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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon production
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Accession:GO:0032606 term browser browse the term
Definition:The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Comment:Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
Synonyms:exact_synonym: type I IFN production
 narrow_synonym: type I interferon biosynthetic process;   type I interferon secretion
 alt_id: GO:0045351;   GO:0072641


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negative regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 ISO (PMID:26492563) UniProtKB PMID:26492563 NCBI chr 5:152,486,125...152,514,004
Ensembl chr 5:159,108,915...159,131,007
JBrowse link
G LILRA4 leukocyte immunoglobulin like receptor A4 ISO (PMID:16735691) UniProtKB PMID:16735691 NCBI chr19:51,287,944...51,294,118
Ensembl chr19:60,128,447...60,134,248
JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISO (MGI:5568884|PMID:24560620) UniProt PMID:24560620 MGI:5568884 NCBI chr16:2,463,940...2,487,961
Ensembl chr16:3,637,612...3,674,088
JBrowse link
G NMI N-myc and STAT interactor ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chr2B:8,574,385...8,603,486
Ensembl chr2B:155,802,720...155,823,142
JBrowse link
G PTPRS protein tyrosine phosphatase receptor type S ISO (PMID:26231120) UniProtKB PMID:26231120 NCBI chr19:4,227,038...4,361,958
Ensembl chr19:5,168,599...5,247,778
JBrowse link
negative regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG9A autophagy related 9A ISO (MGI:5569198|PMID:24670807) MGI PMID:24670807 MGI:5569198 NCBI chr2B:106,477,007...106,487,249
Ensembl chr2B:225,067,590...225,078,065
JBrowse link
G CACTIN cactin, spliceosome C complex subunit ISO (PMID:20829348) UniProtKB PMID:20829348 NCBI chr19:2,636,129...2,652,332
Ensembl chr19:3,586,983...3,601,990
JBrowse link
G CREBBP CREB binding protein ISO (MGI:2151262|PMID:11583620) CAFA PMID:11583620 MGI:2151262 NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:3828224|PMID:18851954) MGI PMID:18851954 MGI:3828224 NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISO (MGI:5568884|PMID:24560620) UniProt PMID:24560620 MGI:5568884 NCBI chr16:2,463,940...2,487,961
Ensembl chr16:3,637,612...3,674,088
JBrowse link
G NLRX1 NLR family member X1 ISO (MGI:5050761|PMID:21703540) MGI PMID:21703540 MGI:5050761 NCBI chr11:114,007,415...114,022,712
Ensembl chr11:117,935,444...117,950,728
JBrowse link
G NMI N-myc and STAT interactor ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chr2B:8,574,385...8,603,486
Ensembl chr2B:155,802,720...155,823,142
JBrowse link
G PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B ISO (PMID:22750291) UniProtKB PMID:22750291 NCBI chr2A:44,254,168...44,325,132 JBrowse link
G PTPRS protein tyrosine phosphatase receptor type S ISO (PMID:26231120) UniProtKB PMID:26231120 NCBI chr19:4,227,038...4,361,958
Ensembl chr19:5,168,599...5,247,778
JBrowse link
G PYCARD PYD and CARD domain containing ISO (PMID:19158675) UniProtKB PMID:19158675 NCBI chr16:23,764,386...23,765,732
Ensembl chr16:31,571,363...31,573,828
JBrowse link
G REL REL proto-oncogene, NF-kB subunit ISO (PMID:22065573) CACAO PMID:22065573 NCBI chr2A:60,972,022...61,013,562
Ensembl chr2A:62,113,581...62,155,241
JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit ISO (PMID:22065573) CACAO PMID:22065573 NCBI chr19:41,948,559...41,987,121
Ensembl chr19:50,554,864...50,590,223
JBrowse link
G SIRPA signal regulatory protein alpha ISO (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chr20:2,006,994...2,052,894
Ensembl chr20:1,773,271...1,818,106
