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ONTOLOGY REPORT - ANNOTATIONS


Term:type I interferon production
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Accession:GO:0032606 term browser browse the term
Definition:The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Comment:Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
Synonyms:exact_synonym: type I IFN production
 narrow_synonym: type I interferon biosynthetic process;   type I interferon secretion
 alt_id: GO:0045351;   GO:0072641


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negative regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 ISO (PMID:26492563) UniProtKB PMID:26492563 NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320
JBrowse link
G Nlrc3 NLR family CARD domain containing 3 ISO (MGI:5568884|PMID:24560620) UniProt PMID:24560620 MGI:5568884 NCBI chrNW_004955442:13,795,322...13,834,362
Ensembl chrNW_004955442:13,814,434...13,833,222
JBrowse link
G Nmi N-myc and STAT interactor ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chrNW_004955440:16,850,469...16,877,295
Ensembl chrNW_004955440:16,848,108...16,877,674
JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S ISO (PMID:26231120) UniProtKB PMID:26231120 NCBI chrNW_004955495:3,943,075...3,991,361
Ensembl chrNW_004955495:3,943,170...3,990,927
JBrowse link
negative regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A ISO (MGI:5569198|PMID:24670807) MGI PMID:24670807 MGI:5569198 NCBI chrNW_004955453:14,203,798...14,214,760 JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) UniProtKB PMID:20829348 NCBI chrNW_004955495:5,561,359...5,571,945
Ensembl chrNW_004955495:5,561,979...5,571,682
JBrowse link
G Crebbp CREB binding protein ISO (MGI:2151262|PMID:11583620) CAFA PMID:11583620 MGI:2151262 NCBI chrNW_004955442:13,559,496...13,691,913
Ensembl chrNW_004955442:13,559,496...13,692,004
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:3828224|PMID:18851954) MGI PMID:18851954 MGI:3828224 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
JBrowse link
G Nlrc3 NLR family CARD domain containing 3 ISO (MGI:5568884|PMID:24560620) UniProt PMID:24560620 MGI:5568884 NCBI chrNW_004955442:13,795,322...13,834,362
Ensembl chrNW_004955442:13,814,434...13,833,222
JBrowse link
G Nlrx1 NLR family member X1 ISO (MGI:5050761|PMID:21703540) MGI PMID:21703540 MGI:5050761 NCBI chrNW_004955412:20,275,767...20,287,414
Ensembl chrNW_004955412:20,275,917...20,287,414
JBrowse link
G Nmi N-myc and STAT interactor ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chrNW_004955440:16,850,469...16,877,295
Ensembl chrNW_004955440:16,848,108...16,877,674
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent 1B ISO (PMID:22750291) UniProtKB PMID:22750291 NCBI chrNW_004955441:11,276,525...11,338,586 JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S ISO (PMID:26231120) UniProtKB PMID:26231120 NCBI chrNW_004955495:3,943,075...3,991,361
Ensembl chrNW_004955495:3,943,170...3,990,927
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO (PMID:22065573) CACAO PMID:22065573 NCBI chrNW_004955424:22,909,035...22,939,651
Ensembl chrNW_004955424:22,911,541...22,939,651
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO (PMID:22065573) CACAO PMID:22065573 NCBI chrNW_004955555:2,060,533...2,086,229
Ensembl chrNW_004955555:2,060,533...2,086,229
JBrowse link
G Sirpa signal regulatory protein alpha ISO (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chrNW_004955415:13,030,752...13,072,735 JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO (MGI:5306204|PMID:22079989) MGI PMID:22079989 MGI:5306204 NCBI chrNW_004955542:2,264,472...2,301,083
Ensembl chrNW_004955542:2,265,901...2,301,215
JBrowse link
G Traip TRAF interacting protein ISO (MGI:5619447|PMID:22945920) CACAO PMID:22945920 MGI:5619447 NCBI chrNW_004955532:1,725,608...1,746,690
Ensembl chrNW_004955532:1,726,061...1,746,591
