ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-12 production
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Accession:GO:0032615 term browser browse the term
Definition:The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IL-12 production


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interleukin-12 production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
interleukin-12 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
RGD:1600115
negative regulation of interleukin-12 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:1624291
RGD:1600115
negative regulation of interleukin-12 production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp5 acid phosphatase 5, tartrate resistant JBrowse link 8 23,142,733 23,149,067 RGD:1624291
RGD:1600115
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
RGD:1600115
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1600115
RGD:1624291
G Cmklr1 chemerin chemokine-like receptor 1 JBrowse link 12 48,743,556 48,796,582 RGD:1600115
RGD:1624291
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
RGD:1600115
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
RGD:13792537
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
RGD:1600115
G Mefv MEFV innate immuity regulator, pyrin JBrowse link 10 12,045,813 12,056,229 RGD:1624291
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 10 11,809,531 11,844,184 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Pibf1 progesterone immunomodulatory binding factor 1 JBrowse link 15 83,494,110 83,663,202 RGD:1624291
RGD:1600115
G Slamf1 signaling lymphocytic activation molecule family member 1 JBrowse link 13 90,184,545 90,219,170 RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Tigit T cell immunoreceptor with Ig and ITIM domains JBrowse link 11 61,966,780 61,987,749 RGD:1624291
RGD:13792537
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
negative regulation of interleukin-12 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lilra5 leukocyte immunoglobulin like receptor A5 JBrowse link 1 73,655,767 73,682,232 RGD:1624291
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1624291
RGD:1600115
G Tnfrsf9 TNF receptor superfamily member 9 JBrowse link 5 168,009,245 168,035,813 RGD:1624291
positive regulation of interleukin-12 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
RGD:1600115
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:1624291
RGD:1600115
G LOC103694381 lymphotoxin-beta JBrowse link 20 4,861,343 4,863,513 RGD:1624291
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
RGD:1600115
positive regulation of interleukin-12 production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
RGD:1600115
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1624291
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:1624291
RGD:1600115
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:2313415
RGD:1624291
RGD:1600115
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:1624291
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link 16 72,216,326 72,228,098 RGD:1624291
RGD:1600115
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
RGD:1600115
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
RGD:1600115
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:1624291
RGD:1600115
G Irf8 interferon regulatory factor 8 JBrowse link 19 54,314,859 54,336,643 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
RGD:1600115
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
RGD:1600115
G Tnfsf9 TNF superfamily member 9 JBrowse link 9 9,909,942 9,912,276 RGD:2317345
positive regulation of interleukin-12 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:1624291
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:1624291
RGD:1600115
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1600115
RGD:1624291
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Unc93b1 unc-93 homolog B1, TLR signaling regulator JBrowse link 1 219,172,987 219,183,941 RGD:1624291
regulation of interleukin-12 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mast2 microtubule associated serine/threonine kinase 2 JBrowse link 5 135,149,336 135,285,337 RGD:1624291
RGD:1600115
regulation of interleukin-12 production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd47 Cd47 molecule JBrowse link 11 53,511,485 53,575,754 RGD:1624291
regulation of interleukin-12 secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp1 forkhead box P1 JBrowse link 4 131,362,178 131,963,466 RGD:1624291

Term paths to the root
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  biological_process 17896
    multicellular organismal process 8524
      cytokine production 771
        interleukin-12 production 59
          interleukin-12 biosynthetic process + 9
          interleukin-12 secretion + 12
          negative regulation of interleukin-12 production + 19
          positive regulation of interleukin-12 production + 35
          regulation of interleukin-12 production + 55
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.