JBrowse link
G TRAF3IP1 TRAF3 interacting protein 1 ISO (MGI:5306204|PMID:22079989) MGI PMID:22079989 MGI:5306204 NCBI chr2B:125,558,537...125,637,733
Ensembl chr2B:244,405,992...244,481,785
JBrowse link
G TRAIP TRAF interacting protein ISO (MGI:5619447|PMID:22945920) CACAO PMID:22945920 MGI:5619447 NCBI chr 3:49,760,528...49,789,637
Ensembl chr 3:50,996,647...51,025,241
JBrowse link
G YY1 YY1 transcription factor ISO (PMID:16260628) UniProtKB PMID:16260628 NCBI chr14:80,859,491...80,903,651 JBrowse link
negative regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chr13:58,166,872...58,176,146
Ensembl chr13:77,211,430...77,222,201
JBrowse link
G DHX58 DExH-box helicase 58 ISO (PMID:21525357)
(MGI:5318004|PMID:21525357)
UniProtKB
UniProt
PMID:21525357 MGI:5318004 NCBI chr17:15,203,216...15,214,559
Ensembl chr17:15,424,437...15,435,582
JBrowse link
G GPATCH3 G-patch domain containing 3 ISO (PMID:28414768) UniProtKB PMID:28414768 NCBI chr 1:26,153,078...26,163,181
Ensembl chr 1:27,209,795...27,220,107
JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 ISO (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chr 5:152,486,125...152,514,004
Ensembl chr 5:159,108,915...159,131,007
JBrowse link
G ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains ISO (PMID:29802199) UniProt PMID:29802199 NCBI chr 6:34,109,140...34,263,529
Ensembl chr 6:35,252,556...35,362,180
JBrowse link
G NMI N-myc and STAT interactor ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chr2B:8,574,385...8,603,486
Ensembl chr2B:155,802,720...155,823,142
JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chr17:76,012,756...76,092,901
Ensembl chr17:81,713,582...81,788,714
JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:5441107|PMID:23042151) MGI PMID:23042151 MGI:5441107 NCBI chr11:61,824,463...61,834,930
Ensembl chr11:65,148,441...65,159,211
JBrowse link
G RNF125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chr18:25,227,353...25,297,186
Ensembl chr18:28,824,183...28,873,068
JBrowse link
G TRAF3IP1 TRAF3 interacting protein 1 ISO (PMID:22079989) CACAO PMID:22079989 NCBI chr2B:125,558,537...125,637,733
Ensembl chr2B:244,405,992...244,481,785
JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chr22:2,209,590...2,238,449
Ensembl chr22:17,885,073...17,913,506
JBrowse link
positive regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO (PMID:24784232)
(MGI:5583923|PMID:24784232)
CAFA PMID:24784232 MGI:5583923 NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked ISO (PMID:30341167) UniProt PMID:30341167 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837
JBrowse link
G DDX58 DExD/H-box helicase 58 ISO (PMID:19576794)
(PMID:19609254), (PMID:21957149)
UniProtKB
UniProt
PMID:19576794, PMID:19609254, PMID:21957149 NCBI chr 9:32,230,012...32,302,159
Ensembl chr 9:33,040,000...33,110,557
JBrowse link
G DHX36 DEAH-box helicase 36 ISO (PMID:20696886) UniProt PMID:20696886 NCBI chr 3:151,331,468...151,382,406
Ensembl chr 3:158,885,541...158,935,871
JBrowse link
G DHX9 DExH-box helicase 9 ISO (PMID:21957149) UniProt PMID:21957149 NCBI chr 1:158,355,472...158,404,178
Ensembl chr 1:162,006,822...162,055,833
JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 ISO (MGI:4452060|PMID:20457904) MGI PMID:20457904 MGI:4452060 NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940
JBrowse link
G HMGB1 high mobility group box 1 ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO (PMID:17164250)
(MGI:3708392|PMID:17164250)
BHF-UCL
MGI
PMID:17164250 MGI:3708392 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959
JBrowse link
