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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-4 production
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Accession:GO:0032633 term browser browse the term
Definition:The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IL-4 production
 narrow_synonym: interleukin-4 biosynthetic process;   interleukin-4 secretion
 alt_id: GO:0042097;   GO:0042224;   GO:0072602


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interleukin-4 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 ISO MGI:MGI:3719568 (MGI:MGI:3718932|PMID:17658279) RGD PMID:17658279 MGI:MGI:3718932 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Il1rap interleukin 1 receptor accessory protein ISO
IEA
(MGI:MGI:4353496|PMID:17675517)
GO_REF:0000107
RGD
Ensembl
PMID:17675517 GO_REF:0000107, MGI:MGI:4353496 NCBI chr11:77,456,648...77,593,208
Ensembl chr11:77,463,954...77,593,207
JBrowse link
G Itk IL2-inducible T-cell kinase ISO MGI:MGI:102960|MGI:MGI:2178928 (MGI:MGI:3773943|PMID:18292523) RGD PMID:18292523 MGI:MGI:3773943 NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419
JBrowse link
G Notch1 notch receptor 1 ISO MGI:MGI:97364 (MGI:MGI:3718932|PMID:17658279) RGD PMID:17658279 MGI:MGI:3718932 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch2 notch receptor 2 ISO
IEA
MGI:MGI:97363 (MGI:MGI:3718932|PMID:17658279)
GO_REF:0000107
RGD
Ensembl
PMID:17658279 GO_REF:0000107, MGI:MGI:3718932 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO MGI:MGI:1857411 (MGI:MGI:3718932|PMID:17658279) RGD PMID:17658279 MGI:MGI:3718932 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Txk TXK tyrosine kinase ISO MGI:MGI:96621 (MGI:MGI:3773943|PMID:18292523) RGD PMID:18292523 MGI:MGI:3773943 NCBI chr14:38,029,809...38,085,822
Ensembl chr14:38,030,189...38,085,919
JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 ISO MGI:MGI:3663315 (MGI:MGI:3655569|PMID:16914726) RGD PMID:16914726 MGI:MGI:3655569 NCBI chr 2:203,200,435...203,274,264
Ensembl chr 2:203,200,427...203,276,142
JBrowse link
G Zg16 zymogen granule protein 16 ISO MGI:MGI:3529206 (MGI:MGI:5824939|PMID:27849619) RGD PMID:27849619 MGI:MGI:5824939 NCBI chr 1:198,483,800...198,486,157
Ensembl chr 1:198,483,805...198,486,157
JBrowse link
negative regulation of interleukin-4 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd83 CD83 molecule ISO MGI:MGI:3055293 (MGI:MGI:3054335|PMID:15322158) RGD PMID:15322158 MGI:MGI:3054335 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO
IEA
(PMID:24038088)
GO_REF:0000107
RGD
Ensembl
PMID:24038088 GO_REF:0000107 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Foxp3 forkhead box P3 ISO (PMID:15466453)
MGI:MGI:3696705 (MGI:MGI:3693968|PMID:16769892), (MGI:MGI:3695768|PMID:16275384)
RGD PMID:15466453, PMID:16275384, PMID:16769892 MGI:MGI:3693968, MGI:MGI:3695768 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA
ISO
GO_REF:0000107
(PMID:18445004)
Ensembl
RGD
PMID:18445004 GO_REF:0000107 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Mir301a microRNA 301a ISO (MGI:MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:MGI:5426073 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 ISO MGI:MGI:3695433 (MGI:MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:MGI:3694584 NCBI chr18:31,574,759...31,625,286
Ensembl chr18:31,574,821...31,625,274
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO MGI:MGI:2386295 (MGI:MGI:3615741|PMID:15356574) RGD PMID:15356574 MGI:MGI:3615741 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Zfpm1 zinc finger protein, multitype 1 ISO (PMID:21646796) RGD PMID:21646796 NCBI chr19:55,094,585...55,150,994
Ensembl chr19:55,094,585...55,150,686
JBrowse link
positive regulation of interleukin-4 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule ISO MGI:MGI:2180711|MGI:MGI:2180713 (MGI:MGI:2180705|PMID:10201995), (MGI:MGI:3041278|PMID:11754812), (MGI:MGI:72888|PMID:7538697), (MGI:MGI:87097|PMID:9133426) RGD PMID:7538697, PMID:9133426, PMID:10201995, PMID:11754812 MGI:MGI:2180705, MGI:MGI:3041278, MGI:MGI:72888, MGI:MGI:87097 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Cd28 Cd28 molecule IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:8617933)
Ensembl
UniProt
RGD
PMID:8617933 GO_REF:0000024, GO_REF:0000107 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd3e CD3e molecule ISO (MGI:MGI:2176424|PMID:11894097) RGD PMID:11894097 MGI:MGI:2176424 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806
JBrowse link
G Cd40lg CD40 ligand IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:8617933)
Ensembl
UniProt
RGD
PMID:8617933 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO
ISS
(MGI:MGI:3773092|PMID:16585579)
GO_REF:0000024
RGD
UniProt
