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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of stress-activated MAPK cascade
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Accession:GO:0032873 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
Synonyms:exact_synonym: down regulation of stress-activated MAPK cascade;   downregulation of stress-activated MAPK cascade;   negative regulation of p38 MAPK signaling;   negative regulation of p38 MAPK signalling;   negative regulation of stress-activated MAPK signaling pathway;   negative regulation of stress-activated MAPK signalling pathway;   negative regulation of stress-activated MAPKKK cascade;   negative regulation of stress-activated MAPKKK signaling pathway;   negative regulation of stress-activated MAPKKK signalling pathway
 narrow_synonym: inhibition of stress-activated MAPK cascade


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negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 ISO MGI:MGI:3052343 (MGI:MGI:4366202|PMID:19696743) RGD PMID:19696743 MGI:MGI:4366202 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Foxm1 forkhead box M1 ISO
IEA
(PMID:19696738)
GO_REF:0000107
RGD
Ensembl
PMID:19696738 GO_REF:0000107 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Foxo1 forkhead box O1 ISO (PMID:19696738) RGD PMID:19696738 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(MGI:MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:16023107 GO_REF:0000024, MGI:MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Igbp1 immunoglobulin binding protein 1 ISO (PMID:17438131) RGD PMID:17438131 NCBI chr  X:70,322,764...70,345,005
Ensembl chr  X:70,322,755...70,345,005
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO (PMID:19545562) RGD PMID:19545562 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pbk PDZ binding kinase ISO MGI:MGI:5293435 (MGI:MGI:5293269|PMID:21715333) RGD PMID:21715333 MGI:MGI:5293269 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Ppia peptidylprolyl isomerase A ISO
ISS
(PMID:26095851)
GO_REF:0000024
RGD
UniProt
PMID:26095851 GO_REF:0000024 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:22,706,906...22,707,648
Ensembl chr14:22,706,901...22,707,668
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO (PMID:11096076) RGD PMID:11096076 NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702
JBrowse link
negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO UniProtKB:O35625 (MGI:MGI:3799599|PMID:17681137) RGD PMID:17681137 MGI:MGI:3799599 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA RGD PMID:17064355 RGD:2298577 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO (MGI:MGI:3693042|PMID:17081782) RGD PMID:17081782 MGI:MGI:3693042 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6162308|PMID:29291351)
(PMID:29291351)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29291351 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6162308 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 ISO
IBA
(PMID:17197390)
PMID:21873635
(MGI:MGI:5437437|PMID:17197390)
RGD PMID:17197390, PMID:21873635 MGI:MGI:5437437, RGD:13792537 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO
IBA
MGI:MGI:3052343 (MGI:MGI:3051749|PMID:15306813)
PMID:21873635
(PMID:10391943)
RGD PMID:10391943, PMID:15306813, PMID:21873635 MGI:MGI:3051749, RGD:13792537 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:MGI:2182169 NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO
IBA
(PMID:11085983), (PMID:19010898)
PMID:21873635
RGD PMID:11085983, PMID:19010898, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fktn fukutin ISO (PMID:18808525) RGD PMID:18808525 NCBI chr 5:70,522,001...70,578,270
Ensembl chr 5:70,528,688...70,578,273
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (PMID:11931768)
(MGI:MGI:6148454|PMID:22424771)
RGD PMID:11931768, PMID:22424771 MGI:MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Hdac3 histone deacetylase 3 IEA
ISO
GO_REF:0000107
(PMID:11931768)
Ensembl
RGD
PMID:11931768 GO_REF:0000107 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO (MGI:MGI:3774677|PMID:18246070) RGD PMID:18246070 MGI:MGI:3774677 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G Klhl31 kelch-like family member 31 ISO (PMID:18719355) RGD PMID:18719355 NCBI chr 8:84,945,444...84,968,811
Ensembl chr 8:84,945,444...84,968,811
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP RGD PMID:12064607 RGD:1299562 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Marveld3 MARVEL domain containing 3 ISO (PMID:24567356) RGD PMID:24567356 NCBI chr19:41,710,076...41,724,923
Ensembl chr19:41,710,102...41,724,923
JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO (PMID:10856240) RGD PMID:10856240 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Men1 menin 1 ISO (PMID:12226747) RGD PMID:12226747 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IEA
ISO
GO_REF:0000107
(PMID:11931768)
Ensembl
RGD
PMID:11931768 GO_REF:0000107 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO MGI:MGI:1100089 (MGI:MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:MGI:5308511 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Per1 period circadian regulator 1 IMP PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Sfrp4 secreted frizzled-related protein 4 IDA RGD PMID:18567805 RGD:4107045 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 IMP PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr18:36,371,041...36,471,020
