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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of natural killer cell activation
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Accession:GO:0032814 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of natural killer cell activation.
Synonyms:exact_synonym: regulation of NK cell activation


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regulation of natural killer cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcaf15 DDB1 and CUL4 associated factor 15 ISO (PMID:31452512) RGD PMID:31452512 NCBI chr19:25,212,469...25,219,803
Ensembl chr19:25,212,661...25,220,010
JBrowse link
G Lep leptin ISO
ISS
(PMID:12504075)
GO_REF:0000024
RGD
UniProt
PMID:12504075 GO_REF:0000024 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 ISO MGI:1922595 (MGI:3836377|PMID:19151721) RGD PMID:19151721 MGI:3836377 NCBI chr13:88,557,361...88,584,078
Ensembl chr13:88,557,860...88,577,691
JBrowse link
G Slamf7 SLAM family member 7 ISO MGI:3622649 (MGI:3836377|PMID:19151721) RGD PMID:19151721 MGI:3836377 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
JBrowse link
negative regulation of natural killer cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clnk cytokine-dependent hematopoietic cell linker ISO (MGI:3047506|PMID:15199160), (MGI:3774350|PMID:16439675) RGD PMID:15199160, PMID:16439675 MGI:3047506, MGI:3774350 NCBI chr14:76,657,165...76,834,050
Ensembl chr14:76,657,311...76,833,161
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISO (MGI:3774350|PMID:16439675) RGD PMID:16439675 MGI:3774350 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO (MGI:5705210|PMID:25337993) RGD PMID:25337993 MGI:5705210 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Lgals9 galectin 9 ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Mill1 MHC I like leukocyte 1 ISO (PMID:20068167) RGD PMID:20068167 NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941
JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 ISO (PMID:12516630) RGD PMID:12516630 NCBI chr15:83,494,110...83,663,202
Ensembl chr15:83,495,377...83,663,143
JBrowse link
G Rhbdd3 rhomboid domain containing 3 ISO MGI:5516031 (MGI:5492204|PMID:23610400) RGD PMID:23610400 MGI:5492204 NCBI chr14:85,350,852...85,357,029
Ensembl chr14:85,351,358...85,357,023
JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 IEA
ISO
GO_REF:0000107
MGI:2670590 (MGI:5297102|PMID:20709292)
Ensembl
RGD
PMID:20709292 GO_REF:0000107, MGI:5297102 NCBI chr 1:79,790,879...79,796,064
Ensembl chr 1:79,790,705...79,796,111
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 ISO MGI:5297105 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 7:14,426,481...14,435,987
Ensembl chr 7:14,429,701...14,435,967
JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 ISO MGI:5297106 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 2:191,903,626...192,264,872
Ensembl chr 2:192,253,629...192,264,840
JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 ISO MGI:5297107 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 2:190,125,655...190,204,230
Ensembl chr 2:190,125,693...190,148,265
JBrowse link
positive regulation of natural killer cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s3 biogenesis of lysosomal organelles complex-1, subunit 3 ISO MGI:1857021 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr 1:80,414,766...80,417,385
Ensembl chr 1:80,415,686...80,416,273
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 ISO MGI:1856982 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr 3:114,869,478...114,880,218
Ensembl chr 3:114,869,459...114,881,590
JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 ISO MGI:1856712 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr 1:261,989,178...262,015,282
Ensembl chr 1:261,989,178...262,015,153
JBrowse link
G Il12a interleukin 12A ISO
IEA
(PMID:1674604)
GO_REF:0000107
RGD
Ensembl
PMID:1674604 GO_REF:0000107 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B ISO (PMID:1674604) RGD PMID:1674604 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Lyst lysosomal trafficking regulator ISO MGI:1855968 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr17:90,323,055...90,522,091 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO (MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:5302428 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 ISO MGI:3701472 (MGI:5293306|PMID:21059856) RGD PMID:21059856 MGI:5293306 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp IBA
ISO
PMID:21873635
(MGI:1276991|PMID:9647200)
RGD PMID:9647200, PMID:21873635 MGI:1276991, RGD:13792537 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
JBrowse link
G Ulbp1 UL16 binding protein 1 ISO (MGI:2450811|PMID:12645935) RGD PMID:12645935 MGI:2450811 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916
JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:41,805,252...41,860,076 JBrowse link