PMID:16585579 GO_REF:0000024, MGI:MGI:3773092 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Epx eosinophil peroxidase ISO MGI:MGI:2182952 (MGI:MGI:3656344|PMID:16926417) RGD PMID:16926417 MGI:MGI:3656344 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig ISS
ISO
GO_REF:0000024
(MGI:MGI:3831068|PMID:19098920)
UniProt
RGD
PMID:19098920 GO_REF:0000024, MGI:MGI:3831068 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Foxp3 forkhead box P3 ISO (MGI:MGI:4837946|PMID:20944002) RGD PMID:20944002 MGI:MGI:4837946 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gata3 GATA binding protein 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:1346931|PMID:10549629), (MGI:MGI:3718933|PMID:17658278)
UniProt
RGD
PMID:10549629, PMID:17658278 GO_REF:0000024, MGI:MGI:1346931, MGI:MGI:3718933 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO UniProtKB:O00182 (PMID:25578313) RGD PMID:25578313 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Icoslg inducible T-cell co-stimulator ligand ISO (MGI:MGI:1929009|PMID:11343123) RGD PMID:11343123 MGI:MGI:1929009 NCBI chr20:11,330,000...11,340,307
Ensembl chr20:11,329,992...11,340,296
JBrowse link
G Il20rb interleukin 20 receptor subunit beta ISO MGI:MGI:3830304 (MGI:MGI:3827040|PMID:19124723) RGD PMID:19124723 MGI:MGI:3827040 NCBI chr 8:108,745,906...108,778,561
Ensembl chr 8:108,747,204...108,777,717
JBrowse link
G Il33 interleukin 33 ISO
IEA
UniProtKB:P08226 (MGI:MGI:3775141|PMID:18268038)
GO_REF:0000107
RGD
Ensembl
PMID:18268038 GO_REF:0000107, MGI:MGI:3775141 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Irf4 interferon regulatory factor 4 ISO (PMID:12374808) RGD PMID:12374808 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Lgals9 galectin 9 ISO UniProtKB:Q8VIM0 (PMID:20209097), (PMID:25578313) RGD PMID:20209097, PMID:25578313 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Prg2 proteoglycan 2 ISO
IEA
MGI:MGI:3027719 (MGI:MGI:3656344|PMID:16926417)
GO_REF:0000107
RGD
Ensembl
PMID:16926417 GO_REF:0000107, MGI:MGI:3656344 NCBI chr 3:72,385,678...72,389,245
Ensembl chr 3:72,385,666...72,389,276
JBrowse link
G Prkcq protein kinase C, theta IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3587418|PMID:15263025)
Ensembl
UniProt
RGD
PMID:15263025 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3587418 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Prkcz protein kinase C, zeta ISO
ISS
(MGI:MGI:3584076|PMID:15987782)
GO_REF:0000024
RGD
UniProt
PMID:15987782 GO_REF:0000024, MGI:MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rara retinoic acid receptor, alpha ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Sash3 SAM and SH3 domain containing 3 ISO MGI:MGI:3716944 (MGI:MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:MGI:3607020 NCBI chr  X:134,979,637...134,994,351
Ensembl chr  X:134,979,646...134,994,349
JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO (PMID:24038088) RGD PMID:24038088 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Syk spleen associated tyrosine kinase ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:3831068|PMID:19098920)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19098920 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3831068 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (PMID:18501882)
(MGI:MGI:3763508|PMID:12496423), (MGI:MGI:4942267|PMID:9670042), (MGI:MGI:4943387|PMID:18354165)
RGD PMID:9670042, PMID:12496423, PMID:18354165, PMID:18501882 MGI:MGI:3763508, MGI:MGI:4942267, MGI:MGI:4943387 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Zp3 zona pellucida glycoprotein 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4943411|PMID:15579591)
Ensembl
UniProt
RGD
PMID:15579591 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4943411 NCBI chr12:23,735,225...23,752,734
Ensembl chr12:23,735,223...23,742,190
JBrowse link
regulation of interleukin-4 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 NOT ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO (PMID:20543955) RGD PMID:20543955 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    multicellular organismal process 9068
      cytokine production 838
        interleukin-4 production 42
          negative regulation of interleukin-4 production 8
          positive regulation of interleukin-4 production 26
          regulation of interleukin-4 production + 34
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          gene expression 6294
            cytokine production 838
              interleukin-4 production 42
                negative regulation of interleukin-4 production 8
                positive regulation of interleukin-4 production 26
                regulation of interleukin-4 production + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.