
PMID:20228790, PMID:20403335 NCBI chrNW_004955406:38,755,220...38,823,094
Ensembl chrNW_004955406:38,755,220...38,823,088
JBrowse link
histone demethylase activity (H4-K20 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm7a lysine demethylase 7A ISO (PMID:20622853) UniProtKB PMID:20622853 NCBI chrNW_004955494:3,018,395...3,110,528
Ensembl chrNW_004955494:3,030,133...3,104,215
JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20622853), (PMID:20622854) UniProtKB PMID:20622853, PMID:20622854 NCBI chrNW_004955475:1,105,619...1,230,758
Ensembl chrNW_004955475:1,105,619...1,230,756
JBrowse link
histone demethylase activity (H4-R3 specific) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISO (PMID:17947579), (PMID:24360279) UniProt PMID:17947579, PMID:24360279 NCBI chrNW_004955506:5,577,735...5,588,307
Ensembl chrNW_004955506:5,577,437...5,588,372
JBrowse link

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.