Ensembl chr18:36,371,041...36,471,015
JBrowse link
G Sirpa signal-regulatory protein alpha ISO
IEA
(MGI:MGI:3760575|PMID:17954568)
GO_REF:0000107
RGD
Ensembl
PMID:17954568 GO_REF:0000107, MGI:MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Taok3 TAO kinase 3 ISO
IEA
(PMID:10559204)
GO_REF:0000107
RGD
Ensembl
PMID:10559204 GO_REF:0000107 NCBI chr12:45,037,951...45,116,593
Ensembl chr12:45,037,883...45,182,974
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 ISO (PMID:20732415) RGD PMID:20732415 NCBI chr17:63,825,616...63,914,740
Ensembl chr17:63,825,627...63,879,171
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO (MGI:MGI:3799599|PMID:17681137)
(PMID:17681137)
RGD PMID:17681137 MGI:MGI:3799599 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 ISO
ISS
(PMID:24512202)
GO_REF:0000024
RGD
UniProt
PMID:24512202 GO_REF:0000024 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO
IBA
MGI:MGI:3052343 (MGI:MGI:3051749|PMID:15306813)
PMID:21873635
(PMID:10391943)
RGD PMID:10391943, PMID:15306813, PMID:21873635 MGI:MGI:3051749, RGD:13792537 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:MGI:2182169 NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(PMID:16636664)
(MGI:MGI:3721484|PMID:12646564), (MGI:MGI:5009198|PMID:10945608), (MGI:MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 GO_REF:0000024, MGI:MGI:3721484, MGI:MGI:5009198, MGI:MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:1913166|PMID:11034606)
Ensembl
RGD
PMID:11034606 GO_REF:0000107, MGI:MGI:1913166 NCBI chr 3:94,349,778...94,419,185
Ensembl chr 3:94,352,969...94,419,048
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP PMID:21076496 RGD
UniProt
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Nppa natriuretic peptide A ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pdcd4 programmed cell death 4 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Serpinb3 serpin family B member 3 ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 ISO
IEA
MGI:MGI:108078|MGI:MGI:1860298 (MGI:MGI:3839161|PMID:19300477)
GO_REF:0000107
RGD
Ensembl
PMID:19300477 GO_REF:0000107, MGI:MGI:3839161 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:MGI:1860298|MGI:MGI:892014 (MGI:MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:MGI:3839161 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 ISO MGI:MGI:108078|MGI:MGI:892014 (MGI:MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:MGI:3839161 NCBI chr 1:261,442,108...261,446,570
Ensembl chr 1:261,442,108...261,446,570
JBrowse link
G Tp73 tumor protein p73 ISO (MGI:MGI:3574697|PMID:15483136) RGD PMID:15483136 MGI:MGI:3574697 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6162308|PMID:29291351)
(PMID:29291351)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29291351 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6162308 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 IEA
ISO
GO_REF:0000107
(PMID:20551903)
Ensembl
RGD
PMID:20551903 GO_REF:0000107 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO
IBA
(PMID:22991462)
PMID:21873635
RGD PMID:22991462, PMID:21873635 RGD:13792537 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:10391943) RGD PMID:10391943 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Ezr ezrin ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO MGI:MGI:1346865 (MGI:MGI:3822965|PMID:18681888) RGD PMID:18681888 MGI:MGI:3822965 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO
IBA
(PMID:23991106)
PMID:21873635
(MGI:MGI:5640942|PMID:23991106)
RGD PMID:23991106, PMID:21873635 MGI:MGI:5640942, RGD:13792537 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      regulation of cellular process 12570
        regulation of cellular response to stress 728
          regulation of stress-activated protein kinase signaling cascade 249
            regulation of stress-activated MAPK cascade 246
              negative regulation of stress-activated MAPK cascade 50
                negative regulation of JNK cascade + 38
                negative regulation of MAPK cascade involved in cell wall organization or biogenesis 0
                negative regulation of p38MAPK cascade 7
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          protein metabolic process 6214
            protein modification process 3937
              cellular protein modification process 3937
                protein phosphorylation 1979
                  signal transduction by protein phosphorylation 851
                    MAPK cascade 841
                      regulation of MAPK cascade 776
                        regulation of stress-activated MAPK cascade 246
                          negative regulation of stress-activated MAPK cascade 50
                            negative regulation of JNK cascade + 38
                            negative regulation of MAPK cascade involved in cell wall organization or biogenesis 0
                            negative regulation of p38MAPK cascade 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.