JBrowse link
G Yy1 YY1 transcription factor ISO (PMID:16260628) UniProtKB PMID:16260628 NCBI chrNW_004955438:21,341,374...21,377,674 JBrowse link
negative regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chrNW_004955404:30,254,934...30,266,898
Ensembl chrNW_004955404:30,254,841...30,270,921
JBrowse link
G Dhx58 DExH-box helicase 58 ISO (PMID:21525357)
(MGI:5318004|PMID:21525357)
UniProtKB
UniProt
PMID:21525357 MGI:5318004 NCBI chrNW_004955451:16,186,263...16,191,928
Ensembl chrNW_004955451:16,185,510...16,191,719
JBrowse link
G Gpatch3 G-patch domain containing 3 ISO (PMID:28414768) UniProtKB PMID:28414768 NCBI chrNW_004955452:6,234,241...6,241,949
Ensembl chrNW_004955452:6,234,241...6,241,991
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320
JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains ISO (PMID:29802199) UniProt PMID:29802199 NCBI chrNW_004955437:2,697,998...2,769,998
Ensembl chrNW_004955437:2,694,945...2,769,998
JBrowse link
G Nmi N-myc and STAT interactor ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chrNW_004955440:16,850,469...16,877,295
Ensembl chrNW_004955440:16,848,108...16,877,674
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chrNW_004955506:1,451,337...1,513,455
Ensembl chrNW_004955506:1,451,337...1,513,455
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO (MGI:5441107|PMID:23042151) MGI PMID:23042151 MGI:5441107 NCBI chrNW_004955422:18,868,696...18,877,826
Ensembl chrNW_004955422:18,868,696...18,877,438
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chrNW_004955402:19,276,157...19,310,605
Ensembl chrNW_004955402:19,295,809...19,309,987
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO (PMID:22079989) CACAO PMID:22079989 NCBI chrNW_004955542:2,264,472...2,301,083
Ensembl chrNW_004955542:2,265,901...2,301,215
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chrNW_004955442:18,548,545...18,568,989
Ensembl chrNW_004955442:18,548,545...18,569,366
JBrowse link
positive regulation of interferon-alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO (PMID:24784232)
(MGI:5583923|PMID:24784232)
CAFA PMID:24784232 MGI:5583923 NCBI chrNW_004955507:6,066,026...6,102,066
Ensembl chrNW_004955507:6,067,203...6,102,001
JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked ISO (PMID:30341167) UniProt PMID:30341167 NCBI chrNW_004955565:1,387,043...1,403,624
Ensembl chrNW_004955565:1,386,973...1,404,220
JBrowse link
G Ddx58 DExD/H-box helicase 58 ISO (PMID:19576794)
(PMID:19609254), (PMID:21957149)
UniProtKB
UniProt
PMID:19576794, PMID:19609254, PMID:21957149 NCBI chrNW_004955472:3,093,895...3,135,524
Ensembl chrNW_004955472:3,093,939...3,133,987
JBrowse link
G Dhx36 DEAH-box helicase 36 ISO (PMID:20696886) UniProt PMID:20696886 NCBI chrNW_004955448:5,634,072...5,676,272
Ensembl chrNW_004955448:5,634,072...5,676,319
JBrowse link
G Dhx9 DExH-box helicase 9 ISO (PMID:21957149) UniProt PMID:21957149 NCBI chrNW_004955406:21,697,813...21,743,551
Ensembl chrNW_004955406:21,697,813...21,745,011
JBrowse link
G Flt3 fms related receptor tyrosine kinase 3 ISO (MGI:4452060|PMID:20457904) MGI PMID:20457904 MGI:4452060 NCBI chrNW_004955497:7,357,533...7,441,215
Ensembl chrNW_004955497:7,357,212...7,461,439
JBrowse link
G Hmgb1 high mobility group box 1 ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chrNW_004955431:15,373,207...15,377,339 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO (PMID:17164250)
(MGI:3708392|PMID:17164250)
BHF-UCL
MGI
PMID:17164250 MGI:3708392 NCBI chrNW_004955403:3,062,724...3,073,419 JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO (PMID:19656871), (PMID:21957149) UniProt PMID:19656871, PMID:21957149 NCBI chrNW_004955449:11,538,869...11,596,502
Ensembl chrNW_004955449:11,538,889...11,593,349
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:4365354|PMID:18562536) UniProt PMID:18562536 MGI:4365354 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (PMID:16127453) BHF-UCL PMID:16127453 NCBI chrNW_004955476:11,442,781...11,445,706
