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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon production
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Accession:GO:0032606 term browser browse the term
Definition:The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: type I IFN production
 narrow_synonym: type I interferon biosynthetic process
 alt_id: GO:0045351


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type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 ISO (MGI:MGI:4830377|PMID:20847273) RGD PMID:20847273 MGI:MGI:4830377 NCBI chr 2:24,022,815...24,227,522
Ensembl chr 2:24,024,791...24,226,224
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 ISO (PMID:30510222), (PMID:30804210) RGD PMID:30510222, PMID:30804210 NCBI chr10:40,812,858...40,846,252
Ensembl chr10:40,812,858...40,846,252
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 ISO (MGI:MGI:3575992|PMID:15800576) RGD PMID:15800576 MGI:MGI:3575992 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061
JBrowse link
G Irf3 interferon regulatory factor 3 ISO
IEA
MGI:MGI:1859212 (MGI:MGI:3575992|PMID:15800576)
GO_REF:0000107
RGD
Ensembl
PMID:15800576 GO_REF:0000107, MGI:MGI:3575992 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 ISO MGI:MGI:3577089 (MGI:MGI:3575992|PMID:15800576) RGD PMID:15800576 MGI:MGI:3575992 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irf9 interferon regulatory factor 9 ISO MGI:MGI:2446102 (MGI:MGI:3575992|PMID:15800576) RGD PMID:15800576 MGI:MGI:3575992 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO
IEA
MGI:MGI:2385681 (MGI:MGI:3575992|PMID:15800576)
GO_REF:0000107
RGD
Ensembl
PMID:15800576 GO_REF:0000107, MGI:MGI:3575992 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 ISO (MGI:MGI:4830377|PMID:20847273) RGD PMID:20847273 MGI:MGI:4830377 NCBI chr 2:24,022,815...24,227,522
Ensembl chr 2:24,024,791...24,226,224
JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 ISO (MGI:MGI:4830377|PMID:20847273) RGD PMID:20847273 MGI:MGI:4830377 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984
JBrowse link
G Azi2 5-azacytidine induced 2 IEA
ISO
GO_REF:0000107
MGI:MGI:5544312 (MGI:MGI:5543352|PMID:23610142)
Ensembl
RGD
PMID:23610142 GO_REF:0000107, MGI:MGI:5543352 NCBI chr 8:126,411,030...126,435,581
Ensembl chr 8:126,411,829...126,434,579
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:3575992|PMID:15800576) RGD PMID:15800576 MGI:MGI:3575992 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO MGI:MGI:3052754 (MGI:MGI:5554502|PMID:24218451) RGD PMID:24218451 MGI:MGI:5554502 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:3575992|PMID:15800576) RGD PMID:15800576 MGI:MGI:3575992 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:3849536|PMID:19433799), (MGI:MGI:4365649|PMID:19776740)
(PMID:19433799), (PMID:21074459), (PMID:25254379)
UniProt
RGD
PMID:19433799, PMID:19776740, PMID:21074459, PMID:25254379 GO_REF:0000024, MGI:MGI:3849536, MGI:MGI:4365649 NCBI chr18:28,529,537...28,535,828
Ensembl chr18:28,529,576...28,535,828
JBrowse link
interferon-tau production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 ISO (PMID:16792532) RGD PMID:16792532 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
negative regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 ISO (MGI:MGI:5568884|PMID:24560620) RGD PMID:24560620 MGI:MGI:5568884 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nmi N-myc (and STAT) interactor ISO (MGI:MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S IEA
ISO
GO_REF:0000107
(PMID:26231120)
Ensembl
RGD
PMID:26231120 GO_REF:0000107 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
negative regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A ISO (MGI:MGI:5569198|PMID:24670807) RGD PMID:24670807 MGI:MGI:5569198 NCBI chr 9:82,382,800...82,393,429
Ensembl chr 9:82,382,800...82,393,382
JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:11,258,526...11,266,509
Ensembl chr 7:11,261,201...11,266,630
JBrowse link
