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ONTOLOGY REPORT - ANNOTATIONS


Term:receptor catabolic process
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Accession:GO:0032801 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Synonyms:exact_synonym: receptor breakdown;   receptor catabolism;   receptor degradation


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receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 ISO (PMID:20643123) RGD PMID:20643123 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Capn1 calpain 1 ISO
IEA
(MGI:MGI:3720432|PMID:17529984)
GO_REF:0000107
RGD
Ensembl
PMID:17529984 GO_REF:0000107, MGI:MGI:3720432 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO MGI:MGI:3720892|MGI:MGI:3720937 (MGI:MGI:3720432|PMID:17529984) RGD PMID:17529984 MGI:MGI:3720432 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Kif16b kinesin family member 16B ISO (PMID:15882625) RGD PMID:15882625 NCBI chr 3:136,596,621...136,936,809
Ensembl chr 3:136,657,480...136,936,674
JBrowse link
G Lgmn legumain IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5008720|PMID:21292981)
Ensembl
UniProt
RGD
PMID:21292981 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5008720 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
G Mvb12a multivesicular body subunit 12A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:19,973,611...19,978,479
Ensembl chr16:19,973,636...19,978,478
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase ISO
IBA
(PMID:18544533)
PMID:21873635
RGD PMID:18544533, PMID:21873635 RGD:13792537 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 ISO (PMID:20643123) RGD PMID:20643123 NCBI chr 8:114,300,248...114,350,686
Ensembl chr 8:114,300,257...114,350,681
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 ISO (PMID:20643123) RGD PMID:20643123 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO (PMID:12151385) RGD PMID:12151385 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Snx25 sorting nexin 25 ISO (PMID:21266196)
(MGI:MGI:5545984|PMID:21266196)
RGD PMID:21266196 MGI:MGI:5545984 NCBI chr16:49,328,958...49,432,415
Ensembl chr16:49,350,884...49,432,118
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
ISS
(PMID:17878231)
GO_REF:0000024
RGD
UniProt
PMID:17878231 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Uvrag UV radiation resistance associated ISO (PMID:20643123) RGD PMID:20643123 NCBI chr 1:163,844,804...164,101,568
Ensembl chr 1:163,844,818...164,101,578
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn2 beclin 2 ISO UniProtKB:Q5JY77 (PMID:23954414)
MGI:MGI:5550535 (MGI:MGI:5528919|PMID:23954414)
RGD PMID:23954414 MGI:MGI:5528919 NCBI chr13:93,971,720...93,974,467
Ensembl chr13:93,972,426...93,974,410
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 ISO
IEA
ISS
UniProtKB:A8MW95 (PMID:23954414)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23954414 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:106,306,795...106,313,904
Ensembl chr  X:106,306,795...106,313,853
JBrowse link
low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ISS
ISO
GO_REF:0000024
(PMID:16912035), (PMID:18197702)
PMID:12552133
UniProt
RGD
PMID:16912035, PMID:18197702, PMID:12552133 GO_REF:0000024, RGD:629554 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
negative regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 ISO (PMID:22848640)
(MGI:MGI:5446858|PMID:22848640)
RGD PMID:22848640 MGI:MGI:5446858 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO
IEA
(PMID:16912035)
GO_REF:0000107
RGD
Ensembl
PMID:16912035 GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
negative regulation of receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtmr2 myotubularin related protein 2 IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
positive regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IEA
(PMID:21810484)
GO_REF:0000107
RGD
Ensembl
PMID:21810484 GO_REF:0000107 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Apoe apolipoprotein E ISO
IEA
(PMID:15950758)
GO_REF:0000107
RGD
Ensembl
PMID:15950758 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
positive regulation of receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dtx3l deltex E3 ubiquitin ligase 3L ISO (PMID:24790097) RGD PMID:24790097 NCBI chr11:67,758,093...67,767,623
NCBI chr11:67,768,542...67,772,428
Ensembl chr11:67,757,928...67,767,622
JBrowse link
G Git1 GIT ArfGAP 1 IMP RGD PMID:18523162 RGD:13513208 NCBI chr10:62,656,000...62,664,467
Ensembl chr10:62,656,000...62,664,466
JBrowse link
G Hamp hepcidin antimicrobial peptide ISO (PMID:15514116) RGD PMID:15514116 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO (PMID:24790097) RGD PMID:24790097 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO (PMID:22045810) RGD PMID:22045810 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylip myosin regulatory light chain interacting protein ISO (MGI:MGI:3849777|PMID:19520913) RGD PMID:19520913 MGI:MGI:3849777 NCBI chr17:19,682,040...19,703,681
Ensembl chr17:19,682,040...19,703,681
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ISO MGI:MGI:3577021 (MGI:MGI:3576461|PMID:15805190), (MGI:MGI:3583861|PMID:15741654) RGD PMID:15741654, PMID:15805190 MGI:MGI:3576461, MGI:MGI:3583861 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
Wnt receptor catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf43 ring finger protein 43 ISO
IBA
(PMID:22895187)
PMID:21873635
RGD PMID:22895187, PMID:21873635 RGD:13792537 NCBI chr10:74,956,411...75,028,951
Ensembl chr10:74,959,285...75,028,951
JBrowse link
G Znrf3 zinc and ring finger 3 ISO (PMID:22575959) RGD PMID:22575959 NCBI chr14:85,527,099...85,586,294 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      catabolic process 2543
        cellular catabolic process 2170
          receptor catabolic process 29
            G protein-coupled receptor catabolic process 2
            Wnt receptor catabolic process 2
            low-density lipoprotein particle receptor catabolic process + 6
            negative regulation of receptor catabolic process + 3
            neurotransmitter receptor catabolic process 0
            positive regulation of receptor catabolic process + 8
            regulation of receptor catabolic process + 12
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          cellular macromolecule metabolic process 8535
            receptor metabolic process 191
              receptor catabolic process 29
                G protein-coupled receptor catabolic process 2
                Wnt receptor catabolic process 2
                low-density lipoprotein particle receptor catabolic process + 6
                negative regulation of receptor catabolic process + 3
                neurotransmitter receptor catabolic process 0
                positive regulation of receptor catabolic process + 8
                regulation of receptor catabolic process + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.