G Cd160 CD160 molecule ISO (PMID:19109136) RGD PMID:19109136 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 ISO (PMID:23632890) RGD PMID:23632890 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 ISO (PMID:27455421) RGD PMID:27455421 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand ISO MGI:2158499 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413
JBrowse link
G Gas6 growth arrest specific 6 ISO
ISS
(PMID:18840707)
GO_REF:0000024
RGD
UniProt
PMID:18840707 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Il15 interleukin 15 ISO MGI:1931086|MGI:2136897 (MGI:3701546|PMID:14607906), (MGI:3703651|PMID:17318811) RGD PMID:14607906, PMID:17318811 MGI:3701546, MGI:3703651 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha ISO MGI:1934016 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr17:70,451,861...70,481,838
Ensembl chr17:70,451,411...70,481,750
JBrowse link
G Il21 interleukin 21 ISO (MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:3028812 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO (MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:5302428 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO MGI:1857249 (MGI:3655409|PMID:9841920) RGD PMID:9841920 MGI:3655409 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B IEA
ISO
GO_REF:0000107
MGI:2181592 (MGI:3655409|PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107, MGI:3655409 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO MGI:3773716 (MGI:4834966|PMID:20818394) RGD PMID:20818394 MGI:4834966 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 ISO (MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:5446979 NCBI chr 6:99,401,775...99,425,739
Ensembl chr 6:99,402,360...99,424,019
JBrowse link
positive regulation of natural killer cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd244 CD244 molecule ISO (MGI:3773416|PMID:15905190) RGD PMID:15905190 MGI:3773416 NCBI chr13:89,959,091...89,995,993
Ensembl chr13:89,975,267...89,995,974
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand IDA RGD PMID:16528542 RGD:11049499 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413
JBrowse link
G Il12b interleukin 12B ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il15 interleukin 15 ISO (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il18 interleukin 18 ISO
IEA
(PMID:19088061)
GO_REF:0000107
RGD
Ensembl
PMID:19088061 GO_REF:0000107 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il23a interleukin 23 subunit alpha ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 ISO (PMID:30134159) RGD PMID:30134159 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Stat5b signal transducer and activator of transcription 5B IEA
ISO
GO_REF:0000107
MGI:2181592 (MGI:3655409|PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107, MGI:3655409 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Prdm1 PR/SET domain 1 ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Zfp683 zinc finger protein 683 ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr 5:152,280,982...152,288,208 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 ISO (MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:5437828 NCBI chr 5:152,280,982...152,288,208 JBrowse link
regulation of natural killer cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lep leptin ISO
ISS
(PMID:12504075)
GO_REF:0000024
RGD
UniProt
PMID:12504075 GO_REF:0000024 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
ISS
(PMID:20522204)
GO_REF:0000024
RGD
BHF-UCL
PMID:20522204 GO_REF:0000024 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    immune system process 2840
      leukocyte activation 1058
        regulation of leukocyte activation 698
          regulation of lymphocyte activation 583
            regulation of natural killer cell activation 46
              negative regulation of natural killer cell activation + 12
              positive regulation of natural killer cell activation + 28
              regulation of natural killer cell degranulation + 5
              regulation of natural killer cell differentiation + 18
              regulation of natural killer cell proliferation + 10
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          regulation of cell activation 744
            regulation of leukocyte activation 698
              regulation of lymphocyte activation 583
                regulation of natural killer cell activation 46
                  negative regulation of natural killer cell activation + 12
                  positive regulation of natural killer cell activation + 28
                  regulation of natural killer cell degranulation + 5
                  regulation of natural killer cell differentiation + 18
                  regulation of natural killer cell proliferation + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.