G Crebbp CREB binding protein ISO (MGI:MGI:2151262|PMID:11583620) RGD PMID:11583620 MGI:MGI:2151262 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:3828224|PMID:18851954) RGD PMID:18851954 MGI:MGI:3828224 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 ISO (MGI:MGI:5568884|PMID:24560620) RGD PMID:24560620 MGI:MGI:5568884 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nlrx1 NLR family member X1 ISO
IEA
MGI:MGI:5141085 (MGI:MGI:5050761|PMID:21703540)
GO_REF:0000107
RGD
Ensembl
PMID:21703540 GO_REF:0000107, MGI:MGI:5050761 NCBI chr 8:48,583,559...48,600,203
Ensembl chr 8:48,584,071...48,597,867
JBrowse link
G Nmi N-myc (and STAT) interactor ISO (MGI:MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B ISO
ISS
(PMID:22750291)
GO_REF:0000024
RGD
UniProt
PMID:22750291 GO_REF:0000024 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S IEA
ISO
GO_REF:0000107
(PMID:26231120)
Ensembl
RGD
PMID:26231120 GO_REF:0000107 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:19158675) RGD PMID:19158675 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO (PMID:22065573) RGD PMID:22065573 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO (PMID:22065573) RGD PMID:22065573 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Sirpa signal-regulatory protein alpha ISO
IEA
(MGI:MGI:3760575|PMID:17954568)
GO_REF:0000107
RGD
Ensembl
PMID:17954568 GO_REF:0000107, MGI:MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO (MGI:MGI:5306204|PMID:22079989) RGD PMID:22079989 MGI:MGI:5306204 NCBI chr 9:98,621,499...98,658,223
Ensembl chr 9:98,621,506...98,656,901
JBrowse link
G Traip TRAF-interacting protein ISO (MGI:MGI:5619447|PMID:22945920) RGD PMID:22945920 MGI:MGI:5619447 NCBI chr 8:116,730,170...116,750,528
Ensembl chr 8:116,730,641...116,750,709
JBrowse link
G Yy1 YY1 transcription factor ISO (PMID:16260628) RGD PMID:16260628 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link
negative regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 ISO (MGI:MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:MGI:5490396 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (PMID:21525357)
(MGI:MGI:5318004|PMID:21525357)
RGD PMID:21525357 MGI:MGI:5318004 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Gpatch3 G patch domain containing 3 ISO
IBA
(PMID:28414768)
PMID:21873635
RGD PMID:28414768, PMID:21873635 RGD:13792537 NCBI chr 5:151,796,456...151,806,007
Ensembl chr 5:151,796,814...151,805,976
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO (MGI:MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:MGI:5437532 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains ISO (PMID:29802199) RGD PMID:29802199 NCBI chr20:7,331,321...7,397,588
Ensembl chr20:7,331,326...7,397,448
JBrowse link
G Nmi N-myc (and STAT) interactor ISO MGI:MGI:1859212 (MGI:MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:MGI:5546557 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26471729)
Ensembl
UniProt
RGD
PMID:26471729 GO_REF:0000024, GO_REF:0000107 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO MGI:MGI:5441750 (MGI:MGI:5441107|PMID:23042151) RGD PMID:23042151 MGI:MGI:5441107 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) RGD PMID:17460044, PMID:26471729 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO
IEA
(PMID:22079989)
GO_REF:0000107
RGD
Ensembl
PMID:22079989 GO_REF:0000107 NCBI chr 9:98,621,499...98,658,223
Ensembl chr 9:98,621,506...98,656,901
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO
ISS
(PMID:26471729)
GO_REF:0000024
RGD
UniProt
PMID:26471729 GO_REF:0000024 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
positive regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07014739.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr14:29,232,295...29,232,537 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO
IEA
(MGI:MGI:5583923|PMID:24784232)
GO_REF:0000107
(PMID:24784232)
RGD
Ensembl
PMID:24784232 GO_REF:0000107, MGI:MGI:5583923 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked ISO (PMID:30341167) RGD PMID:30341167 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx58 DEXD/H-box helicase 58 ISO (PMID:19576794), (PMID:19609254), (PMID:21957149) RGD PMID:19576794, PMID:19609254, PMID:21957149 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dhx36 DEAH-box helicase 36 ISO