Ensembl chrNW_004955476:11,443,272...11,445,657
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:16127453)
(PMID:19609254), (PMID:21957149)
BHF-UCL
UniProt
PMID:16127453, PMID:19609254, PMID:21957149 NCBI chrNW_004955415:14,691,918...14,704,782
Ensembl chrNW_004955415:14,695,438...14,703,672
JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO (MGI:5583923|PMID:24784232) CAFA PMID:24784232 MGI:5583923 NCBI chrNW_004955412:6,045,146...6,057,112
Ensembl chrNW_004955412:6,045,100...6,057,262
JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (MGI:5562517|PMID:23871208) UniProt PMID:23871208 MGI:5562517 NCBI chrNW_004955435:17,082,762...17,139,067 JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase ISO (PMID:28753426) UniProtKB PMID:28753426 NCBI chrNW_004955420:25,070,626...25,178,410
Ensembl chrNW_004955420:25,090,798...25,177,760
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO (PMID:28753426) UniProtKB PMID:28753426 NCBI chrNW_004955403:8,156,660...8,192,018
Ensembl chrNW_004955403:8,156,660...8,194,762
JBrowse link
G Tbk1 TANK binding kinase 1 ISO (PMID:16127453) BHF-UCL PMID:16127453 NCBI chrNW_004955458:11,210,120...11,263,632
Ensembl chrNW_004955458:11,211,398...11,263,867
JBrowse link
G Tlr3 toll like receptor 3 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
JBrowse link
G Tlr4 toll like receptor 4 ISO (MGI:4456948|PMID:15356140) BHF-UCL PMID:15356140 MGI:4456948 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tlr7 toll like receptor 7 ISO (PMID:16286015)
(MGI:3042320|PMID:14976261)
UniProt PMID:14976261, PMID:16286015 MGI:3042320 NCBI chrNW_004955544:424,897...443,562
Ensembl chrNW_004955544:424,850...443,564
JBrowse link
G Tlr8 toll like receptor 8 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chrNW_004955544:302,027...317,110
Ensembl chrNW_004955544:303,319...306,426
JBrowse link
G Tlr9 toll like receptor 9 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chrNW_004955532:3,828,645...3,832,699 JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) UniProtKB PMID:21102435 NCBI chrNW_004955494:3,925,478...3,985,469
Ensembl chrNW_004955494:3,926,413...3,983,736
JBrowse link
positive regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3 X-linked ISO (PMID:27980081), (PMID:31575075) UniProt PMID:27980081, PMID:31575075 NCBI chrNW_004955565:1,387,043...1,403,624
Ensembl chrNW_004955565:1,386,973...1,404,220
JBrowse link
G Ddx58 DExD/H-box helicase 58 ISO (PMID:17079289)
(MGI:5318026|PMID:17942531)
(PMID:19211564), (PMID:19609254), (PMID:19631370), (PMID:21957149)
BHF-UCL
UniProt
PMID:17079289, PMID:17942531, PMID:19211564, PMID:19609254, PMID:19631370, PMID:21957149 MGI:5318026 NCBI chrNW_004955472:3,093,895...3,135,524
Ensembl chrNW_004955472:3,093,939...3,133,987
JBrowse link
G Dhx9 DExH-box helicase 9 ISO (PMID:21957149) UniProt PMID:21957149 NCBI chrNW_004955406:21,697,813...21,743,551
Ensembl chrNW_004955406:21,697,813...21,745,011
JBrowse link
G Flot1 flotillin 1 ISO (PMID:25204797) UniProtKB PMID:25204797 NCBI chrNW_004955583:717,246...729,924
Ensembl chrNW_004955583:713,560...729,924
JBrowse link
G Hmgb1 high mobility group box 1 ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chrNW_004955431:15,373,207...15,377,339 JBrowse link
G Hmgb2 high mobility group box 2 ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chrNW_004955403:33,656,314...33,659,115
Ensembl chrNW_004955403:33,656,300...33,659,428
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO (PMID:17600090)
(PMID:19211564), (PMID:19656871), (PMID:21957149)
UniProtKB
UniProt
PMID:17600090, PMID:19211564, PMID:19656871, PMID:21957149 NCBI chrNW_004955449:11,538,869...11,596,502
Ensembl chrNW_004955449:11,538,889...11,593,349
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 ISO (MGI:5619426|PMID:24598055) CACAO PMID:24598055 MGI:5619426 NCBI chrNW_004955407:32,730,973...32,755,404
