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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-12 production
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Accession:GO:0032615 term browser browse the term
Definition:The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IL-12 production
 narrow_synonym: CLMF production;   NKSF production;   interleukin-12 biosynthetic process;   interleukin-12 secretion
 alt_id: GO:0042090;   GO:0072610


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interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase ISO MGI:MGI:2182739 (MGI:MGI:3581936|PMID:15817708) RGD PMID:15817708 MGI:MGI:3581936 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Lep leptin ISO
ISS
(MGI:MGI:3690675|PMID:9438411)
GO_REF:0000024
RGD
UniProt
PMID:9438411 GO_REF:0000024, MGI:MGI:3690675 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
(MGI:MGI:3581936|PMID:15817708)
GO_REF:0000107
RGD
Ensembl
PMID:15817708 GO_REF:0000107, MGI:MGI:3581936 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Tnfsf18 TNF superfamily member 18 NOT ISO (MGI:MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
negative regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant ISO
IEA
MGI:MGI:2180086 (MGI:MGI:1930064|PMID:11168643)
GO_REF:0000107
RGD
Ensembl
PMID:11168643 GO_REF:0000107, MGI:MGI:1930064 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Arrb2 arrestin, beta 2 ISO (MGI:MGI:3662828|PMID:16378096) RGD PMID:16378096 MGI:MGI:3662828 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G C1qbp complement C1q binding protein ISS
ISO
GO_REF:0000024
(PMID:16177118), (PMID:17881511)
UniProt
RGD
PMID:16177118, PMID:17881511 GO_REF:0000024 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO (MGI:MGI:4441559|PMID:20176793) RGD PMID:20176793 MGI:MGI:4441559 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5009414|PMID:15753205)
Ensembl
UniProt
RGD
PMID:15753205 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5009414 NCBI chr12:48,743,556...48,796,582
Ensembl chr12:48,789,261...48,793,553
JBrowse link
G Il10 interleukin 10 ISO MGI:MGI:1857199 (MGI:MGI:3051177|PMID:15240714) RGD PMID:15240714 MGI:MGI:3051177 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO
IBA
(PMID:18156187)
PMID:21873635
(MGI:MGI:2183694|PMID:12150927)
RGD PMID:12150927, PMID:18156187, PMID:21873635 MGI:MGI:2183694, RGD:13792537 NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281
JBrowse link
G Jak3 Janus kinase 3 ISO
ISS
(MGI:MGI:3719947|PMID:16020505)
GO_REF:0000024
RGD
BHF-UCL
PMID:16020505 GO_REF:0000024, MGI:MGI:3719947 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 ISO (PMID:19009525) RGD PMID:19009525 NCBI chr 1:73,655,767...73,682,232
Ensembl chr 1:73,656,028...73,682,247
JBrowse link
G Mefv MEFV innate immuity regulator, pyrin ISO (PMID:20041150) RGD PMID:20041150 NCBI chr10:12,045,813...12,056,229
Ensembl chr10:12,046,541...12,056,311
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO
IEA
(MGI:MGI:2679145|PMID:14568984)
GO_REF:0000107
RGD
Ensembl
PMID:14568984 GO_REF:0000107, MGI:MGI:2679145 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 ISO (MGI:MGI:5437524|PMID:22863753) RGD PMID:22863753 MGI:MGI:5437524 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO MGI:MGI:2680581 (MGI:MGI:3050756|PMID:15220916), (MGI:MGI:3686795|PMID:16949315) RGD PMID:15220916, PMID:16949315 MGI:MGI:3050756, MGI:MGI:3686795 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 ISO (PMID:14634107) RGD PMID:14634107 NCBI chr15:83,494,110...83,663,202
Ensembl chr15:83,495,377...83,663,143
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 ISO (PMID:16317102) RGD PMID:16317102 NCBI chr13:90,184,545...90,219,170
Ensembl chr13:90,184,569...90,219,217
JBrowse link
G Thbs1 thrombospondin 1 ISO (PMID:16882710) RGD PMID:16882710 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tigit T cell immunoreceptor with Ig and ITIM domains ISO
IBA
(PMID:19011627)
PMID:21873635
RGD PMID:19011627, PMID:21873635 RGD:13792537 NCBI chr11:61,966,780...61,987,749