IEA
(PMID:20696886)
GO_REF:0000107
RGD
Ensembl
PMID:20696886 GO_REF:0000107 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547
JBrowse link
G Dhx9 DExH-box helicase 9 ISO
IEA
(PMID:21957149)
GO_REF:0000107
RGD
Ensembl
PMID:21957149 GO_REF:0000107 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 ISO MGI:MGI:3628823 (MGI:MGI:4452060|PMID:20457904) RGD PMID:20457904 MGI:MGI:4452060 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Hmgb1 high mobility group box 1 ISO (MGI:MGI:4367121|PMID:19890330) RGD PMID:19890330 MGI:MGI:4367121 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO
IBA
(PMID:17164250)
PMID:21873635
(MGI:MGI:3708392|PMID:17164250)
RGD PMID:17164250, PMID:21873635 MGI:MGI:3708392, RGD:13792537 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO (PMID:19656871), (PMID:21957149) RGD PMID:19656871, PMID:21957149 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:4365354|PMID:18562536) RGD PMID:18562536 MGI:MGI:4365354 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (PMID:16127453) RGD PMID:16127453 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISS
ISO
GO_REF:0000024
(PMID:16127453), (PMID:19609254), (PMID:21957149)
UniProt
RGD
PMID:16127453, PMID:19609254, PMID:21957149 GO_REF:0000024 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO
IEA
(MGI:MGI:5583923|PMID:24784232)
GO_REF:0000107
RGD
Ensembl
PMID:24784232 GO_REF:0000107, MGI:MGI:5583923 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
IEA
(MGI:MGI:5562517|PMID:23871208)
GO_REF:0000107
RGD
Ensembl
PMID:23871208 GO_REF:0000107, MGI:MGI:5562517 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase ISO (PMID:28753426) RGD PMID:28753426 NCBI chr 8:118,802,478...118,888,224
Ensembl chr 8:118,803,075...118,888,224
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (PMID:28753426) RGD PMID:28753426 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tbk1 TANK-binding kinase 1 ISO (PMID:16127453) RGD PMID:16127453 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Tlr3 toll-like receptor 3 ISO
IEA
(PMID:16286015)
GO_REF:0000107
RGD
Ensembl
PMID:16286015 GO_REF:0000107 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEA
(MGI:MGI:4456948|PMID:15356140)
GO_REF:0000107
RGD
Ensembl
PMID:15356140 GO_REF:0000107, MGI:MGI:4456948 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr7 toll-like receptor 7 ISO
IEA
(MGI:MGI:3042320|PMID:14976261)
GO_REF:0000107
(PMID:16286015)
RGD
Ensembl
PMID:14976261, PMID:16286015 GO_REF:0000107, MGI:MGI:3042320 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tlr8 toll-like receptor 8 ISO
IEA
(PMID:16286015)
GO_REF:0000107
RGD
Ensembl
PMID:16286015 GO_REF:0000107 NCBI chr  X:28,539,158...28,562,803
Ensembl chr  X:28,539,158...28,562,803
JBrowse link
G Tlr9 toll-like receptor 9 ISO (PMID:16286015) RGD PMID:16286015 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) RGD PMID:21102435 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
positive regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked ISO (PMID:27980081), (PMID:31575075) RGD PMID:27980081, PMID:31575075 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx58 DEXD/H-box helicase 58 ISO
IBA
(MGI:MGI:5318026|PMID:17942531)
(PMID:17079289), (PMID:19211564), (PMID:19609254), (PMID:19631370), (PMID:21957149)
PMID:21873635
RGD PMID:17079289, PMID:17942531, PMID:19211564, PMID:19609254, PMID:19631370, PMID:21957149, PMID:21873635 MGI:MGI:5318026, RGD:13792537 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dhx58 DEXH-box helicase 58 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Dhx9 DExH-box helicase 9 ISO
IEA
(PMID:21957149)
GO_REF:0000107
RGD
Ensembl
PMID:21957149 GO_REF:0000107 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Flot1 flotillin 1 ISO (PMID:25204797) RGD PMID:25204797 NCBI chr20:3,427,890...3,438,418
Ensembl chr20:3,427,880...3,438,396
JBrowse link