G IFIH1 interferon induced with helicase C domain 1 ISO (PMID:19656871), (PMID:21957149) UniProt PMID:19656871, PMID:21957149 NCBI chr2B:49,560,620...49,612,086
Ensembl chr2B:166,928,994...166,980,170
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:4365354|PMID:18562536) UniProt PMID:18562536 MGI:4365354 NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
JBrowse link
G MAVS mitochondrial antiviral signaling protein ISO (PMID:16127453)
(PMID:19609254), (PMID:21957149)
BHF-UCL
UniProt
PMID:16127453, PMID:19609254, PMID:21957149 NCBI chr20:3,885,044...3,903,554
Ensembl chr20:3,659,559...3,701,089
JBrowse link
G MMP12 matrix metallopeptidase 12 ISO (MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:5583923 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (MGI:5562517|PMID:23871208) UniProt PMID:23871208 MGI:5562517 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase ISO (PMID:28753426) UniProtKB PMID:28753426 NCBI chr 3:46,916,615...47,064,046
Ensembl chr 3:48,018,517...48,163,999
JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO (PMID:28753426) UniProtKB PMID:28753426 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280
JBrowse link
G TBK1 TANK binding kinase 1 ISO (PMID:16127453) BHF-UCL PMID:16127453 NCBI chr12:24,419,271...24,469,164
Ensembl chr12:24,917,246...24,968,587
JBrowse link
G TLR3 toll like receptor 3 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
JBrowse link
G TLR4 toll like receptor 4 ISO (MGI:4456948|PMID:15356140) BHF-UCL PMID:15356140 MGI:4456948 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
G TLR7 toll like receptor 7 ISO (PMID:16286015)
(MGI:3042320|PMID:14976261)
UniProt PMID:14976261, PMID:16286015 MGI:3042320 NCBI chr  X:5,479,247...5,504,810
Ensembl chr  X:12,767,981...12,790,517
JBrowse link
G TLR8 toll like receptor 8 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chr  X:5,518,742...5,535,304 JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) UniProtKB PMID:21102435 NCBI chr 7:131,002,580...131,068,513
Ensembl chr 7:143,489,750...143,555,438
JBrowse link
positive regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked ISO (PMID:27980081), (PMID:31575075) UniProt PMID:27980081, PMID:31575075 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837
JBrowse link
G DDX58 DExD/H-box helicase 58 ISO (PMID:17079289)
(MGI:5318026|PMID:17942531)
(PMID:19211564), (PMID:19609254), (PMID:19631370), (PMID:21957149)
BHF-UCL
UniProt
PMID:17079289, PMID:17942531, PMID:19211564, PMID:19609254, PMID:19631370, PMID:21957149 MGI:5318026 NCBI chr 9:32,230,012...32,302,159
Ensembl chr 9:33,040,000...33,110,557
JBrowse link
G DHX9 DExH-box helicase 9 ISO (PMID:21957149) UniProt PMID:21957149 NCBI chr 1:158,355,472...158,404,178
Ensembl chr 1:162,006,822...162,055,833
JBrowse link
G FLOT1 flotillin 1 ISO (PMID:25204797) UniProtKB PMID:25204797 NCBI chr 6:30,472,839...30,487,809
Ensembl chr 6:31,342,033...31,357,559
JBrowse link
G HMGB1 high mobility group box 1 ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527
JBrowse link
G HMGB2 high mobility group box 2 ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952
JBrowse link
G IFIH1 interferon induced with helicase C domain 1 ISO (PMID:17600090)
(PMID:19211564), (PMID:19656871), (PMID:21957149)
UniProtKB
UniProt
PMID:17600090, PMID:19211564, PMID:19656871, PMID:21957149 NCBI chr2B:49,560,620...49,612,086
Ensembl chr2B:166,928,994...166,980,170
JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 ISO (MGI:5619426|PMID:24598055) CACAO PMID:24598055 MGI:5619426 NCBI chr21:19,683,496...19,719,034
Ensembl chr21:33,058,396...33,093,824
JBrowse link