Ensembl chr11:61,970,976...61,987,760
JBrowse link
G Tlr2 toll-like receptor 2 ISO (MGI:MGI:3686795|PMID:16949315) RGD PMID:16949315 MGI:MGI:3686795 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr8 toll-like receptor 8 ISO (PMID:24942581) RGD PMID:24942581 NCBI chr  X:28,539,158...28,562,803
Ensembl chr  X:28,539,158...28,562,803
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 ISO (MGI:MGI:3807131|PMID:18640726) RGD PMID:18640726 MGI:MGI:3807131 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
positive regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEA
ISO
GO_REF:0000107
(PMID:15944249)
Ensembl
RGD
PMID:15944249 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO (MGI:MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:MGI:3576832 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO (MGI:MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:MGI:3576832 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cd36 CD36 molecule ISO MGI:MGI:2447190 (MGI:MGI:3587138|PMID:16061696) RGD PMID:16061696 MGI:MGI:3587138 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40 CD40 molecule ISO
IBA
(MGI:MGI:3051177|PMID:15240714)
PMID:21873635
RGD PMID:15240714, PMID:21873635 MGI:MGI:3051177, RGD:13792537 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand IDA
ISO
IEA
(PMID:9922218)
GO_REF:0000107
RGD
Ensembl
PMID:9922218, PMID:18384807 GO_REF:0000107, RGD:2313415 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Clec7a C-type lectin domain containing 7A ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Defb25 defensin beta 25 ISO (PMID:24955228) RGD PMID:24955228 NCBI chr 3:148,103,643...148,104,483
Ensembl chr 3:148,103,643...148,104,483
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 ISO MGI:MGI:3628823 (MGI:MGI:4452060|PMID:20457904) RGD PMID:20457904 MGI:MGI:4452060 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Hmgb1 high mobility group box 1 ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO (PMID:17164250) RGD PMID:17164250 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO
IEA
MGI:MGI:3505776 (MGI:MGI:3837074|PMID:19234212)
GO_REF:0000107
RGD
Ensembl
PMID:19234212 GO_REF:0000107, MGI:MGI:3837074 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ifng interferon gamma ISO (PMID:7605994), (PMID:8557999)
(MGI:MGI:2679145|PMID:14568984), (MGI:MGI:3653161|PMID:9348310)
RGD PMID:7605994, PMID:8557999, PMID:9348310, PMID:14568984 MGI:MGI:2679145, MGI:MGI:3653161 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B ISO (PMID:20027291) RGD PMID:20027291 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il16 interleukin 16 ISO (PMID:30634164) RGD PMID:30634164 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il17a interleukin 17A ISO
IEA
(PMID:29734196)
GO_REF:0000107
RGD
Ensembl
PMID:29734196 GO_REF:0000107 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il23a interleukin 23 subunit alpha ISO (PMID:20027291) RGD PMID:20027291 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il23r interleukin 23 receptor ISO (PMID:20027291) RGD PMID:20027291 NCBI chr 4:98,203,788...98,306,729
Ensembl chr 4:98,203,958...98,305,173
JBrowse link
G Irf1 interferon regulatory factor 1 ISO
IEA
MGI:MGI:1857205 (MGI:MGI:2679145|PMID:14568984)
GO_REF:0000107
RGD
Ensembl
PMID:14568984 GO_REF:0000107, MGI:MGI:2679145 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irf8 interferon regulatory factor 8 ISO MGI:MGI:1926332 (MGI:MGI:3653161|PMID:9348310) RGD PMID:9348310 MGI:MGI:3653161 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO (MGI:MGI:5437583|PMID:22727192) RGD PMID:22727192 MGI:MGI:5437583 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Lgals9 galectin 9 ISO (PMID:16116184), (PMID:25754930) RGD PMID:16116184, PMID:25754930 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G LOC103694381 lymphotoxin-beta ISO (MGI:MGI:3773766|PMID:17982081) RGD PMID:17982081 MGI:MGI:3773766 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO (PMID:25754930) RGD PMID:25754930 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO
IEA
(PMID:25754930)
GO_REF:0000107
RGD
Ensembl
PMID:25754930 GO_REF:0000107 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mdk midkine ISO
ISS
(PMID:22323540)
GO_REF:0000024
RGD
UniProt
PMID:22323540 GO_REF:0000024 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO MGI:MGI:2680581|MGI:MGI:3529594 (MGI:MGI:2679172|PMID:14560001), (MGI:MGI:3050756|PMID:15220916), (MGI:MGI:3528786|PMID:15692051) RGD PMID:14560001, PMID:15220916, PMID:15692051 MGI:MGI:2679172, MGI:MGI:3050756, MGI:MGI:3528786 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Plcb1 phospholipase C beta 1 ISO
ISS
(MGI:MGI:4943671|PMID:9444325)
GO_REF:0000024
RGD
BHF-UCL
PMID:9444325 GO_REF:0000024, MGI:MGI:4943671 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO (MGI:MGI:2679145|PMID:14568984) RGD PMID:14568984 MGI:MGI:2679145 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (MGI:MGI:2679145|PMID:14568984) RGD PMID:14568984 MGI:MGI:2679145 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein ISO (MGI:MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:MGI:5913054 NCBI chr10:57,415,429...57,436,412
Ensembl chr10:57,415,832...57,436,368
JBrowse link
G Syk spleen associated tyrosine kinase ISO
IEA
(PMID:19358895)
GO_REF:0000107
RGD
Ensembl
PMID:19358895 GO_REF:0000107 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tirap TIR domain containing adaptor protein ISO (MGI:MGI:3531416|PMID:12447442) RGD PMID:12447442 MGI:MGI:3531416 NCBI chr 8:36,382,029...36,399,625
Ensembl chr 8:36,385,353...36,388,224
JBrowse link
G Tlr2 toll-like receptor 2 ISO (MGI:MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:MGI:4456948 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr3 toll-like receptor 3 ISO (MGI:MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:MGI:4456948 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEA
(MGI:MGI:4456948|PMID:15356140), (MGI:MGI:5913054|PMID:28098138)
GO_REF:0000107
(PMID:15027902)
RGD
Ensembl
PMID:15027902, PMID:15356140, PMID:28098138 GO_REF:0000107, MGI:MGI:4456948, MGI:MGI:5913054 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr9 toll-like receptor 9 ISO (MGI:MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:MGI:4456948 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:4835591|PMID:20844189) RGD PMID:20844189 MGI:MGI:4835591 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Tnfsf9 TNF superfamily member 9 IDA RGD PMID:18687212 RGD:2317345 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Traf6 TNF receptor associated factor 6 ISO MGI:MGI:2678775 (MGI:MGI:2677080|PMID:14499111) RGD PMID:14499111 MGI:MGI:2677080 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator ISO MGI:MGI:3619211 (MGI:MGI:4452060|PMID:20457904) RGD PMID:20457904 MGI:MGI:4452060 NCBI chr 1:219,172,987...219,183,941
Ensembl chr 1:219,144,205...219,183,963
JBrowse link
regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd47 Cd47 molecule ISO (PMID:11509594) RGD PMID:11509594 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Foxp1 forkhead box P1 ISO (PMID:18799727) RGD PMID:18799727 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 ISO (MGI:MGI:3029081|PMID:14764729) RGD PMID:14764729 MGI:MGI:3029081 NCBI chr 5:135,149,336...135,285,337
Ensembl chr 5:135,149,307...135,285,337
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    multicellular organismal process 9068
      cytokine production 838
        interleukin-12 production 65
          negative regulation of interleukin-12 production 20
          positive regulation of interleukin-12 production 41
          regulation of interleukin-12 production + 61
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          gene expression 6294
            cytokine production 838
              interleukin-12 production 65
                negative regulation of interleukin-12 production 20
                positive regulation of interleukin-12 production 41
                regulation of interleukin-12 production + 61
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.