G Hmgb1 high mobility group box 1 ISO (MGI:MGI:4367121|PMID:19890330) RGD PMID:19890330 MGI:MGI:4367121 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgb2 high mobility group box 2 ISO (MGI:MGI:4367121|PMID:19890330) RGD PMID:19890330 MGI:MGI:4367121 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 IBA
ISO
PMID:21873635
(PMID:17600090), (PMID:19211564), (PMID:19656871), (PMID:21957149)
RGD PMID:17600090, PMID:19211564, PMID:19656871, PMID:21957149, PMID:21873635 RGD:13792537 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 ISO (MGI:MGI:5619426|PMID:24598055) RGD PMID:24598055 MGI:MGI:5619426 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061
JBrowse link
G Irf1 interferon regulatory factor 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21389130)
Ensembl
UniProt
RGD
PMID:21389130 GO_REF:0000024, GO_REF:0000107 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:4365354|PMID:18562536) RGD PMID:18562536 MGI:MGI:4365354 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (PMID:22065573) RGD PMID:22065573 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISS
ISO
GO_REF:0000024
(PMID:16127453), (PMID:19609254), (PMID:19631370), (PMID:21957149)
UniProt
RGD
PMID:16127453, PMID:19609254, PMID:19631370, PMID:21957149 GO_REF:0000024 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Polr3a RNA polymerase III subunit A ISO (PMID:19609254) RGD PMID:19609254 NCBI chr16:717,821...756,002
Ensembl chr16:716,683...755,990
JBrowse link
G Polr3b RNA polymerase III subunit B ISO (PMID:19609254) RGD PMID:19609254 NCBI chr 7:24,745,051...24,851,227
Ensembl chr 7:24,745,051...24,851,227
JBrowse link
G Polr3c RNA polymerase III subunit C ISO
ISS
(PMID:19609254)
GO_REF:0000024
RGD
UniProt
PMID:19609254 GO_REF:0000024 NCBI chr 2:198,836,282...198,852,368
Ensembl chr 2:198,836,285...198,852,161
JBrowse link
G Polr3d RNA polymerase III subunit D ISO (PMID:19631370) RGD PMID:19631370 NCBI chr15:52,129,471...52,134,140
Ensembl chr15:52,129,471...52,134,140
JBrowse link
G Polr3f RNA polymerase III subunit F ISO (PMID:19631370) RGD PMID:19631370 NCBI chr 3:138,684,685...138,701,055
Ensembl chr 3:138,684,685...138,701,055
JBrowse link
G Polr3g RNA polymerase III subunit G ISO (PMID:19609254), (PMID:19631370) RGD PMID:19609254, PMID:19631370 NCBI chr 2:9,537,642...9,578,551
Ensembl chr 2:9,537,642...9,578,310
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO (MGI:MGI:3760575|PMID:17954568) RGD PMID:17954568 MGI:MGI:3760575 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
IEA
(MGI:MGI:5562517|PMID:23871208)
GO_REF:0000107
RGD
Ensembl
PMID:23871208 GO_REF:0000107, MGI:MGI:5562517 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Riok3 RIO kinase 3 ISO (PMID:24807708) RGD PMID:24807708 NCBI chr18:3,565,166...3,590,739
Ensembl chr18:3,565,166...3,590,739
JBrowse link
G Rnf135 ring finger protein 135 ISO
ISS
(PMID:19017631)
GO_REF:0000024
RGD
UniProt
PMID:19017631 GO_REF:0000024 NCBI chr10:67,531,989...67,551,237 JBrowse link
G Tbk1 TANK-binding kinase 1 ISO (PMID:16127453)
MGI:MGI:3046789 (MGI:MGI:3530402|PMID:15661922)
RGD PMID:15661922, PMID:16127453 MGI:MGI:3530402 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 ISO MGI:MGI:2679794|MGI:MGI:3029019 (MGI:MGI:2669022|PMID:12855817), (MGI:MGI:2670551|PMID:12872135) RGD PMID:12855817, PMID:12872135 MGI:MGI:2669022, MGI:MGI:2670551 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tlr2 toll-like receptor 2 ISO (MGI:MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:MGI:4456948 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr3 toll-like receptor 3 ISO (MGI:MGI:4456948|PMID:15356140)
(PMID:12054664), (PMID:16286015)
RGD PMID:12054664, PMID:15356140, PMID:16286015 MGI:MGI:4456948 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEA
MGI:MGI:1860885 (MGI:MGI:3530402|PMID:15661922), (MGI:MGI:4456948|PMID:15356140)
GO_REF:0000107
RGD
Ensembl
PMID:15356140, PMID:15661922 GO_REF:0000107, MGI:MGI:3530402, MGI:MGI:4456948 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr7 toll-like receptor 7 ISO
IEA
(PMID:16286015)
GO_REF:0000107
RGD
Ensembl
PMID:16286015 GO_REF:0000107 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tlr8 toll-like receptor 8 ISO