G IRF1 interferon regulatory factor 1 ISO (PMID:21389130) UniProtKB PMID:21389130 NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (MGI:4365354|PMID:18562536) UniProt PMID:18562536 MGI:4365354 NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
JBrowse link
G MAVS mitochondrial antiviral signaling protein ISO (PMID:16127453)
(PMID:19609254), (PMID:19631370), (PMID:21957149)
BHF-UCL
UniProt
PMID:16127453, PMID:19609254, PMID:19631370, PMID:21957149 NCBI chr20:3,885,044...3,903,554
Ensembl chr20:3,659,559...3,701,089
JBrowse link
G POLR3A RNA polymerase III subunit A ISO (PMID:19609254) UniProtKB PMID:19609254 NCBI chr10:74,496,121...74,550,054 JBrowse link
G POLR3B RNA polymerase III subunit B ISO (PMID:19609254) UniProtKB PMID:19609254 NCBI chr12:103,936,650...104,083,470
Ensembl chr12:107,330,306...107,477,279
JBrowse link
G POLR3C RNA polymerase III subunit C ISO (PMID:19609254) UniProtKB PMID:19609254 NCBI chr 1:121,917,371...121,935,976
Ensembl chr 1:113,733,846...113,752,486
JBrowse link
G POLR3D RNA polymerase III subunit D ISO (PMID:19631370) UniProtKB PMID:19631370 NCBI chr 8:21,489,492...21,499,948
Ensembl chr 8:18,429,013...18,435,060
JBrowse link
G POLR3F RNA polymerase III subunit F ISO (PMID:19631370) UniProtKB PMID:19631370 NCBI chr20:18,429,402...18,447,634
Ensembl chr20:18,400,976...18,418,225
JBrowse link
G POLR3G RNA polymerase III subunit G ISO (PMID:19609254), (PMID:19631370) UniProtKB PMID:19609254, PMID:19631370 NCBI chr 5:24,855,517...24,896,051
Ensembl chr 5:24,992,158...25,019,272
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (MGI:5562517|PMID:23871208) UniProt PMID:23871208 MGI:5562517 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G RIOK3 RIO kinase 3 ISO (PMID:24807708) UniProtKB PMID:24807708 NCBI chr18:16,703,893...16,734,160
Ensembl chr18:20,331,222...20,360,825
JBrowse link
G RNF135 ring finger protein 135 ISO (PMID:19017631) UniProtKB PMID:19017631 NCBI chr17:25,843,447...25,869,874 JBrowse link
G TBK1 TANK binding kinase 1 ISO (PMID:16127453)
(MGI:3530402|PMID:15661922)
BHF-UCL
MGI
PMID:15661922, PMID:16127453 MGI:3530402 NCBI chr12:24,419,271...24,469,164
Ensembl chr12:24,917,246...24,968,587
JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 ISO (MGI:2670551|PMID:12872135)
(MGI:2669022|PMID:12855817)
MGI PMID:12855817, PMID:12872135 MGI:2669022, MGI:2670551 NCBI chr19:3,836,100...3,852,017
Ensembl chr19:4,787,557...4,790,206
JBrowse link
G TLR2 toll like receptor 2 ISO (MGI:4456948|PMID:15356140) BHF-UCL PMID:15356140 MGI:4456948 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
JBrowse link
G TLR3 toll like receptor 3 ISO (PMID:16286015)
(MGI:4456948|PMID:15356140)
(PMID:12054664)
UniProt
BHF-UCL
PMID:12054664, PMID:15356140, PMID:16286015 MGI:4456948 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
JBrowse link
G TLR4 toll like receptor 4 ISO (MGI:3530402|PMID:15661922)
(MGI:4456948|PMID:15356140)
MGI
BHF-UCL
PMID:15356140, PMID:15661922 MGI:3530402, MGI:4456948 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
G TLR7 toll like receptor 7 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chr  X:5,479,247...5,504,810
Ensembl chr  X:12,767,981...12,790,517
JBrowse link
G TLR8 toll like receptor 8 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chr  X:5,518,742...5,535,304 JBrowse link
G ZBTB20 zinc finger and BTB domain containing 20 ISO (MGI:5619432|PMID:23776228) CACAO PMID:23776228 MGI:5619432 NCBI chr 3:111,445,520...112,275,946
Ensembl chr 3:118,389,250...118,431,453
JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) UniProtKB PMID:21102435 NCBI chr 7:131,002,580...131,068,513
Ensembl chr 7:143,489,750...143,555,438
JBrowse link