Ensembl chrNW_004955407:32,730,953...32,754,651
JBrowse link
G Irf1 interferon regulatory factor 1 ISO (PMID:21389130) UniProtKB PMID:21389130 NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:4365354|PMID:18562536) UniProt PMID:18562536 MGI:4365354 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (PMID:22065573) CACAO PMID:22065573 NCBI chrNW_004955476:11,442,781...11,445,706
Ensembl chrNW_004955476:11,443,272...11,445,657
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:16127453)
(PMID:19609254), (PMID:19631370), (PMID:21957149)
BHF-UCL
UniProt
PMID:16127453, PMID:19609254, PMID:19631370, PMID:21957149 NCBI chrNW_004955415:14,691,918...14,704,782
Ensembl chrNW_004955415:14,695,438...14,703,672
JBrowse link
G Polr3a RNA polymerase III subunit A ISO (PMID:19609254) UniProtKB PMID:19609254 NCBI chrNW_004955437:14,446,059...14,483,336
Ensembl chrNW_004955437:14,446,024...14,483,336
JBrowse link
G Polr3b RNA polymerase III subunit B ISO (PMID:19609254) UniProtKB PMID:19609254 NCBI chrNW_004955405:40,353,289...40,451,445
Ensembl chrNW_004955405:40,353,281...40,451,479
JBrowse link
G Polr3c RNA polymerase III subunit C ISO (PMID:19609254) UniProtKB PMID:19609254 NCBI chrNW_004955568:242,834...263,053
Ensembl chrNW_004955568:243,073...261,418
JBrowse link
G Polr3d RNA polymerase III subunit D ISO (PMID:19631370) UniProtKB PMID:19631370 NCBI chrNW_004955403:45,721,266...45,727,214
Ensembl chrNW_004955403:45,721,266...45,727,214
JBrowse link
G Polr3f RNA polymerase III subunit F ISO (PMID:19631370) UniProtKB PMID:19631370 NCBI chrNW_004955415:27,022,081...27,036,475
Ensembl chrNW_004955415:27,022,081...27,036,475
JBrowse link
G Polr3g RNA polymerase III subunit G ISO (PMID:19609254), (PMID:19631370) UniProtKB PMID:19609254, PMID:19631370 NCBI chrNW_004955418:21,116,812...21,149,818 JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 ISO (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chrNW_004955482:8,934,734...9,031,230
Ensembl chrNW_004955482:8,934,306...9,035,203
JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (MGI:5562517|PMID:23871208) UniProt PMID:23871208 MGI:5562517 NCBI chrNW_004955435:17,082,762...17,139,067 JBrowse link
G Riok3 RIO kinase 3 ISO (PMID:24807708) UniProtKB PMID:24807708 NCBI chrNW_004955402:11,649,160...11,670,010
Ensembl chrNW_004955402:11,648,849...11,672,545
JBrowse link
G Rnf135 ring finger protein 135 ISO (PMID:19017631) UniProtKB PMID:19017631 NCBI chrNW_004955481:7,111,760...7,122,800 JBrowse link
G Tbk1 TANK binding kinase 1 ISO (PMID:16127453)
(MGI:3530402|PMID:15661922)
BHF-UCL
MGI
PMID:15661922, PMID:16127453 MGI:3530402 NCBI chrNW_004955458:11,210,120...11,263,632
Ensembl chrNW_004955458:11,211,398...11,263,867
JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 ISO (MGI:2669022|PMID:12855817)
(MGI:2670551|PMID:12872135)
MGI PMID:12855817, PMID:12872135 MGI:2669022, MGI:2670551 NCBI chrNW_004955495:4,197,083...4,204,999
Ensembl chrNW_004955495:4,202,372...4,204,513
JBrowse link
G Tlr2 toll like receptor 2 ISO (MGI:4456948|PMID:15356140) BHF-UCL PMID:15356140 MGI:4456948 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr3 toll like receptor 3 ISO (PMID:12054664)
(MGI:4456948|PMID:15356140)
(PMID:16286015)
UniProt
BHF-UCL
PMID:12054664, PMID:15356140, PMID:16286015 MGI:4456948 NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
JBrowse link
G Tlr4 toll like receptor 4 ISO (MGI:3530402|PMID:15661922)
(MGI:4456948|PMID:15356140)
MGI
BHF-UCL
PMID:15356140, PMID:15661922 MGI:3530402, MGI:4456948 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tlr7 toll like receptor 7 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chrNW_004955544:424,897...443,562
Ensembl chrNW_004955544:424,850...443,564
JBrowse link
G Tlr8 toll like receptor 8 ISO (PMID:16286015) UniProt PMID:16286015 NCBI chrNW_004955544:302,027...317,110