IEA
(PMID:16286015)
GO_REF:0000107
RGD
Ensembl
PMID:16286015 GO_REF:0000107 NCBI chr  X:28,539,158...28,562,803
Ensembl chr  X:28,539,158...28,562,803
JBrowse link
G Tlr9 toll-like receptor 9 ISO (MGI:MGI:4456948|PMID:15356140)
(PMID:16286015)
RGD PMID:15356140, PMID:16286015 MGI:MGI:4456948 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 ISO (MGI:MGI:5619432|PMID:23776228) RGD PMID:23776228 MGI:MGI:5619432 NCBI chr11:62,014,925...62,561,113
Ensembl chr11:62,014,925...62,451,184
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) RGD PMID:21102435 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
G Zfp64 zinc finger protein 64 ISO (MGI:MGI:5619431|PMID:23857586) RGD PMID:23857586 MGI:MGI:5619431 NCBI chr 3:165,713,070...165,741,932
Ensembl chr 3:165,713,020...165,741,967
JBrowse link
positive regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule ISO
IBA
(MGI:MGI:5300392|PMID:22078883)
PMID:21873635
RGD PMID:22078883, PMID:21873635 MGI:MGI:5300392, RGD:13792537 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cgas cyclic GMP-AMP synthase ISO
IBA
(PMID:24077100), (PMID:26046437), (PMID:28363908), (PMID:28738408)
PMID:21873635
(MGI:MGI:5908326|PMID:24077100), (MGI:MGI:5909141|PMID:28759889), (MGI:MGI:5909142|PMID:28759028)
RGD PMID:24077100, PMID:26046437, PMID:28363908, PMID:28738408, PMID:28759028, PMID:28759889, PMID:21873635 MGI:MGI:5908326, MGI:MGI:5909141, MGI:MGI:5909142, RGD:13792537 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Dhx33 DEAH-box helicase 33 ISO (MGI:MGI:6120210|PMID:24037184) RGD PMID:24037184 MGI:MGI:6120210 NCBI chr10:57,622,022...57,638,485
Ensembl chr10:57,622,022...57,638,485
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (MGI:MGI:4421606|PMID:20080593) RGD PMID:20080593 MGI:MGI:4421606 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO (PMID:23633945) RGD PMID:23633945 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Irf1 interferon regulatory factor 1 ISO
ISS
(MGI:MGI:3691368|PMID:17018642)
GO_REF:0000024
RGD
UniProt
PMID:17018642 GO_REF:0000024, MGI:MGI:3691368 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (PMID:25636800) RGD PMID:25636800 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf5 interferon regulatory factor 5 ISO
IEA
(PMID:32433612)
GO_REF:0000107
RGD
Ensembl
PMID:32433612 GO_REF:0000107 NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543
JBrowse link
G Irf7 interferon regulatory factor 7 ISO MGI:MGI:1928368 (MGI:MGI:5546557|PMID:23956435) RGD PMID:23956435 MGI:MGI:5546557 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO MGI:MGI:3654145 (MGI:MGI:3807296|PMID:18780793) RGD PMID:18780793 MGI:MGI:3807296 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO (PMID:23633945) RGD PMID:23633945 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Plcg2 phospholipase C, gamma 2 ISO
IEA
(MGI:MGI:5300392|PMID:22078883)
GO_REF:0000107
RGD
Ensembl
PMID:22078883 GO_REF:0000107, MGI:MGI:5300392 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Pqbp1 polyglutamine binding protein 1 ISO
IEA
ISS
(PMID:26046437)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26046437 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:15,448,570...15,453,130
Ensembl chr  X:15,348,138...15,453,130
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO (PMID:23871208) RGD PMID:23871208 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 IDA
IBA
ISO
PMID:26669264
PMID:21873635
(PMID:22394562), (PMID:23747010), (PMID:26669264), (PMID:29694889), (PMID:30842659)
(MGI:MGI:5787716|PMID:26669264)
RGD PMID:22394562, PMID:23747010, PMID:26669264, PMID:29694889, PMID:30842659, PMID:26669264, PMID:21873635 MGI:MGI:5787716, RGD:11344949, RGD:13792537 NCBI chr18:28,529,537...28,535,828
Ensembl chr18:28,529,576...28,535,828
JBrowse link
G Syk spleen associated tyrosine kinase ISO
IEA
(MGI:MGI:5300392|PMID:22078883)
GO_REF:0000107
RGD
Ensembl
