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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of type I interferon production
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Accession:GO:0032480 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: down regulation of type I interferon production;   downregulation of type I interferon production;   negative regulation of type I IFN production
 narrow_synonym: inhibition of type I interferon production


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negative regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 ISO (MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:5490396 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (PMID:21525357)
(MGI:5318004|PMID:21525357)
RGD PMID:21525357 MGI:5318004 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Gpatch3 G patch domain containing 3 ISO
IBA
(PMID:28414768)
PMID:21873635
RGD PMID:28414768, PMID:21873635 RGD:13792537 NCBI chr 5:151,796,456...151,806,007
Ensembl chr 5:151,796,814...151,805,976
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains ISO (PMID:29802199) RGD PMID:29802199 NCBI chr20:7,331,321...7,397,588
Ensembl chr20:7,331,326...7,397,448
JBrowse link
G Nmi N-myc (and STAT) interactor ISO MGI:1859212 (MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26471729)
Ensembl
UniProt
RGD
PMID:26471729 GO_REF:0000024, GO_REF:0000107 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO MGI:5441750 (MGI:5441107|PMID:23042151) RGD PMID:23042151 MGI:5441107 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) RGD PMID:17460044, PMID:26471729 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO
IEA
(PMID:22079989)
GO_REF:0000107
RGD
Ensembl
PMID:22079989 GO_REF:0000107 NCBI chr 9:98,621,499...98,658,223
Ensembl chr 9:98,621,506...98,656,901
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO
ISS
(PMID:26471729)
GO_REF:0000024
RGD
UniProt
PMID:26471729 GO_REF:0000024 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
negative regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 ISO (MGI:5568884|PMID:24560620) RGD PMID:24560620 MGI:5568884 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nmi N-myc (and STAT) interactor ISO (MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S IEA
ISO
GO_REF:0000107
(PMID:26231120)
Ensembl
RGD
PMID:26231120 GO_REF:0000107 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
negative regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A ISO (MGI:5569198|PMID:24670807) RGD PMID:24670807 MGI:5569198 NCBI chr 9:82,382,800...82,393,429
Ensembl chr 9:82,382,800...82,393,382
JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:11,258,526...11,266,509
Ensembl chr 7:11,261,201...11,266,630
JBrowse link
G Crebbp CREB binding protein ISO (MGI:2151262|PMID:11583620) RGD PMID:11583620 MGI:2151262 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:3828224|PMID:18851954) RGD PMID:18851954 MGI:3828224 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 ISO (MGI:5568884|PMID:24560620) RGD PMID:24560620 MGI:5568884 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nlrx1 NLR family member X1 IEA
ISO
GO_REF:0000107
MGI:5141085 (MGI:5050761|PMID:21703540)
Ensembl
RGD
PMID:21703540 GO_REF:0000107, MGI:5050761 NCBI chr 8:48,583,559...48,600,203
Ensembl chr 8:48,584,071...48,597,867
JBrowse link
G Nmi N-myc (and STAT) interactor ISO (MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B ISO
ISS
(PMID:22750291)
GO_REF:0000024
RGD
UniProt
PMID:22750291 GO_REF:0000024 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S IEA
ISO
GO_REF:0000107
(PMID:26231120)
Ensembl
RGD
PMID:26231120 GO_REF:0000107 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:19158675) RGD PMID:19158675 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO (PMID:22065573) RGD PMID:22065573 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO (PMID:22065573) RGD PMID:22065573 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Sirpa signal-regulatory protein alpha IEA
ISO
GO_REF:0000107
(MGI:3760575|PMID:17954568)
Ensembl
RGD
PMID:17954568 GO_REF:0000107, MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO (MGI:5306204|PMID:22079989) RGD PMID:22079989 MGI:5306204 NCBI chr 9:98,621,499...98,658,223
Ensembl chr 9:98,621,506...98,656,901
JBrowse link
G Traip TRAF-interacting protein ISO (MGI:5619447|PMID:22945920) RGD PMID:22945920 MGI:5619447 NCBI chr 8:116,730,170...116,750,528
Ensembl chr 8:116,730,641...116,750,709
JBrowse link
G Yy1 YY1 transcription factor ISO (PMID:16260628) RGD PMID:16260628 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    negative regulation of biological process 5689
      negative regulation of multicellular organismal process 1124
        negative regulation of cytokine production 283
          negative regulation of type I interferon production 25
            negative regulation of interferon-alpha production 4
            negative regulation of interferon-beta production 16
            suppression by virus of host type I interferon production 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        negative regulation of biological process 5689
          negative regulation of metabolic process 3311
            negative regulation of macromolecule metabolic process 3047
              negative regulation of gene expression 2169
                negative regulation of cytokine production 283
                  negative regulation of type I interferon production 25
                    negative regulation of interferon-alpha production 4
                    negative regulation of interferon-beta production 16
                    suppression by virus of host type I interferon production 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.