Ensembl chrNW_004955544:303,319...306,426
JBrowse link
G Tlr9 toll like receptor 9 ISO (PMID:16286015)
(MGI:4456948|PMID:15356140)
UniProt
BHF-UCL
PMID:15356140, PMID:16286015 MGI:4456948 NCBI chrNW_004955532:3,828,645...3,832,699 JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 ISO (MGI:5619432|PMID:23776228) CACAO PMID:23776228 MGI:5619432 NCBI chrNW_004955427:14,409,700...15,231,495
Ensembl chrNW_004955427:14,409,700...14,453,926
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) UniProtKB PMID:21102435 NCBI chrNW_004955494:3,925,478...3,985,469
Ensembl chrNW_004955494:3,926,413...3,983,736
JBrowse link
positive regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule ISO (MGI:5300392|PMID:22078883) CACAO PMID:22078883 MGI:5300392 NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
JBrowse link
G Cgas cyclic GMP-AMP synthase ISO (PMID:24077100), (PMID:26046437), (PMID:28363908), (PMID:28738408)
(MGI:5908326|PMID:24077100), (MGI:5909141|PMID:28759889), (MGI:5909142|PMID:28759028)
UniProtKB
UniProt
PMID:24077100, PMID:26046437, PMID:28363908, PMID:28738408, PMID:28759028, PMID:28759889 MGI:5908326, MGI:5909141, MGI:5909142 NCBI chrNW_004955493:8,593,104...8,607,297 JBrowse link
G Dhx33 DEAH-box helicase 33 ISO (MGI:6120210|PMID:24037184) UniProt PMID:24037184 MGI:6120210 NCBI chrNW_004955467:10,797,464...10,819,083
Ensembl chrNW_004955467:10,793,934...10,818,898
JBrowse link
G Dhx58 DExH-box helicase 58 ISO (MGI:4421606|PMID:20080593) UniProt PMID:20080593 MGI:4421606 NCBI chrNW_004955451:16,186,263...16,191,928
Ensembl chrNW_004955451:16,185,510...16,191,719
JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chrNW_004955580:663,651...668,622
Ensembl chrNW_004955580:661,609...668,622
JBrowse link
G Irf1 interferon regulatory factor 1 ISO (MGI:3691368|PMID:17018642) UniProt PMID:17018642 MGI:3691368 NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (PMID:25636800) UniProt PMID:25636800 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:5546557|PMID:23956435) MGI PMID:23956435 MGI:5546557 NCBI chrNW_004955476:11,442,781...11,445,706
Ensembl chrNW_004955476:11,443,272...11,445,657
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (MGI:3807296|PMID:18780793) MGI PMID:18780793 MGI:3807296 NCBI chrNW_004955415:14,691,918...14,704,782
Ensembl chrNW_004955415:14,695,438...14,703,672
JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138
JBrowse link
G Plcg2 phospholipase C gamma 2 ISO (MGI:5300392|PMID:22078883) CACAO PMID:22078883 MGI:5300392 NCBI chrNW_004955522:4,352,890...4,480,735
Ensembl chrNW_004955522:4,358,233...4,468,986
JBrowse link
G Pqbp1 polyglutamine binding protein 1 ISO (PMID:26046437) UniProtKB PMID:26046437 NCBI chrNW_004955543:430,324...434,205
Ensembl chrNW_004955543:430,853...434,205
JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23871208) UniProtKB PMID:23871208 NCBI chrNW_004955435:17,082,762...17,139,067 JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO (PMID:22394562), (PMID:23747010), (PMID:26669264), (PMID:29694889), (PMID:30842659)
(MGI:5787716|PMID:26669264)
UniProt PMID:22394562, PMID:23747010, PMID:26669264, PMID:29694889, PMID:30842659 MGI:5787716, RGD:11344949 NCBI chrNW_004955418:1,091,022...1,097,064
Ensembl chrNW_004955418:1,083,613...1,100,448
JBrowse link
G Syk spleen associated tyrosine kinase ISO (MGI:5300392|PMID:22078883) CACAO PMID:22078883 MGI:5300392 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581
JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 ISO (MGI:2670551|PMID:12872135) MGI PMID:12872135 MGI:2670551 NCBI chrNW_004955495:4,197,083...4,204,999
Ensembl chrNW_004955495:4,202,372...4,204,513
JBrowse link
G Tlr3 toll like receptor 3 ISO (MGI:3774796|PMID:18207576) MGI PMID:18207576 MGI:3774796 NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
JBrowse link
