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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-18 production
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Accession:GO:0032621 term browser browse the term
Definition:The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IGIF production;   IL-18 production
 narrow_synonym: IL1F4 production;   interleukin-18 biosynthetic process;   interleukin-18 secretion
 alt_id: GO:0042241;   GO:0072616


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interleukin-18 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbp5 guanylate binding protein 5 ISO (MGI:MGI:5319585|PMID:22461501) RGD PMID:22461501 MGI:MGI:5319585 NCBI chr 2:248,178,441...248,196,873
Ensembl chr 2:248,178,389...248,197,160
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO MGI:MGI:3686871 (MGI:MGI:3697006|PMID:17008311) RGD PMID:17008311 MGI:MGI:3697006 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
negative regulation of interleukin-18 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd84 CD84 molecule ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865
JBrowse link
G Mir223 microRNA 223 IMP RGD PMID:31237865 RGD:25824937 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO MGI:MGI:2680581 (MGI:MGI:3050756|PMID:15220916) RGD PMID:15220916 MGI:MGI:3050756 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
positive regulation of interleukin-18 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhx9 DExH-box helicase 9 ISO (MGI:MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:MGI:5908739 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Nlrp9 NLR family, pyrin domain containing 9 ISO (MGI:MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:MGI:5908739 NCBI chr 1:71,859,390...71,917,337
Ensembl chr 1:71,859,390...71,909,138
JBrowse link
G Tlr2 toll-like receptor 2 ISO (MGI:MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:MGI:4456948 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr9 toll-like receptor 9 ISO (MGI:MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:MGI:4456948 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:16269520 RGD:1580205 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Usp50 ubiquitin specific peptidase 50 ISO (MGI:MGI:5888801|PMID:28094437) RGD PMID:28094437 MGI:MGI:5888801 NCBI chr 3:119,225,055...119,247,442
Ensembl chr 3:119,224,943...119,247,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    multicellular organismal process 9068
      cytokine production 838
        interleukin-18 production 11
          negative regulation of interleukin-18 production 3
          positive regulation of interleukin-18 production 6
          regulation of interleukin-18 production + 9
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          gene expression 6294
            cytokine production 838
              interleukin-18 production 11
                negative regulation of interleukin-18 production 3
                positive regulation of interleukin-18 production 6
                regulation of interleukin-18 production + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.