PMID:22078883 GO_REF:0000107, MGI:MGI:5300392 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 ISO MGI:MGI:2679794 (MGI:MGI:2670551|PMID:12872135) RGD PMID:12872135 MGI:MGI:2670551 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tlr3 toll-like receptor 3 ISO (MGI:MGI:3774796|PMID:18207576) RGD PMID:18207576 MGI:MGI:3774796 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Trim15 tripartite motif containing 15 ISO (PMID:23077300) RGD PMID:23077300 NCBI chr20:2,194,293...2,203,636
Ensembl chr20:2,194,709...2,201,668
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (MGI:MGI:4868308|PMID:21102435) RGD PMID:21102435 MGI:MGI:4868308 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
G Zcchc3 zinc finger CCHC-type containing 3 ISO (MGI:MGI:6209107|PMID:30135424) RGD PMID:30135424 MGI:MGI:6209107 NCBI chr 3:147,877,321...147,881,434
Ensembl chr 3:147,878,936...147,880,138
JBrowse link
regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf216 ring finger protein 216 ISO (PMID:19893624) RGD PMID:19893624 NCBI chr12:13,508,429...13,631,689
Ensembl chr12:13,508,429...13,632,304
JBrowse link
G Tirap TIR domain containing adaptor protein ISO (MGI:MGI:4942245|PMID:14630816) RGD PMID:14630816 MGI:MGI:4942245 NCBI chr 8:36,382,029...36,399,625
Ensembl chr 8:36,385,353...36,388,224
JBrowse link
G Traf3 Tnf receptor-associated factor 3 ISO (MGI:MGI:4839450|PMID:16306937) RGD PMID:16306937 MGI:MGI:4839450 NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
JBrowse link
G Trim38 tripartite motif containing 38 ISO (MGI:MGI:5441682|PMID:22539786) RGD PMID:22539786 MGI:MGI:5441682 NCBI chr17:43,600,006...43,607,879 JBrowse link
regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase ISO MGI:MGI:1328317 (MGI:MGI:5699498|PMID:26371324) RGD PMID:26371324 MGI:MGI:5699498 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Irf8 interferon regulatory factor 8 IEA
ISO
GO_REF:0000107
(MGI:MGI:3654212|PMID:12461077)
Ensembl
RGD
PMID:12461077 GO_REF:0000107, MGI:MGI:3654212 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit ISS
ISO
GO_REF:0000024
(PMID:27019227)
UniProt
RGD
PMID:27019227 GO_REF:0000024 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Rnf26 ring finger protein 26 ISO (PMID:25254379) RGD PMID:25254379 NCBI chr 8:48,447,113...48,449,311
Ensembl chr 8:48,447,113...48,449,311
JBrowse link
G Tbk1 TANK-binding kinase 1 ISO (PMID:25636800) RGD PMID:25636800 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO MGI:MGI:2442261|MGI:MGI:3052754 (MGI:MGI:4848004|PMID:20871604), (MGI:MGI:5523362|PMID:24154727), (MGI:MGI:5699498|PMID:26371324) RGD PMID:20871604, PMID:24154727, PMID:26371324 MGI:MGI:4848004, MGI:MGI:5523362, MGI:MGI:5699498 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    multicellular organismal process 9056
      cytokine production 846
        type I interferon production 91
          interferon-alpha production + 32
          interferon-beta production + 54
          interferon-delta production 0
          interferon-epsilon production 0
          interferon-kappa production 0
          interferon-omega production 0
          interferon-tau production 1
          negative regulation of type I interferon production + 25
          positive regulation of type I interferon production + 54
          regulation of type I interferon production + 85
          type I interferon secretion 0
Path 2
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      organic substance metabolic process 11639
        macromolecule metabolic process 10084
          gene expression 6295
            cytokine production 846
              type I interferon production 91
                interferon-alpha production + 32
                interferon-beta production + 54
                interferon-delta production 0
                interferon-epsilon production 0
                interferon-kappa production 0
                interferon-omega production 0
                interferon-tau production 1
                negative regulation of type I interferon production + 25
                positive regulation of type I interferon production + 54
                regulation of type I interferon production + 85
                type I interferon secretion 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.