G ZFP64 ZFP64 zinc finger protein ISO (MGI:5619431|PMID:23857586) CACAO PMID:23857586 MGI:5619431 NCBI chr20:48,430,392...48,535,618
Ensembl chr20:49,516,786...49,653,435
JBrowse link
positive regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule ISO (MGI:5300392|PMID:22078883) CACAO PMID:22078883 MGI:5300392 NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966
JBrowse link
G CGAS cyclic GMP-AMP synthase ISO (PMID:24077100), (PMID:26046437), (PMID:28363908), (PMID:28738408)
(MGI:5908326|PMID:24077100), (MGI:5909141|PMID:28759889), (MGI:5909142|PMID:28759028)
UniProtKB
UniProt
PMID:24077100, PMID:26046437, PMID:28363908, PMID:28738408, PMID:28759028, PMID:28759889 MGI:5908326, MGI:5909141, MGI:5909142 NCBI chr 6:71,252,050...71,279,121
Ensembl chr 6:74,544,251...74,566,965
JBrowse link
G DHX33 DEAH-box helicase 33 ISO (MGI:6120210|PMID:24037184) UniProt PMID:24037184 MGI:6120210 NCBI chr17:5,490,642...5,517,192
Ensembl chr17:5,484,093...5,508,926
JBrowse link
G DHX58 DExH-box helicase 58 ISO (MGI:4421606|PMID:20080593) UniProt PMID:20080593 MGI:4421606 NCBI chr17:15,203,216...15,214,559
Ensembl chr17:15,424,437...15,435,582
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr  X:143,560,802...143,570,185
Ensembl chr  X:153,446,827...153,460,602
JBrowse link
G IRF1 interferon regulatory factor 1 ISO (MGI:3691368|PMID:17018642) UniProt PMID:17018642 MGI:3691368 NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035
JBrowse link
G IRF3 interferon regulatory factor 3 ISO (PMID:25636800) UniProt PMID:25636800 NCBI chr19:46,674,193...46,680,464
Ensembl chr19:55,593,627...55,599,903
JBrowse link
G IRF5 interferon regulatory factor 5 ISO (PMID:32433612) UniProt PMID:32433612 NCBI chr 7:120,889,752...120,902,096
Ensembl chr 7:133,415,170...133,426,356
JBrowse link
G MAVS mitochondrial antiviral signaling protein ISO (MGI:3807296|PMID:18780793) MGI PMID:18780793 MGI:3807296 NCBI chr20:3,885,044...3,903,554
Ensembl chr20:3,659,559...3,701,089
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572
JBrowse link
G PLCG2 phospholipase C gamma 2 ISO (MGI:5300392|PMID:22078883) CACAO PMID:22078883 MGI:5300392 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064
JBrowse link
G PQBP1 polyglutamine binding protein 1 ISO (PMID:26046437) UniProtKB PMID:26046437 NCBI chr  X:41,188,244...41,200,312
Ensembl chr  X:49,053,030...49,058,585
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23871208) UniProtKB PMID:23871208 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 ISO PMID:26669264
(MGI:5787716|PMID:26669264)
(PMID:22394562), (PMID:23747010), (PMID:26669264), (PMID:29694889), (PMID:30842659)
UniProt PMID:22394562, PMID:23747010, PMID:26669264, PMID:29694889, PMID:30842659 MGI:5787716, RGD:11344949 NCBI chr 5:134,845,689...134,852,938
Ensembl chr 5:140,967,399...140,973,846
JBrowse link
G SYK spleen associated tyrosine kinase ISO (MGI:5300392|PMID:22078883) CACAO PMID:22078883 MGI:5300392 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101
JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 ISO (MGI:2670551|PMID:12872135) MGI PMID:12872135 MGI:2670551 NCBI chr19:3,836,100...3,852,017
Ensembl chr19:4,787,557...4,790,206
JBrowse link
G TLR3 toll like receptor 3 ISO (MGI:3774796|PMID:18207576) MGI PMID:18207576 MGI:3774796 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
JBrowse link
G TRIM15 tripartite motif containing 15 ISO (PMID:23077300) UniProtKB PMID:23077300 NCBI chr 6:29,939,261...29,949,706
Ensembl chr 6:30,610,348...30,619,826
JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 ISO (MGI:4868308|PMID:21102435) MGI PMID:21102435 MGI:4868308 NCBI chr 7:131,002,580...131,068,513