G Trim15 tripartite motif containing 15 ISO (PMID:23077300) UniProtKB PMID:23077300 NCBI chrNW_004955583:277,564...283,422 JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (MGI:4868308|PMID:21102435) MGI PMID:21102435 MGI:4868308 NCBI chrNW_004955494:3,925,478...3,985,469
Ensembl chrNW_004955494:3,926,413...3,983,736
JBrowse link
G Zcchc3 zinc finger CCHC-type containing 3 ISO (MGI:6209107|PMID:30135424) UniProt PMID:30135424 MGI:6209107 NCBI chrNW_004955597:194,912...197,697
Ensembl chrNW_004955597:195,002...196,231
JBrowse link
regulation of interferon-beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf216 ring finger protein 216 ISO (PMID:19893624) UniProtKB PMID:19893624 NCBI chrNW_004955460:10,423,736...10,578,421
Ensembl chrNW_004955460:10,425,885...10,551,295
JBrowse link
G Tirap TIR domain containing adaptor protein ISO (MGI:4942245|PMID:14630816) BHF-UCL PMID:14630816 MGI:4942245 NCBI chrNW_004955412:27,303,548...27,315,031
Ensembl chrNW_004955412:27,312,489...27,315,031
JBrowse link
G Traf3 TNF receptor associated factor 3 ISO (MGI:4839450|PMID:16306937) UniProt PMID:16306937 MGI:4839450 NCBI chrNW_004955538:1,954,152...2,013,367
Ensembl chrNW_004955538:1,954,152...2,013,367
JBrowse link
regulation of type I interferon production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase ISO (MGI:5699498|PMID:26371324) MGI PMID:26371324 MGI:5699498 NCBI chrNW_004955493:8,593,104...8,607,297 JBrowse link
G Irf8 interferon regulatory factor 8 ISO (MGI:3654212|PMID:12461077) UniProt PMID:12461077 MGI:3654212 NCBI chrNW_004955541:973,004...988,493
Ensembl chrNW_004955541:973,022...990,106
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit ISO (PMID:27019227) UniProt PMID:27019227 NCBI chrNW_004955509:5,007,385...5,319,683
Ensembl chrNW_004955509:5,007,182...5,319,894
JBrowse link
G Rnf26 ring finger protein 26 ISO (PMID:25254379) UniProtKB PMID:25254379 NCBI chrNW_004955412:20,415,468...20,418,263
Ensembl chrNW_004955412:20,416,067...20,417,368
JBrowse link
G Tbk1 TANK binding kinase 1 ISO (PMID:25636800) UniProt PMID:25636800 NCBI chrNW_004955458:11,210,120...11,263,632
Ensembl chrNW_004955458:11,211,398...11,263,867
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:5699498|PMID:26371324)
(MGI:4848004|PMID:20871604)
(MGI:5523362|PMID:24154727)
MGI PMID:20871604, PMID:24154727, PMID:26371324 MGI:4848004, MGI:5523362, MGI:5699498 NCBI chrNW_004955532:533,877...535,767
Ensembl chrNW_004955532:533,877...535,767
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    multicellular organismal process 6168
      cytokine production 638
        type I interferon production 80
          interferon-alpha production + 27
          interferon-beta production + 49
          interferon-delta production 0
          interferon-epsilon production 0
          interferon-kappa production 0
          interferon-omega production 0
          interferon-tau production 0
          negative regulation of type I interferon production + 24
          positive regulation of type I interferon production + 51
          regulation of type I interferon production + 80
Path 2
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7608
      organic substance metabolic process 7317
        macromolecule metabolic process 6343
          gene expression 3928
            cytokine production 638
              type I interferon production 80
                interferon-alpha production + 27
                interferon-beta production + 49
                interferon-delta production 0
                interferon-epsilon production 0
                interferon-kappa production 0
                interferon-omega production 0
                interferon-tau production 0
                negative regulation of type I interferon production + 24
                positive regulation of type I interferon production + 51
                regulation of type I interferon production + 80
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.