Ensembl chr 7:143,489,750...143,555,438
JBrowse link
G ZCCHC3 zinc finger CCHC-type containing 3 ISO (MGI:6209107|PMID:30135424) UniProt PMID:30135424 MGI:6209107 NCBI chr20:504,967...508,354 JBrowse link
regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RNF216 ring finger protein 216 ISO (PMID:19893624) UniProtKB PMID:19893624 NCBI chr 7:5,872,118...6,037,073
Ensembl chr 7:5,891,909...6,051,979
JBrowse link
G TIRAP TIR domain containing adaptor protein ISO (MGI:4942245|PMID:14630816) BHF-UCL PMID:14630816 MGI:4942245 NCBI chr11:121,100,558...121,112,844
Ensembl chr11:125,018,064...125,022,309
JBrowse link
G TRAF3 TNF receptor associated factor 3 ISO (MGI:4839450|PMID:16306937) UniProt PMID:16306937 MGI:4839450 NCBI chr14:83,392,689...83,530,974
Ensembl chr14:103,263,440...103,340,670
JBrowse link
G TRIM38 tripartite motif containing 38 ISO (MGI:5441682|PMID:22539786) MGI PMID:22539786 MGI:5441682 NCBI chr 6:25,796,278...25,818,610
Ensembl chr 6:26,454,051...26,475,842
JBrowse link
regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGAS cyclic GMP-AMP synthase ISO (MGI:5699498|PMID:26371324) MGI PMID:26371324 MGI:5699498 NCBI chr 6:71,252,050...71,279,121
Ensembl chr 6:74,544,251...74,566,965
JBrowse link
G IRF8 interferon regulatory factor 8 ISO (MGI:3654212|PMID:12461077) UniProt PMID:12461077 MGI:3654212 NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073
JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit ISO (PMID:27019227) UniProt PMID:27019227 NCBI chr  X:17,290,805...17,592,163
Ensembl chr  X:24,657,878...24,960,231
JBrowse link
G RNF26 ring finger protein 26 ISO (PMID:25254379) UniProtKB PMID:25254379 NCBI chr11:114,175,586...114,178,379
Ensembl chr11:118,103,505...118,104,806
JBrowse link
G TBK1 TANK binding kinase 1 ISO (PMID:25636800) UniProt PMID:25636800 NCBI chr12:24,419,271...24,469,164
Ensembl chr12:24,917,246...24,968,587
JBrowse link
G TREX1 three prime repair exonuclease 1 ISO (MGI:5523362|PMID:24154727)
(MGI:4848004|PMID:20871604)
(MGI:5699498|PMID:26371324)
MGI PMID:20871604, PMID:24154727, PMID:26371324 MGI:4848004, MGI:5523362, MGI:5699498 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12566
    multicellular organismal process 6470
      cytokine production 698
        type I interferon production 83
          interferon-alpha production + 26
          interferon-beta production + 50
          interferon-delta production 0
          interferon-epsilon production 0
          interferon-kappa production 0
          interferon-omega production 0
          interferon-tau production 0
          negative regulation of type I interferon production + 26
          positive regulation of type I interferon production + 51
          regulation of type I interferon production + 83
Path 2
Term Annotations click to browse term
  biological_process 12566
    metabolic process 7977
      organic substance metabolic process 7668
        macromolecule metabolic process 6619
          gene expression 4106
            cytokine production 698
              type I interferon production 83
                interferon-alpha production + 26
                interferon-beta production + 50
                interferon-delta production 0
                interferon-epsilon production 0
                interferon-kappa production 0
                interferon-omega production 0
                interferon-tau production 0
                negative regulation of type I interferon production + 26
                positive regulation of type I interferon production + 51
                regulation of type I interferon production + 83
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.